Thomas N. Kakuda - Publications, H-index & Citations

Thomas N. Kakuda

johnson & johnson

35H指数

157论文数

4.3K被引数

收录论文 41

发表时间

Viral Dynamic Model-Informed Dose Selection of Mosnodenvir Prophylaxis against DENV-3 in a Controlled Human Infection Model 基于病毒动力学模型的莫索诺韦尔预防登革热3型病毒感染剂量选择：一项受控人类感染模型研究

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2026-08-11

OAAI

Nele Goeyvaerts; Xavier Woot de Trixhe; Martine Neyens; Thomas N. Kakuda; Liesbeth Van Wesenbeeck; Annemie Buelens; Freya Rasschaert; Anna Durbin; Oliver Ackaert

Corrigendum to “Peginterferon-alpha-2a add-on to treatment with siRNA JNJ-73763989 in virologically suppressed chronic hepatitis B: The phase II PENGUIN study” [JHEP Reports 2025 7(10) 101516]勘误：“Peginterferon-alpha-2a add-on to treatment with siRNA JNJ-73763989 in virologically suppressed chronic hepatitis B: The phase II PENGUIN study” [JHEP Reports 2025 7(10) 101516]

JHEP Reports

IF7.5

2025-11-24

OAAI

Edward Gane; Ewa Janczewska; Tetsuo Takehara; Wan-Long Chuang; Cheng-Yuan Peng; Maria Hlebowicz; Yasuhiro Asahina; Ting-Tsung Chang; Ronald Kalmeijer; John Jezorwski; Gloria Kim; Zacharias Anastasiou; Thomas N. Kakuda; Thierry Verbinnen; Nonko Pehlivanov; Adam Bakala; Oliver Lenz; Michael Biermer

Translational and clinical development of therapeutic siRNA and ASOs: current industry practices, perspectives, and recommendations 治疗性siRNA和ASOs的转化与临床开发：当前行业实践、观点和建议

NUCLEIC ACIDS RESEARCH

IF13.1

2025-10-14

PREAI

Christensen, Jesper Kammersgaard; Colletti, Nicholas; Hooshfar, Shirin; Jiang, Rongrong(Rosa); Kuo, Carol; Lindmark, Bosse; Lumen, Annie; Youssef, Amir S.; Albertolle, Matthew; Aluri, Krishna C.; Chen, Linzhi; Chen, Jingxian; Chopda, Girish; Chua, Xien Yu; Morais, Pedro; Dubois, Barent; Gibbons, Francis (Frank); Gudey, Shyam Kumar; Gupta, Swati; Hood, Steve; Humphreys, Sara; Husser, Christophe; Huth, Felix; Jani, Darshana; Jian, Wenying; Kakuda, Thomas; Kurz, Jeffrey; Linnebjerg, Helle; Liu, Jing; Lohmann, Sabine; Niu, Tao; Root, Katharina; Singla, Sumeet; Tang, Chenxiao; Veluri, Ravikanth; Zhang, Guangnong (Sunny); Zhang, Steven; Jawa, Vibha

Peginterferon-alpha-2a add-on to treatment with siRNA JNJ-73763989 in virologically suppressed chronic hepatitis B: the phase 2 PENGUIN study 聚乙二醇干扰素-α-2a联合siRNA JNJ-73763989治疗病毒学抑制的慢性乙型肝炎：PENGUIN二期研究

JHEP Reports

IF7.5

2025-07-09

OAAI

Population Pharmacokinetics of siRNA JNJ-73763989 in Healthy Participants and Patients With Chronic Hepatitis B 健康受试者和慢性乙型肝炎患者中siRNA JNJ-73763989的群体药代动力学

Clinical Pharmacology & Therapeutics

IF5.5

2025-05-15

PREAI

Tetsuro Ogawa; Nele Goeyvaerts; Thomas N. Kakuda; Joris J. Vandenbossche; Juan José Pérez-Ruixo; Oliver Ackaert; Emmanuel Njumbe Ediage; Michael Biermer; Oliver Lenz; Hong Su; Huybrecht T'jollyn

Serum levels of hepatitis B core antibodies and hepatitis B core-related antigen at the time of nucleos(t)ide analog cessation and risk of severe flares in patients with chronic hepatitis B

HEPATOLOGY COMMUNICATIONS

IF4.6

2025-03-01

PREAI

van Boemmel, Florian; Verbinnen, Thierry; Agarwal, Kosh; Vanwolleghem, Thomas; Lampertico, Pietro; Buti, Maria; Janczewska, Ewa; Bourliere, Marc; Jezorwski, John; Donohue, Kathleen; Kim, Gloria; Kakuda, Thomas N.; De Meyer, Sandra; Bakala, Adam; Biermer, Michael; Lenz, Oliver

JNJ-73763989 and bersacapavir treatment in nucleos(t)ide analogue-suppressed patients with chronic hepatitis B: REEF-2

JOURNAL OF HEPATOLOGY

IF33

2024-09-01

OAAI

Agarwal, Kosh; Buti, Maria; van Boemmel, Florian; Lampertico, Pietro; Janczewska, Ewa; Bourliere, Marc; Vanwolleghem, Thomas; Lenz, Oliver; Verbinnen, Thierry; Kakuda, Thomas N.; Mayer, Cristiana; Jezorwski, John; Muenz, Daniel; Beumont, Maria; Kalmeijer, Ronald; Biermer, Michael; Lonjon-Domanec, Isabelle

Efficacy and safety of the siRNAJNJ-73763989 and the capsid assembly modulator JNJ-56136379 (bersacapavir) with nucleos(t)ide analogues for the treatment of chronic hepatitis B virus infection (REEF-1): a multicentre, double-blind, active-controlled, randomised, phase 2btrial siRNAJNJ-73763989和衣壳组装调节剂JNJ-56136379 (bersacapavir) 与核苷 (酸) 类似物治疗慢性乙型肝炎病毒感染 (REEF-1) 的疗效和安全性: 多中心，双盲，主动控制，随机，2期btrial

LANCET GASTROENTEROLOGY & HEPATOLOGY

IF38.6

2023-09-01

PREAI

Yuen, Man-Fung; Asselah, Tarik; Jacobson, Ira M.; Brunetto, Maurizia Rossana; Janssen, Harry L. A.; Takehara, Tetsuo; Hou, Jin Lin; Kakuda, Thomas N.; Lambrecht, Tom; Beumont, Maria; Kalmeijer, Ronald; Guinard-Azadian, Carine; Mayer, Cristiana; Jezorwski, John; Verbinnen, Thierry; Lenz, Oliver; Shukla, Umesh; Biermer, Michael

Safety, antiviral activity and pharmacokinetics of JNJ-64530440, a novel capsid assembly modulator, as 4 week monotherapy in treatment-naive patients with chronic hepatitis B virus infection

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

IF3.6

2022-01-19

OAAI

Gane, Ed J.; Schwabe, Christian; Berliba, Elina; Tangkijvanich, Pisit; Jucov, Alina; Ghicavii, Nelea; Verbinnen, Thierry; Lenz, Oliver; Talloen, Willem; Kakuda, Thomas N.; Westland, Chris; Patel, Megha; Yogaratnam, Jeysen Z.; Dragone, Leonard; Van Remoortere, Pieter

JNJ-64530440, a novel capsid assembly modulator: single- and multiple-ascending dose safety, tolerability and pharmacokinetics in healthy volunteers

JOURNAL OF HEPATOLOGY

IF33

2019-04-01

PREAI

Kakuda, Thomas; Yogaratnam, Jeysen; Westland, Christopher; Gane, Edward; Schwabe, Christian; Patel, Megha; Talloen, Willem; Lenz, Oliver; van Remoortere, Pieter

Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection

GASTROENTEROLOGY

IF25.1

2019-04-01

114

OAAI

Yuen, Man Fung; Gane, Edward J.; Kim, Dong Joon; Weilert, Frank; Chan, Henry Lik Yuen; Lalezari, Jacob; Hwang, Seong Gyu; Tuan Nguyen; Flores, Osvaldo; Hartman, George; Liaw, Sandy; Lenz, Oliver; Kakuda, Thomas N.; Talloen, Willem; Schwabe, Christian; Klumpp, Klaus; Brown, Nathaniel

Short-Duration AL-335, Odalasvir, With or Without Simeprevir, in Patients With HCV GT1 or 3 Infection Without Cirrhosis

HEPATOLOGY

IF15.8

2018-11-19

PREAI

Gane, Edward J.; Stedman, Catherine A.; Schwabe, Christian; Vijgen, Leen; Chanda, Sushmita; Kakuda, Thomas N.; Fry, John; Blatt, Lawrence M.; McClure, Matthew W.

Population Pharmacokinetics of AL-335 and Its Two Main Metabolites (ALS-022399, ALS-022227) in Monotherapy and in Combination with Odalasvir and/or Simeprevir

AAPS JOURNAL

IF3.7

2018-10-24

PREAI

Valade, Elodie; Kakuda, Thomas N.; McClure, Matthew W.; Westland, Christopher; Valenzuela, Belen; Ouwerkerk-Mahadevan, Sivi; Perez-Ruixo, Juan Jose; Ackaert, Oliver

Characterizing the Pharmacokinetic Interaction Between Simeprevir and Odalasvir in Healthy Volunteers Using a Population Modeling Approach

AAPS JOURNAL

IF3.7

2018-10-22

PREAI

Valade, Elodie; Valenzuela, Belen; Kakuda, Thomas N.; Westland, Christopher; McClure, Matthew W.; Ouwerkerk-Mahadevan, Sivi; Perez-Ruixo, Juan Jose; Ackaert, Oliver

Single- and multiple-dose pharmacokinetics and safety of pimodivir, a novel, non-nucleoside polymerase basic protein 2 subunit inhibitor of the influenza A virus polymerase complex, and interaction with oseltamivir: a Phase 1 open-label study in healthy volunteers

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IF3

2018-09-14

OAAI

Deleu, Sofie; Kakuda, Thomas N.; Spittaels, Kurt; Vercauteren, Jurgen J.; Hillewaert, Vera; Lwin, Amy; Leopold, Lorant; Hoetelmans, Richard M. W.

Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study 新型口服流感核酸内切酶抑制剂AL-794的抗病毒活性，安全性和药代动力学: 流感人类挑战研究的结果

JOURNAL OF INFECTIOUS DISEASES

IF4.5

2018-07-26

OAAI

Yogaratnam, Jeysen; Rito, Jennifer; Kakuda, Thomas N.; Fennema, Hein; Gupta, Kusum; Jekle, C. Andreas; Mitchell, Toni; Boyce, Malcolm; Sahgal, Omair; Balaratnam, Ganesh; Chanda, Sushmita; Van Remoortere, Pieter; Symons, Julian A.; Fry, John

Short duration treatment with AL-335 and odalasvir, with or without simeprevir, in treatment naive patients with hepatitis C infection with or without cirrhosis

JOURNAL OF HEPATOLOGY

IF33

2017-01-01

PREAI

Gane, E.; Stedman, C.; McClure, M.; Apelian, D.; Westland, C.; Vuong, J.; Patel, M.; Kakuda, T.; Chanda, S.; Blatt, L.; Beigelman, L.; Smith, D.; Fry, J.

Darunavir/cobicistat once daily for the treatment of HIV

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY

IF3.8

2015-05-11

PREAI

Kakuda, Thomas N.; Crauwels, Herta; Opsomer, Magda; Tomaka, Frank; van de Casteele, Tom; Vanveggel, Simon; Iterbeke, Koen; de Smedt, Goedele

SIMEPREVIR (SMV) PLUS DACLATASVIR (DCV) AND SOFOSBUVIR (SOF) IN TREATMENT-NAIVE AND -EXPERIENCED PATIENTS WITH CHRONIC HEPATITIS C VIRUS GENOTYPE 1 OR 4 INFECTION AND DECOMPENSATED LIVER DISEASE: INTERIM RESULTS FROM THE PHASE II IMPACT STUDY

JOURNAL OF HEPATOLOGY

IF33

2015-04-01

PREAI

Lawitz, E.; Poordad, F.; Gutierrez, J.; Kakuda, T.; Picchio, G.; De La Rosa, G.; Beets, G.; Vandevoorde, A.; Van Remoortere, P.; Jacquemyn, B.; Quinn, G.; Luo, D.; Ouwerkerk-Mahadevan, S.; Vijgen, L.; Van Eygen, V.; Beumont, M.

Pharmacokinetics and pharmacodynamics of boosted once-daily darunavir

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

IF3.6

2014-06-20

OAAI

Kakuda, Thomas N.; Brochot, Anne; Tomaka, Frank L.; Vangeneugden, Tony; Van De Casteele, Tom; Hoetelmans, Richard M. W.

研究方向