未登录 Selective Targeting of Cyclin E1 Using Molecular Glue Degraders in CCNE1 Amplified Solid Malignancies Ilic-Widlund, N.; Tahaney, W.; Liu, Y.; Gkountela, S.; Quan, C.; Lucas, X.; Emil, N.; Diesslin, A.; King, C.; Dubois, A.; Osmont, A.; Zlotosch, M.; Bianda, C.; Alers, J.; Demarco, B.; Warmuth, M.; Townson, S.; Fasching, B.; Ranieri, B.; Tiedt, R. 分享 收藏
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The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity Tuong-Vi Nguyen; Yao, Shihua; Wang, Yahong; Rolfe, Alan; Selvaraj, Anand; Darman, Rachel; Ke, Jiyuan; Warmuth, Markus; Smith, Peter G.; Larsen, Nicholas A.; Yu, Lihua; Zhu, Ping; Fekkes, Peter; Vaillancourt, Frederic H.; Bolduc, David M. 分享 收藏
Sensitivity to splicing modulation of BCL2 family genes reveals cancer therapeutic strategies for splicing modulators Aird, Daniel; Teng, Teng; Huang, Chia-Ling; Pazolli, Ermira; Banka, Deepti; Cheung-Ong, Kahlin; Eifert, Cheryl; Furman, Craig; Wu, Jeremy; Seiler, Michael; Buonamici, Silvia; Fekkes, Peter; Karr, Craig; Palacino, James; Park, Eunice; Smith, Peter; Yu, Lihua; Mizui, Yoshiharu; Warmuth, Markus; Chicas, Agustin; Corson, Laura; Zhu, Ping 分享 收藏
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer (vol 8, 103, 2017) Korpal, Manav; Puyang, Xiaoling; Wu, Zhenhua Jeremy; Seiler, Roland; Furman, Craig; Oo, Htoo Zarni; Seiler, Michael; Irwin, Sean; Subramanian, Vanitha; Joshi, Jaya Julie; Wang, Chris K.; Rimkunas, Victoria; Tortora, Davide; Yang, Hua; Kumar, Namita; Kuznetsov, Galina; Matijevic, Mark; Chow, Jesse; Kumar, Pavan; Zou, Jian; Feala, Jacob; Corson, Laura; Henry, Ryan; Selvaraj, Anand; Davis, Allison; Bloudoff, Kristjan; Douglas, James; Kiss, Bernhard; Roberts, Morgan; Fazli, Ladan; Black, Peter C.; Fekkes, Peter; Smith, Peter G.; Warmuth, Markus; Yu, Lihua; Hao, Ming-Hong; Larsen, Nicholas; Daugaard, Mads; Zhu, Ping 分享 收藏
Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators Aird, Daniel; Teng, Teng; Huang, Chia-Ling; Pazolli, Ermira; Banka, Deepti; Cheung-Ong, Kahlin; Eifert, Cheryl; Furman, Craig; Wu, Zhenhua Jeremy; Seiler, Michael; Buonamici, Silvia; Fekkes, Peter; Karr, Craig; Palacino, James; Park, Eunice; Smith, Peter G.; Yu, Lihua; Mizui, Yoshiharu; Warmuth, Markus; Chicas, Agustin; Corson, Laura; Zhu, Ping 分享 收藏
Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer Puyang, Xiaoling; Furman, Craig; Zheng, Guo Zhu; Wu, Zhenhua J.; Banka, Deepti; Aithal, Kiran; Agoulnik, Sergei; Bolduc, David M.; Buonamici, Silvia; Caleb, Benjamin; Das, Subhasree; Eckley, Sean; Fekkes, Peter; Hao, Ming-Hong; Hart, Andrew; Houtman, Rene; Irwin, Sean; Joshi, Jaya J.; Karr, Craig; Kim, Amy; Kumar, Namita; Kumar, Pavan; Kuznetsov, Galina; Lai, Weidong G.; Larsen, Nicholas; Mackenzie, Crystal; Martin, Lesley-Ann; Melchers, Diana; Moriarty, Alyssa; Tuong-Vi Nguyen; Norris, John; O'Shea, Morgan; Pancholi, Sunil; Prajapati, Sudeep; Rajagopalan, Sujatha; Reynolds, Dominic J.; Rimkunas, Victoria; Rioux, Nathalie; Ribas, Ricardo; Siu, Amy; Sivakumar, Sasirekha; Subramanian, Vanitha; Thomas, Michael; Vaillancourt, Frederic H.; Wang, John; Wardell, Suzanne; Wick, Michael J.; Yao, Shihua; Yu, Lihua; Warmuth, Markus; Smith, Peter G.; Zhu, Ping; Korpal, Manav 分享 收藏
Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1 Schoepfer, Joseph; Jahnke, Wolfgang; Berellini, Giuliano; Buonamici, Silvia; Cotesta, Simona; Cowan-Jacob, Sandra W.; Dodd, Stephanie; Drueckes, Peter; Fabbro, Doriano; Gabriel, Tobias; Groell, Jean-Marc; Grotzfeld, Robert M.; Hassan, A. Quamrul; Henry, Chrystele; Iyer, Varsha; Jones, Darryl; Lombardo, Franco; Loo, Alice; Manley, Paul W.; Pelle, Xavier; Rummel, Gabriele; Salem, Bahaa; Warmuth, Markus; Wylie, Andrew A.; Zoller, Thomas; Marzinzik, Andreas L.; Furet, Pascal 分享 收藏
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H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers Seiler, Michael; Yoshimi, Akihide; Darman, Rachel; Chan, Betty; Keaney, Gregg; Thomas, Michael; Agrawal, Anant A.; Caleb, Benjamin; Csibi, Alfredo; Sean, Eckley; Fekkes, Peter; Karr, Craig; Klimek, Virginia; Lai, George; Lee, Linda; Kumar, Pavan; Lee, Stanley Chun-Wei; Liu, Xiang; Mackenzie, Crystal; Meeske, Carol; Mizui, Yoshiharu; Padron, Eric; Park, Eunice; Pazolli, Ermira; Peng, Shouyong; Prajapati, Sudeep; Taylor, Justin; Teng, Teng; Wang, John; Warmuth, Markus; Yao, Huilan; Yu, Lihua; Zhu, Ping; Abdel-Wahab, Omar; Smith, Peter G.; Buonamici, Silvia 分享 收藏
H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma Joshi, Jaya Julie; Coffey, Heather; Corcoran, Erik; Tsai, Jennifer; Huang, Chia-Ling; Ichikawa, Kana; Prajapati, Sudeep; Hao, Ming-Hong; Bailey, Suzanna; Wu, Jeremy; Rimkunas, Victoria; Karr, Craig; Subramanian, Vanitha; Kumar, Pavan; MacKenzie, Crystal; Hurley, Raelene; Satoh, Takashi; Yu, Kun; Park, Eunice; Rioux, Nathalie; Kim, Amy; Lai, Weidong G.; Yu, Lihua; Zhu, Ping; Buonamici, Silvia; Larsen, Nicholas; Fekkes, Peter; Wang, John; Warmuth, Markus; Reynolds, Dominic J.; Smith, Peter G.; Selvaraj, Anand 分享 收藏
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer Korpal, Manav; Puyang, Xiaoling; Wu, Zhenhua Jeremy; Seiler, Roland; Furman, Craig; Oo, Htoo Z.; Seiler, Michael; Irwin, Sean; Subramanian, Vanitha; Joshi, Jaya Julie; Wang, Chris K.; Rimkunas, Victoria; Tortora, Davide; Yang, Hua; Kumar, Namita; Kuznetsov, Galina; Matijevic, Mark; Chow, Jesse; Kumar, Pavan; Zou, Jian; Feala, Jacob; Corson, Laura; Henry, Ryan; Selvaraj, Anand; Davis, Allison; Bloudoff, Kristjan; Douglas, James; Kiss, Bernhard; Roberts, Morgan; Fazli, Ladan; Black, Peter C.; Fekkes, Peter; Smith, Peter G.; Warmuth, Markus; Yu, Lihua; Hao, Ming-Hong; Larsen, Nicholas; Daugaard, Mads; Zhu, Ping 分享 收藏
H3B-8800, a novel orally available SF3b modulator, shows preclinical efficacy across spliceosome mutant cancers Buonamici, Silvia; Yoshimi, Akihide; Thomas, Michael; Seiler, Michael; Chan, Betty; Caleb, Benjamin; Csibi, Fred; Darman, Rachel; Fekkes, Peter; Karr, Craig; Keaney, Gregg; Kim, Amy; Klimek, Virginia; Kumar, Pavan; Kunii, Kaiko; Lee, Stanley Chun-Wei; Liu, Xiang; MacKenzie, Crystal; Meeske, Carol; Mizui, Yoshiharu; Padron, Eric; Park, Eunice; Pazolli, Ermira; Prajapati, Sudeep; Rioux, Nathalie; Taylor, Justin; Wang, John; Warmuth, Markus; Yao, Huilan; Yu, Lihua; Zhu, Ping; Abdel-Wahab, Omar; Smith, Peter 分享 收藏
Conformational activation and allosteric inhibition of SHP2 in RTK-driven cancers Acker, Michael G.; Chen, Ying-Nan P.; LaMarche, Matthew J.; Chan, Ho Man; Fekkes, Peter; Garcia-Fortanet, Jorge; LaRochelle, Jonathan R.; Antonakos, Brandon; Chen, Christine Hiu-Tung; Chen, Zhuoliang; Cooke, Vesselina G.; Dobson, Jason R.; Deng, Zhan; Feng, Fei; Firestone, Brant; Fodor, Michelle; Fridrich, Cary; Gao, Hui; Hao, Huai-Xiang; Jacob, Jaison; Ho, Samuel; Hsiao, Kathy; Kang, Zhao B.; Karki, Rajesh; Kato, Mitsunori; Larrow, Jay; La Bonte, Laura R.; Liu, Gang; Liu, Shumei; Majumdar, Dyuti; Meyer, Matthew J.; Palermo, Mark; Pu, Minying; Price, Edmund; Shakya, Subarna; Shultz, Michael D.; Venkatesan, Kavitha; Wang, Ping; Warmuth, Markus; Williams, Sarah; Yang, Guizhi; Yuan, Jing; Zhang, Ji-Hu; Zhu, Ping; Blacklow, Stephen C.; Ramsey, Timothy; Keen, Nicholas J.; Sellers, William R.; Stams, Travis; Fortin, Pascal D. 分享 收藏
H3B6527, a selective and potent FGFR4 inhibitor for FGF19-driven hepatocellular carcinoma Selvaraj, Anand; Corcoran, Erik; Coffey, Heather; Prajapati, Sudeep; Hao, Ming-Hong; Larsen, Nicholas; Tsai, Jennifer; Satoh, Takashi; Ichikawa, Kana; Joshi, Julie Jaya; Hurley, Raelene; Wu, Jeremy; Huang, Chia-Ling; Bailey, Suzanna; Karr, Craig; Kumar, Pavan; Rimkunas, Victoria; Mackenzie, Crystal; Rioux, Nathalie; Kim, Amy; Akare, Sandeep; Lai, George; Yu, Lihua; Fekkes, Peter; Wang, John; Warmuth, Markus; Smith, Peter; Reynolds, Dominic 分享 收藏
A chemogenomic approach reveals the action of splicing modulators at the branch point adenosine binding pocket defined by the PHF5A/SF3b complex Teng, Teng; Tsai, Jennifer; Puyang, Xiaoling; Seiler, Michael; Peng, Shouyong; Aird, Daniel; Buonamici, Silvia; Caleb, Benjamin; Chan, Betty; Corson, Laura; Feala, Jacob; Fekkes, Peter; Karr, Craig; Korpal, Manav; Mizui, Yoshiharu; Park, Eunice; Palacino, James; Smith, Peter; Subramanian, Vanitha; Wu, Jeremy; Yu, Lihua; Chicas, Agustin; Warmuth, Markus; Larsen, Nicholas; Zhu, Ping 分享 收藏
Discovery and development of H3B-6545: A novel, oral, selective estrogen receptor covalent antagonist (SERCA) for the treatment of breast cancer Smith, Peter G.; Puyang, Xiaoling; Furman, Craig; Zheng, Guo Zhu; Banka, Deepti; Thomas, Michael; Subramanian, Vanitha; Irwin, Sean; Larsen, Nicholas; Caleb, Benjamin; Karr, Craig; Wu, Jeremy; O'Shea, Morgan; Yang, Joyce; Davis, Allison; Kim, Amy; Rioux, Nathalie; Rimkunas, Victoria; Yao, Huilan; MacKenzie, Crystal; Kumar, Pavan; Smith, Sherri; Eckley, Sean; Hart, Andrew; Lai, George; Rowbottom, Christopher; Fekkes, Peter; Buonamici, Silvia; Reynolds, Dominic; Yu, Lihua; Sahmoud, Tarek; Warmuth, Markus; Mitchell, Lorna; Zhu, Ping; Korpal, Manav 分享 收藏
Novel SF3B1 in-frame deletions result in aberrant RNA splicing in CLL patients Agrawal, Anant A.; Seiler, Michael; Brinton, Lindsey T.; Mantel, Rose; Lapalombella, Rosa; Woyach, Jennifer A.; Johnson, Amy J.; Zhu, Ping; Warmuth, Markus; Yu, Lihua; Byrd, John C.; Smith, Peter G.; Blachly, James S.; Buonamici, Silvia 分享 收藏
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