Antonı́n Holý - Publications, H-index & Citations

Antonı́n Holý

nih eunice kennedy shriver national institute of child health & human development (nichd)

53H指数

891论文数

1.5W被引数

收录论文 82

发表时间

Investigation of the acid-base and electromigration properties of 5-azacytosine derivatives using capillary electrophoresis and density functional theory calculations

JOURNAL OF CHROMATOGRAPHY A

IF4

2017-01-01

PREAI

Geffertova, Denisa; Ali, Syed Tahir; Solinova, Veronika; Krecmerova, Marcela; Holy, Antonin; Havlas, Zdenek; Kasicka, Vaclav

Estimation of apparent binding constant of complexes of selected acyclic nucleoside phosphonates with -cyclodextrin by affinity capillary electrophoresis

ELECTROPHORESIS

IF2.5

2015-11-06

PREAI

Solinova, Veronika; Mikyskova, Hana; Kaiser, Martin Maxmilian; Janeba, Zlatko; Holy, Antonin; Kasicka, Vaclav

The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases 新型 [3-氟-(2-膦酰基乙氧基) 丙基] 嘌呤对恶性疟原虫，间日疟原虫和人次黄嘌呤-鸟嘌呤-(黄嘌呤) 磷酸核糖基转移酶的抑制作用

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2013-09-01

PREAI

Baszczynski, Ondrej; Hockova, Dana; Janeba, Zlatko; Holy, Antonin; Jansa, Petr; Dracinsky, Martin; Keough, Dianne T.; Guddat, Luke W.

A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity

PLOS PATHOGENS

IF4.9

2013-07-25

OAAI

Balzarini, Jan; Andrei, Graciela; Balestra, Emanuela; Huskens, Dana; Vanpouille, Christophe; Introini, Andrea; Zicari, Sonia; Liekens, Sandra; Snoeck, Robert; Holy, Antonin; Perno, Carlo-Federico; Margolis, Leonid; Schols, Dominique

Antiviral effect of HPMPC (Cidofovir®), entrapped in cationic liposomes: In vitro study on MDBK cell and BHV-1 virus

JOURNAL OF CONTROLLED RELEASE

IF11.5

2012-06-01

PREAI

Korvasova, Zina; Drasar, Lukas; Masek, Josef; Knotigova, Pavlina Turanek; Kulich, Pavel; Matiasovic, Jan; Kovarcik, Kamil; Bartheldyova, Eliska; Koudelka, Stepan; Skrabalova, Michaela; Miller, Andrew D.; Holy, Antonin; Ledvina, Miroslav; Turanek, Jaroslav

An enzymatic glycosylation of nucleoside analogues using β-galactosidase from Escherichia coli

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2012-05-01

PREAI

Blazek, Jiri; Jansa, Petr; Baszczynski, Ondrej; Kaiser, Martin Maxmilian; Otmar, Miroslav; Krecmerova, Marcela; Drancinsky, Martin; Holy, Antonin; Kralova, Blanka

Differential effects of acyclic nucleoside phosphonates on nitric oxide and cytokines in rat hepatocytes and macrophages 无环核苷膦酸酯对大鼠肝细胞和巨噬细胞中一氧化氮和细胞因子的差异作用

INTERNATIONAL IMMUNOPHARMACOLOGY

IF4.7

2012-02-01

PREAI

Kostecka, Petra; Holy, Antonin; Farghali, Hassan; Zidek, Zdenek; Kmonickova, Eva

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2012-02-01

PREAI

Krecmerova, Marcela; Dracinsky, Martin; Hockova, Dana; Holy, Antonin; Keough, Dianne T.; Guddat, Luke W.

Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases 9-膦酰基烷基和9-膦酰基烷氧基烷基嘌呤的合成: 评估它们作为恶性疟原虫，间日疟原虫和人次黄嘌呤-鸟嘌呤-(黄嘌呤) 磷酸核糖基转移酶的抑制剂的能力

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2012-01-01

PREAI

Cesnek, Michal; Hockova, Dana; Holy, Antonin; Dracinsky, Martin; Baszczynski, Ondrej; de Jersey, John; Keough, Dianne T.; Guddat, Luke W.

Determination of the antioxidative activity of substituted 5-aminopyrimidines

FREE RADICAL RESEARCH

IF2.9

2011-11-28

PREAI

Prochazkova, Eliska; Jansa, Petr; Dracinsky, Martin; Holy, Antonin; Mertlikova-Kaiserova, Helena

A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities 一锅法合成无环核苷膦酸酯对称二酰胺 (双酰胺酯) 前药及其生物活性评价

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2011-09-01

PREAI

Jansa, Petr; Baszczynski, Ondrej; Dracinsky, Martin; Votruba, Ivan; Zidek, Zdenek; Bahador, Gina; Stepan, George; Cihlar, Tomas; Mackman, Richard; Holy, Antonin; Janeba, Zlatko

Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity 具有支链2-(2-膦酰基乙氧基) 乙基链的无环核苷膦酸酯: 有效的合成和抗病毒活性

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2011-08-01

OAAI

Hockova, Dana; Holy, Antonin; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan

Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG

BIOCHEMICAL PHARMACOLOGY

IF5.6

2011-07-01

OAAI

Mertlikova-Kaiserova, Helena; Rumlova, Michaela; Tloustova, Eva; Prochazkova, Eliska; Holy, Antonin; Votruba, Ivan

Enhanced Topical and Transdermal Delivery of Antineoplastic and Antiviral Acyclic Nucleoside Phosphonate cPr-PMEDAP 增强抗肿瘤和抗病毒无环核苷膦酸酯cpr-pmedap的局部和透皮递送

PHARMACEUTICAL RESEARCH

IF4.3

2011-06-14

PREAI

Vavrova, Katerina; Kovarikova, Petra; Skolova, Barbora; Libalova, Martina; Roh, Jaroslav; Cap, Robert; Holy, Antonin; Hrabalek, Alexandr

New prodrugs of Adefovir and Cidofovir

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2011-06-01

OAAI

Tichy, Tomas; Andrei, Graciela; Dracinsky, Martin; Holy, Antonin; Balzarini, Jan; Snoeck, Robert; Krecmerova, Marcela

Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2011-04-01

OAAI

Baszczynski, Ondrej; Jansa, Petr; Dracinsky, Martin; Klepetarova, Blanka; Holy, Antonin; Votruba, Ivan; de Clercq, Erik; Balzarini, Jan; Janeba, Zlatko

Efficient and 'green' microwave-assisted synthesis of haloalkylphosphonates via the Michaelis-Arbuzov reaction

GREEN CHEMISTRY

IF9.2

2011-01-01

PREAI

Jansa, Petr; Holy, Antonin; Dracinsky, Martin; Baszczynski, Ondrej; Cesnek, Michal; Janeba, Zlatko

Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2010-09-01

PREAI

Hajek, Miroslav; Cvilink, Viktor; Votruba, Ivan; Holy, Antonin; Mertlikova-Kaiserova, Helena

Synthesis of Ester Prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as Anti-Poxvirus Agents

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2010-09-01

PREAI

Krecmerova, Marcela; Holy, Antonin; Andrei, Graciela; Pomeisl, Karel; Tichy, Tomas; Brehova, Peter; Masojidkova, Milena; Dracinsky, Martin; Pohl, Radek; Laflamme, Genevieve; Naesens, Lieve; Hui, Hon; Cihlar, Tomas; Neyts, Johan; De Clercq, Erik; Balzarini, Jan; Snoeck, Robert

Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2010-06-01

PREAI

Sala, Michal; De Palma, Armando M.; Hrebabecky, Hubert; Nencka, Radim; Dracinsky, Martin; Leyssen, Pieter; Neyts, Johan; Holy, Antonin

研究方向