未登录 Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension (vol 124, pg 3514, 2014) Bertero, Thomas; Lu, Yu; Annis, Sofia; Hale, Andrew; Bhat, Balkrishen; Saggar, Rajan; Saggar, Rajeev; Wallace, W. Dean; Ross, David J.; Vargas, Sara O.; Graham, Brian B.; Kumar, Rahul; Black, Stephen M.; Fratz, Sohrab; Fineman, Jeffrey R.; West, James D.; Haley, Kathleen J.; Waxman, Aaron B.; Chau, B. Nelson; Cottrill, Katherine A.; Chan, Stephen Y. 分享 收藏
Targeting 3′ and 5′ untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression Li, Yanjie; Li, Jixue; Wang, Jun; Lynch, David R.; Shen, Xiulong; Corey, David R.; Parekh, Darshan; Bhat, Balkrishen; Woo, Caroline; Cherry, Jonathan J.; Napierala, Jill S.; Napierala, Marek 分享 收藏
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Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity (vol 43, pg 2993, 2015) Prakash, Thazha P.; Lima, Walt F.; Murray, Heather M.; Li, Wenyu; Kinberger, Garth A.; Chappell, Alfred E.; Gaus, Hans; Seth, Punit P.; Bhat, Balkrishen; Crooke, Stanley T.; Swayze, Eric E. 分享 收藏
Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatment of spinal muscular atrophy Woo, Caroline J.; Maier, Verena K.; Davey, Roshni; Brennan, James; Li, Guangde; Brothers, John, II; Schwartz, Brian; Gordo, Susana; Kasper, Anne; Okamoto, Trevor R.; Johansson, Hans E.; Mandefro, Berhan; Sareen, Dhruv; Bialek, Peter; Chau, B. Nelson; Bhat, Balkrishen; Bullough, David; Barsoum, James 分享 收藏
A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions Bertero, Thomas; Cottrill, Katherine A.; Annis, Sofia; Bhat, Balkrishen; Gochuico, Bernadette R.; Osorio, Juan C.; Rosas, Ivan; Haley, Kathleen J.; Corey, Kathleen E.; Chung, Raymond T.; Chau, B. Nelson; Chan, Stephen Y. 分享 收藏
Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit Bertero, Thomas; Cottrill, Katherine A.; Lu, Yu; Haeger, Christina M.; Dieffenbach, Paul; Annis, Sofia; Hale, Andrew; Bhat, Balkrishen; Kaimal, Vivek; Zhang, Ying-Yi; Graham, Brian B.; Kumar, Rahul; Saggar, Rajan; Saggar, Rajeev; Wallace, W. Dean; Ross, David J.; Black, Stephen M.; Fratz, Sohrab; Fineman, Jeffrey R.; Vargas, Sara O.; Haley, Kathleen J.; Waxman, Aaron B.; Chau, B. Nelson; Fredenburgh, Laura E.; Chan, Stephen Y. 分享 收藏
PHARMACOKINETICS, PHARMACODYNAMICS, AND TOXICITY PROFILE OF RG-101, A NOVEL GalNAc-CONJUGATED HEPATOCYTE-TARGETNG INHIBITOR OF MICRORNA-122, IN RODENTS AND CYNOMOLGUS MONKEYS Neben, S.; Liu, K.; Berman, C.; Tay, J.; Esau, C.; Kaiser, R.; Wahle, B.; Chau, N.; Bhat, B.; Gibson, N. W. 分享 收藏
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Identification of metabolically stable 5′- phosphate analogs that support single-stranded siRNA activity Prakash, Thazha P.; Lima, Walt F.; Murray, Heather M.; Li, Wenyu; Kinberger, Garth A.; Chappell, Alfred E.; Gaus, Hans; Seth, Punit P.; Bhat, Balkrishen; Crooke, Stanley T.; Swayze, Eric E. 分享 收藏
The MicroRNA-130/301 Family Controls Vasoconstriction in Pulmonary Hypertension Bertero, Thomas; Cottrill, Katherine; Krauszman, Adrienn; Lu, Yu; Annis, Sofia; Hale, Andrew; Bhat, Balkrishen; Waxman, Aaron B.; Chau, B. Nelson; Kuebler, Wolfgang M.; Chan, Stephen Y. 分享 收藏
G-Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5) Agonists Reduce the Production of Proinflammatory Cytokines and Stabilize the Alternative Macrophage Phenotype Hoegenauer, Klemens; Arista, Luca; Schmiedeberg, Niko; Werner, Gudrun; Jaksche, Herbert; Bouhelal, Rochdi; Nguyen, Deborah G.; Bhat, B. Ganesh; Raad, Layla; Rauld, Celine; Carballido, Jose M. 分享 收藏
microRNA-mediated leukemia-initiating cell activity Velu, Chinavenmeni S.; Chaubey, Aditya; Phelan, James D.; Meyer, Sara; Horman, Shane R.; Wunderlich, Mark; Guzman, Monica L.; Jegga, Anil G.; Zeleznik-Le, Nancy J.; Chen, Jianjun; Mulloy, James C.; Cancelas, Jose A.; Jordan, Craig T.; Aronow, Bruce J.; Marcucci, Guido; Bhat, Balkrishen; Gebelein, Brian; Grimes, H. Leighton 分享 收藏
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension Bertero, Thomas; Lu, Yu; Annis, Sofia; Hale, Andrew; Bhat, Balkrishen; Saggar, Rajan; Saggar, Rajeev; Wallace, W. Dean; Ross, David J.; Vargas, Sara O.; Graham, Brian B.; Kumar, Rahul; Black, Stephen M.; Fratz, Sohrab; Fineman, Jeffrey R.; West, James D.; Haley, Kathleen J.; Waxman, Aaron B.; Chau, B. Nelson; Cottrill, Katherine A.; Chan, Stephen Y. 分享 收藏
Discovery of Trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as Potent, Orally Bioavailable TGR5 (GPBAR1) Agonists: Structure-Activity Relationships, Lead Optimization, and Chronic In Vivo Efficacy Phillips, Dean P.; Gao, Wenqi; Yang, Yang; Zhang, Guobao; Lerario, Isabelle K.; Lau, Thomas L.; Jiang, Jiqing; Wang, Xia; Nguyen, Deborah G.; Bhat, B. Ganesh; Trotter, Carol; Sullivan, Heather; Welzel, Gustav; Landry, Jannine; Chen, Yali; Joseph, Sean B.; Li, Chun; Gordon, W. Perry; Richmond, Wendy; Johnson, Kevin; Bretz, Angela; Bursulaya, Badry; Pan, Shifeng; McNamara, Peter; Seidel, H. Martin 分享 收藏
Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity Velu, Chinavenmeni S.; Chaubey, Aditya; Phelan, James D.; Horman, Shane R.; Wunderlich, Mark; Guzman, Monica L.; Jegga, Anil G.; Zeleznik-Le, Nancy J.; Chen, Jianjun; Mulloy, James C.; Cancelas, Jose A.; Jordan, Craig T.; Aronow, Bruce J.; Marcucci, Guido; Bhat, Balkrishen; Gebelein, Brian; Grimes, H. Leighton 分享 收藏
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Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides Egli, Martin; Pallan, Pradeep S.; Allerson, Charles R.; Prakash, Thazha P.; Berdeja, Andres; Yu, Jinghua; Lee, Sam; Watt, Andrew; Gaus, Hans; Bhat, Balkrishen; Swayze, Eric E.; Seth, Punit P. 分享 收藏
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