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P

Pablo Gaínza

Monte Rosa Therapeutics

18H指数
52论文数
2.5K被引数
收录论文 20
发表时间
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Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry
errNature Structural & Molecular Biology
IF10.1
err2026-01-20
err0
errOAAI
errStefano Annunziato; Chao Quan; Etienne J. Donckele; Ilaria Lamberto; Richard D. Bunker; Mary Zlotosch; Laura Schwander; Anastasia Murthy; Lars Wiedmer; Camille Staehly; Michelle Matysik; Samuel Gilberto; Despina Kapsitidou; Daric Wible; Gian Marco De Donatis; Peter Trenh; Rohitha SriRamaratnam; Vaik Strande; Raphael Lieberherr; David Lyon; Danielle Steiner; Joao Silva; Reinaldo Almeida; Elena Dolgikh; Bradley DeMarco; Jennifer Tsai; Amine Sadok; Vladislav Zarayskiy; Magnus Walter; Ralph Tiedt; Kevin J. Lumb; Debora Bonenfant; Bernhard Fasching; John C. Castle; Sharon A. Townson; Pablo Gainza; Georg Petzold
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A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation一个模拟去泛素化信号序列的分子胶驱动CRBN同源二聚化和降解
errNature Communications
IF15.7
err2025-11-19
err0
errOAAI
errGerasimos Langousis; Pablo Gainza; Moritz Hunkeler; Despoina Kapsitidou; Etienne J. Donckele; Stefano Annunziato; Lars Wiedmer; Katherine F. M. Jones; Bradley DeMarco; Chao Quan; Richard D. Bunker; Kevin J. Lumb; Bernhard Fasching; John C. Castle; Sharon A. Townson; Débora Bonenfant
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Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition挖掘CRBN靶点空间重新定义了分子胶诱导的新型底物识别规则
errScience
IF45.8
err2025-07-03
err0
errOAAI
errGeorg Petzold; Pablo Gainza; Stefano Annunziato; Ilaria Lamberto; Peter Trenh; Laura A. McAllister; Bradley DeMarco; Laura Schwander; Richard D. Bunker; Mary Zlotosch; Rohitha SriRamaratnam; Samuel Gilberto; Gerasimos Langousis; Etienne J. Donckele; Chao Quan; Vaik Strande; Gian Marco De Donatis; Shanique B. Alabi; Jessica Alers; Michelle Matysik; Camille Staehly; Aurélie Dubois; Arnaud Osmont; Mackenzie Garskovas; David Lyon; Lars Wiedmer; Vladimiras Oleinikovas; Raphael Lieberherr; Nooreen T. Rubin; Daniel T. Lam; Xavier Lucas; Elisa Liardo; Nina Ilic Widlund; Andreas Ritzén; Ramon Miguel Caceres; Dominico Vigil; Jennifer Tsai; Owen Wallace; Marisa Peluso; Amine Sadok; Ralph Tiedt; Alison M. Paterson; Vladislav Zarayskiy; Bernhard Fasching; Debora Bonenfant; Markus Warmuth; John C. Castle; Sharon A. Townson
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Machine learning to predict de novo protein–protein interactionsGainza, P.; Bunker, R.D.; Townson, S.A.; Castle, J.C. 机器学习预测全新蛋白质-蛋白质相互作用。Trends Biotechnol. 2025. [Google Scholar] [CrossRef]
errTrends in Biotechnology
IF14.9
err2025-05-26
err0
errOAAI
errPablo Gainza; Richard D. Bunker; Sharon A. Townson; John C. Castle
err分享
err收藏
Dual ON/OFF- switch chimeric antigen receptor controlled by two clinically approved drugs由两种临床批准的药物控制的双开关嵌合抗原受体
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-10-25
err0
errOAAI
errAttianese, Greta Maria Paola Giordano; Shui, Sailan; Cribioli, Elisabetta; Triboulet, Melanie; Scheller, Leo; Hafezi, Morteza; Reichenbach, Patrick; Gainza, Pablo; Georgeon, Sandrine; Correia, Bruno E.; Irving, Melita
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A Synthetic Multivalent Lipopeptide Derived from Pam3CSK4 with Irreversible Influenza Inhibition and Immuno-Stimulating Effects
errSMALL
IF12.1
err2024-03-04
err0
errOAAI
errZhu, Yong; Wei, Lixia; Zwygart, Arnaud Charles-Antoine; Gainza, Pablo; Khac, Quy Ong; Olgiati, Francesca; Kurum, Armand; Tang, Li; Correia, Bruno; Tapparel, Caroline; Stellacci, Francesco
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From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation从沙利度胺到靶向蛋白降解的理性分子胶设计
errANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
IF13.1
err2024-01-23
err28
errOAAI
errOleinikovas, Vladas; Gainza, Pablo; Ryckmans, Thomas; Fasching, Bernhard; Thoma, Nicolas H.
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Rules and mechanisms governing G protein coupling selectivity of GPCRs
errCELL REPORTS
IF6.9
err2023-10-01
err18
errOAAI
errMasuho, Ikuo; Kise, Ryoji; Gainza, Pablo; Von Moo, Ee; Li, Xiaona; Tany, Ryosuke; Wakasugi-Masuho, Hideko; Correia, Bruno E.; Martemyanov, Kirill A.
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Rational Design of Chemically Controlled Antibodies and Protein Therapeutics
errACS CHEMICAL BIOLOGY
IF3.8
err2023-05-30
err8
errOAAI
errMarchand, Anthony; Bonati, Lucia; Shui, Sailan; Scheller, Leo; Gainza, Pablo; Rosset, Steïphane; Georgeon, Sandrine; Tang, Li; Correia, Bruno E.
err分享
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A rational blueprint for the design of chemically-controlled protein switches
errNATURE COMMUNICATIONS
IF15.7
err2021-10-01
err20
errOAAI
errShui, Sailan; Gainza, Pablo; Scheller, Leo; Yang, Che; Kurumida, Yoichi; Rosset, Stephane; Georgeon, Sandrine; Di Roberto, Raphael B.; Castellanos-Rueda, Rocio; Reddy, Sai T.; Correia, Bruno E.
err分享
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Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning
errNATURE BIOMEDICAL ENGINEERING
IF26.6
err2021-04-15
err138
PREAI
errMason, Derek M.; Friedensohn, Simon; Weber, Cedric R.; Jordi, Christian; Wagner, Bastian; Meng, Simon M.; Ehling, Roy A.; Bonati, Lucia; Dahinden, Jan; Gainza, Pablo; Correia, Bruno E.; Reddy, Sai T.
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A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy (vol 41, pg 568, 2019)
errNATURE BIOTECHNOLOGY
IF41.7
err2020-03-03
err5
errOAAI
errGiordano-Attianese, Greta; Gainza, Pablo; Gray-Gaillard, Elise; Cribioli, Elisabetta; Shui, Sailan; Kim, Seonghoon; Kwak, Mi-Jeong; Vollers, Sabrina; Corria Osorio, Angel De Jesus; Reichenbach, Patrick; Bonet, Jaume; Oh, Byung-Ha; Irving, Melita; Coukos, George; Correia, Bruno E.
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A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy计算设计的嵌合抗原受体为T细胞治疗提供了一个小分子安全开关
errNATURE BIOTECHNOLOGY
IF41.7
err2020-02-03
err110
PREAI
errGiordano-Attianese, Greta; Gainza, Pablo; Gray-Gaillard, Elise; Cribioli, Elisabetta; Shui, Sailan; Kim, Seonghoon; Kwak, Mi-Jeong; Vollers, Sabrina; Osorio, Angel De Jesus Corria; Reichenbach, Patrick; Bonet, Jaume; Oh, Byung-Ha; Irving, Melita; Coukos, George; Correia, Bruno E.
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Deciphering interaction fingerprints from protein molecular surfaces using geometric deep learning
errNATURE METHODS
IF32.1
err2019-12-09
err409
errOAAI
errGainza, P.; Sverrisson, F.; Monti, F.; Rodola, E.; Boscaini, D.; Bronstein, M. M.; Correia, B. E.
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OSPREY 3.0: Open-source protein redesign for you, with powerful new features
errJOURNAL OF COMPUTATIONAL CHEMISTRY
IF4.8
err2018-10-14
err54
errOAAI
errHallen, Mark A.; Martin, Jeffrey W.; Ojewole, Adegoke; Jou, Jonathan D.; Lowegard, Anna U.; Frenkel, Marcel S.; Gainza, Pablo; Nisonoff, Hunter M.; Mukund, Aditya; Wang, Siyu; Holt, Graham T.; Zhou, David; Dowd, Elizabeth; Donald, Bruce R.
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Algorithms for protein design
errCURRENT OPINION IN STRUCTURAL BIOLOGY
IF7
err2016-08-01
err68
errOAAI
errGainza, Pablo; Nisonoff, Hunter M.; Donald, Bruce R.
err分享
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Fast gap-free enumeration of conformations and sequences for protein design
errPROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
IF2.8
err2015-08-24
err19
errOAAI
errRoberts, Kyle E.; Gainza, Pablo; Hallen, Mark A.; Donald, Bruce R.
err分享
err收藏
Compact Representation of Continuous Energy Surfaces for More Efficient Protein Design
errJOURNAL OF CHEMICAL THEORY AND COMPUTATION
IF5.5
err2015-04-10
err22
errOAAI
errHallen, Mark A.; Gainza, Pablo; Donald, Bruce R.
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err收藏
Protein design algorithms predict viable resistance to an experimental antifolate
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2014-12-31
err52
errOAAI
errReeve, Stephanie M.; Gainza, Pablo; Frey, Kathleen M.; Georgiev, Ivelin; Donald, Bruce R.; Anderson, Amy C.
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Computing Conformational Entropy in Antibody Interfaces
errBIOPHYSICAL JOURNAL
IF3.1
err2014-01-01
err0
errOAAI
errGainza, Pablo; Roberts, Kyle E.; Hallen, Mark A.; Donald, Bruce R.
err分享
err收藏

研究方向

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合作学者
合作期刊
G
George Coukos
H 指数: 111 · 论文数: 865
F
Francesco Stellacci
H 指数: 75 · 论文数: 414
M
Michael M. Bronstein
H 指数: 74 · 论文数: 499
I
Ivelin S. Georgiev
H 指数: 65 · 论文数: 186
Li Tang 封面图
Li Tang (Li Tang)
H 指数: 55 · 论文数: 251
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