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梁

梁广 (Guang Liang)

hangzhou medical college

44H指数
167论文数
5.8K被引数
收录论文 100
发表时间
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Discovery of a covalent FGFR2-selective inhibitor overcoming clinically-acquired resistance mutations发现一种克服临床获得性耐药突变的共价FGFR2选择性抑制剂
errNature Communications
IF15.7
err2026-08-03
err0
errOAAI
errXiaohao Huang; Xiansheng Cao; Lulu Zheng; Ruixiang Luo; Zhenglan Fang; Yongling Liang; Yongjuan Zhu; Shiyan Chen; Lei Zheng; Zheng Xu; Xiaokun Li; Guang Liang; Lingfeng Chen
err分享
err收藏
Microglial OTUD6A promotes neuroinflammation and Alzheimer’s disease pathogenesis by deubiquitinating C/EBPβ小胶质细胞OTUD6A通过去泛素化C/EBPβ促进神经炎症和阿尔茨海默病发病机制
errPharmacological Research
IF10.5
err2026-06-03
err0
errOAAI
errLingyu She; Mengqing Li; Fan Chen; Xiaoting Wu; Jingtao Zhang; Wei Jiang; Zefeng Sun; Luyao Li; Juan Ren; Dazhi Chen; Xia Zhao; Guang Liang
err分享
err收藏
The E3 Ubiquitin Ligase RNF123 Mediates Pathological Cardiac Hypertrophy by Ubiquitinating PRDX1 and Upregulating Oxidative Stress in CardiomyocytesE3泛素连接酶RNF123通过泛素化PRDX1并在心肌细胞中上调氧化应激介导病理性心肌肥厚
errActa Physiologica
IF5.6
err2026-05-10
err0
PREAI
errQinyan Wang; Xiaochen Guo; Jiachen Xu; Jinfu Qian; Tianxiang Yu; Qingsong Zheng; Mengyang Wang; Wu Luo; Guang Liang
err分享
err收藏
Osthole targets doublecortin like kinase 1 (DCLK1/DCAMKL1) in macrophages to inhibit NF-κB-mediated inflammation and alleviate atherosclerosis蛇床子素靶向巨噬细胞中的双皮质素样激酶1（DCLK1/DCAMKL1）以抑制NF-κB介导的炎症并缓解动脉粥样硬化
errBritish Journal of Pharmacology
IF7.7
err2026-04-30
err0
PREAI
errSirui Shen; Wu Luo; Yue Guan; Yudie Yang; Pan Chen; Jiaqi Xu; Tong Zhou; Yongping Chen; Guang Liang
err分享
err收藏
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4-Mediated Acute Hepatitis肝细胞BDNF作为新型免疫检查点以抑制TLR4介导的急性肝炎
errAdvanced Science
IF14.1
err2026-03-25
err0
errOAAI
errWeiwei Zhu; Yaqian Cui; Yongqiang Zhou; Yihui Zheng; Lijiang Huang; Leiming Jin; Qianhui Zhang; Pan Chen; Mengsha Lin; Jiaxi Ye; Yongqiang Xiong; Joo Young Huh; Xiang Hu; Xiaokun Li; Wu Luo; Guang Liang
err分享
err收藏
Cardiomyocyte Cyclin-dependent kinase 9 directly binds to and phosphorylates NF-κB p65 subunit to drive cardiac inflammation and remodeling心肌细胞周期素依赖性激酶9直接结合并磷酸化NF-κB p65亚基，以驱动心脏炎症和重塑
errNature Communications
IF15.7
err2026-03-24
err0
errOAAI
errShiju Ye; Yanbo Zhao; Hanxiao Tu; Xue Han; Tong Liu; Yingchao Gong; Jiangting Lu; Tingting Jin; Wu Luo; Xuefeng Qu; Dongwu Lai; Guosheng Fu; Guang Liang
err分享
err收藏
Brain-derived neurotrophic factor and the derived dodecapeptide function as Toll-like receptor 4 antagonists in acute lung injury脑源性神经营养因子及其衍生的十二肽在急性肺损伤中作为Toll样受体4的拮抗剂发挥作用。
errNature Communications
IF15.7
err2026-02-14
err0
errOAAI
errWeiwei Zhu; Leiming Jin; Qianhui Zhang; Yaqian Cui; Yu Zou; Pan Chen; Jiaxi Ye; Yongqiang Xiong; Mengsha Lin; Yongqiang Zhou; Renlv Wu; Yan Liang; Zaishou Zhuang; Joo Young Huh; Wu Luo; Guang Liang
err分享
err收藏
Inhibiting SHP2 improves ventricular remodeling by restoring AMPK phosphorylation and mitochondrial homeostasis抑制SHP2通过恢复AMPK磷酸化和线粒体稳态改善心室重塑
errCell Communication and Signaling
IF8.9
err2026-01-07
err0
errOAAI
errQiao-Juan Shi; Wei-Qi Li; Ya-Nan Liu; Guo-Xuan Liu; Jia-Ning Zheng; Ming-Yang He; Chen-Lu Liu; Yu-Rou Wu; Jie Tong; Meng Zhang; Guang Liang; Hua-Zhong Ying; Xue Han
err分享
err收藏
Arteannuin B, a novel NLRP3 inhibitor, suppresses NLRP3 inflammasome in macrophages and alleviates NLRP3-related diseases青蒿素B，一种新型NLRP3抑制剂，抑制巨噬细胞中的NLRP3炎症小体并缓解NLRP3相关疾病
errInternational Immunopharmacology
IF4.7
err2025-12-29
err0
PREAI
errWeifeng Li; Zhiyu Liang; Mingxiang Jiang; Jingjing Shao; Zhihui Wei; Jinfeng Sun; Haowen Xu; Qiluo Ni; Xinting Lv; Guang Liang; Xiangwei Xu
err分享
err收藏
Corrigendum to “Bicyclol ameliorates nonalcoholic fatty liver disease in mice via inhibiting MAPKs and NF-κB signaling pathways” [Biomed. Pharmacother. 141 (2021) 1–12/111874]勘误：“Bicyclol ameliorates nonalcoholic fatty liver disease in mice via inhibiting MAPKs and NF-κB signaling pathways” [Biomed. Pharmacother. 141 (2021) 1–12/111874]
errBiomedicine & Pharmacotherapy
IF7.5
err2025-12-08
err0
errOAAI
errWeixin Zhao; Yixiao Yan; Zhongxiang Xiao; Meihong Wang; Mingjiang Xu; Zhe Wang; Yi Wang; Zaishou Zhuang; Daona Yang; Gaozhi Chen; Guang Liang
err分享
err收藏
USP13 ameliorates diabetic cardiomyopathy via deubiquitinating NLRP3 and inhibiting pyroptosis in cardiomyocytesUSP13 通过去泛素化 NLRP3 并抑制心肌细胞中的焦亡，改善糖尿病心肌病。
errCell Death & Differentiation
IF0
err2025-11-08
err0
PREAI
errDiyun Xu; Jibo Han; Bozhi Ye; Liming Lin; Jiaji Chen; Yanhong Jin; Ying Zhao; Yi Wang; Peiren Shan; Guang Liang
err分享
err收藏
Isolinderalactone regulates macrophage polarization and efferocytosis by activating the LXRα pathway against ulcerative colitisIsolinderalactone通过激活LXRα通路调节巨噬细胞极化和清除凋亡细胞，以对抗溃疡性结肠炎。
errChinese Medicine
IF5.7
err2025-10-02
err0
errOAAI
errMincong Huang; Mengyao Lan; Xin Liu; Cailu Lin; Lulu Zeng; Ying Li; Feng Li; Xiaotong Dou; Yan Zhao; Yuan Shi; Xiangwei Xu; Jinfeng Sun; Guang Liang
err分享
err收藏
Taxifolin Attenuates Cisplatin-Induced Acute Kidney Injury by Promoting Fatty Acid Oxidation槲皮素通过促进脂肪酸氧化减轻顺铂诱导的急性肾损伤
errJOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
IF2.8
err2025-10-01
err0
PREAI
errJin, Xuejin; Wang, Lingkun; Yuan, Miao; Tao, Huanyan; Zha, Huiyan; Xu, Zheng; Liang, Guang; Xu, Xiangwei; Zhou, Qian
err分享
err收藏
Angiotensin II-induced phosphorylation of CHK1 at serine-280 drives cardiac remodelling by direct phosphorylation of JAK1, thus activating JAK1-STAT signalling in murine cardiomyocytes血管紧张素II诱导的CHK1在丝氨酸-280处的磷酸化通过直接磷酸化JAK1，从而在鼠心肌细胞中激活JAK1-STAT信号通路，驱动心脏重塑。
errBritish Journal of Pharmacology
IF7.7
err2025-08-24
err0
PREAI
errZheng Xu; Yihan Shen; Xiaoting Luo; Jingru Wang; Qian Zhou; Xue Han; Juan Ren; Lihong Wang; Guang Liang
err分享
err收藏
USP13 promotes hepatic stellate cells activation and aggravates liver fibrosis through deubiquitinating SMAD3USP13通过去泛素化SMAD3促进肝星状细胞活化并加重肝纤维化
errHepatology International
IF6.1
err2025-07-28
err0
PREAI
errAo Wang; Hui Dong; Yaqian Cui; Weiwei Zhu; Jiaxi Ye; Leiming Jin; Yongqiang Xiong; Qianhui Zhang; Mengsha Lin; Jibo Han; Zimin Fang; Xiang Hu; Wu Luo; Guang Liang
err分享
err收藏
YOD1 mediates isoproterenol-induced cardiac remodeling by deubiquitinating PKM2 and reducing PKM2 tetramerization in cardiomyocytesYOD1通过去泛素化PKM2并在心肌细胞中降低PKM2四聚化，介导异丙肾上腺素诱导的心脏重塑。
errActa Pharmacologica Sinica
IF8.4
err2025-06-11
err0
PREAI
errQing-song Zheng; Yong-qiang Xiong; Jia-chen Xu; Jin-fu Qian; Wu Luo; Qin-yan Wang; Yan-ni Zhao; Yue Luo; Ya-qian Cui; Yi Fang; Xiao-chen Guo; Ding-dao Chen; Yi Wang; Guang Liang
err分享
err收藏
N-Terminal random curl-tandam α-helical peptide 7W: A potent antibacterial and anti-inflammatory dual-effect agent through tryptophan substitutionN端随机卷曲-串联α螺旋肽7W：一种通过色氨酸替换实现的强效抗菌和抗炎双效剂
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-05-10
err0
PREAI
errLou, Jietao; Wu, Xinyi; Ji, Wenwen; Yu, Jiaye; Xu, Yanyan; Xiao, Wanyang; Lu, Weijie; Xin, Kaiyun; Chen, Tianbao; Tang, Qidong; Liang, Guang; Gao, Yitian; Wu, Di
err分享
err收藏
Dehydroabietic acid protects against cerebral ischaemia–reperfusion injury by modulating microglia-mediated neuroinflammation via targeting PKCδ脱氢松香酸通过靶向PKCδ，调节小胶质细胞介导的神经炎症，从而对抗脑缺血-再灌注损伤。
errBritish Journal of Pharmacology
IF7.7
err2025-04-22
err0
PREAI
errLuyao Li; Hao Tang; Lingyu She; Zhen lin; Qin Yu; Yuqing Zeng; Linjie Chen; Fan Chen; Guang Liang; Xia Zhao; Namki Cho; Yi Wang
err分享
err收藏
Macrophage WEE1 Directly Binds to and Phosphorylates NF-κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis巨噬细胞中的WEE1直接结合并磷酸化NF-κB p65亚基，以诱导炎症反应并驱动动脉粥样硬化。
errADVANCED SCIENCE
IF14.1
err2025-04-09
err0
errOAAI
errHuang, ZQ; Shen, SR; Li, WX; Wang, MY; Yang, YD; Luo, W; Han, X; Xu, Z; Min, JL; Long, XH; Huang, WJ; Wu, GJ; Wang, Y; Liang, G
err分享
err收藏
Discovery of c-Kit as a New Therapeutic Target in LPS-Induced Acute Lung Injury through Novel Phenylamide Derivative D9通过新型苯酰胺衍生物D9发现c-Kit可作为LPS诱导的急性肺损伤的新治疗靶点
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-03-24
err0
PREAI
errLuo, Wu; Dong, Ke; Dai, Jintian; Zhang, Anqi; Chen, Pan; Chen, Zhichao; Guo, Mi; Sun, Chenhui; Yang, Jun; Huang, Nan; Zou, Yu; Zheng, Zhiwei; Cho, Won-Jea; Chen, Xiaojun; Cho, Young-Chang; Sun, Jinfeng; Liang, Guang
err分享
err收藏

研究方向

代谢性疾病并发症机制与新药研发
合作学者
合作期刊
C
Carlo M. Croce
H 指数: 209 · 论文数: 1.8K
J
James L. Abbruzzese
H 指数: 129 · 论文数: 783
R
Robert A. Wolff
H 指数: 106 · 论文数: 1.0K
张
张熠 (Yi Zhang)
H 指数: 103 · 论文数: 2.2K
P
Peter Cresswell
H 指数: 99 · 论文数: 363
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