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Health-related quality of life (HRQL) assessments in a 52-week, double-blind, randomized, placebo-controlled phase III study of resmetirom (MGL-3196) in patients with metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis Younossi, Zobair M.; Stepanova, Maria; Racila, Andrei; Henry, Linda; Labriola, Dominic; Taub, Rebecca; Nader, Fatema 分享 收藏
A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis Resmetirom治疗NASH肝纤维化的3期随机对照试验 Harrison, Stephen A.; Bedossa, Pierre; Guy, Cynthia D.; Schattenberg, Joern M.; Loomba, Rohit; Taub, Rebecca; Labriola, Dominic; Moussa, Sam E.; Neff, Guy W.; Rinella, Mary E.; Anstee, Quentin M.; Abdelmalek, Manal F.; Younossi, Zobair; Baum, Seth J.; Francque, Sven; Charlton, Michael R.; Newsome, Philip N.; Lanthier, Nicolas; Schiefke, Ingolf; Mangia, Alessandra; Pericas, Juan M.; Patil, Rashmee; Sanyal, Arun J.; Noureddin, Mazen; Bansal, Meena B.; Alkhouri, Naim; Castera, Laurent; Rudraraju, Madhavi; Ratziu, Vlad 分享 收藏
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Resmetirom for nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled phase 3 trial Resmetirom治疗非酒精性脂肪性肝病: 一项随机,双盲,安慰剂对照的3期试验 Harrison, Stephen A.; Taub, Rebecca; Neff, Guy W.; Lucas, K. Jean; Labriola, Dominic; Moussa, Sam E.; Alkhouri, Naim; Bashir, Mustafa R. 分享 收藏
Design of the phase 3 MAESTRO clinical program to evaluate resmetirom for the treatment of nonalcoholic steatohepatitis Harrison, Stephen A.; Ratziu, Vlad; Anstee, Quentin M.; Noureddin, Mazen; Sanyal, Arun J.; Schattenberg, Joern M.; Bedossa, Pierre; Bashir, Mustafa R.; Schneider, David; Taub, Rebecca; Bansal, Meena; Kowdley, Kris V.; Younossi, Zobair M.; Loomba, Rohit 分享 收藏
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Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial Harrison, Stephen A.; Bashir, Mustafa R.; Guy, Cynthia D.; Zhou, Rong; Moylan, Cynthia A.; Frias, Juan P.; Alkhouri, Naim; Bansal, Meena B.; Baum, Seth; Neuschwander-Tetri, Brent A.; Taub, Rebecca; Moussa, Sam E. 分享 收藏
MGL-3196, a selective thyroid hormone receptor-beta agonist significantly decreases hepatic fat in NASH patients at 12 weeks, the primary endpoint in a 36 week serial liver biopsy study Harrison, S.; Moussa, S.; Bashir, M.; Alkhouri, N.; Frias, J.; Baum, S.; Tetri, B.; Bansal, M.; Taub, R. 分享 收藏
A phase 2 randomized, double-blind, placebo-controlled study of the effect of VIA-2291, a 5-lipoxygenase inhibitor, on vascular inflammation in patients after an acute coronary syndrome Gaztanaga, Juan; Farkouh, Michael; Rudd, James H. F.; Brotz, Tilmann M.; Rosenbaum, David; Mani, Venkatesh; Kerwin, Todd C.; Taub, Rebecca; Tardif, Jean-Claude; Tawakol, Ahmed; Fayad, Zahi A. 分享 收藏
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Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia Kelly, Martha J.; Pietranico-Cole, Sherrie; Larigan, J. Douglas; Haynes, Nancy-Ellen; Reynolds, Charles H.; Scott, Nathan; Vermeulen, John; Dvorozniak, Mark; Conde-Knape, Karin; Huang, Kuo-Sen; So, Sung-Sau; Thakkar, Kshitij; Qian, Yimin; Banner, Bruce; Mennona, Frank; Danzi, Sara; Klein, Irwin; Taub, Rebecca; Tilley, Jefferson 分享 收藏