logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
delete
arrow
返回
A

Alex Aliper

insilico medicine ai

26H指数
111论文数
5.0K被引数
收录论文 36
发表时间
logo
An open benchmark and language models for AI in aging biology用于衰老生物学中的人工智能开放基准和语言模型
errCell
IF42.5
err2026-09-17
err0
errOAAI
errAlex Zhavoronkov; Vladimir Naumov; Denis Sidorenko; Alex Aliper; Vladimir Aladinskiy; Ramin Hasani; Alexander Amini; Katerina Nasto; Mathieu Reymond; Rim Shayakhmetov; Zulfat Miftakhutdinov; Vadim N. Gladyshev; Fedor Galkin
err分享
err收藏
Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment将蛋白质组学衰老时钟整合到2a期临床试验中支持同步的抗衰老评估
errNature Biotechnology
IF41.7
err2026-09-07
err0
errOAAI
errAlex Zhavoronkov; Fedor Galkin; Shan Chen; Feng Ren; Alex Aliper; Mikhail Durymanov; Denis Sidorenko; Hui Cui; Jing-Dong J. Han; Hao Xu; Xiaodong Liu; Zuojun Xu; Christoph Kuppe; M. Austin Argentieri; Kejun Ying; Ludger J. E. Goeminne; Mahdi Moqri; Alexander Tyshkovskiy; Vadim N. Gladyshev
err分享
err收藏
NDRG1 expression in cancers confers dependence on DNA damage repair and sensitivity to quinacrineNDRG1在癌症中的表达赋予了对DNA损伤修复的依赖性和对喹纳克林敏感性
errScience Signaling
IF6.6
err2026-07-21
err0
PREAI
errGarik V. Mkrtchyan; Alexander Veviorskiy; Zarah G. Meisen; Michael A. Petr; Tobias Clausen Mercurio; Daniela Bakula; Peter Sykora; Li-Wei Kuo; Dean S. Rosenthal; Cynthia M. Simbulan-Rosenthal; Peiran Zhang; Qiuqiong Tang; Andreyan N. Osipov; Ivan V. Ozerov; Alex Aliper; Alex Zhavoronkov; Morten Scheibye-Knudsen
err分享
err收藏
An Internal Sulfur-Lone Pair Interaction Enabled the Discovery of Potent and Sub-Family Selective PKMYT1 Inhibitors内部硫-孤对电子相互作用促成了高效且亚家族选择性的PKMYT1抑制剂的发现
errChemMedChem
IF3.4
err2026-03-27
err0
PREAI
errWang, Yazhou; Wang, Chao; Wang, Xiaomin; Liu, Tingting; Cai, Xin; Zhang, Man; Aliper, Alex; Ren, Feng; Ding, Xiao; Zhavoronkov, Alex
err分享
err收藏
Discovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation人工智能赋能的双功能PKMYT1靶向PROTAC的发现
errNature Communications
IF15.7
err2025-11-28
err0
errOAAI
errYazhou Wang; Xiaomin Wang; Tingting Liu; Chao Wang; Qingshuo Meng; Fanye Meng; Jiaojiao Yu; Jinxin Liu; Yaya Fan; David Gennert; Frank W. Pun; Alex Aliper; Feng Ren; Man Zhang; Xin Cai; Xiao Ding; Alex Zhavoronkov
err分享
err收藏
AlphaFold Kinase Optimizer: Enhancing Virtual Screening Performance Through Automated Refinement of AlphaFold-Based Kinase StructuresAlphaFold激酶优化器：通过自动化优化AlphaFold基激酶结构来增强虚拟筛选性能
errPROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
IF2.8
err2025-09-01
err0
PREAI
errEvteev, Sergei; Ivanenkov, Yan; Aiginin, Andrew; Kuznetsov, Maksim; Shayakhmetov, Rim; Knyazev, Maksim; Bezrukov, Dmitry; Malyshev, Alex; Malkov, Maxim; Aliper, Alex; Zhavoronkov, Alex
err分享
err收藏
Discovery of pyrrolopyrimidinone derivatives as potent PKMYT1 inhibitors for the treatment of cancer
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-01-01
err0
PREAI
errWang, Chao; Wang, Yazhou; Meng, Fanye; Liu, Tingting; Wang, Xiaomin; Cai, Xin; Zhang, Man; Aliper, Alex; Ren, Feng; Zhavoronkov, Alex; Ding, Xiao
err分享
err收藏
AttenhERG: a reliable and interpretable graph neural network framework for predicting hERG channel blockersAttenhERG: 一种用于预测hERG通道阻滞剂的可靠且可解释的图形神经网络框架
errJOURNAL OF CHEMINFORMATICS
IF5.7
err2024-12-23
err0
errOAAI
errYang, Tianbiao; Ding, Xiaoyu; Mcmichael, Elizabeth; Pun, Frank W.; Aliper, Alex; Ren, Feng; Zhavoronkov, Alex; Ding, Xiao
err分享
err收藏
Discovery of 1(2H)-phthalazinone and 1(2H)-isoquinolinone derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-12-01
err0
PREAI
errPeng, Jingjing; Ding, Xiaoyu; Shih, Pei-Yu; Meng, Qingyuan; Ding, Xiao; Zhang, Man; Aliper, Alex; Ren, Feng; Lu, Hongfu; Zhavoronkov, Alex
err分享
err收藏
Precious2GPT: the combination of multiomics pretrained transformer and conditional diffusion for artificial multi-omics multi-species multi-tissue sample generation
errNPJ AGING
IF6
err2024-08-08
err2
errOAAI
errSidorenko, Denis; Pushkov, Stefan; Sakip, Akhmed; Leung, Geoffrey Ho Duen; Lok, Sarah Wing Yan; Urban, Anatoly; Zagirova, Diana; Veviorskiy, Alexander; Tihonova, Nina; Kalashnikov, Aleksandr; Kozlova, Ekaterina; Naumov, Vladimir; Pun, Frank W.; Aliper, Alex; Ren, Feng; Zhavoronkov, Alex
err分享
err收藏
TNIK's emerging role in cancer, metabolism, and age-related diseases
errTRENDS IN PHARMACOLOGICAL SCIENCES
IF19.9
err2024-06-01
err4
errOAAI
errEwald, Collin Y.; Pulous, Fadi E.; Lok, Sarah Wing Yan; Pun, Frank W.; Aliper, Alex; Ren, Feng; Zhavoronkov, Alex
err分享
err收藏
Discovery of a Novel and Potent Cyclin-Dependent Kinase 8/19 (CDK8/19) Inhibitor for the Treatment of Cancer
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-05-01
err3
PREAI
errXu, Jianyu; Qi, Hongyun; Wang, Zhen; Wang, Ling; Steurer, Barbara; Cai, Xin; Liu, Jinxin; Aliper, Alex; Zhang, Man; Ren, Feng; Zhavoronkov, Alex; Ding, Xiao
err分享
err收藏
COSMIC: Molecular Conformation Space Modeling in Internal Coordinates with an Adversarial Framework
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-04-26
err1
errOAAI
errKuznetsov, Maksim; Ryabov, Fedor; Schutski, Roman; Shayakhmetov, Rim; Lin, Yen-Chu; Aliper, Alex; Polykovskiy, Daniil
err分享
err收藏
Quantum-assisted fragment-based automated structure generator (QFASG) for small molecule design: an in vitro study
errFRONTIERS IN CHEMISTRY
IF4.2
err2024-04-03
err0
errOAAI
errEvteev, Sergei; Ivanenkov, Yan; Semenov, Ivan; Malkov, Maxim; Mazaleva, Olga; Bodunov, Artem; Bezrukov, Dmitry; Sidorenko, Denis; Terentiev, Victor; Malyshev, Alex; Zagribelnyy, Bogdan; Korzhenevskaya, Anastasia; Aliper, Alex; Zhavoronkov, Alex
err分享
err收藏
Discovery of 3-hydroxymethyl-azetidine derivatives as potent polymerase theta inhibitors
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2024-04-01
err6
PREAI
errWang, Yazhou; Wang, Chao; Liu, Jinxin; Sun, Deheng; Meng, Fanye; Zhang, Man; Aliper, Alex; Ren, Feng; Zhavoronkov, Alex; Ding, Xiao
err分享
err收藏
A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models一种小分子TNIK抑制剂在临床前及临床模型中靶向纤维化
errNATURE BIOTECHNOLOGY
IF41.7
err2024-03-08
err39
errOAAI
errRen, Feng; Aliper, Alex; Chen, Jian; Zhao, Heng; Rao, Sujata; Kuppe, Christoph; Ozerov, Ivan V.; Zhang, Man; Witte, Klaus; Kruse, Chris; Aladinskiy, Vladimir; Ivanenkov, Yan; Polykovskiy, Daniil; Fu, Yanyun; Babin, Eugene; Qiao, Junwen; Liang, Xing; Mou, Zhenzhen; Wang, Hui; Pun, Frank W.; Ayuso, Pedro Torres; Veviorskiy, Alexander; Song, Dandan; Liu, Sang; Zhang, Bei; Naumov, Vladimir; Ding, Xiaoqiang; Kukharenko, Andrey; Izumchenko, Evgeny; Zhavoronkov, Alex
err分享
err收藏
PandaOmics: An AI-Driven Platform for Therapeutic Target and Biomarker DiscoveryPandaOmics：基于人工智能的治疗靶点与生物标志物发现平台
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-02-26
err22
errOAAI
errKamya, Petrina; Ozerov, Ivan V.; Pun, Frank W.; Tretina, Kyle; Fokina, Tatyana; Chen, Shan; Naumov, Vladimir; Long, Xi; Lin, Sha; Korzinkin, Mikhail; Polykovskiy, Daniil; Aliper, Alex; Ren, Feng; Zhavoronkov, Alex
err分享
err收藏
Complexity of life sciences in quantum and AI era
errWILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL MOLECULAR SCIENCE
IF27
err2024-01-17
err2
errOAAI
errPyrkov, Alexey; Aliper, Alex; Bezrukov, Dmitry; Podolskiy, Dmitriy; Ren, Feng; Zhavoronkov, Alex
err分享
err收藏
nach0: multimodal natural and chemical languages foundation model
errCHEMICAL SCIENCE
IF7.4
err2024-01-01
err2
errOAAI
errLivne, Micha; Miftahutdinov, Zulfat; Tutubalina, Elena; Kuznetsov, Maksim; Polykovskiy, Daniil; Brundyn, Annika; Jhunjhunwala, Aastha; Costa, Anthony; Aliper, Alex; Aspuru-Guzik, Alan; Zhavoronkov, Alex
err分享
err收藏
Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-12-26
err6
PREAI
errWang, Yazhou; Wang, Chao; Liu, Tingting; Qi, Hongyun; Chen, Shan; Cai, Xin; Zhang, Man; Aliper, Alex; Ren, Feng; Ding, Xiao; Zhavoronkov, Alex
err分享
err收藏

研究方向

暂时未获取到该数据
合作学者
合作期刊
V
Vadim N. Gladyshev
H 指数: 123 · 论文数: 789
A
Alán Aspuru‐Guzik
H 指数: 114 · 论文数: 938
C
Charles R. Cantor
H 指数: 97 · 论文数: 576
B
Brian K. Kennedy
H 指数: 92 · 论文数: 455
J
João Pedro de Magalhães
H 指数: 74 · 论文数: 299
查看更多