未登录 Design, Synthesis, and Evaluation of Selective PDE4 Inhibitors for the Therapy of Pulmonary Injury 选择性PDE4抑制剂的设计、合成及其在肺损伤治疗中的评价 Li, Mengjie; Li, Gang; Liu, Yuanhui; Li, Jiayu; Ou, Yanghui; Guan, Wen; Zeng, Zhijun; Tang, Haiyang; Bai, Dan; Zhang, Guoping; Huang, Peiming; Song, Liyan; Ye, Lianbao; Ke, Hengming 分享 收藏
Development of selective heterocyclic PDE4 inhibitors for treatment of psoriasis Li, Gang; He, Dengqin; Qian, Xudong; Liu, Yuanhui; Ou, Yanghui; Li, Mengjie; Song, Liyan; Xu, Zichen; Zhang, Guoping; Wang, Jun; Pan, Wei; Chen, Jiaxin; Zhang, Yali; Wu, Jia-Qiang; Chen, Dandan; Chen, Cheng; Peng, Siying; Yao, Hongliang; Ke, Hengming 分享 收藏
Design, Synthesis, and Biological Evaluation of New Selective PDE4 Inhibitors for Topical Treatment of Psoriasis He, Dengqin; Li, Gang; Wu, Jia-Qiang; Geng, Yan; Qian, Xudong; Liu, Yuanhui; Ou, Yanghui; Li, Mengjie; Wang, Jun; Pan, Wei; Zhang, Guoping; Chen, Dandan; Chen, Jiaxin; Xu, Zichen; Ke, Hengming; Yao, Hongliang 分享 收藏
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Phosphodiesterase 2 inhibitor Hcyb1 reverses corticosterone-induced neurotoxicity and depression-like behavior Zhu, Meng-Jia; Shi, Jing; Chen, Yong; Huang, Guobing; Zhu, Xiong-Wei; Zhang, Sam; Huang, Xian-Feng; Song, Guo-Qiang; Zhang, Han-Ting; Ke, Heng-Ming; O'Donnell, James M.; Wang, Li-Qun; Xu, Ying 分享 收藏
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A novel hydroxycinnamoyl transferase for synthesis of hydroxycinnamoyl spermine conjugates in plants Peng, Hui; Meyer, Rachel S.; Yang, Tianbao; Whitaker, Bruce D.; Trouth, Frances; Shangguan, Lingfei; Huang, Jingbing; Litt, Amy; Little, Damon P.; Ke, Hengming; Jurick, Wayne M., II 分享 收藏
Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon Li, Xin; Deng, Meng; Petrucelli, Alex S.; Zhu, Cheng; Mo, Jinyao; Zhang, Lu; Tam, Jason W.; Ariel, Pablo; Zhao, Baoyu; Zhang, Song; Ke, Hengming; Li, Pingwei; Dokholyan, Nikolay, V; Duncan, Joseph A.; Ting, Jenny P-Y 分享 收藏
A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling Huang, Xian-Feng; Jiang, Wen-Tao; Liu, Li; Song, Fang-Chen; Zhu, Xia; Shi, Gui-Lan; Ding, Shu-Ming; Ke, Heng-Ming; Wang, Wei; O'Donnell, James M.; Zhang, Han-Ting; Luo, Hai-Bin; Wan, Yi-Qian; Song, Guo-Qiang; Xu, Ying 分享 收藏
The neuroprotective and antidepressant-like effects of Hcyb1, a novel selective PDE2 inhibitor Liu, Li; Zheng, Jing; Huang, Xian-Feng; Zhu, Xia; Ding, Shu-Ming; Ke, Heng-Ming; O'Donnell, James M.; Zhang, Han-Ting; Song, Guo-Qiang; Xu, Ying 分享 收藏
Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK Park, Sung-Jun; Ahmad, Faiyaz; Um, Jee-Hyun; Brown, Alexandra L.; Xu, Xihui; Kang, Hyeog; Ke, Hengming; Feng, Xuesong; Ryall, James; Philp, Andrew; Schenk, Simon; Kim, Myung K.; Sartorelli, Vittorio; Chung, Jay H. 分享 收藏
Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor Huang, Manna; Shao, Yongxian; Hou, Jianying; Cui, Wenjun; Liang, Beibei; Huang, Yingchun; Li, Zhe; Wu, Yinuo; Zhu, Xinhai; Liu, Peiqing; Wan, Yiqian; Ke, Hengming; Luo, Hai-Bin 分享 收藏
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Discovery of a Phosphodiesterase 9A Inhibitor as a Potential Hypoglycemic Agent Shao, Yong-xian; Huang, Manna; Cuo, Wenjun; Feng, Ling-Jun; Wu, Yinuo; Cai, Yinghong; Li, Zhe; Zhu, Xinhai; Liu, Peiqing; Wan, Yiqian; Ke, Hengming; Luo, Hai-Bin 分享 收藏
Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno [2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure Shang, Na-Na; Shao, Yong-Xian; Cai, Ying-Hong; Guan, Matthew; Huang, Manna; Cui, Wenjun; He, Lin; Yu, Yan-Jun; Huang, Lei; Li, Zhe; Bu, Xian-Zhang; Ke, Hengming; Luo, Hai-Bin 分享 收藏
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Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure Jansen, Chimed; Wang, Huanchen; Kooistra, Albert J.; de Graaf, Chris; Orrling, Kristina M.; Tenor, Hermann; Seebeck, Thomas; Bailey, David; de Esch, Iwan J. P.; Ke, Hengming; Leurs, Rob 分享 收藏
Structure-Based Discovery of Highly Selective Phosphodiesterase-9A Inhibitors and Implications for Inhibitor Design Meng, Fei; Hou, Jing; Shao, Yong-Xian; Wu, Pei-Ying; Huang, Manna; Zhu, Xinhai; Cai, Yonghong; Li, Zhe; Xu, Jie; Liu, Peiqing; Luo, Hai-Bin; Wan, Yiqian; Ke, Hengming 分享 收藏
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