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J

Ján Dušek

Charles University

26H指数
163论文数
2.1K被引数
收录论文 47
发表时间
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Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene RegulationPXR拮抗剂MI891和PXR降解剂MI1013的发现及其在肝脏基因调控中的作用
errJournal of Medicinal Chemistry
IF6.8
err2025-07-12
err0
errOAAI
errRajamanikkam Kamaraj; Ivana Mejdrová; Maria Krutakova; Tomas Smutny; Kryštof Škach; Klara Dohnalova; Lucie Smutna; Dharani Sai Sreekanth Nellore; Jan Dusek; Karel Chalupsky; Jana Hricová; Thales Kronenberger; Aaron Stahl; Markus Templin; Albert Braeuning; Radim Nencka; Petr Pavek
err分享
err收藏
An immersed boundary method for particle-resolved simulations of arbitrary-shaped rigid particles
errINTERNATIONAL JOURNAL OF MULTIPHASE FLOW
IF3.8
err2025-07-01
err0
PREAI
errSchenk, Maximilian; Garcia-Villalba, Manuel; Dusek, Jan; Uhlmann, Markus; Moriche, Manuel
err分享
err收藏
Freely falling cylinders of length to diameter ratio around one
errINTERNATIONAL JOURNAL OF MULTIPHASE FLOW
IF3.8
err2025-03-01
err0
PREAI
errBouchet, G.; Dusek, J.
err分享
err收藏
The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia modelMI-883（一种CAR激动剂/PXR拮抗剂）在饮食诱导的高胆固醇血症模型中的降脂效果
errNATURE COMMUNICATIONS
IF15.7
err2025-02-06
err0
errOAAI
errDusek, Jan; Mejdrova, Ivana; Dohnalova, Klara; Smutny, Tomas; Chalupsky, Karel; Krutakova, Maria; Skoda, Josef; Rashidian, Azam; Pavkova, Ivona; Skach, Krystof; Hricova, Jana; Chocholouskova, Michaela; Lenicek, Martin; Pijnenburg, Dirk; van Beuningen, Rinie; Holcapek, Michal; Ingelman-Sundberg, Magnus; Burk, Oliver; Kronenberger, Thales; Nencka, Radim; Pavek, Petr
err分享
err收藏
Dexamethasone Acetate-Loaded PLGA Nanospheres Targeting Liver Macrophages
errMACROMOLECULAR BIOSCIENCE
IF4.1
err2024-11-29
err1
PREAI
errBoltnarova, Barbora; Durinova, Anna; Jandova, Lenka; Micuda, Stanislav; Kucera, Otto; Pavkova, Ivona; Machacek, Miloslav; Nemeckova, Ivana; Vojta, Marek; Dusek, Jan; Krutakova, Maria; Nachtigal, Petr; Pavek, Petr; Holas, Ondrej
err分享
err收藏
Path instabilities of freely falling oblong cylinders
errJOURNAL OF FLUID MECHANICS
IF3.9
err2024-11-27
err1
errOAAI
errBouchet, G.; Dusek, J.
err分享
err收藏
Filling the Blank Space: Branched 4-Nonylphenol Isomers Are Responsible for Robust Constitutive Androstane Receptor (CAR) Activation by Nonylphenol填补空白: 支链4-壬基酚异构体负责壬基酚对组成性雄烷受体 (CAR) 的激活
errENVIRONMENTAL SCIENCE & TECHNOLOGY
IF11.3
err2024-04-09
err0
PREAI
errRashidian, Azam; Dusek, Jan; Drastik, Martin; Smutna, Lucie; Fritsche, Kristin; Braeuning, Albert; Pijnenburg, Dirk; van Beuningen, Rinie; Honkakoski, Paavo; Poso, Antti; Kronenberger, Thales; Pavek, Petr
err分享
err收藏
Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-12-29
err1
errOAAI
errKarabanovich, Galina; Fabianova, Viktoria; Vocat, Anthony; Dusek, Jan; Valaskova, Lenka; Stolarikova, Jirina; Kitson, Russell R. A.; Pavek, Petr; Vavrova, Katerina; Djaout, Kamel; Mikusova, Katarina; Baulard, Alain R.; Cole, Stewart T.; Kordulakova, Jana; Roh, Jaroslav
err分享
err收藏
Comparison of HepaRG and HepG2 cell lines to model mitochondrial respiratory adaptations in non-alcoholic fatty liver disease
errINTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
IF5.8
err2023-12-22
err5
errOAAI
errMaseko, Tumisang Edward; Elkalaf, Moustafa; Peterova, Eva; Lotkova, Halka; Stankova, Pavla; Melek, Jan; Dusek, Jan; Zadnikova, Petra; Cizkova, Dana; Bezrouk, Ales; Pavek, Petr; Cervinkova, Zuzana; Kucera, Otto
err分享
err收藏
2-Substituted quinazolines: Partial agonistic and antagonistic ligands of the constitutive androstane receptor (CAR)
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2023-11-01
err6
PREAI
errBrozova, Zuzana Rania; Dusek, Jan; Palsa, Norbert; Maixnerova, Jana; Kamaraj, Rajamanikkam; Smutna, Lucie; Matous, Petr; Braeuning, Albert; Pavek, Petr; Kunes, Jiri; Gathergood, Nicholas; Spulak, Marcel; Pour, Milan; Carazo, Alejandro
err分享
err收藏
Carvedilol impairs bile acid homeostasis in mice: implication for nonalcoholic steatohepatitis卡维地洛损害小鼠的胆汁酸稳态: 对非酒精性脂肪性肝炎的影响
errTOXICOLOGICAL SCIENCES
IF4.1
err2023-08-26
err3
errOAAI
errLastuvkova, Hana; Nova, Zuzana; Hroch, Milos; Faradonbeh, Fatemeh Alaei; Schreiberova, Jolana; Mokry, Jaroslav; Faistova, Hana; Stefela, Alzbeta; Dusek, Jan; Kucera, Otto; Hyspler, Radomir; Dohnalkova, Ester; Bayer, Rachel L.; Hirsova, Petra; Pavek, Petr; Micuda, Stanislav
err分享
err收藏
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-02-09
err5
errOAAI
errMejdrova, Ivana; Dusek, Jan; Skach, Krystof; Stefela, Alzbeta; Skoda, Josef; Chalupsky, Karel; Dohnalova, Klara; Pavkova, Ivona; Kronenberger, Thales; Rashidian, Azam; Smutna, Lucie; Duchoslav, Vojtech; Smutny, Tomas; Pavek, Petr; Nencka, Radim
err分享
err收藏
Real-time monitoring of Metridia luciferase release from cells upon interaction with model toxic substances by a fully automatic flow setup - A proof of concept
errTALANTA
IF6.1
err2022-08-01
err1
PREAI
errMartinez, Maite V. Aguinaga; Jozicova, Natali; Dusek, Jan; Horstkotte, Burkhard; Pavek, Petr; Miro, Manuel; Sklenarova, Hana
err分享
err收藏
Secondary instabilities in Taylor-Couette flow of shear-thinning fluids
errJOURNAL OF FLUID MECHANICS
IF3.9
err2021-12-17
err3
errOAAI
errTopayev, S.; Nouar, C.; Dusek, J.
err分享
err收藏
Measurement-Based Domain Parameter Optimization in Electrical Impedance Tomography Imaging电阻抗层析成像中基于测量的域参数优化
errSENSORS
IF3.5
err2021-04-03
err25
errOAAI
errDusek, Jan; Mikulka, Jan
err分享
err收藏
A single oblate spheroid settling in unbounded ambient fluid: A benchmark for simulations in steady and unsteady wake regimes
errINTERNATIONAL JOURNAL OF MULTIPHASE FLOW
IF3.8
err2021-03-01
err17
errOAAI
errMoriche, Manuel; Uhlmann, Markus; Dusek, Jan
err分享
err收藏
Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain
errCELLS
IF5.2
err2020-11-24
err9
errOAAI
errSkoda, Josef; Dusek, Jan; Drastik, Martin; Stefela, Alzbeta; Dohnalova, Klara; Chalupsky, Karel; Smutny, Tomas; Micuda, Stanislav; Gerbal-Chaloin, Sabine; Pavek, Petr
err分享
err收藏
The 3′-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids
errACTA PHARMACEUTICA SINICA B
IF14.6
err2020-01-01
err22
errOAAI
errSmutny, Tomas; Dusek, Jan; Hyrsova, Lucie; Nekvindova, Jana; Horvatova, Alzbeta; Micuda, Stanislav; Gerbal-Chaloin, Sabine; Pavek, Petr
err分享
err收藏
Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-D-ribofuranose 2′-Oxidase
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2019-08-08
err41
PREAI
errKarabanovich, Galina; Dusek, Jan; Savkova, Karin; Pavlis, Oto; Pavkova, Ivona; Korabecny, Jan; Kucera, Tomas; Vlckova, Hana Kocova; Huszar, Stanislav; Konyarikova, Zuzana; Konecna, Klara; Jand'ourek, Ondrej; Stolarikova, Jirina; Kordulakova, Jana; Vavrova, Katerina; Pavek, Petr; Klimesova, Vera; Hrabalek, Alexandr; Mikusova, Katarina; Roh, Jaroslav
err分享
err收藏
Path instabilities of oblate spheroids
errJOURNAL OF FLUID MECHANICS
IF3.9
err2017-11-06
err24
PREAI
errZhou, W.; Chrust, M.; Dusek, J.
err分享
err收藏

研究方向

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合作学者
合作期刊
S
Stewart T. Cole
H 指数: 113 · 论文数: 497
J
Jacques Pelon
H 指数: 58 · 论文数: 433
R
Robert M. Banta
H 指数: 57 · 论文数: 238
C
Cyrille Flamant
H 指数: 56 · 论文数: 499
M
Manuel Miró
H 指数: 47 · 论文数: 545
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