Hitoshi Endou - Publications, H-index & Citations

Hitoshi Endou

Kyorin University

100H指数

847论文数

3.4W被引数

收录论文 165

发表时间

Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells

JOURNAL OF PHARMACOLOGICAL SCIENCES

IF2.9

2024-05-01

OAAI

Ma, Yu; Okuda, Suguru; Okanishi, Hiroki; Xu, Minhui; Jin, Chunhuan; Endou, Hitoshi; Ohgaki, Ryuichi; Kanai, Yoshikatsu

Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/ G1-S transition by downregulating cyclin D1 via p38 MAPK activation

JOURNAL OF PHARMACOLOGICAL SCIENCES

IF2.9

2024-03-01

OAAI

Zhou, Xinyu; Ohgaki, Ryuichi; Jin, Chunhuan; Xu, Minhui; Okanishi, Hiroki; Endou, Hitoshi; Kanai, Yoshikatsu

Inhibition of cancer-type amino acid transporter LAT1 suppresses B16-F10 melanoma metastasis in mouse models

SCIENTIFIC REPORTS

IF3.9

2023-08-25

OAAI

Shi, Zitong; Kaneda-Nakashima, Kazuko; Ohgaki, Ryuichi; Xu, Minhui; Okanishi, Hiroki; Endou, Hitoshi; Nagamori, Shushi; Kanai, Yoshikatsu

LAT1 enables T cell activation under inflammatory conditions

JOURNAL OF AUTOIMMUNITY

IF7

2023-07-01

PREAI

Ogbechi, Joy; Wright, Helen L.; Balint, Stefan; Topping, Louise M.; Kristina, Zec; Huang, Yi-Shu; Pantazi, Eirini; Swart, Maarten; Windell, Dylan; Marin, Eros; Wempe, Michael F.; Endou, Hitoshi; Thomas, Andrew M.; Filer, Andrew; Stone, Trevor W.; Clarke, Alexander J.; Dustin, Michael L.; Williams, Richard O.

JPH203, a LAT1 inhibitor, alleviates steroid-resistant murine airway inflammation mediated by Th17 cells

ALLERGY

IF12

2023-06-29

PREAI

Hayashi, Keitaro; Saeki, Mayumi; Miura, Kento; Yamasaki, Norimasa; Matsuda, Masaya; Shimora, Hayato; Nabe, Takeshi; Shimizu, Yasuo; Fujita, Tomoe; Endou, Hitoshi; Kaminuma, Osamu

Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells

CANCER CELL INTERNATIONAL

IF6

2023-06-15

OAAI

Nishikubo, Kou; Ohgaki, Ryuichi; Liu, Xingming; Okanishi, Hiroki; Xu, Minhui; Endou, Hitoshi; Kanai, Yoshikatsu

Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment

BLOOD ADVANCES

IF7.1

2023-04-27

OAAI

Panetti, Silvia; McJannett, Nicola; Fultang, Livingstone; Booth, Sarah; Gneo, Luciana; Scarpa, Ugo; Smith, Charles; Vardon, Ashley; Vettore, Lisa; Whalley, Celina; Pan, Yi; Varnai, Csilla; Endou, Hitoshi; Barlow, Jonathan; Tennant, Daniel; Beggs, Andrew; Mussai, Francis; De Santo, Carmela

Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1

CANCER & METABOLISM

IF5.3

2022-11-10

OAAI

Okanishi, Hiroki; Ohgaki, Ryuichi; Xu, Minhui; Endou, Hitoshi; Kanai, Yoshikatsu

LAT1-specific inhibitor ameliorates severe autoimmune arthritis in SKG mouse

INTERNATIONAL IMMUNOPHARMACOLOGY

IF4.7

2022-08-01

PREAI

Owada, Takayoshi; Kurasawa, Kazuhiro; Endou, Hitoshi; Fujita, Tomoe; Anzai, Naohiko; Hayashi, Keitaro

Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin's lymphoma

SCIENTIFIC REPORTS

IF3.9

2021-11-04

OAAI

Jigjidkhorloo, Narangerel; Kanekura, Kohsuke; Matsubayashi, Jun; Akahane, Daigo; Fujita, Koji; Oikawa, Keiki; Kurata, Atsushi; Takanashi, Masakatsu; Endou, Hitoshi; Nagao, Toshitaka; Gotoh, Akihiko; Norov, Oyundelger; Kuroda, Masahiko

Antitumor effect of dimethyl itaconate on thymic carcinoma by targeting LDHA-mTOR axis

LIFE SCIENCES

IF5.1

2021-10-01

PREAI

Hayashi, Keitaro; Nakazato, Yoshimasa; Ouchi, Motoshi; Fujita, Tomoe; Endou, Hitoshi; Chida, Masayuki

Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IF12.8

2020-11-30

OAAI

Quan, Lili; Ohgaki, Ryuichi; Hara, Saori; Okuda, Suguru; Wei, Ling; Okanishi, Hiroki; Nagamori, Shushi; Endou, Hitoshi; Kanai, Yoshikatsu

First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors

INVESTIGATIONAL NEW DRUGS

IF2.7

2020-03-20

PREAI

Okano, Naohiro; Naruge, Daisuke; Kawai, Kirio; Kobayashi, Takaaki; Nagashima, Fumio; Endou, Hitoshi; Furuse, Junji

LAT1-specific inhibitor is effective against T cell-mediated allergic skin inflammation

ALLERGY

IF12

2019-09-03

PREAI

Hayashi, Keitaro; Kaminuma, Osamu; Nishimura, Tomoe; Saeki, Mayumi; Matsuoka, Kunie; Hiroi, Takachika; Jutabha, Promsuk; Iwata, Yohei; Sugiura, Kazumitsu; Owada, Takayoshi; Kurasawa, Kazuhiro; Okayasu, Isao; Ouchi, Motoshi; Fujita, Tomoe; Kanai, Yoshikatsu; Endou, Hitoshi; Anzai, Naohiko

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2019-06-03

110

OAAI

Lee, Yongchan; Wiriyasermkul, Pattama; Jin, Chunhuan; Quan, Lili; Ohgaki, Ryuichi; Okuda, Suguru; Kusakizako, Tsukasa; Nishizawa, Tomohiro; Oda, Kazumasa; Ishitani, Ryuichiro; Yokoyama, Takeshi; Nakane, Takanori; Shirouzu, Mikako; Endou, Hitoshi; Nagamori, Shushi; Kanai, Yoshikatsu; Nureki, Osamu

The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-02-01

144

OAAI

Cormerais, Yann; Massard, Pierre Andre; Vucetic, Milica; Giuliano, Sandy; Tambutte, Eric; Durivault, Jerome; Vial, Valerie; Endou, Hitoshi; Wempe, Michael F.; Parks, Scott K.; Pouyssegur, Jacques

LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells

JOURNAL OF PHARMACOLOGICAL SCIENCES

IF2.9

2016-11-01

OAAI

Hayashi, Keitaro; Jutabha, Promsuk; Maeda, Sumiko; Supak, Yothaisong; Ouchi, Motoshi; Endou, Hitoshi; Fujita, Tomoe; Chida, Masayuki; Anzai, Naohiko

Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth

CANCER RESEARCH

IF16.6

2016-07-31

146

OAAI

Cormerais, Yann; Giuliano, Sandy; LeFloch, Renaud; Front, Benoit; Durivault, Jerome; Tambutte, Eric; Massard, Pierre-Andre; Rodriguez de la Ballina, Laura; Endou, Hitoshi; Wempe, Michael F.; Palacin, Manuel; Parks, Scott K.; Pouyssegur, Jacques

Dissecting the pro-tumoural role of the essential amino-acid transporter complex CD98/LAT1

EUROPEAN JOURNAL OF CANCER

IF7.1

2016-07-01

PREAI

Cormerais, Y.; Giuliano, S.; Massard, P. A.; Durivault, J.; Hitoshi, E.; Michael, W.; Parks, S.; Pouyssegur, J.

Metformin enhances anti- tumor effect of L-type amino acid transporter 1 (LAT1) inhibitor

JOURNAL OF PHARMACOLOGICAL SCIENCES

IF2.9

2016-06-01

OAAI

Ueno, Seiji; Kimura, Toru; Yamaga, Takashi; Kawada, Akihiko; Ochiai, Toshiaki; Endou, Hitoshi; Sakurai, Hiroyuki

研究方向