Larissa M. Podust - Publications, H-index & Citations

Larissa M. Podust

eberhard karls university of tubingen

45H指数

144论文数

5.3K被引数

收录论文 60

发表时间

Miconazole-like Scaffold is a Promising Lead for Naegleria fowleri-Specific CYP51 Inhibitors 咪康唑样支架是fowleria特异性CYP51抑制剂的有希望的线索

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-12-12

OAAI

Sharma, Vandna; Madia, Valentina Noemi; Tudino, Valeria; Nguyen, Jennifer V.; Debnath, Anjan; Messore, Antonella; Ialongo, Davide; Patacchini, Elisa; Palenca, Irene; Basili Franzin, Silvia; Seguella, Luisa; Esposito, Giuseppe; Petrucci, Rita; Di Matteo, Paola; Bortolami, Martina; Saccoliti, Francesco; Di Santo, Roberto; Scipione, Luigi; Costi, Roberta; Podust, Larissa M.

Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors 氨基硫脲作为SARS-CoV-2主要蛋白酶抑制剂的基于结构的发现

FUTURE MEDICINAL CHEMISTRY

IF3.4

2023-07-12

PREAI

Maltarollo, Vinicius Goncalves; da Silva, Elany Barbosa; Kronenberger, Thales; Andrade, Marina Mol Sena; Marques, Gabriel V. de Lima; Oliveira, Nereu J. Candido; Santos, Lucianna H.; Rezende Junior, Celso de Oliveira; Martinho, Ana C. Cassiano; Skinner, Danielle; Fajtova, Pavla; Fernandes, Thais H.; dos Santos, Eduardo da Silveira; Gazolla, Poliana A. Rodrigues; de Souza, Ana P. Martins; da Silva, Milene Lopes; dos Santos, Fabiola S.; Lavorato, Stefania N.; Bretas, Ana C. Oliveira; Carvalho, Diogo Teixeira; Franco, Lucas Lopardi; Luedtke, Stephanie; Giardini, Miriam A.; Poso, Antti; Dias, Luiz C.; Podust, Larissa M.; Alves, Ricardo J.; McKerrow, James; Andrade, Saulo F.; Teixeira, Robson R.; Siqueira-Neto, Jair L.; O'Donoghue, Anthony; de Oliveira, Renata B.; Ferreira, Rafaela S.

Structural basis for condensation domain independent amide bond formation in lincosamide antibiotic biosynthesis

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-01-01

OAAI

Heberlig, Graham; Podust, Larissa; Burkart, Michael

Essential Role of Loop Dynamics in Typ e II NRPS Biomolecular Recognition br

ACS CHEMICAL BIOLOGY

IF3.8

2022-09-29

OAAI

Corpuz, Joshua C.; Patel, Ashay; Davis, Tony D.; Podust, Larissa M.; McCammon, J. Andrew; Burkart, Michael D.

Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV-2

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2022-08-12

OAAI

Santos, Lucianna H.; Kronenberger, Thales; Almeida, Renata G.; Silva, Elany B.; Rocha, Rafael E. O.; Oliveira, Joyce C.; Barreto, Luiza, V; Skinner, Danielle; Fajtova, Pavla; Giardini, Miriam A.; Woodworth, Brendon; Bardine, Conner; Lourenco, Andre Luiz; Craik, Charles S.; Poso, Antti; Podust, Larissa M.; McKerrow, James H.; Siqueira-Neto, Jair L.; O'Donoghue, Anthony J.; da Silva Junior, Eufranio N.; Ferreira, Rafaela S.

Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-02-21

PREAI

Da Silva, Elany Barbosa; Sharma, Vandna; Hernandez-Alvarez, Lilian; Tang, Arthur H.; Stoye, Alexander; O'Donoghue, Anthony J.; Gerwick, William H.; Payne, Richard J.; McKerrow, James H.; Podust, Larissa M.

Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole 棘阿米巴CYP51的结构域交换二聚化和艾沙康康唑失活的独特机制

MOLECULAR PHARMACOLOGY

IF3

2020-12-01

OAAI

Sharma, Vandna; Shing, Brian; Hernandez-Alvarez, Lilian; Debnath, Anjan; Podust, Larissa M.

Molecular Basis of Iterative C-H Oxidation by TamI, a Multifunctional P450 Monooxygenase from the Tirandamycin Biosynthetic Pathway TamI迭代c-h氧化的分子基础，TamI是来自替兰霉素生物合成途径的多功能P450单加氧酶

ACS CATALYSIS

IF13.1

2020-11-04

OAAI

Newmister, Sean A.; Srivastava, Kinshuk Raj; Espinoza, Rosa, V; Haatveit, Kersti Caddell; Khatri, Yogan; Martini, Rachel M.; Garcia-Borras, Marc; Podust, Larissa M.; Houk, K. N.; Sherman, David H.

HMG-CoA Reductase Inhibitors as Drug Leads against Naegleria fowleri

ACS CHEMICAL NEUROSCIENCE

IF3.9

2020-09-03

OAAI

Hahn, Hye Jee; Abagyan, Ruben; Podust, Larissa M.; Roy, Shantanu; Ali, Ibne Karim M.; Debnath, Anjan

The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2020-04-21

OAAI

Shing, Brian; Singh, Seema; Podust, Larissa M.; McKerrow, James H.; Debnath, Anjan

Mechanistic Insights into Cytochrome P450 Inactivation by Azole Drugs in Acanthamoeba castellanii

FASEB JOURNAL

IF4.2

2020-04-19

PREAI

Sharma, Vandna; Shing, Brian; Debnath, Anjan; Podust, Larissa

Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis

RSC CHEMICAL BIOLOGY

IF3.1

2020-01-01

OAAI

Corpuz, Joshua C.; Podust, Larissa M.; Davis, Tony D.; Jaremko, Matt J.; Burkart, Michael D.

Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2019-11-01

OAAI

DeMars, Matthew D., II; Samora, Nathan L.; Yang, Song; Garcia-Borras, Marc; Sanders, Jacob N.; Houk, K. N.; Podust, Larissa M.; Sherman, David H.

Identification of Four Amoebicidal Nontoxic Compounds by a Molecular Docking Screen of Naegleria fowleri Sterol Δ8-Δ7-Isomerase and Phenotypic Assays

ACS INFECTIOUS DISEASES

IF3.8

2019-10-04

OAAI

Shi, Da; Chahal, Kirti Kandhwal; Oto, Patricia; Nothias, Louis-Felix; Debnath, Anjan; McKerrow, James H.; Podust, Larissa M.; Abagyan, Ruben

Short-lived neutral FMN and FAD semiquinones are transient intermediates in cryo-reduced yeast NADPH-cytochrome P450 reductase

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

IF3

2019-09-01

OAAI

Davydov, Roman M.; Jennings, Gareth; Hoffman, Brian M.; Podust, Larissa M.

Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-innidazole Derivatives as Antiprotozoal Agents

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-01-07

PREAI

Saccoliti, Francesco; Madia, Valentina Noemi; Tudino, Valeria; De Leo, Alessandro; Pescatori, Luca; Messore, Antonella; De Vita, Daniela; Scipione, Luigi; Brun, Reto; Kaiser, Marcel; Maser, Pascal; Calvet, Claudia M.; Jennings, Gareth K.; Podust, Larissa M.; Pepe, Giacomo; Cirilli, Roberto; Faggi, Cristina; Di Marco, Annalise; Battista, Maria Rosaria; Summa, Vincenzo; Costi, Roberta; Di Santo, Roberto

Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri

PLOS PATHOGENS

IF4.9

2018-09-13

OAAI

Zhou, Wenxu; Debnath, Anjan; Jennings, Gareth; Hahn, Hye Jee; Vanderloop, Boden H.; Chaudhuri, Minu; Nes, W. David; Podust, Larissa M.

Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2018-08-01

PREAI

Saccoliti, Francesco; Madia, Valentina Noemi; Tudino, Valeria; De Leo, Alessandro; Pescatori, Luca; Messore, Antonella; De Vita, Daniela; Scipione, Luigi; Brun, Reto; Kaiser, Marcel; Maser, Pascal; Calvet, Claudia Magalhaes; Jennings, Gareth K.; Podust, Larissa M.; Costi, Roberta; Di Santo, Roberto

4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2017-12-27

OAAI

Calvet, Claudia Magalhaes; Choi, Jun Yong; Thomas, Diane; Suzuki, Brian; Hirata, Ken; Lostracco-Johnson, Sharon; de Mesquita, Liliane Batista; Nogueira, Alanderson; Meuser-Batista, Marcelo; Silva, Tatiana Araujo; Siqueira-Neto, Jair Lage; Roush, William R.; de Souza Pereira, Mirian Claudia; McKerrow, James H.; Podust, Larissa M.

Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2017-07-13

OAAI

Long, Thavy; Rojo-Arreola, Liliana; Shi, Da; El-Sakkary, Nelly; Jarnagin, Kurt; Rock, Fernando; Meewan, Maliwan; Rascon, Alberto A., Jr.; Lin, Lin; Cunningham, Katherine A.; Lemieux, George A.; Podust, Larissa; Abagyan, Ruben; Ashrafi, Kaveh; McKerrow, James H.; Caffrey, Conor R.

研究方向