Jorge H. Capdevila - Publications, H-index & Citations

Jorge H. Capdevila

vanderbilt university

68H指数

347论文数

1.4W被引数

收录论文 68

发表时间

Cytochrome P450 epoxygenase metabolism of arachidonic acid inhibits apoptosis

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

155

OAAI

Chen, JK; Capdevila, J; Harris, RC

Mitogenic activity and signaling mechanism of 2-(14,15-epoxyeicosatrienoyl) glycerol, a novel cytochrome P450 arachidonate metabolite 新型细胞色素P450花生四烯酸代谢产物2-(14，15-环氧二十碳三烯酰) 甘油的有丝分裂活性和信号传导机制

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Chen, Jianchun; Chen, Jian-Kang; Falck, John R.; Anjaiah, Siddam; Capdevila, Jorge H.; Harris, Raymond C.

The arachidonic acid monooxygenase: from biochemical curiosity to physiological/pathophysiological significance

JOURNAL OF LIPID RESEARCH

IF4.1

2018-11-01

OAAI

Capdevila, Jorge H.; Falck, John R.

The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production 细胞色素P450慢代谢剂CYP2C9*2和CYP2C9 * 3通过减少环氧二十碳三烯酸的产生直接调节肿瘤发生

CANCER RESEARCH

IF16.6

2018-09-04

OAAI

Sausville, Lindsay N.; Gangadhariah, Mahesha H.; Chiusa, Manuel; Mei, Shaojun; Wei, Shouzuo; Zent, Roy; Luther, James M.; Shuey, Megan M.; Capdevila, Jorge H.; Falck, John R.; Guengerich, F. Peter; Williams, Scott M.; Pozzi, Ambra

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

CELL CHEMICAL BIOLOGY

IF7.2

2017-10-01

OAAI

Guo, Zhijun; Sevrioukova, Irina F.; Denisov, Ilia G.; Zhang, Xia; Chiu, Ting-Lan; Thomas, Dafydd G.; Hanse, Eric A.; Cuellar, Rebecca A. D.; Grinkova, Yelena V.; Langenfeld, Vanessa Wankhede; Swedien, Daniel S.; Stamschror, Justin D.; Alvarez, Juan; Luna, Fernando; Galvan, Adela; Bae, Young Kyung; Wulfkuhle, Julia D.; Gallagher, Rosa I.; Petricoin, Emanuel F.; Norris, Beverly; Flory, Craig M.; Schumacher, Robert J.; O'Sullivan, M. Gerard; Cao, Qing; Chu, Haitao; Lipscomb, John D.; Atkins, William M.; Gupta, Kalpna; Kelekar, Ameeta; Blair, Ian A.; Capdevila, Jorge H.; Falck, John R.; Sligar, Stephen G.; Poulos, Thomas L.; Georg, Gunda I.; Ambrose, Elizabeth; Potter, David A.

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria (vol 24, pg 1259, 2017)

CELL CHEMICAL BIOLOGY

IF7.2

2017-10-01

OAAI

20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension

CIRCULATION RESEARCH

IF16.2

2017-05-26

145

OAAI

Garcia, Victor; Gilani, Ankit; Shkolnik, Brian; Pandey, Varunkumar; Zhang, Frank Fan; Dakarapu, Rambabu; Gandham, Shyam K.; Reddy, N. Rami; Graves, Joan P.; Gruzdev, Artiom; Zeldin, Darryl C.; Capdevila, Jorge H.; Falck, John R.; Schwartzman, Michal Laniado

Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans 细胞色素P450环氧合酶衍生的环氧二十碳三烯酸有助于小鼠和人类的胰岛素敏感性

DIABETOLOGIA

IF10.2

2017-03-28

OAAI

Gangadhariah, Mahesha H.; Dieckmann, Blake W.; Lantier, Louise; Kang, Li; Wasserman, David H.; Chiusa, Manuel; Caskey, Charles F.; Dickerson, Jaime; Luo, Pengcheng; Gamboa, Jorge L.; Capdevila, Jorge H.; Imig, John D.; Yu, Chang; Pozzi, Ambra; Luther, James M.

20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2016-08-01

OAAI

Savas, Szen; Wei, Shouzou; Hsu, Mei-Hui; Falck, John R.; Guengerich, F. Peter; Capdevila, Jorge H.; Johnson, Eric F.

Hexyl-benzyl-biguanide (HBB) potently and selectively inhibits CYP3A4 epoxygenase activity and inhibits EET stabilization of mitochondrial respiration in ER+HER2-breast cancer cells, inducing glycolysis and pyruvate biosynthesis

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Guo, Zhijun; Sevrioukova, Irina; Hanse, Eric; Zhang, Xia; Denisov, Ilia; Chiu, Ting-Lan; Cuellar, Rebecca; Torres, Christian; Wulfkuhle, Julia; Petricoin, Emanuel; Cao, Qing; Chu, Haitao; Norris, Beverly; Schumacher, Robert; Kelekar, Ameeta; Blair, Ian; Capdevila, Jorge; Falck, John; Poulos, Thomas; Sligar, Steven; Georg, Gunda; Amin, Elizabeth; Potter, David A.

CYP3A4 epoxygenase activity mediates ER plus mammary tumor growth and angiogenesis, in part, through EET biosynthesis and is inhibited by biguanides

CANCER RESEARCH

IF16.6

2015-08-01

PREAI

Guo, Zhijun; Sevrioukova, Irina F.; Hanse, Eric; Denisov, Ilia; Zhang, Xia; Chiu, Ting-Lan; Swedien, Daniel; Stamschror, Justin; Alvarez, Juan; Ortiz, William Marerro; Morgan, Monique; Maher, Michael; Chavez, Kathryn J.; Thomas, Dafydd; Bae, Young Kyung; Henriksen, Jonathan; Norris, Beverly; Schumacher, Robert J.; Wang, Henry; Bliss, Robin; Chu, Haitao; Cuellar, Rebecca; Poulos, Thomas L.; Sligar, Stephen G.; Atkins, William; Schmechel, Stephen; Capdevila, Jorge; Falck, John; Blair, Ian; Jones, Jeffrey P.; Georg, Gunda; Gupta, Kalpna; Kelekar, Ameeta; Amin, Elizabeth; Potter, David A.

Ultrasonic velocity of water-ethanol-malic acid-lactic acid mixtures during the malolactic fermentation process 苹果酸乳酸发酵过程中水-乙醇-苹果酸-乳酸混合物的超声速度

JOURNAL OF FOOD ENGINEERING

IF5.8

2015-03-01

PREAI

Amer, M. A.; Novoa-Diaz, D.; Puig-Pujol, A.; Capdevila, J.; Chavez, J. A.; Turo, A.; Garcia-Hernandez, M. J.; Salazar, J.

Hypertension Is a Major Contributor to 20-Hydroxyeicosatetraenoic Acid-Mediated Kidney Injury in Diabetic Nephropathy

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IF9.4

2015-03-01

OAAI

Gangadhariah, Mahesha H.; Luther, James M.; Garcia, Victor; Paueksakon, Paisit; Zhang, Ming-Zhi; Hayward, Simon W.; Love, Harold D.; Falck, John R.; Manthati, Vijaya L.; Imig, John D.; Schwartzman, Michal L.; Zent, Roy; Capdevila, Jorge H.; Pozzi, Ambra

14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates: Carboxylate Modifications (vol 57, pg 6965, 2014)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-11-04

OAAI

Falck, John R.; Koduru, Sreenivasulu Reddy; Mohapatra, Seetaram; Manne, Rajkurnar; Atcha, Krishnam Raju; Manthati, Vijaya L.; Capdevila, Jorge H.; Christian, Sarah; Imig, John D.; Campbell, William B.

Breast cancer inhibition by a novel and potent biguanide, N1-hexyl-N5-benzyl-biguanide

CANCER RESEARCH

IF16.6

2014-10-01

PREAI

Guo, Zhijun; Chavez, Kathryn J.; Alvarez, Juan; Zhang, Xia; Norris, Beverly; Maher, Michael; Morgan, Monique; Schumacher, Robert J.; Cuellar, Rebecca; Sevrioukova, Irina F.; Poulos, Thomas L.; Denisov, Ilia; Sligar, Stephen G.; Gupta, Kalpna; Blair, Ian A.; Capdevila, Jorge; Kelekar, Ameeta; Amin, Elizabeth; Georg, Gunda; Potter, David A.

14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates: Carboxylate Modifications

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-08-19

OAAI

Falck, John R.; Koduru, Sreenivasulu Reddy; Mohapatra, Seetaram; Manne, Rajkumar; Atcha, Raju; Manthati, Vijaya L.; Capdevila, Jorge H.; Christian, Sarah; Imig, John D.; Campbell, William B.

Cyp2c44 epoxygenase in the collecting duct is essential for the high K+ intake-induced antihypertensive effect

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY

IF3.4

2014-08-15

OAAI

Wang, Wen-Hui; Zhang, Chengbiao; Lin, Dao-Hong; Wang, Lijun; Graves, Joan P.; Zeldin, Darryl C.; Capdevila, Jorge H.

Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition

CLINICAL SCIENCE

IF7.7

2014-06-17

OAAI

Khan, Md. Abdul Hye; Pavlov, Tengis S.; Christain, Sarah V.; Neckar, Jan; Staruschenko, Alexander; Gauthier, Kathryn M.; Capdevila, Jorge H.; Falck, John R.; Campbell, William B.; Imig, John D.

The Cyp2c44 Epoxygenase Regulates Epithelial Sodium Channel Activity and the Blood Pressure Responses to Increased Dietary Salt

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-02-01

OAAI

Capdevila, Jorge H.; Pidkovka, Nataliya; Mei, Shaojun; Gong, Yan; Falck, John R.; Imig, John D.; Harris, Raymond C.; Wang, Wenhui

PPARα Activation Can Help Prevent and Treat Non-Small Cell Lung Cancer

CANCER RESEARCH

IF16.6

2014-01-16

OAAI

Skrypnyk, Nataliya; Chen, Xiwu; Hu, Wen; Su, Yan; Mont, Stacey; Yang, Shilin; Gangadhariah, Mahesha; Wei, Shouzuo; Falck, John R.; Jat, Jawahar Lal; Zent, Roy; Capdevila, Jorge H.; Pozzi, Ambra

研究方向