未登录 Discovery and Evaluation of TLR-Targeted Immune Agonists Chernyak, Natalia; Bhagwat, Bhagyashree; Naravula, Saraswathi; Chen, Ying; Solban, Nicolas; Zhang, Fan; Kofman, Esther; Raoufi, Fahimeh; Dang, Xibei; Bao, Jianming; Tomazela, Daniela; Baily, Marc; Geierstanger, Bernhard; Flygare, John A.; Han, Jin-Hwan; Willingham, Aarron; Seganish, W. Michael 分享 收藏
Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody-Drug Conjugate Payloads Patel, Akash M.; Willingham, Aarron; Cheng, Alan C.; Tomazela, Daniela; Bowman, Eddie; Kofman, Esther; Zhang, Fan; Bao, Jianming; Sanzone, Jillian R.; Choy, Jonathan W.; Flygare, John A.; Han, Jin-Hwan; Pradhan, Komal; Kieffer, Madeleine; Chernyak, Natalia; Akbari, Peyman; Liu, Ping; Mehmood, Rimsha; Naravula, Saraswathi; Hollingsworth, Scott A.; Bhagwat, Bhagyashree; Lang, Simon B.; Seganish, W. Michael 分享 收藏
Site-Specific Antibody Conjugation Using Modified Bisected N-Glycans: Method Development and Potential toward Tunable Effector Function Hsu, Yen-Pang; Nourzaie, Omar; Tocher, Ariel E.; Nerella, Kavitha; Ermakov, Grigori; Jung, Jiwon; Fowler, Alexandra; Wu, Peidong; Ayesa, Umme; Willingham, Aarron; Beaumont, Maribel; Ingale, Sampat 分享 收藏
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Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab Hutchins, Beth; Starling, Gary C.; McCoy, Mark A.; Herzyk, Danuta; Poulet, Frederique M.; Dulos, John; Liu, Liming; Kang, Soonmo Peter; Fayadat-Dilman, Laurence; Hsieh, Mark; Andrews, Christine L.; Ayanoglu, Gulesi; Cullen, Constance; Malefyt, Rene de Waal; Kastelein, Robert A.; Le Saux, Sabine; Lee, Julie; Li, Sophie; Malashock, Dan; Sadekova, Svetlana; Soder, George; van Eenennaam, Hans; Willingham, Aarron; Yu, Ying; Streuli, Michel; Carven, Gregory J.; van Elsas, Andrea 分享 收藏
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Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells Sukumar, Selvakumar; Wilson, Douglas C.; Yu, Ying; Wong, Jerelyn; Naravula, Saraswathi; Ermakov, Grigori; Riener, Romina; Bhagwat, Bhagyashree; Necheva, Antoaneta S.; Grein, Jeff; Churakova, Tatyana; Mangadu, Ruban; Georgiev, Peter; Manfra, Denise; Pinheiro, Elaine M.; Sriram, Venkataraman; Bailey, Wendy J.; Herzyk, Danuta; McClanahan, Terrill K.; Willingham, Aarron; Beebe, Amy M.; Sadekova, Svetlana 分享 收藏
Development of the anti-IL-10 mAb MK-1966 in combination with in situ vaccination of a TLR9 agonist SD-101 for cancer immunotherapy Phan, U.; Ueda, R.; Mangadu, R.; Sathe, M.; Rimmer, E.; Vives, F.; Ayanoglu, G.; Yu, Y.; Wong, J.; Sadekova, S.; McClanahan, T.; Bhagwat, B.; Willingham, A.; Raubertas, R.; Kastelein, R. 分享 收藏
Characterization of MK-4166, a clinical agonistic mAb that targets human GITR and inhibits the generation and activity of Tregs Sukumar, S.; Wison, D.; Yu, Y.; Wong, J.; Naravula, S.; Ermakov, G.; Bhagwat, B.; Grein, J.; Churakova, T.; Mangadu, R.; Sriram, V.; Bailey, W.; Herzyk, D.; Mcclanahan, T.; Willingham, A.; Beebe, A.; Sadekova, S. 分享 收藏
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The transcriptional diversity of 25 Drosophila cell lines Cherbas, Lucy; Willingham, Aarron; Zhang, Dayu; Yang, Li; Zou, Yi; Eads, Brian D.; Carlson, Joseph W.; Landolin, Jane M.; Kapranov, Philipp; Dumais, Jacqueline; Samsonova, Anastasia; Choi, Jeong-Hyeon; Roberts, Johnny; Davis, Carrie A.; Tang, Haixu; van Baren, Marijke J.; Ghosh, Srinka; Dobin, Alexander; Bell, Kim; Lin, Wei; Langton, Laura; Duff, Michael O.; Tenney, Aaron E.; Zaleski, Chris; Brent, Michael R.; Hoskins, Roger A.; Kaufman, Thomas C.; Andrews, Justen; Graveley, Brenton R.; Perrimon, Norbert; Celniker, Susan E.; Gingeras, Thomas R.; Cherbas, Peter 分享 收藏
Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo Kenski, Denise M.; Cooper, Abby J.; Li, Jenny J.; Willingham, Aarron T.; Haringsma, Henry J.; Young, Tracy A.; Kuklin, Nelly A.; Jones, Jeffrey J.; Cancilla, Mark T.; McMasters, Daniel R.; Mathur, Melina; Sachs, Alan B.; Flanagan, W. Michael 分享 收藏
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