Pieter Leyssen - Publications, H-index & Citations

Pieter Leyssen

ku leuven

54H指数

285论文数

1.0W被引数

收录论文 107

发表时间

Dual-fluorescence reporter-based assay for rapid quantitative evaluation of antiviral activity against Venezuelan equine encephalitis virus 基于双荧光报告子的快速定量评估抗委内瑞拉马脑炎病毒活性的方法

Scientific Reports

IF3.9

2026-07-27

OAAI

Gabriel Augusto Pires de Souza; Rana Abdelnabi; Lorena Sanchez Felipe; Thibault Francken; Leni Van Eyck; Benjamin Van Loy; Thayara Morais Portal; Joana S. Silva; Nick Verheyen; Wim Smets; Pieter Leyssen; Aleksandra Siekierska; Bert Vanmechelen; Koert Stittelaar; Johan Neyts

A robust cell-based infection model for Rhinovirus C research and antiviral drug discovery 基于细胞的稳健型呼吸道合胞病毒C型感染模型研究及抗病毒药物发现

npj Viruses

IF0

2026-05-11

OAAI

Lyoo, Heyrhyoung; Alpizar, Yeranddy A.; Sablon, Celine; Ropke, Toon; Paulissen, Jasmine; Rasulova, Madina; Thys, Nathalie; Yun, Chang-Soo; Cho, Nam-Chul; Dallmeier, Kai; Leyssen, Pieter; Han, Soo-Bong; Neyts, Johan; Thibaut, Hendrik Jan

Synthesis and antiviral activity of thiazolyl hydrazones against dengue virus 噻唑基腙的合成及其抗登革病毒的活性

Bioorganic & Medicinal Chemistry Letters

IF2.2

2025-10-10

PREAI

Mohd Usman Mohd Siddique; Deepak Shilkar; Vasavi Garisetti; Sheikh Murtuja; Suzanne Kaptein; Pieter Leyssen; Johan Neyts; Vinay N. Basavanakatti; Subodh Mondal; Susanta Kumar Mondal; Gayathri Dasararaju; Velmurugan Devadasan; Barij Nayan Sinha; Venkatesan Jayaprakash

High-throughput split-GFP antiviral screening assay against fusogenic paramyxoviruses 高通量裂解GFP抗病毒筛选实验针对融合性副粘病毒

Antiviral Research

IF4

2025-07-21

PREAI

Laura Vandemaele; Thibault Francken; Joost Schepers; Winston Chiu; Niels Cremers; Hugo Klaassen; Charlène Marcadet; Lorena Sanchez Felipe; Arnaud Marchand; Patrick Chaltin; Pieter Leyssen; Johan Neyts; Manon Laporte

Discovery and Preclinical Profile of ALG-097558; a Pan-Coronavirus 3CLpro Inhibitor ALG-097558的发现与临床前研究；一种广谱冠状病毒3CL蛋白酶抑制剂

Journal of Medicinal Chemistry

IF6.8

2025-06-30

PREAI

Dorothée Bardiot; David C. McGowan; Kusum Gupta; Jerome Deval; Sandra Chang; Andreas Jekle; Cheng Liu; Sarah Stevens; Vladimir Serebryany; Marcel J. Tauchert; Klaus Maskos; Antitsa D. Stoycheva; Suping Ren; Ruchika Jaisinghani; Marine O. Faucher; Tse-I Lin; Sandro Boland; Patrick Chaltin; Arnaud Marchand; Jurgen Wuyts; Steven De Jonghe; Dirk Jochmans; Sreenivasa Anugu; Vamshi Baloju; Kiran Deta; Michael Welch; Pieter Leyssen; Johan Neyts; Manon Laporte; Rana Abdelnabi; Haiyang Hu; Peng Zhang; Kha Le; Sushmita Chanda; David B. Smith; Pierre Raboisson; Leonid Beigelman; Julian A. Symons; Lawrence Blatt; Koen Vandyck

6-Chlorocoumarin Conjugates with Nucleobases and Nucleosides as Potent Anti-Hepatitis C Virus Agents 6-Chlorocoumarin与核碱基和核苷的共轭物作为强效抗丙型肝炎病毒剂

MOLECULES

IF4.6

2025-04-15

OAAI

Lin, Shu-Yu; Huang, Wen-Chieh; Tsay, Shwu-Chen; Neyts, Johan; Leyssen, Pieter; Lin, Chun-Cheng; Hwang, Kuo Chu; Horng, Jia-Cherng; Hwu, Jih Ru

Efficacy of Integrase Strand Transfer Inhibitors and the Capsid Inhibitor Lenacapavir against HIV-2, and Exploring the Effect of Raltegravir on the Activity of SARS-CoV-2

VIRUSES-BASEL

IF3.5

2024-10-13

OAAI

Kiarie, Irene Wanjiru; Hoffka, Gyula; Laporte, Manon; Leyssen, Pieter; Neyts, Johan; Tozser, Jozsef; Mahdi, Mohamed

Multiplexed multicolor antiviral assay amenable for high-throughput research

NATURE COMMUNICATIONS

IF15.7

2024-01-02

OAAI

Li, Li-Hsin; Chiu, Winston; Huang, Yun-An; Rasulova, Madina; Vercruysse, Thomas; Thibaut, Hendrik Jan; ter Horst, Sebastiaan; Rocha-Pereira, Joana; Vanhoof, Greet; Borrenberghs, Doortje; Goethals, Olivia; Kaptein, Suzanne J. F.; Leyssen, Pieter; Neyts, Johan; Dallmeier, Kai

Design, synthesis, and lead optimization of piperazinyl-pyrimidine analogues as potent small molecules targeting the viral capping machinery of Chikungunya virus

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-01-01

OAAI

Battisti, Verena; Moesslacher, Julia; Abdelnabi, Rana; Leyssen, Pieter; Rosas, Ana Lucia Rosales; Langendries, Lana; Aufy, Mohammed; Studenik, Christian; Kratz, Jadel M.; Rollinger, Judith M.; Puerstinger, Gerhard; Neyts, Johan; Delang, Leen; Urban, Ernst; Langer, Thierry

Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys

JOURNAL OF INFECTION

IF11.9

2023-12-01

OAAI

Fenwick, Craig; Turelli, Priscilla; Duhoo, Yoan; Lau, Kelvin; Herate, Cecile; Marlin, Romain; Lamrayah, Myriam; Campos, Jeremy; Esteves-Leuenberger, Line; Farina, Alex; Raclot, Charlene; Genet, Vanessa; Fiscalini, Flurin; Cesborn, Julien; Perez, Laurent; Dereuddre-Bosquet, Nathalie; Contreras, Vanessa; Lheureux, Kyllian; Relouzat, Francis; Abdelnabi, Rana; Leyssen, Pieter; Levy, Yves; Pojer, Florence; Le Grand, Roger; Trono, Didier; Pantaleo, Giuseppe

Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2

MICROORGANISMS

IF4.2

2023-03-10

OAAI

Doijen, Jordi; Temmerman, Koen; van den Eynde, Christel; Diels, Annick; Van den Broeck, Nick; Van Gool, Michiel; Heo, Inha; Jaensch, Steffen; Zwaagstra, Marleen; Toro, Mayra Diosa; Chiu, Winston; De Jonghe, Steven; Leyssen, Pieter; Bojkova, Denisa; Ciesek, Sandra; Cinatl, Jindrich; Verschueren, Lore; Buyck, Christophe; Van Kuppeveld, Frank; Neyts, Johan; Van Loock, Marnix; Van Damme, Ellen

Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication 1-杂芳基-2-烷氧基苯基类似物作为SARS-CoV-2复制抑制剂的合成，构效关系和抗病毒谱

MOLECULES

IF4.6

2022-02-04

OAAI

Bardiot, Dorothee; Vangeel, Laura; Koukni, Mohamed; Arzel, Philippe; Zwaagstra, Marleen; Lyoo, Heyrhyoung; Wanningen, Patrick; Ahmad, Shamshad; Zhang, Linlin; Sun, Xinyuanyuan; Delpal, Adrien; Eydoux, Cecilia; Guillemot, Jean-Claude; Lescrinier, Eveline; Klaassen, Hugo; Leyssen, Pieter; Jochmans, Dirk; Castermans, Karolien; Hilgenfeld, Rolf; Robinson, Colin; Decroly, Etienne; Canard, Bruno; Snijder, Eric J.; van Hemert, Martijn J.; van Kuppeveld, Frank; Chaltin, Patrick; Neyts, Johan; De Jonghe, Steven; Marchand, Arnaud

A highly potent antibody effective against SARS-CoV-2 variants of concern

CELL REPORTS

IF6.9

2021-10-01

OAAI

Fenwick, Craig; Turelli, Priscilla; Perez, Laurent; Pellaton, Celine; Esteves-Leuenberger, Line; Farina, Alex; Campos, Jeremy; Lana, Erica; Fiscalini, Flurin; Raclot, Charlene; Pojer, Florence; Lau, Kelvin; Demurtas, Davide; Descatoire, Marc; Joo, Victor S.; Foglierini, Mathilde; Noto, Alessandra; Abdelnabi, Rana; Foo, Caroline S.; Vangeel, Laura; Neyts, Johan; Du, Wenjuan; Bosch, Berend-Jan; Veldman, Geertruida; Leyssen, Pieter; Thiel, Volker; LeGrand, Roger; Levy, Yves; Trono, Didier; Pantaleo, Giuseppe

The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model

EBIOMEDICINE

IF10.8

2021-10-01

OAAI

Abdelnabi, Rana; Foo, Caroline S.; Kaptein, Suzanne J. F.; Zhang, Xin; Do, Thuc Nguyen Dan; Langendries, Lana; Vangeel, Laura; Breuer, Judith; Pang, Juanita; Williams, Rachel; Vergote, Valentijn; Heylen, Elisabeth; Leyssen, Pieter; Dallmeier, Kai; Coelmont, Lotte; Chatterjee, Arnab K.; Mols, Raf; Augustijns, Patrick; De Jonghe, Steven; Jochmans, Dirk; Weynand, Birgit; Neyts, Johan

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19 (vol 11, 13208, 2021)

SCIENTIFIC REPORTS

IF3.9

2021-09-28

OAAI

Redhead, Martin A.; Owen, C. David; Brewitz, Lennart; Collette, Amelia H.; Lukacik, Petra; Strain-Damerell, Claire; Robinson, Sean W.; Collins, Patrick M.; Schafer, Philipp; Swindells, Mark; Radoux, Chris J.; Hopkins, Iva Navratilova; Fearon, Daren; Douangamath, Alice; von Delft, Frank; Malla, Tika R.; Vangeel, Laura; Vercruysse, Thomas; Thibaut, Jan; Leyssen, Pieter; Nguyen, Tu-Trinh; Hull, Mitchell; Tumber, Anthony; Hallett, David J.; Schofield, Christopher J.; Stuart, David I.; Hopkins, Andrew L.; Walsh, Martin A.

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19

SCIENTIFIC REPORTS

IF3.9

2021-06-24

OAAI

Redhead, Martin A.; Owen, C. David; Brewitz, Lennart; Collette, Amelia H.; Lukacik, Petra; Strain-Damerell, Claire; Robinson, Sean W.; Collins, Patrick M.; Schaefer, Philipp; Swindells, Mark; Radoux, Chris J.; Hopkins, Iva Navratilova; Fearon, Daren; Douangamath, Alice; von Delft, Frank; Malla, Tika R.; Vangeel, Laura; Vercruysse, Thomas; Thibaut, Jan; Leyssen, Pieter; Tu-Trinh Nguyen; Hull, Mitchell; Tumber, Anthony; Hallett, David J.; Schofield, Christopher J.; Stuart, David I.; Hopkins, Andrew L.; Walsh, Martin A.

In vitro activity of itraconazole against SARS-CoV-2

JOURNAL OF MEDICAL VIROLOGY

IF4.6

2021-05-25

OAAI

Van Damme, Ellen; De Meyer, Sandra; Bojkova, Denisa; Ciesek, Sandra; Cinatl, Jindrich; De Jonghe, Steven; Jochmans, Dirk; Leyssen, Pieter; Buyck, Christophe; Neyts, Johan; Van Loock, Marnix

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

NATURE COMMUNICATIONS

IF15.7

2020-11-17

180

OAAI

Boudewijns, Robbert; Thibaut, Hendrik Jan; Kaptein, Suzanne J. F.; Li, Rong; Vergote, Valentijn; Seldeslachts, Laura; Van Weyenbergh, Johan; De Keyzer, Carolien; Bervoets, Lindsey; Sharma, Sapna; Liesenborghs, Laurens; Ma, Ji; Jansen, Sander; Van Looveren, Dominique; Vercruysse, Thomas; Wang, Xinyu; Jochmans, Dirk; Martens, Erik; Roose, Kenny; De Vlieger, Dorien; Schepens, Bert; Van Buyten, Tina; Jacobs, Sofie; Liu, Yanan; Marti-Carreras, Joan; Vanmechelen, Bert; Wawina-Bokalanga, Tony; Delang, Leen; Rocha-Pereira, Joana; Coelmont, Lotte; Chiu, Winston; Leyssen, Pieter; Heylen, Elisabeth; Schols, Dominique; Wang, Lanjiao; Close, Lila; Matthijnssens, Jelle; Van Ranst, Marc; Compernolle, Veerle; SchrammH, Georg; Van Laere, Koen; Saelens, Xavier; Callewaert, Nico; Opdenakker, Ghislain; Maes, Piet; Weynand, Birgit; Cawthorne, Christopher; Vande Velde, Greetje; Wang, Zhongde; Neyts, Johan; Dallmeier, Kai

Enterovirus Inhibition by Hinged Aromatic Compounds with Polynuclei

MOLECULES

IF4.6

2020-08-22

OAAI

Hwu, Jih Ru; Panja, Avijit; Jayakumar, Srinivasan; Tsay, Shwu-Chen; Tan, Kui-Thong; Huang, Wen-Chieh; Hu, Yu-Chen; Leyssen, Pieter; Neyts, Johan

Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2020-06-23

OAAI

Abdelnabi, Rana; Kovacikova, Kristina; Moesslacher, Julia; Donckers, Kim; Battisti, Verena; Leyssen, Pieter; Langer, Thierry; Puerstinger, Gerhard; Querat, Gilles; Li, Changqing; Decroly, Etienne; Tas, Ali; Marchand, Arnaud; Chaltin, Patrick; Coutard, Bruno; van Hemert, Martijn; Neyts, Johan; Delang, Leen

研究方向