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Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor Butler, Christopher R.; Popiolek, Michael; McAllister, Laura A.; LaChapelle, Erik A.; Kramer, Melissa; Beck, Elizabeth M.; Mente, Scot; Brodney, Michael A.; Brown, Matthew; Gilbert, Adam; Helal, Chris; Ogilvie, Kevin; Starr, Jeremy; Uccello, Daniel; Grimwood, Sarah; Edgerton, Jeremy; Garst-Orozko, Jonathan; Kozak, Rouba; Lotarski, Susan; Rossi, Amie; Smith, Deborah; O'Connor, Rebecca; Lazzaro, John; Steppan, Claire; Steyn, Stefanus J. 分享 收藏
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Remote monitoring technologies in Alzheimer's disease: design of the RADAR-AD study Muurling, Marijn; de Boer, Casper; Kozak, Rouba; Religa, Dorota; Koychev, Ivan; Verheij, Herman; Nies, Vera J. M.; Duyndam, Alexander; Sood, Meemansa; Froehlich, Holger; Hannesdottir, Kristin; Erdemli, Gul; Lucivero, Federica; Lancaster, Claire; Hinds, Chris; Stravopoulos, Thanos G.; Nikolopoulos, Spiros; Kompatsiaris, Ioannis; Manyakov, Nikolay V.; Owens, Andrew P.; Narayan, Vaibhav A.; Aarsland, Dag; Visser, Pieter Jelle 分享 收藏
Dopaminergic D1 Receptor Stimulation Affects Effort and Risk Preferences Soutschek, Alexander; Gvozdanovic, Geraldine; Kozak, Rouba; Duwuri, Sridhar; de Martinis, Nicholas; Hare, Brian; Gray, David L.; Fehr, Ernst; Jetter, Alexander; Tobler, Philippe N. 分享 收藏
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Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres Yang, Qingyi; Lachapelle, Erik A.; Kablaoui, Natasha M.; Webb, Damien; Popiolek, Michael; Grimwood, Sarah; Kozak, Rouba; O'Connor, Rebecca E.; Lazzaro, John T.; Butler, Christopher R.; Zhang, Lei 分享 收藏
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Social brain, social dysfunction and social withdrawal Porcelli, Stefano; Van der Wee, Nic; van der Werff, Steven; Aghajani, Moji; Glennon, Jeffrey C.; van Heukelum, Sabrina; Mogavero, Floriana; Lobo, Antonio; Olivera, Francisco Javier; Lobo, Elena; Posadas, Mar; Dukart, Juergen; Kozak, Rouba; Arce, Estibaliz; Ikram, Arfan; Vorstman, Jacob; Bilderbeck, Amy; Saris, Ilja; Kas, Martien J.; Serretti, Alessandro 分享 收藏
Relating constructs of attention and working memory to social withdrawal in Alzheimer's disease and schizophrenia: issues regarding paradigm selection Gilmour, Gary; Porcelli, Stefano; Bertaina-Anglade, Valerie; Arce, Estibaliz; Dukart, Juergen; Hayen, Anja; Lobo, Antonio; Lopez-Anton, Raul; Pich, Emilio Merlo; Pemberton, Darrel J.; Havenith, Martha N.; Glennon, Jeffrey C.; Harel, Brian T.; Dawson, Gerard; Marston, Hugh; Kozak, Rouba; Serretti, Alessandro 分享 收藏
Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization Davoren, Jennifer E.; Nason, Deane; Coe, Jotham; Dlugolenski, Keith; Helal, Christopher; Harris, Anthony R.; LaChapelle, Erik; Liang, Sidney; Liu, Yue; O'Connor, Rebecca; Orozco, Christine C.; Rai, Brajesh K.; Salafia, Michelle; Samas, Brian; Xu, Wenjian; Kozak, Rouba; Gray, David 分享 收藏
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Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor D1多巴胺受体的非儿茶酚激动剂导致的 β-抑制蛋白募集受损和脱敏减少 Gray, David L.; Allen, John A.; Mente, Scot; O'Connor, Rebecca E.; DeMarco, George J.; Efremov, Ivan; Tierney, Patrick; Volfson, Dmitri; Davoren, Jennifer; Guilmette, Edward; Salafia, Michelle; Kozak, Rouba; Ehlers, Michael D. 分享 收藏
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