未登录 Discovery of Galactopyranose-1-carboxamides as a New Class of Small, Novel, Potent, Selective, and Orally Active Galectin-3 Inhibitors Zumbrunn, Cornelia; Remen, Lubos; Sager, Christoph P.; Grisostomi, Corinna; Stamm, Christina; Krusi, Daniela; Glutz, Sven; Schmidt, Gunther; Nayler, Oliver; Iglarz, Marc; Mac Sweeney, Aengus; Chambovey, Alain; Mueller, Manon; Mueller, Celia; Bourquin, Geoffroy; Meyer, Solange; Huhn, Eva; Cattaneo, Christophe; Vercauteren, Magali; Gatfield, John; Bolli, Martin H. 分享 收藏
The novel lysophosphatidic acid receptor 1-selective antagonist, ACT-1016-0707, has unique binding properties that translate into effective antifibrotic and anti-inflammatory activity in different models of pulmonary fibrosis Birker-Robaczewska, Magdalena; Boucher, Maxime; Ranieri, Giulia; Poirey, Sylvie; Studer, Rolf; Freti, Diego; Schnoebelen, Marie; Froidevaux, Sylvie; Morrison, Keith; Wyss, Conrad; Scherer, Jeremy; Lescop, Cyrille; Brotschi, Christine; Bolli, Martin H.; Kramberg, Markus; Di Stefano, Simone; Rey, Markus; Iglarz, Marc; Delahaye, Stephane; Vezzali, Enrico; Sieber, Patrick; Schafer, Anny; Caimi, Silvia L.; Hesse, Christina; Nayler, Oliver 分享 收藏
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Pharmacological Characterization of Aprocitentan, a Dual Endothelin Receptor Antagonist, Alone and in Combination with Blockers of the Renin Angiotensin System, in Two Models of Experimental Hypertension Trensz, Frederic; Bortolamiol, Celine; Kramberg, Markus; Wanner, Daniel; Hadana, Hakim; Rey, Markus; Strasser, Daniel S.; Delahaye, Stephane; Hess, Patrick; Vezzali, Enrico; Mentzel, Ulrich; Menard, Joel; Clozel, Martine; Iglarz, Marc 分享 收藏
Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension Bellaye, Pierre-Simon; Yanagihara, Toyoshi; Granton, Elise; Sato, Seidai; Shimbori, Chiko; Upagupta, Chandak; Imani, Jewel; Hambly, Nathan; Ask, Kjetil; Gauldie, Jack; Iglarz, Marc; Kolb, Martin 分享 收藏
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Selexipag Active Metabolite ACT-333679 Displays Strong Anticontractile and Antiremodeling Effects but Low β-Arrestin Recruitment and Desensitization Potential Gatfield, John; Menyhart, Katalin; Wanner, Daniel; Gnerre, Carmela; Monnier, Lucile; Morrison, Keith; Hess, Patrick; Iglarz, Marc; Clozel, Martine; Nayler, Oliver 分享 收藏
Endothelin ETA Receptor Blockade, by Activating ETB Receptors, Increases Vascular Permeability and Induces Exaggerated Fluid Retentions Vercauteren, Magali; Trensz, Frederic; Pasquali, Anne; Cattaneo, Christophe; Strasser, Daniel S.; Hess, Patrick; Iglarz, Marc; Clozel, Martine 分享 收藏
Lucerastat, an iminosugar for substrate reduction therapy in Fabry disease: preclinical evidence Welford, Richard W. D.; Muhlemann, Andreas; Priestman, David; Garzotti, Marco; Deymier, Caroline; Ertel, Eric A.; Iglarz, Marc; Baldoni, Daniela; Platt, Frances M.; Probst, Markus R. 分享 收藏
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Characterisation of an experimental mouse model of exposure to nanoparticles. Relevance to human sarcoidosis Lebecque, Serge; Renno, Toufic; Bentaher, Azzak; Ponchon, Marine; Calender, Alain; Bernaudin, Jean-Francois; Valeyre, Dominique; Iglarz, Marc; Farine, Herve; Strasser, Daniel; Pacheco, Yves 分享 收藏
The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-β and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist 系统性硬化症中的内皮-间质转化是由Endothelin-1和转化生长因子-β 诱导的，并且可能被双重Endothelin-1受体拮抗剂Macitentan阻断。 Cipriani, Paola; Di Benedetto, Paola; Ruscitti, Piero; Capece, Daria; Zazzeroni, Francesca; Liakouli, Vasiliki; Pantano, Ilenia; Berardicurti, Onorina; Carubbi, Francesco; Pecetti, Gianluca; Turricchia, Stefano; Alesse, Edoardo; Iglarz, Marc; Giacomelli, Roberto 分享 收藏
Chymase: a multifunctional player in pulmonary hypertension associated with lung fibrosis Kosanovic, Djuro; Luitel, Himal; Dahal, Bhola Kumar; Cornitescu, Teodora; Janssen, Wiebke; Danser, A. H. Jan; Garrelds, Ingrid M.; De Mey, Jo G. R.; Fazzi, Gregorio; Schiffers, Paul; Iglarz, Marc; Fischli, Walter; Ghofrani, Hossein Ardeschir; Weissmann, Norbert; Grimminger, Friedrich; Seeger, Werner; Reiss, Irwin; Schermuly, Ralph Theo 分享 收藏
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The Discovery of N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N′-propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor Antagonist Bolli, Martin H.; Boss, Christoph; Binkert, Christoph; Buchmann, Stephan; Bur, Daniel; Hess, Patrick; Iglarz, Marc; Meyer, Solange; Rein, Josiane; Rey, Markus; Treiber, Alexander; Clozel, Martine; Fischli, Walter; Weller, Thomas 分享 收藏
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