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Evofosfamide and Gemcitabine Act Synergistically in Pancreatic Cancer Xenografts by Dual Action on Tumor Vasculature and Inhibition of Homologous Recombination DNA Repair Otowa, Yasunori; Kishimoto, Shun; Saida, Yu; Yamashita, Kota; Yamamoto, Kazutoshi; Chandramouli, Gadisetti V. R.; Devasahayam, Nallathamby; Mitchell, James B.; Krishna, Murali C.; Brender, Jeffrey R. 分享 收藏
Inhibition of USP14 promotes TNFα-induced cell death in head and neck squamous cell carcinoma (HNSCC) Morgan, Ethan L. L.; Toni, Tiffany; Viswanathan, Ramya; Robbins, Yvette; Yang, Xinping; Cheng, Hui; Gunti, Sreenivasulu; Huynh, Angel; Sowers, Anastasia L. L.; Mitchell, James B. B.; Allen, Clint T. T.; Chen, Zhong; Van Waes, Carter 分享 收藏
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PEGPH20, a PEGylated human hyaluronidase, induces radiosensitization by reoxygenation in pancreatic cancer xenografts. A molecular imaging study Seki, Tomohiro; Saida, Yu; Kishimoto, Shun; Lee, Jisook; Otowa, Yasunori; Yamamoto, Kazutoshi; Chandramouli, Gadisetti V. R.; Devasahayam, Nallathamby; Mitchell, James B.; Krishna, Murali C.; Brender, Jeffery R. 分享 收藏
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Pharmacological Inhibition of HSP90 Radiosensitizes Head and Neck Squamous Cell Carcinoma Xenograft by Inhibition of DNA Damage Repair, Nucleotide Metabolism, and Radiation-Induced Tumor Vasculogenesis Naz, Sarwat; Leiker, Andrew J.; Choudhuri, Rajani; Preston, Olivia; Sowers, Anastasia L.; Gohain, Sangeeta; Gamson, Janet; Mathias, Askale; Van Waes, Carter; Cook, John A.; Mitchell, James B. 分享 收藏
Real-Time insight into in vivo redox status utilizing hyperpolarized [1-13C] N-acetyl cysteine Yamamoto, Kazutoshi; Opina, Ana; Sail, Deepak; Blackman, Burchelle; Saito, Keita; Brender, Jeffrey R.; Malinowski, Ronja M.; Seki, Tomohiro; Oshima, Nobu; Crooks, Daniel R.; Kishimoto, Shun; Saida, Yu; Otowa, Yasunori; Choyke, Peter L.; Ardenkjaer-Larsen, Jan H.; Mitchell, James B.; Linehan, W. Marston; Swenson, Rolf E.; Krishna, Murali C. 分享 收藏
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Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy 肿瘤中LDH抑制的动态成像揭示了快速的体内代谢重组和对联合治疗的脆弱性 Oshima, Nobu; Ishida, Ryo; Kishimoto, Shun; Beebe, Kristin; Brender, Jeffrey R.; Yamamoto, Kazutoshi; Urban, Daniel; Rai, Ganesha; Johnson, Michelle S.; Benavides, Gloria; Squadrito, Giuseppe L.; Crooks, Dan; Jackson, Joseph; Joshi, Abhinav; Mott, Bryan T.; Shrimp, Jonathan H.; Moses, Michael A.; Lee, Min-Jung; Yuno, Akira; Lee, Tobie D.; Hu, Xin; Anderson, Tamara; Kusewitt, Donna; Hathaway, Helen H.; Jadhav, Ajit; Picard, Didier; Trepel, Jane B.; Mitchell, James B.; Stott, Gordon M.; Moore, William; Simeonov, Anton; Sklar, Larry A.; Norenberg, Jeffrey P.; Linehan, W. Marston; Maloney, David J.; Dang, Chi V.; Waterson, Alex G.; Hall, Matthew; Darley-Usmar, Victor M.; Krishna, Murali C.; Neckers, Leonard M. 分享 收藏
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Synthesis and evaluation of 13C-labeled 5-5-dimethyl-1-pyrroline-N-oxide aimed at in vivo detection of reactive oxygen species using hyperpolarized 13C-MRI 合成和评估13c标记的5-二甲基-1-吡咯啉-n-氧化物，旨在使用超极化13C-MRI体内检测活性氧 Saito, Keita; Sail, Deepak; Yamamoto, Kazutoshi; Matsumoto, Shingo; Blackman, Burchelle; Kishimoto, Shun; Brender, Jeffrey R.; Swenson, Rolf E.; Mitchell, James B.; Krishna, Murali C. 分享 收藏
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A Multimodal Molecular Imaging Study Evaluates Pharmacological Alteration of the Tumor Microenvironment to Improve Radiation Response Takakusagi, Yoichi; Naz, Sarwat; Takakusagi, Kaori; Ishima, Masahiro; Murata, Hiroshi; Ohta, Keisuke; Miura, Masahiko; Sugawara, Fumio; Sakaguchi, Kengo; Kishimoto, Shun; Munasinghe, Jeeva P.; Mitchell, James B.; Krishna, Murali C. 分享 收藏
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Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Matsumoto, Shingo; Kishimoto, Shun; Saito, Keita; Takakusagi, Yoichi; Munasinghe, Jeeva P.; Devasahayam, Nallathamby; Hart, Charles P.; Gillies, Robert J.; Mitchell, James B.; Krishna, Murali C. 分享 收藏
Evaluation of a novel LDH inhibitor efficacy in vivo in a glycolytic cancer model using hyperpolarized 13C magnetic resonance imaging Oshima, Nobu; Kishimoto, Shun; Beebe, Kristin; Crooks, Dan; Moses, Michael; Yamamoto, Kazutoshi; Brender, Jeffry R.; Sowers, Anastasia; Rai, Ganesha; Urban, Daniel; Benavides, Goria; Squadrito, Giuseppe; Darley-Usmar, Victor; Hall, Matthew; Mitchell, James B.; Krishna, Murali C.; Neckers, Leonard M. 分享 收藏
Hyperpolarized [1-13C]-pyruvate/lactate magnetic resonance spectroscopic imaging of prostate cancer in vivo predicts response to lactate dehydrogenase inhibition Scroggins, Bradley T.; Matsuo, Masayuki; White, Ayla O.; Saito, Keita; Munasinghe, Jeeva P.; Sourbier, Carole; Yamamoto, Kazutoshi; Diaz, Vivian; Mitchell, James B.; Krishna, Murali C.; Citrin, Deborah E. 分享 收藏
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