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Dynamics of spike-specific neutralizing antibodies across five-year emerging SARS-CoV-2 variants of concern reveal conserved epitopes that protect against severe COVID-19 五年新兴SARS-CoV-2变异中刺突特异性中和抗体的动态变化揭示了保护免受严重新型冠状病毒肺炎的保守表位 Zayou, Latifa; Prakash, Swayam; Vahed, Hawa; Dhanushkodi, Nisha Rajeswari; Quadiri, Afshana; Belmouden, Ahmed; Lemkhente, Zohra; Chentoufi, Aziz; Gil, Daniel; Ulmer, Jeffrey B.; Benmohamed, Lbachir 分享 收藏
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High frequencies of alpha common cold coronavirus/SARS-CoV-2 cross-reactive functional CD4+ and CD8+ memory T cells are associated with protection from symptomatic and fatal SARS-CoV-2 infections in unvaccinated COVID-19 patients 在未接种疫苗的新型冠状病毒肺炎患者中，高频率的 α 普通感冒冠状病毒/SARS-CoV-2交叉反应功能性CD4和CD8记忆T细胞与保护免受症状性和致命性SARS-CoV-2感染有关 Coulon, Pierre-Gregoire; Prakash, Swayam; Dhanushkodi, Nisha R.; Srivastava, Ruchi; Zayou, Latifa; Tifrea, Delia F.; Edwards, Robert A.; Figueroa, Cesar J.; Schubl, Sebastian D.; Hsieh, Lanny; Nesburn, Anthony B.; Kuppermann, Baruch D.; Bahraoui, Elmostafa; Vahed, Hawa; Gil, Daniel; Jones, Trevor M.; Ulmer, Jeffrey B.; Benmohamed, Lbachir 分享 收藏
Cross-protection induced by highly conserved human B, CD4+, and CD8+ T-cell epitopes-based vaccine against severe infection, disease, and death caused by multiple SARS-CoV-2 variants of concern 基于高度保守的人B、CD4和CD8 T细胞表位的疫苗对多种SARS-CoV-2变异引起的严重感染、疾病和死亡的交叉保护作用 Prakash, Swayam; Dhanushkodi, Nisha R.; Zayou, Latifa; Ibraim, Izabela Coimbra; Quadiri, Afshana; Coulon, Pierre Gregoire; Tifrea, Delia F.; Suzer, Berfin; Shaik, Amin Mohammed; Chilukuri, Amruth; Edwards, Robert A.; Singer, Mahmoud; Vahed, Hawa; Nesburn, Anthony B.; Kuppermann, Baruch D.; Ulmer, Jeffrey B.; Gil, Daniel; Jones, Trevor M.; BenMohamed, Lbachir 分享 收藏
A multi-epitope/CXCL11 prime/pull coronavirus mucosal vaccine boosts the frequency and the function of lung-resident memory CD4+ and CD8+ T cells and enhanced protection against COVID-19-like symptoms and death caused by SARS-CoV-2 infection 多表位/CXCL11 prime/pull冠状病毒粘膜疫苗可提高肺部记忆性CD4和CD8 T细胞的频率和功能，并增强对SARS-CoV-2感染引起的COVID-19-like症状和死亡的保护 Zayou, Latifa; Prakash, Swayam; Dhanushkodi, Nisha Rajeswari; Quadiri, Afshana; Ibraim, Izabela Coimbra; Singer, Mahmoud; Salem, Amirah; Shaik, Amin Mohammed; Suzer, Berfin; Chilukuri, Amruth; Tran, Jennifer; Nguyen, Pauline Chau; Sun, Miyo; Hormi-Carver, Kathy K.; Belmouden, Ahmed; Vahed, Hawa; Gil, Daniel; Ulmer, Jeffrey B.; Benmohamed, Lbachir 分享 收藏
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A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models Maruggi, Giulietta; Mallett, Corey P.; Westerbeck, Jason W.; Chen, Tiffany; Lofano, Giuseppe; Friedrich, Kristian; Qu, Lin; Sun, Jennifer Tong; McAuliffe, Josie; Kanitkar, Amey; Arrildt, Kathryn T.; Wang, Kai-Fen; McBee, Ian; McCoy, Deborah; Terry, Rebecca; Rowles, Alison; Abrahim, Maia Araujo; Ringenberg, Michael A.; Gains, Malcolm J.; Spickler, Catherine; Xie, Xuping; Zou, Jing; Shi, Pei-Yong; Dutt, Taru; Henao-Tamayo, Marcela; Ragan, Izabela; Bowen, Richard A.; Johnson, Russell; Nuti, Sandra; Luisi, Kate; Ulmer, Jeffrey B.; Steff, Ann-Muriel; Jalah, Rashmi; Bertholet, Sylvie; Stokes, Alan H.; Yu, Dong 分享 收藏
Development of a potent Zika virus vaccine using self-amplifying messenger RNA Luisi, Kate; Morabito, Kaitlyn M.; Burgomaster, Katherine E.; Sharma, Mayuri; Kong, Wing-Pui; Foreman, Bryant M.; Patel, Sonal; Fisher, Brian; Aleshnick, Maya A.; Laliberte, Jason; Wallace, Madison; Ruckwardt, Tracy J.; Gordon, David N.; Linton, Christine; Ruggiero, Nicole; Cohen, Jessica L.; Johnson, Russell; Aggarwal, Kunal; Ko, Sung-Youl; Yang, Eun Sung; Pelc, Rebecca S.; Dowd, Kimberly A.; O'Hagan, Derek; Ulmer, Jeffrey; Mossman, Sally; Sambor, Anna; Lepine, Edith; Mascola, John R.; Pierson, Theodore C.; Graham, Barney S.; Yu, Dong 分享 收藏
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Rapidly produced SAM® vaccine against H7N9 influenza is immunogenic in mice Hekele, Armin; Bertholet, Sylvie; Archer, Jacob; Gibson, Daniel G.; Palladino, Giuseppe; Brito, Luis A.; Otten, Gillis R.; Brazzoli, Michela; Buccato, Scilla; Bonci, Alessandra; Casini, Daniele; Maione, Domenico; Qi, Zhi-Qing; Gill, John E.; Caiazza, Nicky C.; Urano, Jun; Hubby, Bolyn; Gao, George F.; Shu, Yuelong; De Gregorio, Ennio; Mandl, Christian W.; Mason, Peter W.; Settembre, Ethan C.; Ulmer, Jeffrey B.; Venter, J. Craig; Dormitzer, Philip R.; Rappuoli, Rino; Geall, Andrew J. 分享 收藏
Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection Garcia, Alvaro Baeza; Siu, Edwin; Sun, Tiffany; Exler, Valerie; Brito, Luis; Hekele, Armin; Otten, Gib; Augustijn, Kevin; Janse, Chris J.; Ulmer, Jeffrey B.; Bernhagen, Juergen; Fikrig, Erol; Geall, Andrew; Bucala, Richard 分享 收藏
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Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design Pepini, Timothy; Pulichino, Anne-Marie; Carsillo, Thomas; Carlson, Alicia L.; Sari-Sarraf, Farid; Ramsauer, Katrin; Debasitis, Jason C.; Maruggi, Giulietta; Otten, Gillis R.; Geall, Andrew J.; Yu, Dong; Ulmer, Jeffrey B.; Iavarone, Carlo 分享 收藏
Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin Brazzoli, Michela; Magini, Diletta; Bonci, Alessandra; Buccato, Scilla; Giovani, Cinzia; Kratzer, Roland; Zurli, Vanessa; Mangiavacchi, Simona; Casini, Daniele; Brito, Luis M.; De Gregorio, Ennio; Mason, Peter W.; Ulmer, Jeffrey B.; Geall, Andrew J.; Bertholet, Sylvie 分享 收藏
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A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines Brito, Luis A.; Chan, Michelle; Shaw, Christine A.; Hekele, Armin; Carsillo, Thomas; Schaefer, Mary; Archer, Jacob; Seubert, Anja; Otten, Gillis R.; Beard, Clayton W.; Dey, Antu K.; Lilja, Anders; Valiante, Nicholas M.; Mason, Peter W.; Mandl, Christian W.; Barnett, Susan W.; Dormitzer, Philip R.; Ulmer, Jeffrey B.; Singh, Manmohan; O'Hagan, Derek T.; Geall, Andrew J. 分享 收藏
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JOURNAL OF VIROLOGY
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