Victoria M. Richon - Publications, H-index & Citations

Victoria M. Richon

epizyme, inc.

77H指数

270论文数

3.1W被引数

收录论文 54

发表时间

A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants 一种有效的选择性PARP14抑制剂可降低肿瘤外植体中的protumor巨噬细胞基因表达并引发炎症反应

CELL CHEMICAL BIOLOGY

IF7.2

2021-08-01

OAAI

Schenkel, Laurie B.; Molina, Jennifer R.; Swinger, Kerren K.; Abo, Ryan; Blackwell, Danielle J.; Lu, Alvin Z.; Cheung, Anne E.; Church, W. David; Kunii, Kaiko; Kuplast-Barr, Kristy G.; Majer, Christina R.; Minissale, Elena; Mo, Jan-Rung; Niepel, Mario; Reik, Christopher; Ren, Yue; Vasbinder, Melissa M.; Wigle, Tim J.; Richon, Victoria M.; Keilhack, Heike; Kuntz, Kevin W.

A potent and selective PARP14 inhibitor decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants

CANCER RESEARCH

IF16.6

2020-08-15

PREAI

Schenkel, Laurie; Molina, Jennifer; Swinger, Kerren; Abo, Ryan; Blackwell, Danielle; Cheung, Anne; Church, William; Kuplast-Barr, Kristy; Lu, Alvin; Minissale, Elena; Niepel, Mario; Vasbinder, Melissa; Wigle, Tim; Richon, Victoria; Keilhack, Heike; Kuntz, Kevin

PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition leads to tumor regression

CANCER RESEARCH

IF16.6

2020-08-15

PREAI

Gozgit, Joseph M.; Vasbinder, Melissa M.; Abo, Ryan P.; Kunii, Kaiko; Kuplast-Barr, Kristy G.; Gui, Bin; Lu, Alvin Z.; Swinger, Kerren K.; Wigle, Tim J.; Blackwell, Danielle J.; Majer, Christina R.; Ren, Yue; Niepel, Mario; Varsamis, Zacharenia A.; Nayak, Sunaina P.; Bamberg, Ellen; Mo, Jan-Rung; Church, William; Song, Jeff; Utley, Luke; Rao, Patricia E.; Mitchison, Timothy J.; Kuntz, Kevin W.; Richon, Victoria M.; Keilhack, Heike

RBN-2397: A first-in-class PARP7 inhibitor targeting a newly discovered cancer vulnerability in stress-signaling pathways

CANCER RESEARCH

IF16.6

2020-08-15

PREAI

Vasbinder, Melissa M.; Gozgit, Joseph M.; Abo, Ryan P.; Kunii, Kaiko; Kuplast-Barr, Kristy G.; Gui, Bin; Lu, Alvin Z.; Swinger, Kerren K.; Wigle, Tim J.; Blackwell, Danielle J.; Majer, Christina R.; Ren, Yue; Niepel, Mario; Varsamis, Zacharenia A.; Nayak, Sunaina P.; Bamberg, Ellen; Mo, Jan-Rung; Church, W. David; Song, Jeff; Utley, Luke; Rao, Patricia E.; Mitchison, Timothy J.; Kuntz, Kevin W.; Richon, Victoria M.; Keilhack, Heike

Identification of SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that has strong anti-tumor activity in wild-type and mutant ER plus breast cancer models

CANCER RESEARCH

IF16.6

2018-07-01

PREAI

Shomali, Maysoun; El-Ahmad, Youssef; Halley, Frank; Cheng, Jane; Weinstein, Michael; Wang, Muchun; Sun, Fangxian; Malkova, Natalia; Levit, Mikhail; Koundinya, Malvika; Gou, Zhuyan; Hebert, Andrew; McManus, Jessica; Hoffman, Dietmar; Cao, Hui; Jung, Joonil; Pollard, Jack; Vincent, Sylvie; Ackerson, Timothy; Adrian, Francisco; Winter, Chris; Richon, Victoria; Chen, Hong; Hsu, Karl; Lager, Joanne; Courjaud, Albane; Arrebola, Rosalia; Besret, Laurent; Abecassis, Pierre-Yves; Schio, Laurent; McCort, Gary; Tabart, Michel; Certal, Victor; Thompson, Fabienne; Filoche-Romme, Bruno; Debussche, Laurent; Cohen, Patrick; Garcia-Echeverria, Carlos; Bouaboula, Monsif

Basal-like breast cancer subtype is characterized by deregulated glutamine metabolism and is sensitive to GLS inhibition

CANCER RESEARCH

IF16.6

2018-07-01

PREAI

Henry, Christophe; Lampa, Michael; He, Timothy; Ospina, Beatriz; Zhang, Bailin; Deng, Gejing; Barberis, Claude; Hoffmann, Dietmar; Pollard, Jack; Francisco, Adrian; Arlt, Heike; Reeves, Jason; Murtie, Joshua; Winter, Christopher; Richon, Victoria; Cheng, Hong; Garcia-Echeverria, Carlos; Wiederschain, Dmitri; Srinivasan, Lakshmi

The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat 成为我的重要性: 神奇的甲基，甲基转移酶抑制剂和Tazemetostat的发现

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-01-27

148

PREAI

Kuntz, Kevin W.; Campbell, John E.; Keilhack, Heike; Pollock, Roy M.; Knutson, Sarah K.; Porter-Scott, Margaret; Richon, Victoria M.; Sneeringer, Chris J.; Wigle, Tim J.; Allain, Christina J.; Majer, Christina R.; Moyer, Mikel P.; Copeland, Robert A.; Chesworth, Richard

Functional genomics reveals genetic dependencies in gastric cancer

CANCER RESEARCH

IF16.6

2015-08-01

PREAI

Kulkarni, Meghana M.; Gurumurthy, Sushma; Schmidt-Kittler, Oleg; Berglund, Jason; Hulton, Christopher H.; Wilson, David J.; Jakubosky, David; Michaud, Daniel; Jones, Robert E.; Sjoblom, Nicole M.; McSweeney, Russell; Zhou, Hongwei; Venkatakrishnan, Annapurna; Jensen, Karin J.; Zhang, Jingxin; Mankoo, Parminder K.; Pollard, Jack; Winter, Christopher; Jaenne, Pasi A.; Wong, Kwok-Kin; Richon, Victoria M.; English, Jessie M.; Bittinger, Mark A.

Focus on Research Structural Approaches to Cancer Drug Development

NEW ENGLAND JOURNAL OF MEDICINE

IF78.5

2015-07-30

PREAI

Chabner, Bruce; Richon, Victoria

Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer

ANTIOXIDANTS & REDOX SIGNALING

IF6.1

2015-07-01

OAAI

Chiaradonna, Ferdinando; Barozzi, Iros; Miccolo, Claudia; Bucci, Gabriele; Palorini, Roberta; Fornasari, Lorenzo; Botrugno, Oronza A.; Pruneri, Giancarlo; Masullo, Michele; Passafaro, Alfonso; Galimberti, Viviana E.; Fantin, Valeria R.; Richon, Victoria M.; Pece, Salvatore; Viale, Giuseppe; Di Fiore, Pier Paolo; Draetta, Giulio; Pelicci, Pier Giuseppe; Minucci, Saverio; Chiocca, Susanna

PTK7 as a potential therapeutic target in ovarian cancer

CANCER RESEARCH

IF16.6

2014-10-01

PREAI

Ding, Zhihu; Lennon, Amanda; Perron, Keli; Harper, David; Su, Hui; Wolfram, Meredith; Murtie, Joshua; Licht, Stuart; Pinckney, Jason; Simonds-Mannes, Helene; Bishop, Kimberly; Gavigan, Julie-Ann; Bangari, Dinesh; Magnay, Maureen; Weber, William; Reczek, David; Brondyk, William; Drewett, Vicky; Trombe, Marc; Hoffmann, Dietmar; Baffa, Raffaele; Silver, Serena; Richon, Victoria; Winter, Christopher; Reddy, Venkat; Gregory, Richard C.

Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma

MOLECULAR CANCER THERAPEUTICS

IF5.5

2014-04-06

538

OAAI

Knutson, Sarah K.; Kawano, Satoshi; Minoshima, Yukinori; Warholic, Natalie M.; Huang, Kuan-Chun; Xiao, Yonghong; Kadowaki, Tadashi; Uesugi, Mai; Kuznetsov, Galina; Kumar, Namita; Wigle, Tim J.; Klaus, Christine R.; Allain, Christina J.; Raimondi, Alejandra; Waters, Nigel J.; Smith, Jesse J.; Porter-Scott, Margaret; Chesworth, Richard; Moyer, Mikel P.; Copeland, Robert A.; Richon, Victoria M.; Uenaka, Toshimitsu; Pollock, Roy M.; Kuntz, Kevin W.; Yokoi, Akira; Keilhack, Heike

Molecular and Biologic Analysis of Histone Deacetylase Inhibitors with Diverse Specificities

MOLECULAR CANCER THERAPEUTICS

IF5.5

2013-12-05

OAAI

Newbold, Andrea; Matthews, Geoffrey M.; Bots, Michael; Cluse, Leonie A.; Clarke, Christopher J. P.; Banks, Kellie-Marie; Cullinane, Carleen; Bolden, Jessica E.; Christiansen, Ailsa J.; Dickins, Ross A.; Miccolo, Claudia; Chiocca, Susanna; Kral, Astrid M.; Ozerova, Nicole D.; Miller, Thomas A.; Methot, Joey L.; Richon, Victoria M.; Secrist, J. Paul; Minucci, Saverio; Johnstone, Ricky W.

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2 通过抑制甲基转移酶EZH2在遗传改变的恶性横纹肌样瘤中持久的肿瘤消退

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2013-04-25

709

OAAI

Knutson, Sarah K.; Warholic, Natalie M.; Wigle, Tim J.; Klaus, Christine R.; Allain, Christina J.; Raimondi, Alejandra; Scott, Margaret Porter; Chesworth, Richard; Moyer, Mikel P.; Copeland, Robert A.; Richon, Victoria M.; Pollock, Roy M.; Kuntz, Kevin W.; Keilhack, Heike

Targeting genetic alterations in protein methyltransferases for personalized cancer therapeutics

ONCOGENE

IF7.3

2012-11-19

OAAI

Copeland, R. A.; Moyer, M. P.; Richon, V. M.

Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l

LEUKEMIA

IF13.4

2012-11-09

122

OAAI

Chen, L.; Deshpande, A. J.; Banka, D.; Bernt, K. M.; Dias, S.; Buske, C.; Olhava, E. J.; Daigle, S. R.; Richon, V. M.; Pollock, R. M.; Armstrong, S. A.

Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L 构象适应驱动人类蛋白甲基转移酶DOT1L的有效，选择性和持久抑制

CHEMICAL BIOLOGY & DRUG DESIGN

IF3.3

2012-10-09

134

OAAI

Basavapathruni, Aravind; Jin, Lei; Daigle, Scott R.; Majer, Christina R. A.; Therkelsen, Carly A.; Wigle, Tim J.; Kuntz, Kevin W.; Chesworth, Richard; Pollock, Roy M.; Scott, Margaret P.; Moyer, Mikel P.; Richon, Victoria M.; Copeland, Robert A.; Olhava, Edward J.

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

NATURE CHEMICAL BIOLOGY

IF13.7

2012-09-30

759

PREAI

Knutson, Sarah K.; Wigle, Tim J.; Warholic, Natalie M.; Sneeringer, Christopher J.; Allain, Christina J.; Klaus, Christine R.; Sacks, Joelle D.; Raimondi, Alejandra; Majer, Christina R.; Song, Jeffrey; Scott, Margaret Porter; Jin, Lei; Smith, Jesse J.; Olhava, Edward J.; Chesworth, Richard; Moyer, Mikel P.; Richon, Victoria M.; Copeland, Robert A.; Keilhack, Heike; Pollock, Roy M.; Kuntz, Kevin W.

A687V EZH2 is a gain-of-function mutation found in lymphoma patients

FEBS LETTERS

IF3

2012-07-28

150

PREAI

Majer, Christina R.; Jin, Lei; Scott, Margaret Porter; Knutson, Sarah K.; Kuntz, Kevin W.; Keilhack, Heike; Smith, Jesse J.; Moyer, Mikel P.; Richon, Victoria M.; Copeland, Robert A.; Wigle, Tim J.

The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states EZH2的Y641C突变改变了组蛋白H3赖氨酸27甲基化状态的底物特异性

FEBS LETTERS

IF3

2011-08-17

104

OAAI

Wigle, Tim J.; Knutson, Sarah K.; Jin, Lei; Kuntz, Kevin W.; Pollock, Roy M.; Richon, Victoria M.; Copeland, Robert A.; Scott, Margaret Porter

研究方向