Chris G. Kruse - Publications, H-index & Citations

Chris G. Kruse

insilico medicine ai ltd.

45H指数

225论文数

5.9K被引数

收录论文 35

发表时间

Identification of Novel pan-KRAS Inhibitors via Structure-Based Drug Design; Scaffold Hopping; and Biological Evaluation 基于结构的药物设计、骨架跳跃和生物评价鉴定新型泛KRAS抑制剂

ACS Medicinal Chemistry Letters

IF4

2025-06-05

PREAI

Vladimir Aladinskiy; Alexey B. Mantsyzov; Chris Kruse; Alexey Noev; Rostislav Petrov; Viktor Reshetnikov; Sujing Shi; Xiao Ding; Xin Cai; Alex Aliper; Alex Zhavoronkov; Feng Ren

Discovery of Bis-imidazolecarboxamide Derivatives as Novel, Potent, and Selective TNIK Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-10-18

PREAI

Aladinskiy, Vladimir; Kruse, Chris; Qin, Luoheng; Babin, Eugene; Fan, Yaya; Andreev, Georgiy; Zhao, Heng; Fu, Yanyun; Zhang, Man; Ivanenkov, Yan; Aliper, Alex; Zhavoronkov, Alex; Ren, Feng

A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models 一种小分子TNIK抑制剂在临床前及临床模型中靶向纤维化

NATURE BIOTECHNOLOGY

IF41.7

2024-03-08

OAAI

Ren, Feng; Aliper, Alex; Chen, Jian; Zhao, Heng; Rao, Sujata; Kuppe, Christoph; Ozerov, Ivan V.; Zhang, Man; Witte, Klaus; Kruse, Chris; Aladinskiy, Vladimir; Ivanenkov, Yan; Polykovskiy, Daniil; Fu, Yanyun; Babin, Eugene; Qiao, Junwen; Liang, Xing; Mou, Zhenzhen; Wang, Hui; Pun, Frank W.; Ayuso, Pedro Torres; Veviorskiy, Alexander; Song, Dandan; Liu, Sang; Zhang, Bei; Naumov, Vladimir; Ding, Xiaoqiang; Kukharenko, Andrey; Izumchenko, Evgeny; Zhavoronkov, Alex

Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2015-07-01

OAAI

Baggelaar, Marc P.; Chameau, Pascal J. P.; Kantae, Vasudev; Hummel, Jessica; Hsu, Ku-Lung; Janssen, Freek; van der Wel, Tom; Soethoudt, Marjolein; Deng, Hui; den Dulk, Hans; Allara, Marco; Florea, Bogdan I.; Di Marzo, Vincenzo; Wadman, Wytse J.; Kruse, Chris G.; Overkleeft, Herman S.; Hankemeier, Thomas; Werkman, Taco R.; Cravatt, Benjamin F.; van der Stelt, Mario

Allosteric Inhibition of the Neuropeptidase Neurolysin

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-12-01

OAAI

Hines, Christina S.; Ray, Kallol; Schmidt, Jack J.; Xiong, Fei; Feenstra, Rolf W.; Pras-Raves, Mia; de Moes, Jan Peter; Lange, Jos H. M.; Melikishvili, Manana; Fried, Michael G.; Mortenson, Paul; Charlton, Michael; Patel, Yogendra; Courtney, Stephen M.; Kruse, Chris G.; Rodgers, David W.

Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2012-02-13

158

OAAI

den Boon, Femke S.; Chameau, Pascal; Schaafsma-Zhao, Qiluan; van Aken, Willem; Bari, Monica; Oddi, Sergio; Kruse, Chris G.; Maccarrone, Mauro; Wadman, Wytse J.; Werkman, Taco R.

Target-drug interactions: first principles and their application to drug discovery 靶-药物相互作用: 第一原理及其在药物发现中的应用

DRUG DISCOVERY TODAY

IF7.5

2012-01-01

171

PREAI

Nunez, Sara; Venhorst, Jennifer; Kruse, Chris G.

Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: Design, synthesis, structure-activity relationships, physicochemical properties and biological activity

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2011-10-01

PREAI

Blaazer, Antoni R.; Lange, Jos H. M.; van der Neut, Martina A. W.; Mulder, Arie; den Boon, Femke S.; Werkman, Taco R.; Kruse, Chris G.; Wadman, Wytse J.

Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors 生物物理和物理化学方法区分高度配体有效的人D-氨基酸氧化酶抑制剂

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2011-10-01

PREAI

Lange, Jos H. M.; Venhorst, Jennifer; van Dongen, Maria J. P.; Frankena, Jurjen; Bassissi, Firas; de Bruin, Natasja M. W. J.; den Besten, Cathaline; de Beer, Stephanie B. A.; Oostenbrink, Chris; Markova, Natalia; Kruse, Chris G.

N′-(Arylsulfonyl)pyrazoline-1-carboxamidines as Novel, Neutral 5-Hydroxytryptamine 6 Receptor (5-HT6R) Antagonists with Unique Structural Features

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2011-09-26

PREAI

van Loevezijn, Arnold; Venhorst, Jennifer; Bakker, Wouter I. Iwema; de Korte, Cor G.; de Looff, Wouter; Verhoog, Stefan; van Wees, Jan-Willem; van Hoeve, Martijn; de Woestijne, Rob P. van; van der Neut, Martina A. W.; Borst, Alice J. M.; van Dongen, Maria J. P.; de Bruin, Natasja M. W. J.; Keizer, Hiskias G.; Kruse, Chris G.

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease 阿尔茨海默氏病的神经病理学先于前额叶皮层转录本的协同变化

BRAIN

IF11.7

2010-10-01

217

OAAI

Bossers, Koen; Wirz, Kerstin T. S.; Meerhoff, Gideon F.; Essing, Anke H. W.; van Dongen, Jeroen W.; Houba, Pieter; Kruse, Chris G.; Verhaagen, Joost; Swaab, Dick F.

Design of a High Fragment Efficiency Library by Molecular Graph Theory

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2010-09-03

OAAI

Venhorst, Jennifer; Nunez, Sara; Kruse, Chris G.

Assessment of a Novel Scoring Method Based on Solvent Accessible Surface Area Descriptors

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2010-03-31

PREAI

Nunez, Sara; Venhors, Jennifer; Kruse, Chris G.

WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: A Novel Dopamine D2 Receptor Partial Agonist/Serotonin Reuptake Inhibitor with Preclinical Antipsychotic-Like and Antidepressant-Like Activity

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2010-01-01

PREAI

Brennan, Julie A.; Graf, Radka; Grauer, Steven M.; Navarra, Rachel L.; Pulicicchio, Claudine M.; Hughes, Zoe A.; Lin, Qian; Wantuch, Caitlin; Rosenzweig-Lipson, Sharon; Pruthi, Farhana; Lai, Margaret; Smith, Deborah; Goutier, Wouter; van de Neut, Martina; Robichaud, Albert J.; Rotella, David; Feenstra, Rolf W.; Kruse, Chris; Broqua, Pierre; Beyer, Chad E.; McCreary, Andrew C.; Pausch, Mark H.; Marquis, Karen L.

Analysis of Gene Expression in Parkinson's Disease: Possible Involvement of Neurotrophic Support and Axon Guidance in Dopaminergic Cell Death

BRAIN PATHOLOGY

IF6.2

2008-12-03

153

OAAI

Bossers, Koen; Meerhoff, Gideon; Balesar, Rawien; van Dongen, Jeroen W.; Kruse, Chris G.; Swaab, Dick F.; Verhaagen, Joost

Structure-activity relationships of phenylalkylamines as agonist ligands for 5-HT2A receptors

CHEMMEDCHEM

IF3.4

2008-09-05

PREAI

Blaazer, Antoni R.; Smid, Pieter; Kruse, Chris G.

Assessment of scaffold hopping efficiency by use of molecular interaction fingerprints

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2008-05-01

PREAI

Venhorst, Jennifer; Nunez, Sara; Terpstra, Jan Willem; Kruse, Chris G.

Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2007-09-19

PREAI

Lange, Jos H. M.; Reinders, Jan-Hendrik; Tolboom, Jeroen T. B. M.; Glennon, Jeffrey C.; Coolen, Hein K. A. C.; Kruse, Chris G.

SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4-[5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride):: A novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug

NEUROPSYCHOPHARMACOLOGY

IF7.1

2006-05-17

OAAI

McCreary, Andrew C.; Glennon, Jeffrey C.; Ashby, Charles R., Jr.; Meltzer, Herbert Y.; Li, Zhu; Reinders, Jan-Hendrik; Hesselink, Mayke B.; Long, Stephen K.; Herremans, Arnoud H.; van Stuivenberg, Herman; Feenstra, Rolf W.; Kruse, Chris G.

Efficient library synthesis of imidazoles using a multicomponent reaction and microwave irradiation

MOLECULAR DIVERSITY

IF3.8

2006-02-01

PREAI

Gelens, E; De Kanter, FJJ; Schmitz, RF; Sliedregt, LAJM; Van Steen, BJ; Kruse, CG; Leurs, R; Groen', MB; Orru, RA

研究方向