未登录 Discovery of GS-2278, a Potent and Selective LPAR1 Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis Tang, Doris T.; Du, Zhimin; Yang, Kin S.; Bestvater, Brian P.; Kaplan, Joshua; Neubig, Megan E.; Olen, Casey L.; Phillips, Bart; Wang, Peiyuan; Hudson, Thomas; Marchand, Bruno; Chan, Julie; Sharma, Monika; Hu, Yiding; Matles, Mike; Nejati, Elham; Chojnacka, Maja; Adams, Clifton; Pong, Cassie; Holsapple, Kevin; Budas, Grant; Tsui, Vickie; Venkataramani, Chandrasekar; Lazerwith, Scott E.; Notte, Gregory T.; Watkins, William J.; McGlinchey, Ellen; Zagorska, Anna; Farand, Julie 分享 收藏
GS-4571, an Oral Small Molecule GLP-1R Agonist, Improves Glucose Tolerance and Suppresses Food Intake in Obese Diabetic Cynomolgus Monkeys Vogel, Jen; Seung, Minji; Marchand, Bruno; Bhangre, Neeraja; Mukherjee, Jit; Ammann, Stephen E.; Armstrong, Megan; Brizgys, Gediminas; Chin, Elbert; Chou, Chien-Hung; Cottell, Jeromy; Schroeder, Scott D.; Thomas-Tran, Rhiannon; Yang, Zheng-Yu; Peters, Michael; Budas, Grant; Mitchell, Michael L.; Chojnacka, Maja; Jermain, Scott; Hung, Joey; Kulkarni, Supriya; Yue, Qin; Lin, David W.; Miranda, Diego A. 分享 收藏
Development of Cilofexor, an Intestinally-Biased Farnesoid X Receptor Agonist, for the Treatment of Fatty Liver DiseaseS Hollenback, David; Hambruch, Eva; Fink, Gero; Birkel, Manfred; Schulz, Andreas; Hornberger, Martin; Liu, Kathy; Staiger, Kelly MacLennan; Krol, Helen Desiree; Deuschle, Ulrich; Steeneck, Christoph; Kinzel, Olaf; Liles, John T.; Budas, Grant; Watkins, William J.; Kremoser, Claus 分享 收藏
ASK1/p38 axis inhibition blocks the release of mitochondrial danger signals from hepatocytes and suppresses progression to cirrhosis and liver cancer Peng, Zhenwei; Wei, Guangyan; Huang, Pinzhu; Matta, Heansika; Wen, Gao; An, Ping; Zhao, Shuangshuang; Lin, Yi; Tan, Li; Vaid, Kahini; Skelton-Badlani, Disha; Nasser, Imad; Budas, Grant; Lopez, David; Li, Li; Breckenridge, David; Myers, Rob; McHutchison, John; Kuang, Ming; Popov, Yury V. 分享 收藏
Non-steroidal FXR agonist cilofexor improves cholestatic liver injury in the Mdr2-/- mouse model of sclerosing cholangitis Fuchs, Claudia D.; Sroda, Natalie; Scharnagl, Hubert; Gupta, Ruchi; Minto, Wesley; Stojakovic, Tatjana; Liles, John T.; Budas, Grant; Hollenback, David; Trauner, Michael 分享 收藏
Peptide-based urinary monitoring of fibrotic nonalcoholic steatohepatitis by mass-barcoded activity-based sensors Cazanave, Sophie C.; Warren, Andrew D.; Pacula, Maciej; Touti, Faycal; Zagorska, Anna; Gural, Nil; Huang, Eric K.; Sherman, Sarah; Cheema, Mehar; Ibarra, Sabrina; Bates, Jamie; Billin, Andrew N.; Liles, John T.; Budas, Grant R.; Breckenridge, David G.; Tiniakos, Dina; Ratziu, Vlad; Daly, Ann K.; Govaere, Olivier; Anstee, Quentin M.; Gelrud, Louis; Luther, Jay; Chung, Raymond T.; Corey, Kathleen E.; Winckler, Wendy; Bhatia, Sangeeta; Kwong, Gabriel A. 分享 收藏
The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model Schwabl, Philipp; Hambruch, Eva; Budas, Grant R.; Supper, Paul; Burnet, Michael; Liles, John T.; Birkel, Manfred; Brusilovskaya, Ksenia; Konigshofer, Philipp; Peck-Radosavljevic, Markus; Watkins, William J.; Trauner, Michael; Breckenridge, David G.; Kremoser, Claus; Reiberger, Thomas 分享 收藏
ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model Schuster-Gaul, Susanne; Geisler, Lukas Jonathan; McGeough, Matthew D.; Johnson, Casey D.; Zagorska, Anna; Li, Li; Wree, Alexander; Barry, Vivian; Mikaelian, Igor; Jih, Lily J.; Papouchado, Bettina G.; Budas, Grant; Hoffman, Hal M.; Feldstein, Ariel E. 分享 收藏
Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis 单细胞转录组学揭示肝纤维化期间间充质功能的分区 Dobie, Ross; Wilson-Kanamori, John R.; Henderson, Beth E. P.; Smith, James R.; Matchett, Kylie P.; Portman, Jordan R.; Wallenborg, Karolina; Picelli, Simone; Zagorska, Anna; Pendem, Swetha V.; Hudson, Thomas E.; Wu, Minnie M.; Budas, Grant R.; Breckenridge, David G.; Harrison, Ewen M.; Mole, Damian J.; Wigmore, Stephen J.; Ramachandran, Prakash; Ponting, Chris P.; Teichmann, Sarah A.; Marioni, John C.; Henderson, Neil C. 分享 收藏
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ASK1 contributes to fibrosis and dysfunction in mode of kidney disease Liles, John T.; Corkey, Britton K.; Nolte, Gregory T.; Budas, Grant R.; Lansdon, Eric B.; Hinojosa-Kirschenbaum, Ford; Badal, Shawn S.; Lee, Michael; Schultz, Brian E.; Wise, Sarah; Pendem, Swetha; Graupe, Michael; Castonguay, Laurie; Koch, Keith A.; Wong, Melanie H.; Papalia, Giuseppe A.; French, Dorothy M.; Sullivan, Theodore; Huntzicker, Erik G.; Ma, Frank Y.; Nikolic-Paterson, David J.; Altuhaifi, Tareq; Yang, Haichun; Fogo, Agnes B.; Breckenridge, David G. 分享 收藏
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The FXR agonist GS-9674 reduces fibrosis and portal hypertension in a rat model of NASH Schwabl, P.; Budas, G.; Hambruch, E.; Supper, P.; Burnet, M.; Liles, J.; Sullivan, T.; Huntzicker, E.; Birkel, M.; French, D.; Tumas, D.; Peck-Radosavljevic, M.; Watkins, W.; Trauner, M.; Breckenridge, D.; Kremoser, C.; Reiberger, T. 分享 收藏
Combination of an FXR agonist and an ACC inhibitor increases anti-fibrotic efficacy in rodent models of NASH Bates, J.; Hollenback, D.; Zagorska, A.; Budas, G.; Liles, J.; Liu, H.; Liu, K.; Kusam, S.; Brockett, R.; Newstrom, D.; Mikaelian, I.; Wang, T.; Ray, A.; Breckenridge, D. 分享 收藏
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ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension Budas, Grant R.; Boehm, Mario; Kojonazarov, Baktybek; Viswanathan, Gayathri; Tian, Xia; Veeroju, Swathi; Novoyatleva, Tatyana; Grimminger, Friedrich; Hinojosa-Kirschenbaum, Ford; Ghofrani, Hossein A.; Weissmann, Norbert; Seeger, Werner; Liles, John T.; Schermuly, Ralph T. 分享 收藏
Reversal of pulmonary hypertension in a sugen/hypoxic rat model using an ASK1 inhibitor Wilson, Kathryn; Buist, Hanna; Jayasekera, Geeshath; Liles, John; Budas, Grant; Fairfax, Seth; Hughes, Colin; NIlsen, Margaret; Church, Colin; MacLean, Mandy; Peacock, Andrew; Welsh, David 分享 收藏
Combination of an ASK1 inhibitor and FXR agonist increases efficacy in a mouse model of non-alcoholic steatohepatitis Liles, J. T.; Zagorska, A.; Hollenback, D.; Budas, G. R.; Liu, H.; Liu, K.; Brockett, R.; Shauf, A.; Tumas, D.; Breckenridge, D. G. 分享 收藏
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