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H

Helai P. Mohammad

sk life sciences laboratories
H指数:30
被引数:5,357

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Overcoming CK1α liability in the discovery of a series of isoIndolinone Glutarimides as selective IKZF2 molecular glue degraders

在发现一系列异吲哚啉酮戊二酰亚胺作为选择性IKZF2分子胶降解剂时克服CK1α 责任

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
2025-05-150
PRE
Zhang, Xuqing; Deng, Qiaolin; Dhruv, Harshil; Tudor, Matthew; Nagilla, Rakesh; Jolivette, Larry J.; Rice, Cory T.; Orth, Peter; Behshad, Elham; Strickland, Corey O.; Mohammad, Helai P.; Sui, Zhihua; Priestley, E. Scott
Discovery and Characterization of PVTX-321 as a Potent and Orally Bioavailable Estrogen Receptor Degrader for ER+/HER2-Breast Cancer

PVTX-321的发现与表征：一种强效且口服生物利用度高的雌激素受体降解剂，用于ER+/HER2-乳腺癌

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-05-140
PRE
Xu, Guozhang; Havens, Courtney G.; Deng, Qiaolin; Lowenstein, Cassandra; Samanta, Debangshu; Vidal, Brian; Behshad, Elham; Russell, Mike; Orth, Peter; Rice, Cory T.; Nagilla, Rakesh; Kirchhoff, Paul; Chen, Zhixiang; Rej, Rohan Kalyan; Acharyya, Ranjan Kumar; Wu, Dimin; Wang, Shaomeng; Zhang, Weihong; Wu, Wenxue; Jolivette, Larry; Strickland, Corey; Sui, Zhihua; Mohammad, Helai P.; Zhang, Xuqing; Priestley, E. Scott
The selective IKZF2 molecular glue degrader, PVTX-405, counters Treg immune suppression,shows significant tumor growth delay as single agent and synergistic response with immune checkpoint therapies (ICTs)
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Dhruv, Harshil D.; McEachern, Donna; Bai, Longchuan; Zhang, Xuqing; Chen, Zhixiang; Nagilla, Rakesh; Behshad, Elham; Han, Bomie; Orth, Peter; Rej, Rohan; Kirchhoff, Paul; Shin, Niu; Jolivette, Larry; Strickland, Corey; Sui, Zhihua; Priestley, Scott; Wang, Shaomeng; Mohammad, Helai
Predictive wild-type RAS/BRAF and pharmacogenetic biomarkers drive selection of metastatic colorectal cancer patients fit for intensive first-line FIr-C/FOx-C schedule adding cetuximab to triplet chemotherapy
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Russell, Mike; Lowenstein, Cassandra L.; Zhang, Xuqing; Roach, Jeremy; Song, Jianing; Nagilla, Rakesh; Orth, Peter; Tudor, Matt; Deng, Qiaolin; Sui, Zhihua; Strickland, Corey; Jolivette, Larry J.; Priestley, E. Scott; Mohammad, Helai P.
Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia
NATURE CANCER
IF28.5
2021-09-27141
PREAI
Pappalardi, Melissa B.; Keenan, Kathryn; Cockerill, Mark; Kellner, Wendy A.; Stowell, Alexandra; Sherk, Christian; Wong, Kristen; Pathuri, Sarath; Briand, Jacques; Steidel, Michael; Chapman, Philip; Groy, Arthur; Wiseman, Ashley K.; McHugh, Charles F.; Campobasso, Nino; Graves, Alan P.; Fairweather, Emma; Werner, Thilo; Raoof, Ali; Butlin, Roger J.; Rueda, Lourdes; Horton, John R.; Fosbenner, David T.; Zhang, Cunyu; Handler, Jessica L.; Muliaditan, Morris; Mebrahtu, Makda; Jaworski, Jon-Paul; McNulty, Dean E.; Burt, Charlotte; Eberl, H. Christian; Taylor, Amy N.; Ho, Thau; Merrihew, Susan; Foley, Shawn W.; Rutkowska, Anna; Li, Mei; Romeril, Stuart P.; Goldberg, Kristin; Zhang, Xing; Kershaw, Christopher S.; Bantscheff, Marcus; Jurewicz, Anthony J.; Minthorn, Elisabeth; Grandi, Paola; Patel, Mehul; Benowitz, Andrew B.; Mohammad, Helai P.; Gilmartin, Aidan G.; Prinjha, Rab K.; Ogilvie, Donald; Carpenter, Christopher; Heerding, Dirk; Baylin, Stephen B.; Jones, Peter A.; Cheng, Xiaodong; King, Bryan W.; Luengo, Juan, I; Jordan, Allan M.; Waddell, Ian; Kruger, Ryan G.; McCabe, Michael T.
Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2019-12-2712
OAAI
Su, Dai-Shi; Qu, Junya; Schulz, Mark; Blackledge, Chuck W.; Yu, Hongyi; Zeng, Jenny; Burgess, Joelle; Reif, Alexander; Stern, Melissa; Nagarajan, Raman; Pappalardi, Melissa Baker; Wong, Kristen; Graves, Alan P.; Bonnette, William; Wang, Liping; Elkins, Patricia; Knapp-Reed, Beth; Carson, Jeffrey D.; McHugh, Charles; Mohammad, Helai; Kruger, Ryan; Luengo, Juan; Heerding, Dirk A.; Creasy, Caretha L.
Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML
CANCER DISCOVERY
IF33.3
2019-07-0137
OAAI
Duy, Cihangir; Teater, Matt; Garrett-Bakelman, Francine E.; Lee, Tak C.; Meydan, Cem; Glass, Jacob L.; Li, Meng; Hellmuth, Johannes C.; Mohammad, Helai P.; Smitheman, Kimberly N.; Shih, Alan H.; Abdel-Wahab, Omar; Tallman, Martin S.; Guzman, Monica L.; Muench, David; Grimes, H. Leighton; Roboz, Gail J.; Kruger, Ryan G.; Creasy, Caretha L.; Paietta, Elisabeth M.; Levine, Ross L.; Carroll, Martin; Melnick, Ari M.
Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
NATURE COMMUNICATIONS
IF15.7
2019-06-20124
OAAI
Bell, Charles C.; Fenne, Katie A.; Chan, Yih-Chih; Rambow, Florian; Yeung, Miriam M.; Vassiliadis, Dane; Lara, Luis; Yeh, Paul; Martelotto, Luciano G.; Rogiers, Aljosja; Kremer, Brandon E.; Barbash, Olena; Mohammad, Helai P.; Johanson, Timothy M.; Burr, Marian L.; Dhar, Arindam; Karpinich, Natalie; Tian, Luyi; Tyler, Dean S.; MacPherson, Laura; Shi, Junwei; Pinnawala, Nathan; Fong, Chun Yew; Papenfuss, Anthony T.; Grimmond, Sean M.; Dawson, Sarah-Jane; Allan, Rhys S.; Kruger, Ryan G.; Vakoc, Christopher R.; Goode, David L.; Naik, Shalin H.; Gilan, Omer; Lam, Enid Y. N.; Marine, Jean-Christophe; Prinjha, Rab K.; Dawson, Mark A.
Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma
NATURE COMMUNICATIONS
IF15.7
2019-01-1872
OAAI
Lee, Catherine; Rudneva, Vasilisa A.; Erkek, Serap; Zapatka, Marc; Chau, Lianne Q.; Tacheva-Grigorova, Silvia K.; Garancher, Alexandra; Rusert, Jessica M.; Aksoy, Ozlem; Lea, Robin; Mohammad, Helai P.; Wang, Jianxun; Weiss, William A.; Grimes, H. Leighton; Pfister, Stefan M.; Northcott, Paul A.; Wechsler-Reya, Robert J.

研究方向

暂未获取到该数据
S
Stephen B. Baylin
H 指数:182论文数:1,323被引数:17.8万
R
Ryan G. Kruger
H 指数:41论文数:248被引数:1.0万
Z
Zhihua Sui
H 指数:33论文数:238被引数:4,051
R
Rakesh Nagilla
H 指数:20论文数:74被引数:2,167
E
Elham Behshad
H 指数:12论文数:67被引数:811
L
Larry J. Jolivette
H 指数:16论文数:54被引数:1,057
Q
Qiaolin Deng
H 指数:19论文数:76被引数:1,159
P
Peter Orth
H 指数:37论文数:135被引数:5,871
C
Corey Strickland
H 指数:22论文数:95被引数:2,308
M
Melissa B. Pappalardi
H 指数:20论文数:68被引数:3,183