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Plasticity of the mammalian integrated stress response 哺乳动物整合应激反应的塑性 Chen, Chien-Wen; Papadopoli, David; Szkop, Krzysztof J.; Guan, Bo-Jhih; Alzahrani, Mohammed; Wu, Jing; Jobava, Raul; Asraf, Mais M.; Krokowski, Dawid; Vourekas, Anastasios; Merrick, William C.; Komar, Anton A.; Koromilas, Antonis E.; Gorospe, Myriam; Payea, Matthew J.; Wang, Fangfang; Clayton, Benjamin L. L.; Tesar, Paul J.; Schaffer, Ashleigh; Miron, Alexander; Bederman, Ilya; Jankowsky, Eckhard; Vogel, Christine; Valasek, Leos Shivaya; Dinman, Jonathan D.; Zhang, Youwei; Tirosh, Boaz; Larsson, Ola; Topisirovic, Ivan; Hatzoglou, Maria 分享 收藏
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Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex (vol 13, 1029093, 2022) 通过靶向eIF4F复合体抑制冠状病毒HCoV-OC43 (vol 13, 1029093, 2022) Feng, Yongmei; Grotegut, Stefan; Jovanovic, Predrag; Gandin, Valentina; Olson, Steven H.; Murad, Rabi; Beall, Anne; Colayco, Sharon; De-Jesus, Paul; Chanda, Sumit; English, Brian P.; Singer, Robert H.; Jackson, Michael; Topisirovic, Ivan; Ronai, Ze'ev A. 分享 收藏
Perturbations in eIF3 subunit stoichiometry alter expression of ribosomal proteins and key components of the MAPK signaling pathways Herrmannova, Anna; Jelinek, Jan; Pospisilova, Klara; Kerenyi, Farkas; Vomastek, Tomas; Watt, Kathleen; Brabek, Jan; Mohammad, Mahabub Pasha; Wagner, Susan; Topisirovic, Ivan; Valasek, Leos Shivaya 分享 收藏
ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis El Bakkouri, Yassine; Chidiac, Rony; Delisle, Chantal; Corriveau, Jeanne; Cagnone, Gael; Gaonac'h-Lovejoy, Vanda; Chin, Ashley; Lecuyer, Eric; Angers, Stephane; Joyal, Jean-Sebastien; Topisirovic, Ivan; Hulea, Laura; Dubrac, Alexandre; Gratton, Jean-Philippe 分享 收藏
Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses (vol 131, e140752, 2021) Huang, Fan; Goncalves, Christophe; Bartish, Margarita; Remy-Sarrazin, Joelle; Issa, Mark E.; Cordeiro, Brendan; Guo, Qianyu; Emond, Audrey; Attias, Mikhael; Yang, William; Plourde, Dany; Su, Jie; Gimeno, Marina Godoy; Zhan, Yao; Galan, Alba; Rzymski, Tomasz; Mazan, Milena; Masiejczyk, Magdalena; Faber, Jacek; Khoury, Elie; Benoit, Alexandre; Gagnon, Natascha; Dankort, David; Journe, Fabrice; Ghanem, Ghanem E.; Krawczyk, Connie M.; Saragovi, H. Uri; Piccirillo, Ciriaco A.; Sonenberg, Nahum; Topisirovic, Ivan; Rudd, Christopher E.; Miller Jr, Wilson H.; del Rincon, Sonia V. 分享 收藏
MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma (vol 127, pg 4179, 2017) Zhan, Yao; Guo, Jun; Yang, William; Goncalves, Christophe; Rzymski, Tomasz; Dreas, Agnieszka; Zylkiewicz, Eliza; Mikulski, Maciej; Brzozka, Krzysztof; Golas, Aniela; Kong, Yan; Ma, Meng; Huang, Fan; Huor, Bonnie; Guo, Qianyu; da Silva, Sabrina Daniela; Torres, Jose; Cai, Yutian; Topisirovic, Ivan; Su, Jie; Bijian, Krikor; Alaoui-Jamali, Moulay A.; Huang, Sidong; Journe, Fabrice; Ghanem, Ghanem E.; Miller Jr, Wilson H.; Rincon, Sonia V. del 分享 收藏
A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer 第二代eIF4A RNA解旋酶抑制剂利用翻译重编程作为三阴性乳腺癌的脆弱性 Cencic, Regina; Im, Young K.; Naineni, Sai Kiran; Moustafa-Kamal, Mohamed; Jovanovic, Predrag; Sabourin, Valerie; Annis, Matthew G.; Robert, Francis; Schmeing, T. Martin; Koromilas, Antonis; Paquet, Marilene; Teodoro, Jose G.; Huang, Sidong; Siegel, Peter M.; Topisirovic, Ivan; Ursini-Siegel, Josie; Pelletier, Jerry 分享 收藏
The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma Findlay, Steven; Nair, Remya; Merrill, Ronald A.; Kaiser, Zafir; Cajelot, Alexandre; Aryanpour, Zahra; Heath, John; St-Louis, Catherine; Papadopoli, David; Topisirovic, Ivan; St-Pierre, Julie; Sebag, Michael; Kesarwala, Aparna H.; Hulea, Laura; Taylor, Eric B.; Shanmugam, Mala; Orthwein, Alexandre 分享 收藏
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Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids Abdullah, Mahmud O.; Zeng, Run X.; Margerum, Chelsea L.; Papadopoli, David; Monnin, Cian; Punter, Kaylee B.; Chu, Charles; Al-Rofaidi, Mohammad; Al-Tannak, Naser F.; Berardi, Domenica; Rattray, Zahra; Rattray, Nicholas J. W.; Abraham, Sheela A.; Eskelinen, Eeva-Liisa; Watson, David G.; Avizonis, Daina; Topisirovic, Ivan; Chan, Edmond Y. W. 分享 收藏
Arginyl-tRNA-protein transferase 1 (ATE1) promotes melanoma cell growth and migration Lazar, Ikrame; Fabre, Bertrand; Feng, Yongmei; Khateb, Ali; Frit, Philippe; Kashina, Anna; Zhang, Tongwu; Avitan-Hersh, Emily; Kim, Hyungsoo; Brown, Kevin; Topisirovic, Ivan; Ronai, Ze'ev A. 分享 收藏
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth (vol 17, pg 1065, 2021) Lee, Bianca J.; Boyer, Jacob A.; Burnett, G. Leslie; Thottumkara, Arun P.; Tibrewal, Nidhi; Wilson, Stacy L.; Hsieh, Tientien; Marquez, Abby; Lorenzana, Edward G.; Evans, James W.; Hulea, Laura; Kiss, Gert; Liu, Hui; Lee, Dong; Larsson, Ola; McLaughlan, Shannon; Topisirovic, Ivan; Wang, Zhengping; Wang, Zhican; Zhao, Yongyuan; Wildes, David; Aggen, James B.; Singh, Mallika; Gill, Adrian L.; Smith, Jacqueline A. M.; Rosen, Neal 分享 收藏
Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress Jobava, Raul; Mao, Yuanhui; Guan, Bo-Jhih; Hu, Di; Krokowski, Dawid; Chen, Chien-Wen; Shu, Xin Erica; Chukwurah, Evelyn; Wu, Jing; Gao, Zhaofeng; Zagore, Leah L.; Merrick, William C.; Trifunovic, Aleksandra; Hsieh, Andrew C.; Valadkhan, Saba; Zhang, Youwei; Qi, Xin; Jankowsky, Eckhard; Topisirovic, Ivan; Licatalosi, Donny D.; Qian, Shu-Bing; Hatzoglou, Maria 分享 收藏
A hydride transfer complex reprograms NAD metabolism and bypasses senescence 氢化物转移复合物重新编程NAD代谢并绕过衰老 Igelmann, Sebastian; Lessard, Frederic; Uchenunu, Oro; Bouchard, Jacob; Fernandez-Ruiz, Ana; Rowell, Marie-Camille; Lopes-Paciencia, Stephane; Papadopoli, David; Fouillen, Aurelien; Ponce, Katia Julissa; Huot, Genevieve; Mignacca, Lian; Benfdil, Mehdi; Kalegari, Paloma; Wahba, Haytham M.; Pencik, Jan; Vuong, Nhung; Quenneville, Jordan; Guillon, Jordan; Bourdeau, Veronique; Hulea, Laura; Gagnon, Etienne; Kenner, Lukas; Moriggl, Richard; Nanci, Antonio; Pollak, Michael N.; Omichinski, James G.; Topisirovic, Ivan; Ferbeyre, Gerardo 分享 收藏
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer Ghaddar, Nour; Wang, Shuo; Woodvine, Bethany; Krishnamoorthy, Jothilatha; van Hoef, Vincent; Darini, Cedric; Kazimierczak, Urszula; Ah-son, Nicolas; Popper, Helmuth; Johnson, Myriam; Officer, Leah; Teodosio, Ana; Broggini, Massimo; Mann, Koren K.; Hatzoglou, Maria; Topisirovic, Ivan; Larsson, Ola; Le Quesne, John; Koromilas, Antonis E. 分享 收藏
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