未登录 Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration Jiang, Ying; Alam, John J.; Gomperts, Stephen N.; Maruff, Paul; Lemstra, Afina W.; Germann, Ursula A.; Stavrides, Philip H.; Darji, Sandipkumar; Malampati, Sandeep; Peddy, James; Bleiwas, Cynthia; Pawlik, Monika; Pensalfini, Anna; Yang, Dun-Sheng; Subbanna, Shivakumar; Basavarajappa, Balapal S.; Smiley, John F.; Gardner, Amanda; Blackburn, Kelly; Chu, Hui-May; Prins, Niels D.; Teunissen, Charlotte E.; Harrison, John E.; Scheltens, Philip; Nixon, Ralph A. 分享 收藏
Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib) Germann, Ursula A.; Furey, Brinley F.; Markland, William; Hoover, Russell R.; Aronov, Alex M.; Roix, Jeffrey J.; Hale, Michael; Boucher, Diane M.; Sorrell, David A.; Martinez-Botella, Gabriel; Fitzgibbon, Matthew; Shapiro, Paul; Wick, Michael J.; Samadani, Ramin; Meshaw, Kathryn; Groover, Anna; DeCrescenzo, Gary; Namchuk, Mark; Emery, Caroline M.; Saha, Saurabh; Welsch, Dean J. 分享 收藏
Novel Ranking System for Identifying Efficacious Anti-Influenza Virus PB2 Inhibitors Tsai, Alice W.; McNeil, Colleen F.; Leeman, Joshua R.; Bennett, Hamilton B.; Nti-Addae, Kwame; Huang, Cassey; Germann, Ursula A.; Byrn, Randal A.; Berlioz-Seux, Francoise; Rijnbrand, Rene; Clark, Michael P.; Charifson, Paul S.; Jones, Steven M. 分享 收藏
The selective ERK inhibitor BVD-523 is active in models of MAPK pathway-dependent cancers, including those with intrinsic and acquired drug resistance Germann, Ursula; Furey, Brinley; Roix, Jeff; Markland, William; Hoover, Russell; Aronov, Alex; Hale, Michael; Chen, Guanjing; Martinez-Botella, Gabriel; Alargova, Rossitza; Fan, Bin; Sorrell, David; Meshaw, Kay; Shapiro, Paul; Wick, Michael J.; Benes, Cyril; Garnett, Mathew; DeCrescenzo, Gary; Namchuk, Mark; Saha, Saurabh; Welsch, Dean J. 分享 收藏
Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2 Clark, Michael P.; Ledeboer, Mark W.; Davies, Ioana; Byrn, Randal A.; Jones, Steven M.; Perola, Emanuele; Tsai, Alice; Jacobs, Marc; Nti-Addae, Kwame; Bandarage, Upul K.; Boyd, Michael J.; Bethiel, Randy S.; Court, John J.; Deng, Hongbo; Duffy, John P.; Dorsch, Warren A.; Farmer, Luc J.; Gao, Huai; Gu, Wenxin; Jackson, Katrina; Jacobs, Dylan H.; Kennedy, Joseph M.; Ledford, Brian; Liang, Jianglin; Maltais, Francois; Murcko, Mark; Wang, Tiansheng; Wannamaker, M. Woods; Bennett, Hamilton B.; Leeman, Joshua R.; McNeil, Colleen; Taylor, William P.; Memmott, Christine; Jiang, Min; Rijnbrand, Rene; Bral, Christopher; Germann, Ursula; Nezami, Azin; Zhang, Yuegang; Salituro, Francesco G.; Bennani, Youssef L.; Charifson, Paul S. 分享 收藏
The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor Duffy, John P.; Harrington, Edmund M.; Salituro, Francesco G.; Cochran, John E.; Green, Jeremy; Gao, Huai; Bemis, Guy W.; Evindar, Ghotas; Galullo, Vincent P.; Ford, Pamella J.; Germann, Ursula A.; Wilson, Keith P.; Bellon, Steven F.; Chen, Guanging; Taslimi, Paul; Jones, Peter; Huang, Cassey; Pazhanisamy, S.; Wang, Yow-Ming; Murcko, Mark A.; Su, Michael S. S. 分享 收藏
Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic Azaindole Wang, Tiansheng; Duffy, John P.; Wang, Jian; Halas, Summer; Salituro, Francesco G.; Pierce, Albert C.; Zuccola, Harmon J.; Black, James R.; Hogan, James K.; Jepson, Scott; Shlyakter, Dina; Mahajan, Sudipta; Gu, Yong; Hoock, Thomas; Wood, Mark; Furey, Brinley F.; Frantz, J. Daniel; Dauffenbach, Lisa M.; Germann, Ursula A.; Fan, Bin; Namchuk, Mark; Bennani, Youssef L.; Ledeboer, Mark W. 分享 收藏
Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (ERK) Using Conformational Control Aronov, Alex M.; Tang, Qing; Martinez-Botella, Gabriel; Bemis, Guy W.; Cao, Jingrong; Chen, Guanjing; Ewing, Nigel P.; Ford, Pamella J.; Germann, Ursula A.; Green, Jeremy; Hale, Michael R.; Jacobs, Marc; Janetka, James W.; Maltais, Francois; Markland, William; Namchuk, Mark N.; Nanthakumar, Suganthini; Poondru, Srinivasu; Straub, Judy; ter Haar, Ernst; Xie, Xiaoling 分享 收藏
(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1β and IL-18 (S)-1-((S)-2-{[1-(4-氨基-3-氯-苯基)-甲酰基]-氨基}-3，3-二甲基-丁酰基)-pyrrolidine-2-carboxylic ((2R，3s)-2-乙氧基-5-氧代-四氢呋喃-3-基)-酰胺 (VX-765)，一种口服的选择性白细胞介素 (IL) 转化酶/caspase-1抑制剂，通过抑制IL-1β 和IL-18的释放表现出有效的抗炎活性 Wannamaker, Woods; Davies, Robert; Namchuk, Mark; Pollard, John; Ford, Pamella; Ku, George; Decker, Caroline; Charifson, Paul; Weber, Peter; Germann, Ursula A.; Kuida, Keisuke; Randle, John C. R. 分享 收藏
Flipped out: Structure-guided design of selective pyrazolylpyrrole ERK inhibitors Aronov, Alex M.; Baker, Christopher; Bemis, Guy W.; Cao, Jingrong; Chen, Guanjing; Ford, Pamella J.; Germann, Ursula A.; Green, Jeremy; Hale, Michael R.; Jacobs, Marc; Janetka, James W.; Maltais, Francois; Martinez-Botella, Gabriel; Namchuk, Mark N.; Straub, Judy; Tang, Qing; Xie, Xiaoling 分享 收藏
c-jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo Shao, ZL; Bhattacharya, K; Hsich, E; Park, L; Walters, B; Germann, U; Wang, YM; Kyriakis, J; Mohanlal, R; Kuida, K; Namchuk, M; Salituro, F; Yao, YM; Hou, WM; Chen, X; Aronovitz, M; Tsichlis, PN; Bhattacharya, S; Force, T; Kilter, H 分享 收藏
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