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The Polybrominated Diphenyl Ether Bromoxib Disrupts Nuclear Import and Export by Affecting Nucleoporins of the Nuclear Pore Complex 多溴联苯醚溴oxib通过影响核孔复合体的核孔蛋白来破坏核输入和输出。 Krings, Karina S.; Ritchie, Anastasia; Schmitt, Laura; Hatzfeld, Judith; Totzke, Gudrun; Lenz, Thomas; Mendiburo, Maria Jose; Stork, Bjoern; Teusch, Nicole; Proksch, Peter; Stuehler, Kai; Mueller, Lisa; Wesselborg, Sebastian 分享 收藏
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Targeting mitochondrial metabolism by the mitotoxin bromoxib in leukemia and lymphoma cells Schmitt, Laura; Krings, Karina S.; Wolsing, Andre; Buque, Xabier; Zimmermann, Marcel; Flores-Romero, Hector; Lenz, Thomas; Lechtenberg, Ilka; Peter, Christoph; Stork, Bjoern; Teusch, Nicole; Proksch, Peter; Stuehler, Kai; Garcia-Saez, Ana J.; Reichert, Andreas S.; Aspichueta, Patricia; Bhatia, Sanil; Wesselborg, Sebastian 分享 收藏
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Novel meriolin derivatives potently inhibit cell cycle progression and transcription in leukemia and lymphoma cells via inhibition of cyclin-dependent kinases (CDKs) Schmitt, Laura; Hoppe, Julia; Cea-Medina, Pablo; Bruch, Peter-Martin; Krings, Karina S.; Lechtenberg, Ilka; Driessen, Daniel; Peter, Christoph; Bhatia, Sanil; Dietrich, Sascha; Stork, Bjoern; Fritz, Gerhard; Gohlke, Holger; Mueller, Thomas J. J.; Wesselborg, Sebastian 分享 收藏
Combined inhibition of class 1-PI3K-alpha and delta isoforms causes senolysis by inducing p21WAF1/CIP1 proteasomal degradation in senescent cells Neuwahl, Judith; Neumann, Chantal A.; Fitz, Annika C.; Biermann, Anica D.; Magel, Maja; Friedrich, Annabelle; Sellin, Lorenz; Stork, Bjoern; Piekorz, Roland P.; Proksch, Peter; Budach, Wilfried; Jaenicke, Reiner U.; Sohn, Dennis 分享 收藏
Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2 Schmitt, Laura; Lechtenberg, Ilka; Driessen, Daniel; Flores-Romero, Hector; Skowron, Margaretha A.; Sekeres, Marlena; Hoppe, Julia; Krings, Karina S.; Llewellyn, Tanya R.; Peter, Christoph; Stork, Bjorn; Qin, Nan; Bhatia, Sanil; Nettersheim, Daniel; Fritz, Gerhard; Garcia-Saez, Ana J.; Mueller, Thomas J. J.; Wesselborg, Sebastian 分享 收藏
Modular Approach for the Synthesis and Bioactivity Profiling of 8,8′-Biflavones Klischan, Moritz K. T.; Mazzone, Flaminia; Berning, Lena; Greb, Julian; Schlamkow, Max; Haase, Mona; Frey, Wolfgang; Stork, Bjoern; Pfeffer, Klaus; Pietruszka, Joerg 分享 收藏
The Golgi stacking protein GRASP55 is targeted by the natural compound prodigiosin Berning, Lena; Lenz, Thomas; Bergmann, Ann Kathrin; Poschmann, Gereon; Brass, Hannah U. C.; Schluetermann, David; Friedrich, Annabelle; Mendiburo, Maria Jose; David, Celine; Akguen, Seda; Pietruszka, Jorg; Stuehler, Kai; Stork, Bjorn 分享 收藏
Metamorphic proteins at the basis of human autophagy initiation and lipid transfer Nguyen, Anh; Lugarini, Francesca; David, Celine; Hosnani, Pouya; Alagoez, Cagla; Friedrich, Annabelle; Schluetermann, David; Knotkova, Barbora; Patel, Anoshi; Parfentev, Iwan; Urlaub, Henning; Meinecke, Michael; Stork, Bjorn; Faesen, Alex C. 分享 收藏
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The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism 霉菌毒素病毒毒素通过靶向线粒体代谢诱导白血病和淋巴瘤特异性细胞凋亡 Stuhldreier, Fabian; Schmitt, Laura; Lenz, Thomas; Hinxlage, Ilka; Zimmermann, Marcel; Wollnitzke, Philipp; Schliehe-Diecks, Julian; Liu, Yang; Jaeger, Paul; Geyh, Stefanie; Teusch, Nicole; Peter, Christoph; Bhatia, Sanil; Haas, Rainer; Levkau, Bodo; Reichert, Andreas S.; Stuehler, Kai; Proksch, Peter; Stork, Bjoern; Wesselborg, Sebastian 分享 收藏
Drug affinity-responsive target stability unveils filamins as biological targets for artemetin, an anti-cancer flavonoid 药物亲和力响应性靶标稳定性揭示了丝状维生素作为抗癌黄酮类化合物artemetin的生物靶标 Ferraro, Giusy; Belvedere, Raffaella; Petrella, Antonello; Tosco, Alessandra; Stork, Bjoern; Salamone, Stefano; Minassi, Alberto; Pollastro, Federica; Morretta, Elva; Monti, Maria Chiara 分享 收藏
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Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells Fin56-induced铁死亡由自噬介导的GPX4降解支持，并与mTOR抑制协同作用杀死膀胱癌细胞 Sun, Yadong; Berleth, Niklas; Wu, Wenxian; Schluetermann, David; Deitersen, Jana; Stuhldreier, Fabian; Berning, Lena; Friedrich, Annabelle; Akguen, Seda; Mendiburo, Maria Jose; Wesselborg, Sebastian; Conrad, Marcus; Berndt, Carsten; Stork, Bjorn 分享 收藏
ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy Hu, Zehan; Sankar, Devanarayanan Siva; Vu, Bich; Leytens, Alexandre; Vionnet, Christine; Wu, Wenxian; Stumpe, Michael; Martinez-Martinez, Esther; Stork, Bjoern; Dengjel, Joern 分享 收藏
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