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mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node mTOR通路疾病：从实验室到临床的挑战与机遇及mTOR节点 Mantoan Ritter, Laura; Annear, Nicholas M. P.; Baple, Emma L.; Ben-Chaabane, Leila Y.; Bodi, Istvan; Brosson, Lauren; Cadwgan, Jill E.; Coslett, Bryn; Crosby, Andrew H.; Davies, D. Mark; Daykin, Nicola; Dedeurwaerdere, Stefanie; Duehring Fenger, Christina; Dunlop, Elaine A.; Elmslie, Frances V.; Girodengo, Marie; Hambleton, Sophie; Jansen, Anna C.; Johnson, Simon R.; Kearley, Kelly C.; Kingswood, John C.; Laaniste, Liisi; Lachlan, Katherine; Latchford, Andrew; Madsen, Ralitsa R.; Mansour, Sahar; Mihaylov, Simeon R.; Muhammed, Louwai; Oliver, Claire; Pepper, Tom; Rawlins, Lettie E.; Schim van der Loeff, Ina; Siddiqui, Ata; Takhar, Pooja; Tatton-Brown, Katrina; Tee, Andrew R.; Tibarewal, Priyanka; Tye, Charlotte; Ultanir, Sila K.; Vanhaesebroeck, Bart; Zare, Benjamin; Pal, Deb K.; Bateman, Joseph M. 分享 收藏
Oncogenic PIK3CA corrupts growth factor signaling specificity Madsen, Ralitsa R.; Le Marois, Alix; Mruk, Oliwia N.; Voliotis, Margaritis; Yin, Shaozhen; Sufi, Jahangir; Qin, Xiao; Zhao, Salome J.; Gorczynska, Julia; Morelli, Daniele; Davidson, Lindsay; Sahai, Erik; Korolchuk, Viktor, I; Tape, Christopher J.; Vanhaesebroeck, Bart 分享 收藏
Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development Courreges, Christina J. F.; Davenport, Elizabeth C. M.; Bilanges, Benoit; Rebollo-Gomez, Elena; Hukelmann, Jens; Schoenfelder, Priya; Edgar, James R.; Sansom, David; Scudamore, Cheryl L.; Roychoudhuri, Rahul; Garden, Oliver A.; Vanhaesebroeck, Bart; Okkenhaug, Klaus 分享 收藏
An integrated approach identifies the molecular underpinnings of murine anterior visceral endoderm migration Thowfeequ, Shifaan; Fiorentino, Jonathan; Hu, Di; Solovey, Maria; Ruane, Sharon; Whitehead, Maria; Zhou, Felix; Godwin, Jonathan; Mateo-Otero, Yentel; Vanhaesebroeck, Bart; Scialdone, Antonio; Srinivas, Shankar 分享 收藏
A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease Conduit, Sarah E.; Pearce, Wayne; Bhamra, Amandeep; Bilanges, Benoit; Bozal-Basterra, Laura; Foukas, Lazaros C.; Cobbaut, Mathias; Castillo, Sandra D.; Danesh, Mohammad Amin; Adil, Mahreen; Carracedo, Arkaitz; Graupera, Mariona; McDonald, Neil Q.; Parker, Peter J.; Cutillas, Pedro R.; Surinova, Silvia; Vanhaesebroeck, Bart 分享 收藏
Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus Herms, Albert; Colom, Bartomeu; Piedrafita, Gabriel; Kalogeropoulou, Argyro; Banerjee, Ujjwal; King, Charlotte; Abby, Emilie; Murai, Kasumi; Caseda, Irene; Fernandez-Antoran, David; Ong, Swee Hoe; Hall, Michael W. J.; Bryant, Christopher; Sood, Roshan K.; Fowler, Joanna C.; Pol, Albert; Frezza, Christian; Vanhaesebroeck, Bart; Jones, Philip H. 分享 收藏
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PI3K-C2β limits mTORC1 signaling and angiogenic growth Kobialka, Piotr; Llena, Judith; Deleyto-Seldas, Nerea; Munar-Gelabert, Margalida; Dengra, Jose A.; Villacampa, Pilar; Albinya-Pedros, Alba; Muixi, Laia; Andrade, Jorge; van Splunder, Hielke; Angulo-Urarte, Ana; Potente, Michael; Grego-Bessa, Joaquim; Castillo, Sandra D.; Vanhaesebroeck, Bart; Efeyan, Alejo; Graupera, Mariona 分享 收藏
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Leverage of nuclease-deficient CasX for preventing pathological angiogenesis Han, Haote; Yang, Yanhui; Jiao, Yunjuan; Qi, Hui; Han, Zhuo; Wang, Luping; Dong, Lijun; Tian, Jingkui; Vanhaesebroeck, Bart; Li, Xiaopeng; Liu, Junwen; Ma, Gaoen; Lei, Hetian 分享 收藏
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Endothelial phosphoinositide 3-kinase-β inactivation confers protection from immune-mediated vascular injury Masoud, Andrew G.; Lin, Jiaxin; Zhu, Lin F.; Tao, Kesheng; Ness, Nathan W.; Kassiri, Zamaneh; Moore, Ronald B.; Vanhaesebroeck, Bart; West, Lori; Anderson, Colin C.; Oudit, Gavin Y.; Murray, Allan G. 分享 收藏
NFκB-Mediated Expression of Phosphoinositide 3-Kinase δ Is Critical for Mesenchymal Transition in Retinal Pigment Epithelial Cells Han, Haote; Yang, Yanhui; Han, Zhuo; Wang, Luping; Dong, Lijun; Qi, Hui; Liu, Bing; Tian, Jingkui; Vanhaesebroeck, Bart; Kazlauskas, Andrius; Zhang, Guoming; Zhang, Shaochong; Lei, Hetian 分享 收藏
Idelalisib inhibits experimental proliferative vitroretinopathy Dong, Lijun; Han, Haote; Huang, Xionggao; Ma, Gaoen; Fang, Dong; Qi, Hui; Han, Zhuo; Wang, Luping; Tian, Jingkui; Vanhaesebroeck, Bart; Zhang, Guoming; Zhang, Shaochong; Lei, Hetian 分享 收藏
Long-term treatment of cancer-prone germline PTEN mutant mice with low-dose rapamycin extends lifespan and delays tumour development Tibarewal, Priyanka; Rathbone, Victoria; Constantinou, Georgia; Pearce, Wayne; Adil, Mahreen; Varyova, Zofia; Folkes, Lisa; Hampson, Alix; Classen, Gala Anastasia Electra; Alves, Adriana; Carvalho, Sara; Scudamore, Cheryl L.; Vanhaesebroeck, Bart 分享 收藏
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Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma 嗅神经母细胞瘤中生长抑素受体2的临床结果，kdish-insica分期和治疗靶点 Lechner, Matt; Takahashi, Yoko; Turri-Zanoni, Mario; Liu, Jacklyn; Counsell, Nicholas; Hermsen, Mario; Kaur, Raman Preet; Zhao, Tianna; Ramanathan, Murugappan, Jr.; Schartinger, Volker H.; Emanuel, Oscar; Helman, Sam; Varghese, Jordan; Dudas, Jozsef; Riechelmann, Herbert; Sprung, Susanne; Haybaeck, Johannes; Howard, David; Engel, Nils Wolfgang; Stewart, Sarah; Brooks, Laura; Pickles, Jessica C.; Jacques, Thomas S.; Fenton, Tim R.; Williams, Luke; Vaz, Francis M.; O'Flynn, Paul; Stimpson, Paul; Wang, Simon; Hannan, S. Alam; Unadkat, Samit; Hughes, Jonathan; Dwivedi, Raghav; Forde, Cillian T.; Randhawa, Premjit; Gane, Simon; Joseph, Jonathan; Andrews, Peter J.; Royle, Gary; Franchi, Alessandro; Maragliano, Roberta; Battocchio, Simonetta; Bewicke-Copley, Helen; Pipinikas, Christodoulos; Webster, Amy; Thirlwell, Chrissie; Ho, Debbie; Teschendorff, Andrew; Zhu, Tianyu; Steele, Christopher D.; Pillay, Nischalan; Vanhaesebroeck, Bart; Mohyeldin, Ahmed; Fernandez-Miranda, Juan; Park, Ki Wan; Le, Quynh-Thu; West, Robert B.; Saade, Rami; Manes, R. Peter; Omay, Sacit Bulent; Vining, Eugenia M.; Judson, Benjamin L.; Yarbrough, Wendell G.; Sansovini, Maddalena; Silvia, Nicolini; Grassi, Ilaria; Bongiovanni, Alberto; Capper, David; Schueller, Ulrich; Thavaraj, Selvam; Sandison, Ann; Surda, Pavol; Hopkins, Claire; Ferrari, Marco; Mattavelli, Davide; Rampinelli, Vittori; Facchetti, Fabio; Nicolai, Piero; Bossi, Paolo; Henriquez, Oswaldo A.; Magliocca, Kelly; Solares, C. Arturo; Wise, Sarah K.; Llorente, Jose L.; Patel, Zara M.; Nayak, Jayakar, V; Hwang, Peter H.; Lacy, Peter D.; Woods, Robbie; O'Neill, James P.; Jay, Amrita; Carnell, Dawn; Forster, Martin D.; Ishii, Masaru; London, Nyall R., Jr.; Bell, Diana M.; Gallia, Gary L.; Castelnuovo, Paolo; Severi, Stefano; Lund, Valerie J.; Hanna, Ehab Y. 分享 收藏
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