Robert J. Bridges - Publications, H-index & Citations

Robert J. Bridges

pennsylvania commonwealth system of higher education (pcshe)

48H指数

162论文数

7.2K被引数

收录论文 38

发表时间

VX-445 (elexacaftor) inhibits chloride secretion across human bronchial epithelial cells by directly blocking KCa3.1 channels VX-445 (elexacaftor)通过直接阻断KCa3.1通道来抑制氯离子分泌穿过人支气管上皮细胞。

PNAS NEXUS

IF3.8

2025-07-01

OAAI

Kolski-Andreaco, Aaron; Balut, Corina M.; Green, Matthew D.; Sembrat, John; Bridges, Robert J.; Singh, Ashvani K.; Tse, Chris; Butterworth, Michael B.; Devor, Daniel C.

Potentiation ofBKCa Ca channels by cystic fibrosis transmembrane conductance regulator correctors VX-445 and VX-121

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2024-07-02

OAAI

Kolski-Andreaco, Aaron; Taiclet, Stefanie; Myerburg, Michael M.; Sembrat, John; Bridges, Robert J.; Straub, Adam C.; Wills, Zachary P.; Butterworth, Michael B.; Devor, Daniel C.

In vitro modulator responsiveness of 655 CFTR variants found in people with cystic fibrosis

JOURNAL OF CYSTIC FIBROSIS

IF6

2024-07-01

OAAI

Bihler, Hermann; Sivachenko, Andrey; Millen, Linda; Bhatt, Priyanka; Patel, Amita Thakerar; Chin, Justin; Bailey, Violaine; Musisi, Isaac; LaPan, Andre; Allaire, Normand E.; Conte, Joshua; Simon, Noah R.; Magaret, Amalia S.; Raraigh, Karen S.; Cutting, Garry R.; Skach, William R.; Bridges, Robert J.; Thomas, Philip J.; Mense, Martin

KCa3.1 potentiation stimulates Cl2 secretion in F508del and G551D CFTR- corrected primary human bronchial epithelial cells

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

IF4.7

2022-10-01

PREAI

Devor, Daniel C.; Green, Matthew D.; Bridges, Robert J.

VX770 Modulated Bicarbonate Conductance in CFTR-expressing FRT Cell

FASEB JOURNAL

IF4.2

2022-05-13

PREAI

Lee, Dongoh; Bridges, Robert; Schultz, Bruce D.

CFTR bearing variant p.Phe312del exhibits function inconsistent with phenotype and negligible response to ivacaftor

JCI INSIGHT

IF6.1

2022-03-22

OAAI

Raraigh, Karen S.; Paul, Kathleen C.; Goralski, Jennifer L.; Worthington, Erin N.; Faino, Anna, V; Sciortino, Stanley; Wang, Yiting; Aksit, Melis A.; Ling, Hua; Osorio, Derek L.; Onchiri, Frankline M.; Patel, Shivani U.; Merlo, Christian A.; Montemayor, Kristina; Gibson, Ronald L.; West, Natalie E.; Thakerar, Amita; Bridges, Robert J.; Sheppard, David N.; Sharma, Neeraj; Cutting, Garry R.

Open reading frame correction using splice-switching antisense oligonucleotides for the treatment of cystic fibrosis 使用剪接转换反义寡核苷酸进行开放阅读框校正，以治疗囊性纤维化

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-01-10

OAAI

Michaels, Wren E.; Pena-Rasgado, Cecilia; Kotaria, Rusudan; Bridges, Robert J.; Hastings, Michelle L.

Translating in vitro CFTR rescue into small molecule correctors for cystic fibrosis using the Library of Integrated Network-based Cellular Signatures drug discovery platform

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2021-12-23

OAAI

Strub, Matthew D.; Ramachandran, Shyam; Boudko, Dmitri Y.; Meleshkevitch, Ella A.; Pezzulo, Alejandro A.; Subramanian, Aravind; Liberzon, Arthur; Bridges, Robert J.; McCray, Paul B., Jr.

Integrative chemogenomic analysis identifies small molecules that partially rescue ΔF508-CFTR for cystic fibrosis

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2021-05-02

OAAI

Hodos, Rachel A.; Strub, Matthew D.; Ramachandran, Shyam; Meleshkevitch, Ella A.; Boudko, Dmitri Y.; Bridges, Robert J.; Dudley, Joel T.; McCray, Paul B., Jr.

Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells

NUCLEIC ACIDS RESEARCH

IF13.1

2020-06-10

OAAI

Michaels, Wren E.; Bridges, Robert J.; Hastings, Michelle L.

CFTR modulator theratyping: Current status, gaps and future directions CFTR调制器治疗: 现状、差距和未来方向

JOURNAL OF CYSTIC FIBROSIS

IF6

2019-01-01

205

OAAI

Clancy, John Paul; Cotton, Calvin U.; Donaldson, Scott H.; Solomon, George M.; VanDevanter, Donald R.; Boyle, Michael P.; Gentzsch, Martina; Nick, Jerry A.; Illek, Beate; Wallenburg, John C.; Sorscher, Eric J.; Amaral, Margarida D.; Beekman, Jeffrey M.; Naren, Anjaparavanda P.; Bridges, Robert J.; Thomas, Philip J.; Cutting, Garry; Rowe, Steven; Durmowicz, Anthony G.; Mense, Martin; Boeck, Kris D.; Skach, William; Penland, Christopher; Joseloff, Elizabeth; Bihler, Hermann; Mahoney, John; Borowitz, Drucy; Tuggle, Katherine L.

Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice

GASTROENTEROLOGY

IF25.1

2017-10-01

OAAI

Zeng, Mei; Szymczak, Mitchell; Ahuja, Malini; Zheng, Changyu; Yin, Hongen; Swaim, William; Chiorini, John A.; Bridges, Robert J.; Muallem, Shmuel

Identification of the amino acids inserted during suppression of CFTR nonsense mutations and determination of their functional consequences

HUMAN MOLECULAR GENETICS

IF3.2

2017-05-31

OAAI

Xue, Xiaojiao; Mutyam, Venkateshwar; Thakerar, Amita; Mobley, James; Bridges, Robert J.; Rowe, Steven M.; Keeling, Kim M.; Bedwell, David M.

Fatty Acid Cysteamine Conjugates as Novel and Potent Autophagy Activators That Enhance the Correction of Misfolded F508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-12-23

PREAI

Vu, Chi B.; Bridges, Robert J.; Pena-Rasgado, Cecilia; Lacerda, Antonio E.; Bordwell, Curtis; Sewell, Abby; Nichols, Andrew J.; Chandran, Sachin; Lonkar, Pallavi; Picarella, Dominic; Ting, Amal; Wensley, Allison; Yeager, Maisy; Liu, Feng

Synthetic Aminoglycosides Efficiently Suppress Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations and Are Enhanced by Ivacaftor

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IF5.3

2014-04-01

145

OAAI

Xue, Xiaojiao; Mutyam, Venkateshwar; Tang, Liping; Biswas, Silpak; Du, Ming; Jackson, Laura A.; Dai, Yanying; Belakhov, Valery; Shalev, Moran; Chen, Fuquan; Schacht, Jochen; Bridges, Robert J.; Baasov, Timor; Hong, Jeong; Bedwell, David M.; Rowe, Steven M.

Effect of apical hyperosmotic sodium challenge and amiloride on sodium transport in human bronchial epithelial cells from cystic fibrosis donors

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

IF4.7

2013-12-01

OAAI

Rasgado-Flores, Hector; Mandava, Vamsi Krishna; Siman, Homayoun; Van Driessche, Willy; Pilewski, Joseph M.; Randell, Scott H.; Bridges, Robert J.

Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

IF3.1

2010-10-26

100

OAAI

Kalid, Ori; Mense, Martin; Fischman, Sharon; Shitrit, Alina; Bihler, Hermann; Ben-Zeev, Efrat; Schutz, Nili; Pedemonte, Nicoletta; Thomas, Philip J.; Bridges, Robert J.; Wetmore, Diana R.; Marantz, Yael; Senderowitz, Hanoch

Dynasore inhibits removal of wild-type and ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) from the plasma membrane

BIOCHEMICAL JOURNAL

IF4.3

2009-07-15

PREAI

Young, Andrew; Gentzsch, Martina; Abban, Cynthia Y.; Jia, Ying; Meneses, Patricio I.; Bridges, Robert J.; Bradbury, Neil A.

Camostat Attenuates Airway Epithelial Sodium Channel Function in Vivo through the Inhibition of a Channel-Activating Protease

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2009-05-01

PREAI

Coote, K.; Atherton-Watson, H. C.; Sugar, R.; Young, A.; MacKenzie-Beevor, A.; Gosling, M.; Bhalay, G.; Bloomfield, G.; Dunstan, A.; Bridges, R. J.; Sabater, J. R.; Abraham, W. M.; Tully, D.; Pacoma, R.; Schumacher, A.; Harris, J.; Danahay, H.

A segment of γ ENaC mediates elastase activation of Na+ transport

JOURNAL OF GENERAL PHYSIOLOGY

IF2.9

2007-11-12

OAAI

Adebamiro, Adedotun; Cheng, Yi; Rao, U. Subrahmanyeswara; Danahay, Henry; Bridges, Robert J.

研究方向