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W

William R. Bishai

Johns Hopkins School of Medicine

87H指数
464论文数
2.5W被引数
收录论文 209
发表时间
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Host-directed treatments for tuberculous meningitis utilizing a multi-platform approach across mouse and human models利用多平台方法在鼠类和人类模型中针对结核性脑膜炎的宿主导向性治疗
errNature Communications
IF15.7
err2026-07-21
err0
errOAAI
errCarlos E. Ruiz-Gonzalez; Medha Singh; Yuderleys Masias-Leon; Xueyi Chen; Mona O. Sarhan; Yazmin B. Martinez-Martinez; Sruti Patel; Madelynn Shambles; Andres Villabona-Rueda; Kadia Lissit; David Tweedie; Michael T. Scerba; William R. Bishai; Dmitri Artemov; Jin-Chong Xu; Franco D’Alessio; Richard Hafner; Nigel H. Greig; Maura Manion; Irini Sereti; Sanjay K. Jain
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Elimination of senescent cells with senolytic drugs as adjunctive host-directed therapy reduces tuberculosis progression in mice使用清除衰老细胞的药物作为辅助宿主导向疗法可减少小鼠结核病的进展
errNature Communications
IF15.7
err2026-05-07
err0
errOAAI
errSomnath Shee; Yazmin B. Martinez-Martinez; Benjamin Koleske; Moagi Tube Shaku; Shivraj Yabaji; Lester Kobzik; Igor Kramnik; William Bishai
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Retraction Note: Re-engineered BCG overexpressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer撤稿说明：经过重新设计的BCG过量表达环二腺苷酸，增强了训练性免疫，并显示出对膀胱癌的改进效果。
errNature Communications
IF15.7
err2026-03-23
err0
errOAAI
errAlok Kumar Singh; Monali Praharaj; Kara A. Lombardo; Takahiro Yoshida; Andres Matoso; Alex S. Baras; Liang Zhao; Geetha Srikrishna; Joy Huang; Pankaj Prasad; Jonathan D. Powell; Max Kates; David McConkey; Drew M. Pardoll; William R. Bishai; Trinity J. Bivalacqua
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Sex as a Biological Variable in Tuberculosis Pathogenesis性别作为结核病发病机制中的生物学变量
errImmunological Reviews
IF8.3
err2026-03-10
err0
PREAI
errManish Gupta; Sabra L. Klein; William R. Bishai
err分享
err收藏
Molecular characterization of non-muscle invasive tumor from N-methyl-N-nitrosourea (MNU)-induced urothelial carcinoma in a rat model reveals hallmarks of both luminal and basal subtypesN-甲基-N-亚硝基脲（MNU）诱导的rat模型中非肌层浸润性肿瘤的分子特征分析揭示了其同时具有腔面型和基底亚型的特征。
errExperimental and Molecular Pathology
IF3.7
err2026-02-09
err0
errOAAI
errKara A. Lombardo; Takahiro Yoshida; Evan Johnson; Kate Fitzgerald; Max Kates; William R. Bishai; Alex S. Baras; Trinity J. Bivalacqua
err分享
err收藏
A novel glutamine metabolism inhibitor improves phagocytic abilities of macrophages by reprogramming glutathione metabolism
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-11-01
err0
PREAI
errNesson, Sadiya Parveen; Murphy, John R.; Slusher, Barbara L.; Bishai, William R.
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Exploration of imidazothiazole and imidazopyrimidine carboxamides for enhanced antitubercular activity咪唑并噻唑和咪唑并嘧啶羧酰胺类化合物的抗结核活性增强研究
errBioorganic & Medicinal Chemistry Letters
IF2.2
err2025-10-21
err0
PREAI
errOluseye K. Onajole; Shichun Lun; Dakoju Ravi Kishore; Anđela Savić; Alexis Morales; Alfredo Guzman; Ethan Schmidt; Adela Lazzara; Gianna Fajardo; Daniel P. Jamieson; A. Jean-Luc Ayitou; William R. Bishai
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Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility脂质过氧化与I型干扰素耦联促进致病性巨噬细胞活化，导致结核病易感性
errELIFE
IF0
err2025-10-02
err0
PREAI
errYabaji, Shivraj M.; Zhernovkov, Vadim; Araveti, Prasanna Babu; Lata, Suruchi; Rukhlenko, Oleksii S.; Abdullatif, Salam Al; Vanvalkenburg, Arthur; Alekseyev, Yuriy O.; Ma, Qicheng; Dayama, Gargi; Lau, Nelson C.; Johnson, W. Evan; Bishai, William R.; Crossland, Nicholas A.; Campbell, Joshua D.; Kholodenko, Boris N.; Gimelbrant, Alexander A.; Kobzik, Lester; Kramnik, Igor
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Dysplastic lung repair fosters a tuberculosis-promoting microenvironment through maladaptive macrophage polarization异型肺修复通过不良的巨噬细胞极化促进结核病促进性微环境的形成。
errPLOS PATHOGENS
IF4.9
err2025-10-01
err0
PREAI
errYabaji, Shivraj M.; Lata, Suruchi; Tseng, Anna E.; Araveti, Prasanna Babu; Lo, Ming; Gavrish, Igor; O'Connell, Aoife K.; Gertje, Hans P.; Belkina, Anna C.; Thurman, Colleen E.; Kiyokawa, Hirofumi; Kotton, Darrell; Tan, Shumin; Endsley, Janice J.; Bishai, William R.; Crossland, Nicholas; Kobzik, Lester; Kramnik, Igor
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err收藏
Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis lineage 2PPE71-esxX-esxY-PPE38位点的缺失驱动分枝杆菌2谱系的适应性转录应答和超强毒力。
errScience Advances
IF12.5
err2025-07-04
err0
PREAI
errBenjamin Koleske; Courtney Schill; Saranathan Rajagopalan; Somnath Shee; Yazmin B. Martinez-Martinez; Manish Gupta; Jessica Shen; William R. Jacobs; William R. Bishai
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err收藏
Structure-Based Development of 3,4-Fused Tricyclic Benzofuran Derivatives as Polyketide Synthase 13 Inhibitors with Negligible hERG Inhibition基于结构的3,4-稠合三环苯并呋喃衍生物的研制：作为聚酮合酶13抑制剂的开发，具有可忽略的hERG抑制活性
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-03-06
err0
PREAI
errZhou, Yu-Xin; Lun, Shichun; Zhang, Wei; Tie, Fa-Jin; Cai, Yan-Peng; Yang, Fan; Tang, Jie; Bishai, William R.; Yu, Li-Fang
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Structure-based development of N-Arylindole derivatives as Pks13 inhibitors against Mycobacterium tuberculosis (vol 283, 117148, 2025)
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-03-01
err0
PREAI
errZhang, Xuan; Lun, Shichun; Li, Yu-Xin; Zhang, Wei; Zhou, Ruo-Yi; Liu, Ting; Yang, Fan; Tang, Jie; Bishai, William R.; Yu, Li-Fang
err分享
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Structure-based development of N-Arylindole derivatives as Pks13 inhibitors against Mycobacterium tuberculosis基于结构的N-芳基吲哚衍生物作为结核分枝杆菌Pks13抑制剂的开发
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-02-01
err1
PREAI
errZhang, Xuan; Lun, Shichun; Li, Yu-Xin; Zhang, Wei; Zhou, Ruo-Yi; Liu, Ting; Yang, Fan; Tang, Jie; Bishai, William R.; Yu, Li-Fang
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Total Syntheses of Cyclomarin and Metamarin Natural Products环霉素和Metamarin天然产物的总合成
errORGANIC LETTERS
IF5
err2024-11-01
err0
errOAAI
errFei, Fan; Lun, Shichun; Saxena, Aditi; Raghavan, Madhura; Derisi, Joseph L.; Bishai, William R.; Sello, Jason K.
err分享
err收藏
Pathogenesis of Post-Tuberculosis Lung Disease
errAMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
IF19.4
err2024-10-15
err0
PREAI
errAuld, Sara C.; Barczak, Amy K.; Bishai, William; Coussens, Anna K.; Dewi, Intan M. W.; Mitini-Nkhoma, Steven C.; Muefong, Caleb; Naidoo, Threnesan; Pooran, Anil; Stek, Cari; Steyn, Adrie J. C.; Tezera, Liku; Walker, Naomi F.
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A modified BCG with depletion of enzymes associated with peptidoglycan amidation induces enhanced protection against tuberculosis in mice
errELIFE
IF0
err2024-04-19
err1
errOAAI
errShaku, Moagi Tube; Um, Peter K.; Ocius, Karl L.; Apostolos, Alexis J.; Pires, Marcos M.; Bishai, William R.; Kana, Bavesh D.
err分享
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Design, synthesis, and biological evaluation of 1,2,4-triazole derivatives as potent antitubercular agents
errCHINESE CHEMICAL LETTERS
IF8.9
err2024-03-01
err7
PREAI
errWen, Yu; Lun, Shichun; Jiao, Yuxue; Zhang, Wei; Hu, Tianyu; Liu, Ting; Yang, Fan; Tang, Jie; Zhang, Bing; Bishai, William R.; Yu, Li-Fang
err分享
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Structure-based virtual screening and in vitro validation of inhibitors of cyclic dinucleotide phosphodiesterases ENPP1 and CdnP
errMICROBIOLOGY SPECTRUM
IF3.8
err2024-01-11
err1
errOAAI
errRohilla, Akshay; Singh, Alok Kumar; Koleske, Benjamin; Srikrishna, Geetha; Bishai, William R.
err分享
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Inhibition of host PARP1 contributes to the anti-inflammatory and antitubercular activity of pyrazinamide
errNATURE COMMUNICATIONS
IF15.7
err2023-12-09
err5
errOAAI
errKrug, Stefanie; Gupta, Manish; Kumar, Pankaj; Feller, Laine; Ihms, Elizabeth A.; Kang, Bong Gu; Srikrishna, Geetha; Dawson, Ted M.; Dawson, Valina L.; Bishai, William R.
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MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival
errJCI INSIGHT
IF6.1
err2023-10-23
err8
errOAAI
errBullen, C. Korin; Singh, Alok K.; Krug, Stefanie; Lun, Shichun; Thakur, Preeti; Srikrishna, Geetha; Bishai, William R.
err分享
err收藏

研究方向

暂无研究方向
合作学者
合作期刊
D
Drew M. Pardoll
H 指数: 164 · 论文数: 892
V
Valina L. Dawson
H 指数: 151 · 论文数: 580
C
Charles G. Drake
H 指数: 133 · 论文数: 1.2K
A
Alan Sher
H 指数: 133 · 论文数: 555
L
Laurent Abel
H 指数: 131 · 论文数: 659
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