未登录 Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens 通过大规模功能性表观基因组筛选揭示的YAP应答元件的癌症谱系特异性调控 Barbosa, Ines A. M.; Gopalakrishnan, Rajaraman; Mercan, Samuele; Mourikis, Thanos P.; Martin, Typhaine; Wengert, Simon; Sheng, Caibin; Ji, Fei; Lopes, Rui; Knehr, Judith; Altorfer, Marc; Lindeman, Alicia; Russ, Carsten; Naumann, Ulrike; Golji, Javad; Sprouffske, Kathleen; Barys, Louise; Tordella, Luca; Schubeler, Dirk; Schmelzle, Tobias; Galli, Giorgio G. 分享 收藏
DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery Li, Jingyao; Ho, Daniel J.; Henault, Martin; Yang, Chian; Neri, Marilisa; Ge, Robin; Renner, Steffen; Mansur, Leandra; Lindeman, Alicia; Kelly, Brian; Tumkaya, Tayfun; Ke, Xiaoling; Soler-Llavina, Gilberto; Shanker, Gopi; Russ, Carsten; Hild, Marc; Keller, Caroline Gubser; Jenkins, Jeremy L.; Worringer, Kathleen A.; Sigoillot, Frederic D.; Ihry, Robert J. 分享 收藏
Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites Paul, Atanu; Annunziato, Stefano; Lu, Bo; Sun, Tianliang; Evrova, Olivera; Planas-Paz, Lara; Orsini, Vanessa; Terracciano, Luigi M.; Charlat, Olga; Loureiro, Zinger Yang; Ji, Lei; Zamponi, Raffaella; Sigoillot, Frederic; Lei, Hong; Lindeman, Alicia; Russ, Carsten; Reece-Hoyes, John S.; Nicholson, Thomas B.; Tchorz, Jan S.; Cong, Feng 分享 收藏
Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons Sanchez, Carlos G.; Acker, Christopher M.; Gray, Audrey; Varadarajan, Malini; Song, Cheng; Cochran, Nadire R.; Paula, Steven; Lindeman, Alicia; An, Shaojian; McAllister, Gregory; Alford, John; Reece-Hoyes, John; Russ, Carsten; Craig, Lucas; Capre, Ketthsy; Doherty, Christian; Hoffman, Gregory R.; Luchansky, Sarah J.; Polydoro, Manuela; Dolmetsch, Ricardo; Elwood, Fiona 分享 收藏
A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production 全基因组CRISPR筛选确定ZCCHC14作为乙型肝炎表面抗原生产所需的宿主因子 Hyrina, Anastasia; Jones, Christopher; Chen, Darlene; Clarkson, Scott; Cochran, Nadire; Feucht, Paul; Hoffman, Gregory; Lindeman, Alicia; Russ, Carsten; Sigoillot, Frederic; Tsang, Tiffany; Uehara, Kyoko; Xie, Lili; Ganem, Don; Holdorf, Meghan 分享 收藏
Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC Zeng, Hao; Castillo-Cabrera, Johnny; Manser, Mika; Lu, Bo; Yang, Zinger; Strande, Vaik; Begue, Damien; Zamponi, Raffaella; Qiu, Shumei; Sigoillot, Frederic; Wang, Qiong; Lindeman, Alicia; Reece-Hoyes, John S.; Russ, Carsten; Bonenfant, Debora; Jiang, Xiaomo; Wang, Youzhen; Cong, Feng 分享 收藏
IRF2 is a master regulator of human keratinocyte stem cell fate Mercado, Nicolas; Schutzius, Gabi; Kolter, Christian; Estoppey, David; Bergling, Sebastian; Roma, Guglielmo; Keller, Caroline Gubser; Nigsch, Florian; Salathe, Adrian; Terranova, Remi; Reece-Hoyes, John; Alford, John; Russ, Carsten; Knehr, Judith; Hoepfner, Dominic; Aebi, Alexandra; Ruffner, Heinz; Beck, Tanner C.; Jagannathan, Sajjeev; Olson, Calla M.; Sheppard, Hadley E.; Elsarrag, Selma Z.; Bouwmeester, Tewis; Frederiksen, Mathias; Lohmann, Felix; Lin, Charles Y.; Kirkland, Susan 分享 收藏
USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin Ji, Lei; Lu, Bo; Zamponi, Raffaella; Charlat, Olga; Aversa, Robert; Yang, Zinger; Sigoillot, Frederic; Zhu, Xiaoping; Hu, Tiancen; Reece-Hoyes, John S.; Russ, Carsten; Michaud, Gregory; Tchorz, Jan S.; Jiang, Xiaomo; Cong, Feng 分享 收藏
YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury Planas-Paz, Lara; Sun, Tianliang; Pikiolek, Monika; Cochran, Nadire R.; Bergling, Sebastian; Orsini, Vanessa; Yang, Zinger; Sigoillot, Frederic; Jetzer, Jasna; Syed, Maryam; Neri, Marilisa; Schuierer, Sven; Morelli, Lapo; Hoppe, Philipp S.; Schwarzer, Wibke; Cobos, Carlos M.; Alford, John L.; Zhang, Le; Cuttat, Rachel; Waldt, Annick; Carballido-Perrig, Nicole; Nigsch, Florian; Kinzel, Bernd; Nicholson, Thomas B.; Yang, Yi; Mao, Xiaohong; Terracciano, Luigi M.; Russ, Carsten; Reece-Hoyes, John S.; Keller, Caroline Gubser; Sailer, Andreas W.; Bouwmeester, Tewis; Greenbaum, Linda E.; Lugus, Jesse J.; Cong, Feng; McAllister, Gregory; Hoffman, Gregory R.; Roma, Guglielmo; Tchorz, Jan S. 分享 收藏
Genome-Scale CRISPR Screens Identify Human Pluripotency-Specific Genes Ihry, Robert J.; Salick, Max R.; Ho, Daniel J.; Sondey, Marie; Kommineni, Sravya; Paula, Steven; Raymond, Joe; Henry, Beata; Frias, Elizabeth; Wang, Qiong; Worringer, Kathleen A.; Ye, Chaoyang; Russ, Carsten; Reece-Hoyes, John S.; Altshuler, Robert C.; Randhawa, Ranjit; Yang, Zinger; McAllister, Gregory; Hoffman, Gregory R.; Dolmetsch, Ricardo; Kaykas, Ajamete 分享 收藏
Bile acid analogues are activators of pyrin inflammasome Alimov, Irina; Menon, Suchithra; Cochran, Nadire; Maher, Rob; Wang, Qiong; Alford, John; Concannon, John B.; Yang, Zinger; Harrington, Edmund; Llamas, Luis; Lindeman, Alicia; Hoffman, Gregory; Schuhmann, Tim; Russ, Carsten; Reece-Hoyes, John; Canham, Stephen M.; Cai, Xinming 分享 收藏
Previously Uncharacterized Vacuolar-type ATPase Binding Site Discovered from Structurally Similar Compounds with Distinct Mechanisms of Action Wang, Andrew C.; Pham, Helen T.; Lipps, Jennifer M.; Brittain, Scott M.; Harrington, Edmund; Wang, Yuan; King, Fred J.; Russ, Carsten; Pan, Xuewen; Hoepfner, Dominic; Tallarico, John; Feng, Yan; Jain, Rishi K.; Schirle, Markus; Thomas, Jason R. 分享 收藏
TRIAMF: A New Method for Delivery of Cas9 Ribonucleoprotein Complex to Human Hematopoietic Stem Cells Yen, Jonathan; Fiorino, Michael; Liu, Yi; Paula, Steve; Clarkson, Scott; Quinn, Lisa; Tschantz, William R.; Klock, Heath; Guo, Ning; Russ, Carsten; Yu, Vionnie W. C.; Mickanin, Craig; Stevenson, Susan C.; Lee, Cameron; Yang, Yi 分享 收藏
Guide Swap enables genome-scale pooled CRISPR-Cas9 screening in human primary cells Ting, Pamela Y.; Parker, Albert E.; Lee, J. Scott; Trussell, Chris; Sharif, Orzala; Luna, Fabio; Federe, Glenn; Barnes, S. Whitney; Walker, John R.; Vance, Julie; Gao, Mu-Yun; Klock, Heath E.; Clarkson, Scott; Russ, Carsten; Miraglia, Loren J.; Cooke, Michael P.; Boitano, Anthony E.; McNamara, Peter; Lamb, John; Schmedt, Christian; Snead, Jennifer L. 分享 收藏
mTORC1 signaling suppresses Wnt/β-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level mTORC1信号通过DVL依赖性调节Wnt受体FZD水平抑制Wnt/β-catenin信号通路 Zeng, Hao; Lu, Bo; Zamponi, Raffaella; Yang, Zinger; Wetzel, Kristie; Loureiro, Joseph; Mohammadi, Sina; Beibel, Martin; Bergling, Sebastian; Reece-Hoyes, John; Russ, Carsten; Roma, Guglielmo; Tchorz, Jan S.; Capodieci, Paola; Cong, Feng 分享 收藏
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TMEM41B is a novel regulator of autophagy and lipid mobilization TMEM41B是自噬和脂质动员的新型调节剂 Moretti, Francesca; Bergman, Phil; Dodgson, Stacie; Marcellin, David; Claerr, Isabelle; Goodwin, Jonathan M.; DeJesus, Rowena; Kang, Zhao; Antczak, Christophe; Begue, Damien; Bonenfant, Debora; Graff, Alexandra; Genoud, Christel; Reece-Hoyes, John S.; Russ, Carsten; Yang, Zinger; Hoffman, Gregory R.; Mueller, Matthias; Murphy, Leon O.; Xavier, Ramnik J.; Nyfeler, Beat 分享 收藏
p53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells p53抑制人多能干细胞的CRISPR-Cas9工程 Ihry, Robert J.; Worringer, Kathleen A.; Salick, Max R.; Frias, Elizabeth; Ho, Daniel; Theriault, Kraig; Kommineni, Sravya; Chen, Julie; Sondey, Marie; Ye, Chaoyang; Randhawa, Ranjit; Kulkarni, Tripti; Yang, Zinger; McAllister, Gregory; Russ, Carsten; Reece-Hoyes, John; Forrester, William; Hoffman, Gregory R.; Dolmetsch, Ricardo; Kaykas, Ajamete 分享 收藏
TRRAP is a central regulator of human multiciliated cell formation Wang, Zhao; Plasschaert, Lindsey W.; Aryal, Shivani; Renaud, Nicole A.; Yang, Zinger; Choo-Wing, Rayman; Pessotti, Angelica D.; Kirkpatrick, Nathaniel D.; Cochran, Nadire R.; Carbone, Walter; Maher, Rob; Lindeman, Alicia; Russ, Carsten; Reece-Hoyes, John; McAllister, Gregory; Hoffman, Gregory R.; Roma, Guglielmo; Jaffe, Aron B. 分享 收藏
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