未登录 分享 收藏
分享 收藏
分享 收藏
分享 收藏
分享 收藏
Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation Dorel, Ruth; Sun, Dawei; Carruthers, Nicholas; Castanedo, Georgette M.; Ung, Peter M. U.; Factor, Daniel C.; Li, Tianbo; Baumann, Hannah; Janota, Danielle; Pang, Jodie; Salphati, Laurent; Meklemburg, Robert; Korman, Allison J.; Harper, Halie E.; Stubblefield, Samantha; Payandeh, Jian; Mchugh, Daniel; Lang, Bradley T.; Tesar, Paul J.; Dere, Edward; Masureel, Matthieu; Adams, Drew J.; Volgraf, Matthew; Braun, Marie-Gabrielle 分享 收藏
Early Stage Preclinical Formulation Strategies to Alter the Pharmacokinetic Profile of Two Small Molecule Therapeutics An, Le; De Bruyn, Tom; Pang, Jodie; Ubhayakar, Savita; Salphati, Laurent; Zhang, Xing; Liu, Liling; Li, Ruina; Chan, Bryan; Dey, Anwesha; Levy, Elizabeth S. 分享 收藏
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα Hanan, Emily J.; Braun, Marie-Gabrielle; Heald, Robert A.; MacLeod, Calum; Chan, Connie; Clausen, Saundra; Edgar, Kyle A.; Eigenbrot, Charles; Elliott, Richard; Endres, Nicholas; Friedman, Lori S.; Gogol, Emily; Gu, Xiao-Hui; Thibodeau, Rebecca Hong; Jackson, Philip S.; Kiefer, James R.; Knight, Jamie D.; Nannini, Michelle; Narukulla, Raman; Pace, Amanda; Pang, Jodie; Purkey, Hans E.; Salphati, Laurent; Sampath, Deepak; Schmidt, Stephen; Sideris, Steve; Song, Kyung; Sujatha-Bhaskar, Swathi; Ultsch, Mark; Wallweber, Heidi; Xin, Jianfeng; Yeap, SiewKuen; Young, Amy; Zhong, Yu; Staben, Steven T. 分享 收藏
分享 收藏
Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1) Chan, Bryan K.; Seward, Eileen; Lainchbury, Michael; Brewer, Thomas F.; An, Le; Blench, Toby; Cartwright, Matthew W.; Chan, Grace Ka Yan; Choo, Edna F.; Drummond, Jason; Elliott, Richard L.; Gancia, Emanuela; Gazzard, Lewis; Hu, Baihua; Jones, Graham E.; Luo, Xifeng; Madin, Andrew; Malhotra, Sushant; Moffat, John G.; Pang, Jodie; Salphati, Laurent; Sneeringer, Christopher J.; Stivala, Craig E.; Wei, Binqing; Wang, Weiru; Wu, Ping; Heffron, Timothy P. 分享 收藏
Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors 基于结构的有效，选择性和口服生物利用度的VPS34激酶抑制剂的设计 Hu, Dennis X.; Patel, Snahel; Chen, Huifen; Wang, Shumei; Staben, Steven T.; Dimitrova, Yoana N.; Wallweber, Heidi Ackerly; Lee, Joanna Y.; Chan, Grace Ka Yan; Sneeringer, Christopher J.; Prangley, Madeleine S.; Moffat, John G.; Wu, Kai C.; Schutt, Leah K.; Salphati, Laurent; Pang, Jodie; McNamara, Erin; Huang, Haochu; Chen, Yong; Wang, Yunli; Zhao, Wensheng; Lim, Junghyun; Murthy, Aditya; Siu, Michael 分享 收藏
分享 收藏
Positron Emission Tomography Imaging of [11C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A Billington, Sarah; Shoner, Steven; Lee, Scott; Clark-Snustad, Kindra; Pennington, Matthew; Lewis, David; Muzi, Mark; Rene, Shirley; Lee, Jean; Tot Bui Nguyen; Kumar, Vineet; Ishida, Kazuya; Chen, Laigo; Chu, Xiaoyan; Lai, Yurong; Salphati, Laurent; Hop, Cornelis E. C. A.; Xiao, Guangqing; Liao, Mingxiang; Unadkat, Jashvant D. 分享 收藏
Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor Ma, Shuguang; Suchomel, Julia; Yanez, Evelyn; Yost, Edward; Liang, Xiaorong; Zhu, Rui; Le, Hoa; Siebers, Nicholas; Joas, Lori; Morley, Roland; Royer-Joo, Stephanie; Pirzkall, Andrea; Salphati, Laurent; Ware, Joseph A.; Morrissey, Kari M. 分享 收藏
Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood-Brain Barrier Measured by Quantitative Targeted Proteomics Billington, Sarah; Salphati, Laurent; Hop, Cornelis E. C. A.; Chu, Xiaoyan; Evers, Raymond; Burdette, Doug; Rowbottom, Christopher; Lai, Yurong; Xiao, Guangqing; Humphreys, W. Griffith; Nguyen, Tot Bui; Prasad, Bhagwat; Unadkat, Jashvant D. 分享 收藏
Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors Nayak-Kapoor, Asha; Hao, Zhonglin; Sadek, Ramses; Dobbins, Robin; Marshall, Lisa; Vahanian, Nicholas N.; Ramsey, W. Jay; Kennedy, Eugene; Mautino, Mario R.; Link, Charles J.; Lin, Ray S.; Royer-Joo, Stephanie; Liang, Xiaorong; Salphati, Laurent; Morrissey, Kari M.; Mahrus, Sami; McCall, Bruce; Pirzkall, Andrea; Munn, David H.; Janik, John E.; Khleif, Samir N. 分享 收藏
Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition Cepa, Steven; Potter, David; Wong, Lisa; Schutt, Leah; Tarrant, Jacqueline; Pang, Jodie; Zhang, Xiaolin; Andaya, Roxanne; Salphati, Laurent; Ran, Yingqing; An, Le; Morgan, Ryan; Maher, Jonathan 分享 收藏
分享 收藏
分享 收藏
Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles Safina, Brian S.; Elliott, Richard L.; Forrest, Andrew K.; Heald, Robert A.; Murray, Jeremy M.; Nonomiya, Jim; Pang, Jodie; Salphati, Laurent; Seward, Eileen M.; Staben, Steven T.; Ultsch, Mark; Wei, Binqing; Yang, Wenqian; Sutherlin, Daniel P. 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
