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Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics 单细胞超高 throughput 多重染色质和 RNA 定制分析揭示了基因调控动态 Lobato-Moreno, Sara; Yildiz, Umut; Claringbould, Annique; Servaas, Nila H.; Vlachou, Evi P.; Arnold, Christian; Bauersachs, Hanke Gwendolyn; Campos-Fornes, Victor; Kim, Minyoung; Berest, Ivan; Prummel, Karin D.; Noh, Kyung-Min; Marttinen, Mikael; Zaugg, Judith B. 分享 收藏
Integration of genetic and chromatin modification data pinpoints autoimmune-specific remodeling of enhancer landscape in CD4+ T cells Daga, Neha; Servaas, Nila H.; Kisand, Kai; Moonen, Dewi; Arnold, Christian; Reyes-Palomares, Armando; Kaleviste, Epp; Kingo, Kulli; Kuuse, Reet; Ulst, Katrin; Steinmetz, Lars; Peterson, Part; Nakic, Nikolina; Zaugg, Judith B. 分享 收藏
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GRaNIE and GRaNPA: inference and evaluation of enhancer-mediated gene regulatory networks Kamal, Aryan; Arnold, Christian; Claringbould, Annique; Moussa, Rim; Servaas, Nila H.; Kholmatov, Maksim; Daga, Neha; Nogina, Daria; Mueller-Dott, Sophia; Reyes-Palomares, Armando; Palla, Giovanni; Sigalova, Olga; Bunina, Daria; Pabst, Caroline; Zaugg, Judith B. 分享 收藏
MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention Weigel, Bettina; Tegethoff, Jana F. F.; Grieder, Sarah D. D.; Lim, Bryce; Nagarajan, Bhuvaneswari; Liu, Yu-Chao; Truberg, Jule; Papageorgiou, Dimitris; Adrian-Segarra, Juan M. M.; Schmidt, Laura K. K.; Kaspar, Janina; Poisel, Eric; Heinzelmann, Elisa; Saraswat, Manu; Christ, Marleen; Arnold, Christian; Ibarra, Ignacio L. L.; Campos, Joaquin; Krijgsveld, Jeroen; Monyer, Hannah; Zaugg, Judith B. B.; Acuna, Claudio; Mall, Moritz 分享 收藏
Identifying a novel role for the master regulator Tal1 in the Endothelial to Hematopoietic Transition Secanechia, Yasmin Natalia Serina; Bergiers, Isabelle; Rogon, Matt; Arnold, Christian; Descostes, Nicolas; Le, Stephanie; Lopez-Anguita, Natalia; Ganter, Kerstin; Kapsali, Chrysi; Bouilleau, Lea; Gut, Aaron; Uzuotaite, Auguste; Aliyeva, Ayshan; Zaugg, Judith B.; Lancrin, Christophe 分享 收藏
CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia He, Lixiazi; Arnold, Christian; Thoma, Judith; Rohde, Christian; Kholmatov, Maksim; Garg, Swati; Hsiao, Cheng-Chih; Viol, Linda; Zhang, Kaiqing; Sun, Rui; Schmidt, Christina; Janssen, Maike; MacRae, Tara; Huber, Karin; Thiede, Christian; Hebert, Josee; Sauvageau, Guy; Spratte, Julia; Fluhr, Herbert; Aust, Gabriela; Muller-Tidow, Carsten; Niehrs, Christof; Pereira, Gislene; Hamann, Joerg; Tanaka, Motomu; Zaugg, Judith B.; Pabst, Caroline 分享 收藏
Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response Scheller, Marina; Ludwig, Anne Kathrin; Goellner, Stefanie; Rohde, Christian; Kraemer, Stephen; Staeble, Sina; Janssen, Maike; Mueller, James-Arne; He, Lixiazi; Baumer, Nicole; Arnold, Christian; Gerss, Joachim; Schoenung, Maximilian; Thiede, Christian; Niederwieser, Christian; Niederwieser, Dietger; Serve, Hubert; Berdel, Wolfgang E.; Thiem, Ulrich; Hemmerling, Inga; Leuschner, Florian; Plass, Christoph; Schlesner, Matthias; Zaugg, Judith; Milsom, Michael D.; Trumpp, Andreas; Pabst, Caroline; Lipka, Daniel B.; Muller-Tidow, Carsten 分享 收藏
Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension Reyes-Palomares, Armando; Gu, Mingxia; Grubert, Fabian; Berest, Ivan; Sa, Silin; Kasowski, Maya; Arnold, Christian; Shuai, Mao; Srivas, Rohith; Miao, Simon; Li, Dan; Snyder, Michael P.; Rabinovitch, Marlene; Zaugg, Judith B. 分享 收藏
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Quantification of Differential Transcription Factor Activity and Multiomics-Based Classification into Activators and Repressors: diffTF Berest, Ivan; Arnold, Christian; Reyes-Palomares, Armando; Palla, Giovanni; Rasmussen, Kasper Dindler; Giles, Holly; Bruch, Peter-Martin; Huber, Wolfgang; Dietrich, Sascha; Helin, Kristian; Zaugg, Judith B. 分享 收藏
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Genomic and epigenomic co-evolution in follicular lymphomas Loeffler, M.; Kreuz, M.; Haake, A.; Hasenclever, D.; Trautmann, H.; Arnold, C.; Winter, K.; Koch, K.; Klapper, W.; Scholtysik, R.; Rosolowski, M.; Hoffmann, S.; Ammerpohl, O.; Szczepanowski, M.; Herrmann, D.; Kueppers, R.; Pott, C.; Siebert, R. 分享 收藏
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Insecticidal heterolignans-Tubuline polymerization inhibitors with activity against chewing pests Frackenpohl, Jens; Adelt, Isabelle; Antonicek, Horst; Arnold, Christian; Behrmann, Patricia; Blaha, Nicole; Boehmer, Jutta; Gutbrod, Oliver; Hanke, Roman; Hohmann, Sabine; van Houtdreve, Marc; Loesel, Peter; Malsam, Olga; Melchers, Martin; Neufert, Valentina; Peschel, Elisabeth; Reckmann, Udo; Schenke, Thomas; Thiesen, Hans-Peter; Velten, Robert; Vogelsang, Kathrin; Weiss, Hans-Christoph 分享 收藏
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