未登录 Inhibition of lysine acetyltransferase KAT6 in ER+HER2- metastatic breast cancer: a phase 1 trial (jun, 10.1038/s41591-024-03060-0, 2024) Mukohara, Toru; Park, Yeon Hee; Sommerhalder, David; Yonemori, Kan; Hamilton, Erika; Kim, Sung-Bae; Kim, Jee Hyun; Iwata, Hiroji; Yamashita, Toshinari; Layman, Rachel M.; Mita, Monica; Clay, Timothy; Chae, Yee Soo; Oakman, Catherine; Yan, Fengting; Kim, Gun Min; Im, Seock-Ah; Lindeman, Geoffrey J.; Rugo, Hope S.; Liyanage, Marlon; Saul, Michelle; Le Corre, Christophe; Skoura, Athanasia; Liu, Li; Li, Meng; LoRusso, Patricia M. 分享 收藏
Inhibition of lysine acetyltransferase KAT6 in ER+HER2- metastatic breast cancer: a phase 1 trial Mukohara, Toru; Park, Yeon Hee; Sommerhalder, David; Yonemori, Kan; Hamilton, Erika; Kim, Sung-Bae; Kim, Jee Hyun; Iwata, Hiroji; Yamashita, Toshinari; Layman, Rachel M.; Mita, Monica; Clay, Timothy; Chae, Yee Soo; Oakman, Catherine; Yan, Fengting; Kim, Gun Min; Im, Seock-Ah; Lindeman, Geoffrey J.; Rugo, Hope S.; Liyanage, Marlon; Saul, Michelle; Le Corre, Christophe; Skoura, Athanasia; Liu, Li; Li, Meng; LoRusso, Patricia M. 分享 收藏
Final outcomes analysis of the cell product SQZ-PBMC-HPV Phase 1 trial in incurable HPV16+solid tumors shows improved overall survival in patients with increased CD8+T cell tumor infiltration Weaver, Alice N.; Iams, Wade T.; Park, Jong Chul; Mita, Monica; Holtick, Udo; Gordon, Michael S.; Rodabaugh, Kerry J.; Dhani, Neesha; Neupane, Prakash; Taylor, Matthew; Amanda Duvall, E.; Jennings, Julia; Miselis, Nathan R.; Loughhead, Scott; Warren, Marshelle S.; Bernstein, Howard; Klussmann, Jens P.; Baranda, Joaquina; Jimeno, Antonio 分享 收藏
A dose escalation and cohort expansion study of the CDK9 inhibitor KB-0742 in triple negative breast cancer and transcriptionally addicted relapsed or refractory solid tumors Mita, Monica; Mita, Alain; Villalona-Calero, Miguel; Federman, Noah; Rasco, Drew; Spigel, David; Luo, Jia; Cote, Gregory; Cutler, Richard; Kumar, Pavan; MacKenzie, Crystal; Lin, Charles; DiMartino, Jorge; Olek, Elizabeth; Van Tine, Brian 分享 收藏
Circulating tumor DNA (ctDNA) monitoring of estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+/HER2-) high risk breast cancer during adjuvant endocrine therapy Pusztai, Lajos; Kalashnikova, Ekaterina; Hobbs, Evthokia; Brown-Glaberman, Ursa; Mita, Monica; Klein, Paula; Yan, Fengting; Ehsani, Sima; Razaq, Wajeeha; Stopeck, Alison; Bhave, Manali; Loch, Michelle; Sardesai, Sagar; Torres, Evanthia Roussos; Burkard, Mark; Okubanjo, Femi; Gauthier, Eric; Rodriguez, Angel; Liu, Minetta; Kabos, Peter 分享 收藏
A Phase I Study Accessing Immunotherapy Combination of Balstilimab and Ivermectin in Patients with Metastatic Triple Negative Breast Cancer Yuan, Yuan; Shiao, Stephen; Tighiouart, Mourad; Mita, Monica; Bitar, Jin-Sun; McAndrew, Philomena; Dorothy, Park; El-Masry, Maryliza; Frankel, Paul; Lee, Peter 分享 收藏
A dose escalation and cohort expansion study of the CDK9 inhibitor KB0742 in relapsed, refractory and transcriptionally addicted solid tumors Calero, Miguel Villalona; Agulnik, Mark; Mita, Monica; Mita, Alain; Federman, Noah; Rasco, Drew; Spigel, David; Luo, Jia; Hanna, Glenn; Cote, Gregory; Salkeni, Mohamad A.; Chugh, Rashmi; Ammakkanavar, Natraj R.; Shah, Satish A.; Rao, Amol; Sankhala, Kamalesh Kumar; Cutler, Richard E.; Hood, Tressa; Carvajal, Luis; MacKenzie, Crystal; Lin, Charles; DiMartino, Jorge; Olek, Elizabeth A.; Van Tine, Brian 分享 收藏
A dose escalation and cohort expansion study of the CDK9 inhibitor KB0742 in relapsed, refractory ovarian cancer and transcriptionally addicted relapsed or refractory solid tumors Villalona-Calero, Miguel; Mita, Monica; Mita, Alain; Federman, Noah; Rasco, Drew; Spigel, David; Luo, Jia; Cote, Gregory M.; Cutler, Richard E.; Kumar, Pavan; MacKenzie, Crystal J.; Lin, Charles; DiMartino, Jorge F.; Olek, Elizabeth A.; Van Tine, Brian 分享 收藏
A first-in-human study of CDK9 inhibitor KB-0742 demonstrates evidence of tolerability and clinical activity Villalona-Calero, Miguel; Mita, Monica; Mita, Alain; Federman, Noah; Rasco, Drew; Spigel, David; Luo, Jia; Hanna, Glenn J.; Cote, Gregory M.; Cutler, Richard E.; Kumar, Pavan; MacKenzie, Crystal; Lin, Charles; DiMartino, Jorge F.; Olek, Elizabeth A.; Van Tine, Brian 分享 收藏
The effect of LNS8801 in combination with pembrolizumab in patients with treatment-refractory cutaneous melanoma Rodon, J.; Chaney, M. F.; Cohen, J.; Garyantes, T. K.; Ishizuka, J.; Lin, J. J.; Lorusso, P.; Mita, A.; Mita, M.; Muller, C.; Natale, C.; Orloff, M.; Papadopoulos, K. P.; Patel, S.; Shoushtari, A. N. 分享 收藏
Phase 1 study to determine the safety and dosing of autologous PBMCs modified to present HPV16 antigens (SQZ-PBMC-HPV) in HLA-A*02+patients with HPV16+solid tumors Jimeno, Antonio; Baranda, Joaquina; Iams, Wade T.; Park, Jong Chul; Mita, Monica; Gordon, Michael S.; Taylor, Matthew; Dhani, Neesha; Leal, Alexis D.; Neupane, Prakash; Eng, Cathy; Yeku, Oladapo; Mita, Alain; Moser, Justin C.; Butler, Marcus; Loughhead, Scott M.; Jennings, Julia; Miselis, Nathan R.; Ji, Rui-Ru; Nair, Nitya; Kornacker, Martin; Zwirtes, Ricardo F.; Bernstein, Howard; Sharei, Armon 分享 收藏
A phase 1 study of the novel immunotoxin MT-5111 in patients with HER2+tumors: interim results Okera, Meena; Van Tine, Brian A.; Hubbard, Joleen M.; Barve, Minal; Hamilton, Erika; Mita, Monica M.; Valdes-Albini, Frances; Ahn, Daniel; Mamuye, Admasu; Pelham, Joshua; Yuet, Amy; Yurewicz, Diana; Liu, Yanning; Sandri, Andres Machado; Edenfield, William J.; Morikawa, Aki; Gradishar, William; Kumar, Rajiv; Wainberg, Zev A. 分享 收藏
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AKT/mTOR signaling modulates resistance to endocrine therapy and CDK4/6 inhibition in metastatic breast cancers AKT/mTOR信号调节转移性乳腺癌对内分泌治疗和CDK4/6抑制的抗性 Abu-Khalaf, Maysa M.; Alex Hodge, K.; Hatzis, Christos; Baldelli, Elisa; El Gazzah, Emna; Valdes, Frances; Sikov, William M.; Mita, Monica M.; Denduluri, Neelima; Murphy, Rita; Zelterman, Daniel; Liotta, Lance; Dunetz, Bryant; Dunetz, Rick; Petricoin, Emanuel F.; Pierobon, Mariaelena 分享 收藏
PHASE 1B STUDY OF LNS8801 IN COMBINATION WITH PEMBROLIZUMAB IN PATIENTS WITH SECONDARY RESISTANCE TO IMMUNE CHECKPOINT INHIBITORS Rodon, Jordi; Chaney, Marya; Cohen, Justine; Garyantes, Tina; Lin, Jessica; Lorusso, Patricia; Mita, Alain; Mita, Monica; Muller, Carolyn; Natale, Christopher; Orloff, Marlana; Papadopoulos, Kyriakos; Patel, Sapna 分享 收藏
TRIAL IN PROGRESS: A PHASE 1 FIRST-IN-HUMAN STUDY OF HMBD-002, AN IGG4 MONOCLONAL ANTIBODY TARGETING VISTA, AS A MONOTHERAPY AND COMBINED WITH PEMBROLIZUMAB IN PATIENTS WITH ADVANCED SOLID MALIGNANCIES Haber, Tom; Symons, Jessica; Dharmadhikari, Bhushan; Mueller, Thomas; Thakkar, Dipti; Rodon, Jordi Ahnert; Gruber, Joshua; Telli, Melinda; Mita, Monica; Mita, Alain; Patel, Meera; Wang, Daniel; Kim, Joseph; Yadav, Shalini; Sharma, Padmanee; DiMascio, Leah; Rowinsky, Eric; Ingram, Piers; Boyd-Kirkup, Jerome 分享 收藏
Pam50 intrinsic subtype and risk of recurrence score (ROR) for the prediction of endocrine (ET) sensitivity and pathologic response to chemotherapy in postmenopausal women with clinical stage II/III estrogen receptor positive (ER+) and HER2 negative (HER2-) breast cancer (BC) in the alternate trial (Alliance A011106) Ma, Cynthia X.; Anurag, Meenakshi; Dockter, Travis; Hoog, Jeremy; Fernandez-Martinez, Aranzazu; Fan, Cheng; Gibbs, Richard; Sanati, Souzan; Vij, Kiran; Watson, Mark; Hahn, Olwen; Guenther, Joseph; Caudle, Abigail; Crouch, Erika; Tiersten, Amy; Mita, Monica; Razaq, Wajeeha; Hieken, Tina J.; Wang, Yang; Leitch, A. Marilyn; Unzeitig, Gary W.; Weiss, Anna; Winer, Eric P.; Hunt, Kelly; Partridge, Ann H.; Carey, Lisa A.; Perou, Charles M.; Ellis, Matthew J.; Suman, Vera 分享 收藏
Interim results of a phase 1 study of the novel immunotoxin MT-5111 in patients with HER2+tumors Van Tine, Brian A.; Mita, Monica; Barve, Minal A.; Hamilton, Erika P.; Brenner, Andrew J.; Valdes, Frances; Ahn, Daniel; Hubbard, Joleen; Starr, Jason; Georgy, Angela; Pelham, Joshua; Anand, Banmeet S.; Strack, Thomas; Sandri, Andres Machado; Wainberg, Zev A. 分享 收藏
Updated analysis of MCLA-128 (zenocutuzumab), trastuzumab, and vinorelbine in patients (pts) with HER2 positive/amplified (HER2+) metastatic breast cancer (MBC) who progressed on previous anti-HER2 ADCs Hamilton, Erika; Petit, Thierry; Pistilli, Barbara; Goncalves, Anthony; Ferreira, Ana Alexandra; Dalenc, Florence; Cardoso, Fatima; Mita, Monica M.; Manso, Luis; Karim, Syed M.; Bidard, Francois-Clement; Aftimos, Philippe; Escrivaa-de-Romanii, Santiago; Afonso, Noemia; Wasserman, Ernesto; Bol, Kees; Stalbovskaya, Viktoriya; Vliet, Anastasia; Murat, Anastasia; Bekradda, Mohamed; Bachelot, Thomas 分享 收藏
The PEARL trial: Pre-operative pembrolizumab with radiation therapy in early stage triple negative breast cancer McArthur, Heather L.; Shiao, Stephen; Karlan, Scott; Basho, Reva; Amersi, Farin; Burnison, Michele; Mirhadi, Amin; Chung, Alice; Chung, Cathie T.; Dang, Catherine; Richardson, Heather; Giuliano, Armando E.; Kapoor, Nimmi; Larkin, Brigid; Godinez, Hector; Dunn, Samantha A.; Khameneh, Negin Habibi; Knott, Simon; McAndrew, Philomena; Mita, Monica; Park, Dorothy J.; Abaya, Christina; Chen, Jonathan H.; Ly, Amy; Bossuyt, Veerle; Ho, Alice 分享 收藏
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