Jacob Piehler - Publications, H-index & Citations

Jacob Piehler

Osnabrück University

71H指数

351论文数

1.4W被引数

收录论文 173

发表时间

Direct visualization of native GSDMD pores reveals lipid-driven stabilization during pyroptosis 直接可视化天然GSDMD孔洞揭示了焦亡过程中脂质驱动的稳定作用

Science Advances

IF12.5

2026-07-10

OAAI

Shirin Kappelhoff; Michael Holtmannspötter; Stefan L. Schaefer; Eleonora G. Margheritis; Özgün Doga Asik; Nadine Gehle; Hannah Veit; John S.H. Danial; Rico Franzkoch; Sebastian Strauss; Jonatan Alvelid; Agnes Koerfer; Christian Eggeling; Olympia E. Psathaki; Ralf Jungmann; Rainer Kurre; Gerhard Hummer; Jacob Piehler; Katia Cosentino

Hour-scale single-molecule imaging reveals dynamic assembly of the Wnt co-receptors LRP6 and ROR2 into common signalosomes 小时尺度单分子成像揭示了Wnt协同受体LRP6和ROR2组装成共同信号体的动态过程

Science Signaling

IF6.6

2026-03-03

PREAI

Michael Philippi; Julia Dohle; Isabelle Watrinet; Michael Holtmannspötter; Yi Miao; Jinye Li; Oliver Birkholz; Ulrich Rothbauer; K. Christopher Garcia; Rainer Kurre; Jacob Piehler; Changjiang You

A Modular Toolkit for Nanoscale Interrogation of Multiprotein Assemblies Inside Living Cells 用于对活细胞内多蛋白复合物进行纳米级探查的模块化工具包

ACS Nano

IF16

2026-03-01

PREAI

Felker, Arthur; Philippi, Michael; Holtmannspotter, Michael; Drees, Christoph; Schafer, Evelin; Steinhart, Martin; Kurre, Rainer; You, Changjiang; Piehler, Jacob

Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling

JOURNAL OF IMMUNOLOGY

IF3.4

2025-11-01

PREAI

Caveney, Nathanael A.; Rodriguez, Grayson E.; Pollmann, Christoph; Meyer, Thomas; Piehler, Jacob; Garcia, K. Christopher

Design of facilitated dissociation enables timing of cytokine signalling 促进解离的设计能够调控细胞因子信号的时间。

Nature

IF48.5

2025-09-24

OAAI

Adam J. Broerman; Christoph Pollmann; Yang Zhao; Mauriz A. Lichtenstein; Mark D. Jackson; Maxx H. Tessmer; Won Hee Ryu; Masato Ogishi; Mohamad H. Abedi; Danny D. Sahtoe; Aza Allen; Alex Kang; Joshmyn De La Cruz; Evans Brackenbrough; Banumathi Sankaran; Asim K. Bera; Daniel M. Zuckerman; Stefan Stoll; K. Christopher Garcia; Florian Praetorius; Jacob Piehler; David Baker

Tuning of G-CSFR signaling by de novo designed agonists 通过全新设计的激动剂对G-CSFR信号进行调谐

Molecular Therapy

IF12

2025-08-29

OAAI

Timo Ullrich; Christoph Pollmann; Malte Ritter; Jérémy Haaf; Narges Aghaallaei; Ivan Tesakov; Valeriia Hatskovska; Maya El-Riz; Kateryna Maksymenko; Sergey Kandabarau; Maksim Klimiankou; Claudia Lengerke; Karl Welte; Birte Hernandez-Alvarez; Patrick Müller; Andrei Lupas; Jacob Piehler; Julia Skokowa; Mohammad ElGamacy

Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration 活细胞磁性操纵回收性内体揭示其对肌动蛋白突起的直接作用以促进侵袭性迁移

Science Advances

IF12.5

2025-07-04

OAAI

Jakub Gemperle; Domenik Liße; Marie Kappen; Emilie Secret; Mathieu Coppey; Martin Gregor; Christine Menager; Jacob Piehler; Patrick Caswell

Promiscuous Janus kinase binding to cytokine receptors modulates signaling efficiencies and contributes to cytokine pleiotropy

SCIENCE SIGNALING

IF6.6

2024-11-19

PREAI

Zoler, Eyal; Meyer, Thomas; Bellon, Junel Sotolongo; Moennig, Mia; Sun, Boyue; Piehler, Jacob; Schreiber, Gideon

Modulating G-CSFR Signaling Using De Novo Designed Cytokines 使用从头设计的细胞因子调节G-CSFR信号通路

BLOOD

IF23.1

2024-11-05

PREAI

Ullrich, Timo; Alvarez, Birte Hernandez; Pollmann, Christoph; Ritter, Malte Ulrich; Haaf, Jeremy; Aghaallaei, Narges; Piehler, Jacob; Tesakov, Ivan; El-Riz, Maya; Maksymenko, Kateryna; Hatskovska, Valeriia; Kandabarau, Sergey; Klimiankou, Maksim; Lengerke, Claudia; Welte, Karl; Lupas, Andrei; Skokowa, Julia; ElGamacy, Mohammad

Correlative single-molecule and structured illumination microscopy of fast dynamics at the plasma membrane 质膜快速动力学的相关单分子和结构化照明显微镜

NATURE COMMUNICATIONS

IF15.7

2024-07-10

OAAI

Winkelmann, Hauke; Richter, Christian P.; Eising, Jasper; Piehler, Jacob; Kurre, Rainer

Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling

MOLECULAR CELL

IF16.6

2024-05-01

OAAI

Caveney, Nathanael A.; Rodriguez, Grayson E.; Pollmann, Christoph; Meyer, Thomas; Borowska, Marta T.; Wilson, Steven C.; Wang, Nan; Xiang, Xinyu; Householder, Karsten D.; Tao, Pingdong; Su, Leon L.; Saxton, Robert A.; Piehler, Jacob; Garcia, K. Christopher

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

NATURE COMMUNICATIONS

IF15.7

2024-03-07

OAAI

Gardner, Scott; Jin, Yibo; Fyfe, Paul K.; Voisin, Tomas B.; Bellon, Junel Sotolongo; Pohler, Elizabeth; Piehler, Jacob; Moraga, Ignacio; Bubeck, Doryen

Glia trigger endocytic clearance of axonal proteins to promote rodent myelination

DEVELOPMENTAL CELL

IF8.7

2024-03-01

PREAI

Bekku, Yoko; Zotter, Brendan; You, Changjiang; Piehler, Jacob; Leonard, Warren J.; Salzer, James L.

Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches

BLOOD CANCER DISCOVERY

IF11.5

2023-07-27

OAAI

Nair, Pramod C.; Piehler, Jacob; Tvorogov, Denis; Ross, David M.; Lopez, Angel F.; Gotlib, Jason; Thomas, Daniel

Mechanism of receptor assembly via the pleiotropic adipokine Leptin

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2023-03-23

PREAI

Tsirigotaki, Alexandra; Dansercoer, Ann; Verschueren, Koen H. G.; Markovic, Iva; Pollmann, Christoph; Hafer, Maximillian; Felix, Jan; Birck, Catherine; Van Putte, Wouter; Catteeuw, Dominiek; Tavernier, Jan; Fernando Bazan, J.; Piehler, Jacob; Savvides, Savvas N.; Verstraete, Kenneth

STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK-STAT endosomal activation

NATURE CELL BIOLOGY

IF19.1

2023-02-16

PREAI

Zanin, Natacha; de Lesegno, Christine Viaris; Podkalicka, Joanna; Meyer, Thomas; Troncoso, Pamela Gonzalez; Bun, Philippe; Danglot, Lydia; Chmiest, Daniela; Urbe, Sylvie; Piehler, Jacob; Blouin, Cedric M.; Lamaze, Christophe

Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters 质膜形貌控制IgM b细胞抗原受体簇的3D动态定位

EMBO JOURNAL

IF8.3

2023-01-03

OAAI

Saltukoglu, Deniz; Oezdemir, Bugra; Holtmannspoetter, Michael; Reski, Ralf; Piehler, Jacob; Kurre, Rainer; Reth, Michael

Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy 易于将肽-MHC限制性抗体重新用于癌症免疫治疗

NATURE BIOTECHNOLOGY

IF41.7

2023-01-02

OAAI

Yang, Xinbo; Nishimiya, Daisuke; Lochte, Sara; Jude, Kevin M.; Borowska, Marta; Savvides, Christina S.; Dougan, Michael; Su, Leon; Zhao, Xiang; Piehler, Jacob; Garcia, K. Christopher

Super-resolution imaging and quantitative analysis of microtubule arrays in model neurons show that epothilone D increases the density but decreases the length and straightness of microtubules in axon-like processes 模型神经元中微管阵列的超分辨率成像和定量分析表明，埃坡霉素D增加了轴突样过程中微管的密度，但降低了微管的长度和直线度

BRAIN RESEARCH BULLETIN

IF3.7

2022-11-01

OAAI

Conze, Christian; Trushina, Nataliya, I; Holtmannspoetter, Michael; Rierola, Marina; Attanasio, Simone; Bakota, Lidia; Piehler, Jacob; Brandt, Roland

Biofunctional Nanodot Arrays in Living Cells Uncover Synergistic Co-Condensation of Wnt Signalodroplets

SMALL

IF12.1

2022-10-20

OAAI

Philippi, Michael; Richter, Christian P.; Kappen, Marie; Watrinet, Isabelle; Miao, Yi; Runge, Mercedes; Jorde, Lara; Korneev, Sergej; Holtmannspoetter, Michael; Kurre, Rainer; Holthuis, Joost C. M.; Garcia, K. Christopher; Plueckthun, Andreas; Steinhart, Martin; Piehler, Jacob; You, Changjiang

研究方向