未登录 Antiviral profile of hepatitis B virus capsid assembly modulator ALG-001075, the parent of pevifoscorvir sodium 乙型肝炎病毒衣壳组装调节剂ALG-001075（pevifoscorvir钠的母体）的抗病毒谱 Debing, Yannick; Vanrusselt, Hannah; Liu, Cheng; Verheyen, Jordi; Degrauwe, Lars; Kum, Dieudonne Buh; Sanchez, Abel Acosta; Francisco, Adilson Carlos; Wanicek, Emma; Netter, Hans J.; Ramsland, Paul A.; Leis, Andrew; Shakeel, Shabih; Deval, Jerome; Welch, Michael; Serebryany, Vladimir; Stoycheva, Antitsa; Beigelman, Leonid; Raboisson, Pierre; Vendeville, Sandrine; Lin, Tse-, I; Blatt, Lawrence M.; Smith, David B.; Symons, Julian A.; Lecoq, Lauriane; Jekle, Andreas 分享 收藏
Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles Vanrusselt, Hannah; Kum, Dieudonne Buh; Taverniti, Valerio; Liu, Cheng; Acosta Sanchez, Abel; Corthout, Nikky; Munck, Sebastian; Baumert, Thomas F.; Beigelman, Leonid; Blatt, Lawrence M.; Symons, Julian A.; Deval, Jerome; Raboisson, Pierre; Verrier, Eloi R.; Jekle, Andreas; Vendeville, Sandrine; Debing, Yannick 分享 收藏
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Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation Kum, Dieudonne Buh; Vanrusselt, Hannah; Acosta Sanchez, Abel; Taverniti, Valerio; Verrier, Eloi R.; Baumert, Thomas F.; Liu, Cheng; Deval, Jerome; Corthout, Nikky; Munck, Sebastian; Beigelman, Leonid; Blatt, Lawrence M.; Symons, Julian A.; Raboisson, Pierre; Jekle, Andreas; Vendeville, Sandrine; Debing, Yannick 分享 收藏
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir Jochmans, Dirk; Liu, Cheng; Donckers, Kim; Stoycheva, Antitsa; Boland, Sandro; Stevens, Sarah K.; De Vita, Chloe; Vanmechelen, Bert; Maes, Piet; Trueb, Bettina; Ebert, Nadine; Thiel, Volker; De Jonghe, Steven; Vangeel, Laura; Bardiot, Dorothee; Jekle, Andreas; Blatt, Lawrence M.; Beigelman, Leonid; Symons, Julian A.; Raboisson, Pierre; Chaltin, Patrick; Marchand, Arnaud; Neyts, Johan; Deval, Jerome; Vandyck, Koen 分享 收藏
Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules Kao, C. Cheng; Nie, Yuchun; Ren, Suping; De Costa, N. Tilani T. S.; Pandey, Rajendra K.; Hong, Jin; Smith, David B.; Symons, Julian A.; Beigelman, Leonid; Blatt, Lawrence M. 分享 收藏
Targeting TLR9 agonists to secondary lymphoid organs induces potent immune responses against HBV infection Ushach, Irina; Zhu, Ren; Rosler, Elen; Pandey, Rajendra K.; De Costa, N. Tilani S.; Pourshahian, Soheil; Han, Qinglin; Li, Chris; Beigelman, Leonid; Gryaznov, Sergei M.; Yun, Theodore 分享 收藏
Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C Wang, Guangyi; Dyatkina, Natalia; Prhavc, Marija; Williams, Caroline; Serebryany, Vladimir; Hu, Yujian; Huang, Yongfei; Wu, Xiangyang; Chen, Tongqian; Huang, Wensheng; Rajwanshi, Vivek K.; Deval, Jerome; Fung, Amy; Jin, Zhinan; Stoycheva, Antitsa; Shaw, Kenneth; Gupta, Kusum; Tam, Yuen; Jekle, Andreas; Smith, David B.; Beigelman, Leonid 分享 收藏
Preclinical characterization of ALG-031048, a novel STING agonist with potent anti-tumor activity in mice Jekle, Andreas; Thatikonda, Santosh; Stevens, Sarah; Williams, Caroline; Kinkade, April; Ren, Suping; Jaisinghani, Ruchika; Zhang, Qingling; Misner, Dinah; Stoycheva, Antitsa; Deval, Jerome; Mukherjee, Sucheta; Gonzalvez, Francois; Chanda, Sushmita; Smith, David B.; Symons, Julian A.; Blatt, Lawrence M.; Beigelman, Leonid 分享 收藏
Discovery of novel potent and selective inhibitors of PRMT5 with anti-tumor activity in hepatocellular carcinoma and lung pre-clinical models Gonzalvez, Francois; Vandyck, Koen; Debing, Yannick; Gupta, Kusum; Misner, Dinah; Zhang, Qingling; Liu, Jyanwei; Stoycheva, Antitsa; Stevens, Sarah; Symons, Julian; Beigelman, Leonid; Raboisson, Pierre; Deval, Jerome 分享 收藏
Synthesis and Anti-HCV Activities of 4′-Fluoro-2′-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4′-Fluoro-2′-C-methyluridine 5′-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection Wang, Guangyi; Dyatkina, Natalia; Prhavc, Marija; Williams, Caroline; Serebryany, Vladimir; Hu, Yujian; Huang, Yongfei; Wan, Jinqiao; Wu, Xiangyang; Deval, Jerome; Fung, Amy; Jin, Zhinan; Fan, Hua; Shaw, Kenneth; Kang, Hyunsoon; Zhang, Qingling; Tam, Yuen; Stoycheva, Antitsa; Jekle, Andreas; Smith, David B.; Beigelman, Leonid 分享 收藏
Preclinical Characterization and Human Microdose Pharmacokinetics of ITMN-8187, a Nonmacrocyclic Inhibitor of the Hepatitis C Virus NS3 Protease Rajagopalan, Ravi; Pan, Lin; Schaefer, Caralee; Nicholas, John; Lim, Sharlene; Misialek, Shawn; Stevens, Sarah; Hooi, Lisa; Aleskovski, Natalia; Ruhrmund, Donald; Kossen, Karl; Huang, Lea; Yap, Sophia; Beigelman, Leonid; Serebryany, Vladimir; Liu, Jyanwei; Sastry, Srikonda; Seiwert, Scott; Buckman, Brad 分享 收藏
Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues Wang, Guangyi; Wan, Jingiao; Hu, Yujian; Wu, Xiangyang; Prhavc, Marija; Dyatkina, Natalia; Rajwanshi, Vivek K.; Smith, David B.; Jekle, Andreas; Kinkade, April; Symons, Julian A.; Jin, Zhinan; Deval, Jerome; Zhang, Qjngling; Tam, Yuen; Chanda, Sushmita; Blatt, Lawrence; Beigelman, Leonid 分享 收藏
Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease Jiang, Yutong; Andrews, Steven W.; Condroski, Kevin R.; Buckman, Brad; Serebryany, Vlad; Wenglowsky, Steve; Kennedy, April L.; Madduru, Machender R.; Wang, Bin; Lyon, Michael; Doherty, George A.; Woodard, Benjamin T.; Lemieux, Christine; Do, Mary Geck; Zhang, Hailong; Ballard, Joshua; Vigers, Guy; Brandhuber, Barbra J.; Stengel, Peter; Josey, John A.; Beigelman, Leonid; Blatt, Lawrence; Seiwert, Scott D. 分享 收藏
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Biochemical Study of the Comparative Inhibition of Hepatitis C Virus RNA Polymerase by VX-222 and Filibuvir Yi, Guanghui; Deval, Jerome; Fan, Baochang; Cai, Hui; Soulard, Charlotte; Ranjith-Kumar, C. T.; Smith, David B.; Blatt, Lawrence; Beigelman, Leonid; Kao, C. Cheng 分享 收藏
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