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收藏Tumour mutational burden: clinical utility, challenges and emerging improvements肿瘤突变负担: 临床效用、挑战和新兴改进
Budczies, Jan; Kazdal, Daniel; Menzel, Michael; Beck, Susanne; Kluck, Klaus; Altbuerger, Christian; Schwab, Constantin; Allgaeuer, Michael; Ahadova, Aysel; Kloor, Matthias; Schirmacher, Peter; Peters, Solange; Kraemer, Alwin; Christopoulos, Petros; Stenzinger, Albrecht 分享 收藏 Molecularly guided therapy versus chemotherapy after disease control in unfavourable cancer of unknown primary (CUPISCO): an open-label, randomised, phase 2 studyKraemer, Alwin; Bochtler, Tilmann; Pauli, Chantal; Shiu, Kai-Keen; Cook, Natalie; de Menezes, Juliana Janoski; Pazo-Cid, Roberto A.; Losa, Ferran; Robbrecht, Debbie G. J.; Tomasek, Jiri; Arslan, Cagatay; Ozguroglu, Mustafa; Stahl, Michael; Bigot, Frederic; Kim, Sun Young; Naito, Yoichi; Italiano, Antoine; Chalabi, Nassera; Duran-Pacheco, Gonzalo; Michaud, Chantal; Scarato, Jeremy; Thomas, Marlene; Ross, Jeffrey S.; Moch, Holger; Mileshkin, Linda 分享 收藏 Frequency and Prognostic Value of Circulating Tumor Cells in Cancer of Unknown PrimaryPouyiourou, Maria; Bochtler, Tilmann; Coith, Cornelia; Wikman, Harriet; Kraft, Bianca; Hielscher, Thomas; Stenzinger, Albrecht; Riethdorf, Sabine; Pantel, Klaus; Kraemer, Alwin 分享 收藏 分享 收藏 Modified study designs to expand treatment options in personalised oncology: a multistakeholder viewLe Tourneau, Christophe; Andre, Fabrice; Helland, Aslaug; Mileshkin, Linda; Minnaard, Warnyta; Schiel, Anja; Tasken, Kjetil; Thomas, David M.; Veronese, Maria Luisa; Duran-Pacheco, Gonzalo; Leyens, Lada; Rufibach, Kaspar; Thomas, Marlene; Kraemer, Alwin 分享 收藏 Nivolumab and ipilimumab in recurrent or refractory cancer of unknown primary: a phase II trialPouyiourou, Maria; Kraft, Bianca N.; Wohlfromm, Timothy; Stahl, Michael; Kubuschok, Boris; Loeffler, Harald; Hacker, Ulrich T.; Huebner, Gerdt; Weiss, Lena; Bitzer, Michael; Ernst, Thomas; Schuett, Philipp; Hielscher, Thomas; Delorme, Stefan; Kirchner, Martina; Kazdal, Daniel; Ball, Markus; Kluck, Klaus; Stenzinger, Albrecht; Bochtler, Tilmann; Kraemer, Alwin 分享 收藏 High-throughput electron tomography identifies centriole over-elongation as an early event in plasma cell disordersKoehrer, Sebastian; Dittrich, Tobias; Schorb, Martin; Weinhold, Niels; Haberbosch, Isabella; Boermel, Mandy; Pajor, Gabor; Goldschmidt, Hartmut; Mueller-Tidow, Carsten; Raab, Marc S.; John, Lukas; Seckinger, Anja; Brobeil, Alexander; Dreger, Peter; Tornoczky, Tamas; Pajor, Laszlo; Hegenbart, Ute; Schoenland, Stefan O.; Schwab, Yannick; Kraemer, Alwin 分享 收藏 Palbociclib in Acute Leukemias With KMT2A-rearrangement: Results of AMLSG 23-14 TrialGaidzik, Verena; Paschka, Peter F.; Schlenk, Richard; Weber, Daniela; Froehling, Stefan; Kraemer, Alwin; Waesch, Ralph; Westermann, Joerg; Mayer, Karin; de Wit, Maike; Fiedler, Walter; Benner, Axel; Heuser, Michael; Thol, Felicitas; Doehner, Konstanze; Ganser, Arnold; Doehner, Hartmut 分享 收藏 Different treatment strategies versus a common standard arm (CSA) in patients with newly diagnosed AML over the age of 60 years: a randomized German inter-group study60岁以上新诊断AML患者的不同治疗策略与共同标准臂 (CSA): 一项随机德国组间研究Niederwieser, Dietger; Lang, Thomas; Krahl, Rainer; Heinicke, Thomas; Maschmeyer, Georg; Al-Ali, Haifa Kathrin; Schwind, Sebastian; Jentzsch, Madlen; Cross, Michael; Kahl, Christoph; Wolf, Hans-Heinrich; Sayer, Herbert; Schulze, Antje; Dreger, Peter; Hegenbart, Ute; Kraemer, Alwin; Junghanss, Christian; Muegge, Lars-Olof; Haehling, Detlev; Hirt, Carsten; Spaeth, Christian; Peter, Norma; Opitz, Bernhard; Florschuetz, Axel; Reifenrath, Kolja; Zojer, Niklas; Scholl, Sebastian; Poenisch, Wolfram; Heyn, Simone; Vucinic, Vladan; Hochhaus, Andreas; Aul, Carlo; Giagounidis, Aristoteles; Balleisen, Leopold; Oldenkott, Bernd; Staib, Peter; Kiehl, Michael; Schuette, Wolfgang; Naumann, Ralph; Eimermacher, Hartmut; Doerken, Bernd; Sauerland, Cristina; Lengfelder, Eva; Hiddemann, Wolfgang; Woermann, Bernhard; Mueller-Tidow, Carsten; Serve, Hubert; Schliemann, Christoph; Hehlmann, Ruediger; Berdel, Wolfgang E.; Pfirrmann, Markus; Krug, Utz; Hoffmann, Verena S. 分享 收藏 Human SLFN5 and its Xenopus Laevis ortholog regulate entry into mitosis and oocyte meiotic resumptionVit, Gianmatteo; Hirth, Alexander; Neugebauer, Nicolas; Kraft, Bianca N.; Sigismondo, Gianluca; Cazzola, Anna; Tessmer, Claudia; Duro, Joana; Krijgsveld, Jeroen; Hofmann, Ilse; Berger, Michael; Klueter, Harald; Niehrs, Christof; Nilsson, Jakob; Kraemer, Alwin 分享 收藏 A high-throughput electron tomography workflow reveals over-elongated centrioles in relapsed/refractory multiple myeloma高通量电子断层扫描工作流程揭示了复发/难治性多发性骨髓瘤中过度拉长的中心粒Dittrich, Tobias; Koehrer, Sebastian; Schorb, Martin; Haberbosch, Isabella; Boermel, Mandy; Goldschmidt, Hartmut; Pajor, Gabor; Mueller-Tidow, Carsten; Raab, Marc S.; Hegenbart, Ute; Schoenland, Stefan O.; Schwab, Yannick; Kraemer, Alwin 分享 收藏 Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantationIDH1和IDH2突变亚群对异基因造血干细胞移植后AML患者的影响Kunadt, Desiree; Stasik, Sebastian; Metzeler, Klaus H.; Roellig, Christoph; Schliemann, Christoph; Greif, Philipp A.; Spiekermann, Karsten; Rothenberg-Thurley, Maja; Krug, Utz; Braess, Jan; Kraemer, Alwin; Hochhaus, Andreas; Scholl, Sebastian; Hilgendorf, Inken; Bruemmendorf, Tim H.; Jost, Edgar; Steffen, Bjoern; Bug, Gesine; Einsele, Hermann; Goerlich, Dennis; Sauerland, Cristina; Schaefer-Eckart, Kerstin; Krause, Stefan W.; Haenel, Mathias; Hanoun, Maher; Kaufmann, Martin; Woermann, Bernhard; Kramer, Michael; Sockel, Katja; Egger-Heidrich, Katharina; Herold, Tobias; Ehninger, Gerhard; Burchert, Andreas; Platzbecker, Uwe; Berdel, Wolfgang E.; Mueller-Tidow, Carsten; Hiddemann, Wolfgang; Serve, Hubert; Stelljes, Matthias; Baldus, Claudia D.; Neubauer, Andreas; Schetelig, Johannes; Thiede, Christian; Bornhaeuser, Martin; Middeke, Jan M.; Stoelzel, Friedrich 分享 收藏 Molecular profiling and clinical implications of patients with acute myeloid leukemia and extramedullary manifestationsEckardt, Jan-Niklas; Stoelzel, Friedrich; Kunadt, Desiree; Roellig, Christoph; Stasik, Sebastian; Wagenfuehr, Lisa; Joehrens, Korinna; Kuithan, Friederike; Kraemer, Alwin; Scholl, Sebastian; Hochhaus, Andreas; Crysandt, Martina; Brummendorf, Tim H.; Naumann, Ralph; Steffen, Bjoern; Kunzmann, Volker; Einsele, Hermann; Schaich, Markus; Burchert, Andreas; Neubauer, Andreas; Schaefer-Eckart, Kerstin; Schliemann, Christoph; Krause, Stefan W.; Herbst, Regina; Haenel, Mathias; Hanoun, Maher; Kaiser, Ulrich; Kaufmann, Martin; Racil, Zdenek; Mayer, Jiri; Kroschinsky, Frank; Berdel, Wolfgang E.; Ehninger, Gerhard; Serve, Hubert; Mueller-Tidow, Carsten; Platzbecker, Uwe; Baldus, Claudia D.; Schetelig, Johannes; Bornhauser, Martin; Thiede, Christian; Middeke, Jan Moritz 分享 收藏 Severe Dysbiosis and Specific Haemophilus and Neisseria Signatures as Hallmarks of the Oropharyngeal Microbiome in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients (ciab902, 2021)严重生态失调和特定嗜血杆菌和奈瑟菌特征是重症冠状病毒疾病2019 (新型冠状病毒肺炎) 患者口咽微生物组的标志 (ciab902，2021)de Castilhos, Juliana; Zamir, Eli; Hippchen, Theresa; Rohrbach, Roman; Schmidt, Sabine; Hengler, Silvana; Schumacher, Hanna; Neubauer, Melanie; Kunz, Sabrina; Mueller-Esch, Tonia; Hiergeist, Andreas; Gessner, Andre; Khalid, Dina; Gaiser, Rogier; Cullin, Nyssa; Papagiannarou, Stamatia M.; Beuthien-Baumann, Bettina; Kraemer, Alwin; Bartenschlager, Ralf; Jaeger, Dirk; Mueller, Michael; Herth, Felix; Duerschmied, Daniel; Schneider, Jochen; Schmid, Roland M.; Eberhardt, Johann F.; Khodamoradi, Yascha; Vehreschild, Maria J. G. T.; Teufel, Andreas; Ebert, Matthias P.; Hau, Peter; Salzberger, Bernd; Schnitzler, Paul; Poeck, Hendrik; Elinav, Eran; Merle, Uta; Stein-Thoeringer, Christoph K. 分享 收藏 Prognostic impact of copy number alterations and tumor mutational burden in carcinoma of unknown primaryBochtler, Tilmann; Wohlfromm, Timothy; Hielscher, Thomas; Stichel, Damian; Pouyiourou, Maria; Kraft, Bianca; Neumann, Olaf; Endris, Volker; Deimling, Andreas; Stenzinger, Albrecht; Kraemer, Alwin 分享 收藏 Local ablative treatment with surgery and/or radiotherapy in single-site and oligometastatic carcinoma of unknown primaryPouyiourou, Maria; Wohlfromm, Timothy; Kraft, Bianca; Hielscher, Thomas; Stichel, Damian; von Deimling, Andreas; Delorme, Stefan; Endris, Volker; Neumann, Olaf; Stenzinger, Albrecht; Kraemer, Alwin; Bochtler, Tilmann 分享 收藏 Severe Dysbiosis and Specific Haemophilus and Neisseria Signatures as Hallmarks of the Oropharyngeal Microbiome in Critically Ill Coronavirus Disease 2019 (COVID-19) Patientsde Castilhos, Juliana; Zamir, Eli; Hippchen, Theresa; Rohrbach, Roman; Schmidt, Sabine; Hengler, Silvana; Schumacher, Hanna; Neubauer, Melanie; Kunz, Sabrina; Mueller-Esch, Tonia; Hiergeist, Andreas; Gessner, Andre; Khalid, Dina; Gaiser, Rogier; Cullin, Nyssa; Papagiannarou, Stamatia M.; Beuthien-Baumann, Bettina; Kraemer, Alwin; Bartenschlager, Ralf; Jaeger, Dirk; Mueller, Michael; Herth, Felix; Duerschmied, Daniel; Schneider, Jochen; Schmid, Roland M.; Eberhardt, Johann F.; Khodamoradi, Yascha; Vehreschild, Maria J. G. T.; Teufel, Andreas; Ebert, Matthias P.; Hau, Peter; Salzberger, Bernd; Schnitzler, Paul; Poeck, Hendrik; Elinav, Eran; Merle, Uta; Stein-Thoeringer, Christoph K. 分享 收藏 Impact of PTPN11 mutations on clinical outcome analyzed in 1529 patients with acute myeloid leukemiaStasik, Sebastian; Eckardt, Jan-Niklas; Kramer, Michael; Roellig, Christoph; Kraemer, Alwin; Scholl, Sebastian; Hochhaus, Andreas; Crysandt, Martina; Bruemmendorf, Tim H.; Naumann, Ralph; Steffen, Bjorn; Kunzmann, Volker; Einsele, Hermann; Schaich, Markus; Burchert, Andreas; Neubauer, Andreas; Schaefer-Eckart, Kerstin; Schliemann, Christoph; Krause, Stefan; Herbst, Regina; Haenel, Mathias; Frickhofen, Norbert; Noppeney, Richard; Kaiser, Ulrich; Baldus, Claudia D.; Kaufmann, Martin; Racil, Zdenek; Platzbecker, Uwe; Berdel, Wolfgang E.; Mayer, Jiri; Serve, Hubert; Mueller-Tidow, Carsten; Ehninger, Gerhard; Bornhaeuser, Martin; Schetelig, Johannes; Middeke, Jan M.; Thiede, Christian 分享 收藏 The RUNX1 database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancyHoman, Claire C.; King-Smith, Sarah L.; Lawrence, David M.; Arts, Peer; Feng, Jinghua; Andrews, James; Armstrong, Mark; Ha, Thuong; Dobbins, Julia; Drazer, Michael W.; Yu, Kai; Bodor, Csaba; Cantor, Alan; Cazzola, Mario; Degelman, Erin; DiNardo, Courtney D.; Duployez, Nicolas; Favier, Remi; Frohling, Stefan; Fitzgibbon, Jude; Klco, Jeffery M.; Kramer, Alwin; Kurokawa, Mineo; Lee, Joanne; Malcovati, Luca; Morgan, Neil V.; Natsoulis, Georges; Owen, Carolyn; Patel, Keyur P.; Preudhomme, Claude; Raslova, Hana; Rienhoff, Hugh; Ripperger, Tim; Schulte, Rachael; Tawana, Kiran; Velloso, Elvira; Yan, Benedict; Liu, Paul; Godley, Lucy A.; Schreiber, Andreas W.; Hahn, Christopher N.; Scott, Hamish S.; Brown, Anna L. 分享 收藏 
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