Metabolism-based drug-drug interactionsDrug-induced liver toxicityMolecular mechanisms of xenobiotic receptor-mediated transcriptional regulationcytochrome P450s and uptake/efflux transportersRoles of specific P450s (e.g. CYP2B6 and CYP3A4)Roles of transporters (e.g. BCRP and BSEP)Effects of xenobiotic receptors on energy homeostasisEffects on cell proliferation