Martijn J. van Hemert - Publications, H-index & Citations

Martijn J. van Hemert

leiden university

31H指数

112论文数

5.7K被引数

收录论文 48

发表时间

4-Octyl itaconate blocks STAT3-induced ACE2 expression to reduce uptake of SARS-CoV-2 4-辛基衣康酸酯通过阻断STAT3诱导的ACE2表达来减少SARS-CoV-2的摄取

Biochemical Pharmacology

IF5.6

2026-04-25

OAAI

Hauke J. Weiss; Alexander Hooftman; Clarisse Salgado-Benvindo; Robbert Boudewijns; Laurens Liesenborghs; Tristram A.J. Ryan; Demi van der Horst; Madalina E. Carter-Timofte; Hossam Gewaid; Andrew Bowie; Hendrik Jan Thibaut; Kai Dallmeier; David Olagnier; Martijn J. van Hemert; Luke A.J. O’Neill

Peptidomimetic Phenoxymethyl Ketone Warheads as Potent Dual-Mode Inhibitors against SARS-CoV-2 Mpro and Cathepsin 肽模拟物苯氧甲基酮基作为对SARS-CoV-2 Mpro和Cathepsin的强效双模式抑制剂

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-05-26

OAAI

Porzberg, Miriam R. B.; Groenewold, G. J. Mirjam; Lyoo, Heyrhyoung; Jakob, Alexander K. M. H.; Titulaer, Willem H. C.; Cavina, Lorenzo; Poelaert, Katrien C. K.; Zwaagstra, Marleen; Dieteren, Cindy E. J.; Lemmers, Jaap G. H.; Hamdani, S. Hakim; van Buuren, Bernd N. M.; Ackerschott, Bart; Platteeuw, Johannes; Michorius, Joey; Martina, Byron E. E.; Feiters, Martin C.; Girones, Daniel; van Kuppeveld, Frank J. M.; van Hemert, Martijn J.; Rutjes, Floris P. J. T.

Attenuating Mutations in Usutu Virus: Towards Understanding Orthoflavivirus Virulence Determinants and Live Attenuated Vaccine Design Usutu病毒衰减突变：阐明正黄病毒属毒力决定因素及减毒活疫苗设计

VACCINES

IF3.4

2025-05-03

OAAI

Duyvestyn, Johanna M.; Bredenbeek, Peter J.; Gruters, Marie J.; Tas, Ali; Nelemans, Tessa; Kikkert, Marjolein; van Hemert, Martijn J.

Usutu virus NS4A induces autophagy and is targeted by the selective autophagy receptor p62/SQSTM1 for degradation 乌斯图病毒NS4A诱导自噬，并被选择性自噬受体p62/SQSTM1靶向降解。

VIROLOGY JOURNAL

IF3.8

2025-04-17

OAAI

Nelemans, Tessa; Tas, Ali; de Beijer, Nina L.; Janssen, George M. C.; van Veelen, Peter A.; van Hemert, Martijn J.; Kikkert, Marjolein

Temperature-driven Modulation of Airway Epithelial Cell Composition and Host Responses: Implications for Chronic Obstructive Pulmonary Disease (COPD)

EUROPEAN RESPIRATORY JOURNAL

IF21

2024-10-30

PREAI

Wessels, Lars A.; Ninaber, Dennis K.; Thaler, Melissa; Wang, Ying; Van Hemert, Martijn J.; Nawroth, Janna C.; Hiemstra, Pieter S.; Faiz, Alen; van der Does, Anne M.

Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α-Glucosidase II Inhibitor, Blocks Replication of SARS-CoV-2 and Other Coronaviruses

ACS CENTRAL SCIENCE

IF10.4

2024-07-25

OAAI

Thaler, Melissa; Ofman, Tim P.; Kok, Ken; Heming, Jurriaan J. A.; Moran, Elisha; Pickles, Isabelle; Leijs, Anouk A.; van den Nieuwendijk, Adrianus M. C. H.; van den Berg, Richard J. B. H. N.; Ruijgrok, Gijs; Armstrong, Zachary; Salgado-Benvindo, Clarisse; Ninaber, Dennis K.; Snijder, Eric J.; van Boeckel, Constant A. A.; Artola, Marta; Davies, Gideon J.; Overkleeft, Herman S.; van Hemert, Martijn J.

Highly Potent Antisense Oligonucleotides Locked Nucleic Acid Gapmers Targeting the SARS-CoV-2 RNA Genome 靶向SARS-CoV-2 RNA基因组的高效反义寡核苷酸锁核酸Gapmers

NUCLEIC ACID THERAPEUTICS

IF4.7

2023-12-01

OAAI

Dauksaite, Vita; Tas, Ali; Wachowius, Falk; Spruit, Anouk; van Hemert, Martijn J.; Snijder, Eric J.; van der Veer, Eric P.; van Zonneveld, Anton Jan

Voclosporin and the Antiviral Effect Against SARS-CoV-2 in Immunocompromised Kidney Patients

KIDNEY INTERNATIONAL REPORTS

IF5.7

2023-12-01

OAAI

Arends, Eline J.; Meziyerh, Soufian; Moes, Dirk Jan A. R.; Kamerling, Sylvia W. A.; van der Kooy, Sandra; Ogando, Natacha S.; Snijder, Eric J.; van Hemert, Martijn; Visser, Leo G.; Feltkamp, Mariet C. W.; Claas, Eric C. J.; Rabelink, Ton J.; van Kooten, Cees; de Vries, Aiko P. J.; Teng, Y. K. Onno

Honokiol Inhibits SARS-CoV-2 Replication in Cell Culture at a Post-Entry Step

MICROBIOLOGY SPECTRUM

IF3.8

2023-06-15

OAAI

Salgado-Benvindo, Clarisse; Leijs, Anouk A.; Thaler, Melissa; Tas, Ali; Arbiser, Jack L.; Snijder, Eric J.; van Hemert, Martijn J.

Novel approaches for the rapid development of rationally designed arbovirus vaccines

ONE HEALTH

IF4.5

2023-06-01

OAAI

van Bree, Joyce W. M.; Visser, Imke; Duyvestyn, Jo M.; Aguilar-Bretones, Muriel; Marshall, Eleanor M.; van Hemert, Martijn J.; Pijlman, Gorben P.; van Nierop, Gijsbert P.; Kikkert, Marjolein; Rockx, Barry H. G.; Miesen, Pascal; Fros, Jelke J.

The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling

PLOS PATHOGENS

IF4.9

2023-02-27

OAAI

Treffers, Emmely E. E.; Tas, Ali; Scholte, Florine E. M.; de Ru, Arnoud H. H.; Snijder, Eric J. J.; van Veelen, Peter A. A.; van Hemert, Martijn J. J.

Developing advanced cell culture models to study COVID-19-associated pulmonary fibrosis

EUROPEAN RESPIRATORY JOURNAL

IF21

2022-12-01

PREAI

Liu, S.; Wang, Y.; Thaler, M.; Van Schadewijk, A.; Van Huizen, M.; Cohen, D.; Kikkert, M.; Van Hemert, M. J.; Ten Dijke, P.; Hiemstra, P. S.; Van Der Does, A. M.

RNA sequencing unravels unique host transcriptional responses to infection with SARS-CoV-2 in well differentiated primary human bronchial epithelial cells compared to other coronaviruses

EUROPEAN RESPIRATORY JOURNAL

IF21

2022-12-01

PREAI

Wang, Y.; Thaler, M.; Salgado-Benvindo, C.; Ly, N.; Leijs, A. A.; Ninaber, D. K.; Van Hemert, M. J.; Hiemstra, P. S.; Van Der Does, A. M.; Faiz, A.

SARS-CoV-2-specific CD4+ and CD8+ T cell responses can originate from cross- reactive CMV- specific T cells

ELIFE

IF0

2022-11-21

OAAI

Pothast, Cilia R.; Dijkland, Romy C.; Thaler, Melissa; Hagedoorn, Renate S.; Kester, Michel G. D.; Wouters, Anne K.; Hiemstra, Pieter S.; van Hemert, Martijn J.; Gras, Stephanie; Falkenburg, J. H. Frederik; Heemskerk, Mirjam H. M.

SHAPE-guided RNA structure homology search and motif discovery

NATURE COMMUNICATIONS

IF15.7

2022-03-31

OAAI

Morandi, Edoardo; van Hemert, Martijn J.; Incarnato, Danny

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2022-02-10

139

OAAI

Luttens, Andreas; Gullberg, Hjalmar; Abdurakhmanov, Eldar; Duy Duc Vo; Akaberi, Dario; Talibov, Vladimir O.; Nekhotiaeva, Natalia; Vangeel, Laura; De Jonghe, Steven; Jochmans, Dirk; Krambrich, Janina; Tas, Ali; Lundgren, Bo; Gravenfors, Ylva; Craig, Alexander J.; Atilaw, Yoseph; Sandstrom, Anja; Moodie, Lindon W. K.; Lundkvist, Ake; van Hemert, Martijn J.; Neyts, Johan; Lennerstrand, Johan; Kihlberg, Jan; Sandberg, Kristian; Danielson, U. Helena; Carlsson, Jens

Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication 1-杂芳基-2-烷氧基苯基类似物作为SARS-CoV-2复制抑制剂的合成，构效关系和抗病毒谱

MOLECULES

IF4.6

2022-02-04

OAAI

Bardiot, Dorothee; Vangeel, Laura; Koukni, Mohamed; Arzel, Philippe; Zwaagstra, Marleen; Lyoo, Heyrhyoung; Wanningen, Patrick; Ahmad, Shamshad; Zhang, Linlin; Sun, Xinyuanyuan; Delpal, Adrien; Eydoux, Cecilia; Guillemot, Jean-Claude; Lescrinier, Eveline; Klaassen, Hugo; Leyssen, Pieter; Jochmans, Dirk; Castermans, Karolien; Hilgenfeld, Rolf; Robinson, Colin; Decroly, Etienne; Canard, Bruno; Snijder, Eric J.; van Hemert, Martijn J.; van Kuppeveld, Frank; Chaltin, Patrick; Neyts, Johan; De Jonghe, Steven; Marchand, Arnaud

Impact of cellular composition on SARS-CoV-2 infection biology and pathogenesis in primary human airway epithelial cells

EUROPEAN RESPIRATORY JOURNAL

IF21

2021-11-25

PREAI

Wang, Ying; Thaler, Melissa; Ninaber, Dennis K.; Van der Does, Anne M.; Ogando, Natacha S.; Beckert, Hendrik; Taube, Christian; Da Silva, Clarisse Salgado Benvindo; Bredenbeek, Peter J.; Hiemstra, Pieter S.; Van Hemert, Martijn J.

LSC-2021-Use of differentiated primary human airway epithelial models to study SARSCoV-2 infection biology and pathogenesis

EUROPEAN RESPIRATORY JOURNAL

IF21

2021-11-25

PREAI

Ying, Wang; Thaler, Melissa; Ninaber, Dennis K.; Van der Does, Anne M.; Ogando, Natacha S.; Beckert, Hendrik; Taube, Christian; Da Silva, Clarisse Salgado Benvindo; Bredenbeek, Peter J.; Hiemstra, Pieter S.; Van Hemert, Martijn J.

Tomatidine reduces Chikungunya virus progeny release by controlling viral protein expression

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2021-11-11

OAAI

Troost-Kind, Berit; van Hemert, Martijn J.; van de Pol, Denise; van der Ende-Metselaar, Heidi; Merits, Andres; Borggrewe, Malte; Rodenhuis-Zybert, Izabela A.; Smit, Jolanda M.

研究方向