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Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT Diong, Sj J.; Jashnani, Aarti; Drake, Andrew W.; Bee, Christine; Findeisen, Felix; Dollinger, Gavin; Wang, Feng; Rajpal, Arvind; Strop, Pavel; Lee, Peter S. 分享 收藏
Residue-Level Characterization of Antibody Binding Epitopes Using Carbene Chemical Footprinting Hogan, Jason M.; Lee, Peter S.; Wong, Susan C.; West, Sean M.; Morishige, Winse H.; Bee, Christine; Tapia, Gamze Camdere; Rajpal, Arvind; Strop, Pavel; Dollinger, Gavin 分享 收藏
Tim-3 mediates T cell trogocytosis to limit antitumor immunity Tim-3介导T细胞胞吞作用以限制抗肿瘤免疫 Pagliano, Ornella; Morrison, Robert M.; Chauvin, Joe-Marc; Banerjee, Hridesh; Davar, Diwakar; Ding, Quanquan; Tanegashima, Tokiyoshi; Gao, Wentao; Chakka, Saranya R.; DeBlasio, Richelle; Lowin, Ava; Kara, Kevin; Ka, Mignane; Zidi, Bochra; Amin, Rada; Raphael, Itay; Zhang, Shuowen; Watkins, Simon C.; Sander, Cindy; Kirkwood, John M.; Bosenberg, Marcus; Anderson, Ana C.; Kuchroo, Vijay K.; Kane, Lawrence P.; Korman, Alan J.; Rajpal, Arvind; West, Sean M.; Han, Minhua; Bee, Christine; Deng, Xiaodi; Schebye, Xiao Min; Strop, Pavel; Zarour, Hassane M. 分享 收藏
Impact of Drug Conjugation on Thermal and Metabolic Stabilities of Aglycosylated and N-Glycosylated Antibodies Yamazoe, Sayumi; Kotapati, Srikanth; Hogan, Jason M.; West, Sean M.; Deng, Xiaodi A.; Diong, S. J.; Arbanas, Jaren; Thien Anh Nguyen; Jashnani, Aarti; Gupta, Diksha; Rajpal, Arvind; Dollinger, Gavin; Strop, Pavel 分享 收藏
Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model Zorn, Julie A.; Wheeler, Matthew L.; Barnes, Ralston M.; Kaberna, Jim; Morishige, Winse; Harris, Marek; Huang, Richard Y-C; Lohre, Jack; Chang, Yu Ching; Chau, Bryant; Powers, Kathleen; Schindler, Ian; Neradugomma, Naveen; Thomas, Winston; Liao, Xiaoyun; Zhou, Yinhan; West, Sean M.; Wang, Feng; Kotapati, Srikanth; Chen, Guodong; Yamazoe, Sayumi; Kosenko, Anastasia; Dollinger, Gavin; Sproul, Tim; Rajpal, Arvind; Strop, Pavel 分享 收藏
Improved therapeutic index of an acidic pH-selective antibody Lee, Peter S.; MacDonald, Katherine G.; Massi, Evan; Chew, Pamela V.; Bee, Christine; Perkins, Padma; Chau, Bryant; Thudium, Kent; Lohre, Jack; Nandi, Pradyot; Deyanova, Ekaterina G.; Barman, Ishita; Gudmundsson, Olafur; Dollinger, Gavin; Sproul, Tim; Engelhardt, John J.; Strop, Pavel; Rajpal, Arvind 分享 收藏
High-Throughput Surface Plasmon Resonance Biosensors for Identifying Diverse Therapeutic Monoclonal Antibodies Matharu, Zimple; Bee, Christine; Schwarz, Flavio; Chen, Haibin; Tomlinson, Matthew; Wu, Gabriel; Rakestraw, Ginger; Hornsby, Michael; Drake, Andrew; Strop, Pavel; Rajpal, Arvind; Dollinger, Gavin 分享 收藏
Antibody blockade of CD96 by distinct molecular mechanisms Lee, Peter S.; Chau, Bryant; Barman, Ishita; Bee, Christine; Jashnani, Aarti; Hogan, Jason M.; Aguilar, Barbara; Dollinger, Gavin; Rajpal, Arvind; Strop, Pavel 分享 收藏
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Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions 小鼠和人gitr-gitrl复合物的结构揭示了独特的TNF超家族相互作用 Wang, Feng; Chau, Bryant; West, Sean M.; Kimberlin, Christopher R.; Cao, Fei; Schwarz, Flavio; Aguilar, Barbara; Han, Minhua; Morishige, Winse; Bee, Christine; Dollinger, Gavin; Rajpal, Arvind; Strop, Pavel 分享 收藏
Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates Chowdari, Naidu S.; Zhang, Yong; McDonald, Ivar; Johnson, Walter; Langley, David R.; Sivaprakasam, Prasanna; Mate, Robert; Huynh, Tram; Kotapati, Srikanth; Deshpande, Madhura; Pan, Chin; Menezes, Daniel; Wang, Yichong; Rao, Chetana; Sarma, Ganapathy; Warrack, Bethanne M.; Rangan, Vangipuram S.; Mei-Chen, Sung; Cardarelli, Pina; Deshpande, Shrikant; Passmore, David; Rampulla, Richard; Mathur, Arvind; Borzilleri, Robert; Rajpal, Arvind; Vite, Gregory; Gangwar, Sanjeev 分享 收藏
Pharmacologic Properties and Preclinical Activity of Sasanlimab, A High-affinity Engineered Anti-Human PD-1 Antibody Al-Khami, Amir A.; Youssef, Sawsan; Abdiche, Yasmina; Nguyen, HoangKim; Chou, Joyce; Kimberlin, Christopher R.; Chin, Sherman M.; Kamperschroer, Cris; Jessen, Bart; Kern, Brent; Budimir, Natalija; Dillon, Christopher P.; Xu, Allison; Clark, Jerry D.; Chou, Jeffrey; Kraynov, Eugenia; Rajpal, Arvind; Lin, John C.; Salek-Ardakani, Shahram 分享 收藏
Highly selective anti-CCR8 antibody-mediated depletion of regulatory T cells leads to potent antitumor activity alone and in combination with anti-PD-1 in preclinical models Lan, Ruth; Jhatakia, Amy; Campbell, Joseph; Siemers, Nathan; Lu, Kai; Nasser, Mohammed; Grigoriev, Tetiana; Singh, Priti; Vlach, Logan; Sproul, Tim; Zhang, Chengyue; Wang, Xi-Tao; Adelakun, Olufemi; Findeisen, Felix; Strop, Pavel; Rajpal, Arvind; Bezman, Natalie; Quigley, Michael; Jain, Renu 分享 收藏
Integrated Approach for Characterizing Bispecific Antibody/Antigens Complexes and Mapping Binding Epitopes with SEC/MALS, Native Mass Spectrometry, and Protein Footprinting Huang, Richard Y-C; Wang, Feng; Wheeler, Matthew; Wang, Yun; Langish, Robert; Chau, Bryant; Dong, Jia; Morishige, Winse; Bezman, Natalie; Strop, Pavel; Rajpal, Arvind; Gudmundsson, Olafur; Chen, Guodong 分享 收藏
High-Throughput Platform to Identify Antibody Conjugation Sites from Antibody-Drug Conjugate Libraries Yamazoe, Sayumi; Hogan, Jason M.; West, Sean M.; Deng, Xiaodi A.; Kotapati, Srikanth; Shao, Xiang; Holder, Patrick; Lamba, Vandana; Huber, Mary; Qiang, Cong; Gangwar, Sanjeev; Rao, Chetana; Dollinger, Gavin; Rajpal, Arvind; Strop, Pavel 分享 收藏
Universal Affinity Capture Liquid Chromatography-Mass Spectrometry Assay for Evaluation of Biotransformation of Site-Specific Antibody Drug Conjugates in Preclinical Studies Kotapati, Srikanth; Passmore, David; Yamazoe, Sayumi; Sanku, Rajesh Kishore Kumar; Cong, Qiang; Poudel, Yam B.; Chowdari, Naidu S.; Gangwar, Sanjeev; Rao, Chetana; Rangan, Vangipuram S.; Cardarelli, Pina M.; Deshpande, Shrikant; Strop, Pavel; Dollinger, Gavin; Rajpal, Arvind 分享 收藏
Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models Wang, Feng; Tsai, Jordan C.; Davis, Jonathan H.; Chau, Bryant; Dong, Jia; West, Sean M.; Hogan, Jason M.; Wheeler, Matthew L.; Bee, Christine; Morishige, Winse; Cayton, Thomas; David-brown, Donata; Zhang, Chengyue; Kozhich, Alexander; Sproul, Tim; Dollinger, Gavin; Rajpal, Arvind; Strop, Pavel 分享 收藏
Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma Panowski, Siler H.; Kuo, Tracy C.; Zhang, Yi; Chen, Amy; Geng, Tao; Aschenbrenner, Laura; Kamperschroer, Cris; Pascua, Edward; Chen, Wei; Delaria, Kathy; Farias, Santiago; Bateman, Marjorie; Dushin, Russell G.; Chin, Sherman M.; Van Blarcom, Thomas J.; Yeung, Yik Andy; Lindquist, Kevin C.; Chunyk, Allison G.; Kuang, Bing; Han, Bora; Mirsky, Michael; Pardo, Ingrid; Buetow, Bernard; Martin, Thomas G.; Wolf, Jeffrey L.; Shelton, David; Rajpal, Arvind; Strop, Pavel; Chaparro-Riggers, Javier; Sasu, Barbra J. 分享 收藏
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