未登录 Discovery and Characterization of PVTX-321 as a Potent and Orally Bioavailable Estrogen Receptor Degrader for ER+/HER2-Breast Cancer PVTX-321的发现与表征：一种强效且口服生物利用度高的雌激素受体降解剂，用于ER+/HER2-乳腺癌 Xu, Guozhang; Havens, Courtney G.; Deng, Qiaolin; Lowenstein, Cassandra; Samanta, Debangshu; Vidal, Brian; Behshad, Elham; Russell, Mike; Orth, Peter; Rice, Cory T.; Nagilla, Rakesh; Kirchhoff, Paul; Chen, Zhixiang; Rej, Rohan Kalyan; Acharyya, Ranjan Kumar; Wu, Dimin; Wang, Shaomeng; Zhang, Weihong; Wu, Wenxue; Jolivette, Larry; Strickland, Corey; Sui, Zhihua; Mohammad, Helai P.; Zhang, Xuqing; Priestley, E. Scott 分享 收藏
Discovery of Potent, Highly Selective, and Efficacious SMARCA2 Degraders Li, Zhenwu; Harikrishnan, Lalgudi S.; Xu, Guozhang; Samanta, Debangshu; Clemente, Jose C.; Leng, Lingying; Tu, Wenbin; Yang, Lin; Huang, Liyue; Wang, Mi; Wang, Shaomeng; Deng, Qiaolin; Behshad, Elham; Nagilla, Rakesh; Orth, Peter; Rice, Cory; Strickland, Corey; Mohammad, Helai P.; Priestley, E. Scott; Sui, Zhihua 分享 收藏
Discovery of oral SMARCA2 degraders for the treatment of SMARCA4 mutant tumors Clemente, Jose C.; Harikrishnan, Lal; Knight, Steve; Samanta, Debangshu; Li, Zhenwu; Nagilla, Rakesh; Kendsersky, Nathan; Joshi, Shreyas; Orth, Peter; Tudor, Matt; Deng, Qiaolin; Aguilar-Bonavides, Clemente; Behshad, Elham; Sui, Zhihua; Strickland, Corey; Jolivette, Larry J.; Mohammad, Helai P. 分享 收藏
Discovery and characterization of a p300-selective degrader with potent anti-tumor activity in CBP mutant cancers Russell, Mike R.; Lowenstein, Cassandra L.; Zhang, Xuqing; Roach, Jeremy; Song, Jianing; Nagilla, Rakesh; Kendsersky, Nathan; Joshi, Shreyas; Orth, Peter; Tudor, Matt; Deng, Qiaolin; Aguilar-Bonavides, Clemente; Behshad, Elham; Banjade, Sudeep; Sui, Zhihua; Strickland, Corey; Jolivette, Larry; Mohammad, Helai P. 分享 收藏
The selective IKZF2 molecular glue degrader, PVTX-405, counters Treg immune suppression,shows significant tumor growth delay as single agent and synergistic response with immune checkpoint therapies (ICTs) Dhruv, Harshil D.; McEachern, Donna; Bai, Longchuan; Zhang, Xuqing; Chen, Zhixiang; Nagilla, Rakesh; Behshad, Elham; Han, Bomie; Orth, Peter; Rej, Rohan; Kirchhoff, Paul; Shin, Niu; Jolivette, Larry; Strickland, Corey; Sui, Zhihua; Priestley, Scott; Wang, Shaomeng; Mohammad, Helai 分享 收藏
Predictive wild-type RAS/BRAF and pharmacogenetic biomarkers drive selection of metastatic colorectal cancer patients fit for intensive first-line FIr-C/FOx-C schedule adding cetuximab to triplet chemotherapy Russell, Mike; Lowenstein, Cassandra L.; Zhang, Xuqing; Roach, Jeremy; Song, Jianing; Nagilla, Rakesh; Orth, Peter; Tudor, Matt; Deng, Qiaolin; Sui, Zhihua; Strickland, Corey; Jolivette, Larry J.; Priestley, E. Scott; Mohammad, Helai P. 分享 收藏
Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels Chen, Yun-Ting; Hong, Mee Ra; Zhang, Xin-Jun; Kostas, James; Li, Yuxing; Kraus, Richard L.; Santarelli, Vincent P.; Wang, Deping; Gomez-Llorente, Yacob; Brooun, Alexei; Strickland, Corey; Soisson, Stephen M.; Klein, Daniel J.; Ginnetti, Anthony T.; Marino, Michael J.; Stachel, Shawn J.; Ishchenko, Andrii 分享 收藏
Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1 Ng, Simon; Brueckner, Alexander C.; Bahmanjah, Soheila; Deng, Qiaolin; Johnston, Jennifer M.; Ge, Lan; Duggal, Ruchia; Habulihaz, Bahanu; Barlock, Benjamin; Ha, Sookhee; Sadruddin, Ahmad; Yeo, Constance; Strickland, Corey; Peier, Andrea; Henry, Brian; Sherer, Edward C.; Partridge, Anthony W. 分享 收藏
Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action (vol 4, 927, 2021) Palte, Rachel L.; Juan, Veronica; Gomez-Llorente, Yacob; Bailly, Marc Andre; Chakravarthy, Kalyan; Chen, Xun; Cipriano, Daniel; Fayad, Ghassan N.; Fayadat-Dilman, Laurence; Gathiaka, Symon; Greb, Heiko; Hall, Brian; Handa, Mas; Hsieh, Mark; Kofman, Esther; Lin, Heping; Miller, J. Richard; Nguyen, Nhung; O'Neil, Jennifer; Shaheen, Hussam; Sterner, Eric; Strickland, Corey; Sun, Angie; Taremi, Shane; Scapin, Giovanna 分享 收藏
Characterization and Modeling of Reversible Antibody Self-Association Provide Insights into Behavior, Prediction, and Correction Mieczkowski, Carl; Cheng, Alan; Fischmann, Thierry; Hsieh, Mark; Baker, Jeanne; Uchida, Makiko; Raghunathan, Gopalan; Strickland, Corey; Fayadat-Dilman, Laurence 分享 收藏
Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation Hong, Chuan; Byrne, Noel J.; Zamlynny, Beata; Tummala, Srivanya; Xiao, Li; Shipman, Jennifer M.; Partridge, Andrea T.; Minnick, Christina; Breslin, Michael J.; Rudd, Michael T.; Stachel, Shawn J.; Rada, Vanessa L.; Kern, Jeffrey C.; Armacost, Kira A.; Hollingsworth, Scott A.; O'Brien, Julie A.; Hall, Dawn L.; McDonald, Terrence P.; Strickland, Corey; Brooun, Alexei; Soisson, Stephen M.; Hollenstein, Kaspar 分享 收藏
Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen Bukhtiyarova, Marina; Cook, Erica M.; Hancock, Paula J.; Hruza, Alan W.; Shaw, Anthony W.; Adam, Gregory C.; Barnard, Richard J. O.; McKenna, Philip M.; Holloway, M. Katharine; Bell, Ian M.; Carroll, Steve; Cornella-Taracido, Ivan; Cox, Christopher D.; Kutchukian, Peter S.; Powell, David A.; Strickland, Corey; Trotter, B. Wesley; Tudor, Matthew; Wolkenberg, Scott; Li, Jing; Tellers, David M. 分享 收藏
Crystal Structure and Characterization of Human Heavy-Chain Only Antibodies Reveals a Novel, Stable Dimeric Structure Similar to Monoclonal Antibodies Mieczkowski, Carl; Bahmanjah, Soheila; Yu, Yao; Baker, Jeanne; Raghunathan, Gopalan; Tomazela, Daniela; Hsieh, Mark; McCoy, Mark; Strickland, Corey; Fayadat-Dilman, Laurence 分享 收藏
Pembrolizumab microgravity crystallization experimentation Pembrolizumab微重力结晶实验 Reichert, Paul; Prosise, Winifred; Fischmann, Thierry O.; Scapin, Giovanna; Narasimhan, Chakravarthy; Spinale, April; Polniak, Ray; Yang, Xiaoyu; Walsh, Erika; Patel, Daya; Benjamin, Wendy; Welch, Johnathan; Simmons, Denarra; Strickland, Corey 分享 收藏
Discovery of Selective RNA-Binding Small Molecules by Affinity Selection Mass Spectrometry Rizvi, Noreen F.; Howe, John A.; Nahvi, Ali; Klein, Daniel J.; Fischmann, Thierry O.; Kim, Hai-Young; McCoy, Mark A.; Walker, Scott S.; Hruza, Alan; Richards, Matthew P.; Chamberlin, Chad; Saradjian, Peter; Butko, Margaret T.; Mercado, Gabriel; Burchard, Julja; Strickland, Corey; Dandliker, Peter J.; Smith, Graham F.; Nickbarg, Elliott B. 分享 收藏
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Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates Mandal, Mihirbaran; Wu, Yusheng; Misiaszek, Jeffrey; Li, Guoqing; Buevich, Alexei; Caldwell, John P.; Liu, Xiaoxiang; Mazzola, Robert D.; Orth, Peter; Strickland, Corey; Voigt, Johannes; Wang, Hongwu; Zhu, Zhaoning; Chen, Xia; Grzelak, Michael; Hyde, Lynn A.; Kuvelkar, Reshma; Leach, Prescott T.; Terracina, Giuseppe; Zhang, Lili; Zhang, Qi; Michener, Maria S.; Smith, Brad; Cox, Kathleen; Grotz, Diane; Favreau, Leonard; Mitra, Kaushik; Kazakevich, Irina; McKittrick, Brian A.; Greenlee, William; Kennedy, Matthew E.; Parker, Eric M.; Cumming, Jared N.; Stamford, Andrew W. 分享 收藏
Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors Bogen, Stephane L.; Pan, Weidong; Gibeau, Craig R.; Lahue, Brian R.; Ma, Yao; Nair, Latha G.; Seigel, Elise; Shipps, Gerald W., Jr.; Tian, Yuan; Wang, Yaolin; Lin, Yinghui; Liu, Ming; Liu, Suxing; Mirza, Asra; Wang, Xiaoying; Lipar, Philip; Seidel-Dugan, Cynthia; Hicklin, Daniel J.; Bishop, W. Robert; Rindgen, Diane; Nomeir, Amin; Prosise, Winifred; Reichert, Paul; Scapin, Giovanna; Strickland, Corey; Doll, Ronald J. 分享 收藏
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Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography Orth, Peter; Xiao, Li; Hernandez, Lorraine D.; Reichert, Paul; Sheth, Payal R.; Beaumont, Maribel; Yang, Xiaoyu; Murgolo, Nicholas; Ermakov, Grigori; DiNunzio, Edward; Racine, Fred; Karczewski, Jerzy; Secore, Susan; Ingram, Richard N.; Mayhood, Todd; Strickland, Corey; Therien, Alex G. 分享 收藏
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