未登录 BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models Rauh, Ulrike; Wei, Guo; Serrano-Wu, Michael; Kosmidis, Georgios; Kaulfuss, Stefan; Siegel, Franziska; Thede, Kai; Mcfarland, James; Lemke, Christopher T.; Werbeck, Nicolas; Nowak-Reppel, Katrin; Pilari, Sabine; Menz, Stephan; Ocker, Matthias; Zhang, Weiqun; Davis, Kyle; Poncet-Montange, Guillaume; Roth, Jennifer; Daniels, Douglas; Kaushik, Virendar K.; Hubbard, Brian; Ziegelbauer, Karl; Golub, Todd R. 分享 收藏
ANJ810 is a highly selective novel MCL1 inhibitor with optimized in vivo clearance showing robust efficacy in preclinical solid and hematological tumor models Rauh, Ulrike; Wei, Guo; Serrano-Wu, Michael; Kosmidis, Georgios; Kaulfuss, Stefan; Siegel, Franziska; Thede, Kai; McFarland, James; Lemke, Christopher; Werbeck, Nicolas; Nowak-Reppel, Katrin; Pillari, Sabine; Menz, Stephan; Ocker, Matthias; Hubbard, Brian; Kaushik, Virendar; Ziegelbauer, Karl; Golub, Todd 分享 收藏
Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase Schulze, Volker K.; Klar, Ulrich; Kosemund, Dirk; Wengner, Antje M.; Siemeister, Gerhard; Stockigt, Detlef; Neuhaus, Roland; Lienau, Philip; Bader, Benjamin; Prechtl, Stefan; Holton, Simon J.; Briem, Hans; Marquardt, Tobias; Schirok, Hartmut; Jautelat, Rolf; Bohlmann, Rolf; Nguyen, Duy; Fernandez-Montalvan, Amaury E.; Bomer, Ulf; Eberspaecher, Uwe; Bruning, Michael; Dohr, Olaf; Raschke, Marian; Kreft, Bertolt; Mumberg, Dominik; Ziegelbauer, Karl; Brands, Michael; von Nussbaum, Franz; Koppitz, Marcus 分享 收藏
The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models Wengner, Antje M.; Siemeister, Gerhard; Luecking, Ulrich; Lefranc, Julien; Wortmann, Lars; Lienau, Philip; Bader, Benjamin; Boemer, Ulf; Moosmayer, Dieter; Eberspaecher, Uwe; Golfier, Sven; Schatz, Christoph A.; Baumgart, Simon J.; Haendler, Bernard; Lejeune, Pascale; Schlicker, Andreas; von Nussbaum, Franz; Brands, Michael; Ziegelbauer, Karl; Mumberg, Dominik 分享 收藏
Leveraging Human Genetics to Estimate Clinical Risk Reductions Achievable by Inhibiting Factor XI Georgi, Benjamin; Mielke, Johanna; Chaffin, Mark; Khera, Amit V.; Gelis, Lian; Mundl, Hardi; van Giezen, J. J. J.; Ellinor, Patrick; Kathiresan, Sekar; Ziegelbauer, Karl; Freitag, Daniel F. 分享 收藏
Mesothelin-Targeted Thorium-227 Conjugate (MSLN-TTC): Preclinical Evaluation of a New Targeted Alpha Therapy for Mesothelin-Positive Cancers 间皮素靶向钍-227结合物 (msln-ttc): 一种新的靶向 α 治疗间皮素阳性癌症的临床前评估 Hagemann, Urs B.; Ellingsen, Christine; Schuhmacher, Joachim; Kristian, Alexander; Mobergslien, Anne; Cruciani, Veronique; Wickstroem, Katrine; Schatz, Christoph A.; Kneip, Christoph; Golfier, Sven; Smeets, Roger; Uran, Steinar; Hennekes, Hartwig; Karlsson, Jenny; Bjerke, Roger M.; Ryan, Olav B.; Mumberg, Dominik; Ziegelbauer, Karl; Cuthbertson, Alan S. 分享 收藏
MSLN-TTC (BAY 2287411) demonstrates increased activity in comparison to standard of care chemotherapy in models of acquired drug resistance Hagemann, Urs B.; Zitzmann-Kolbe, Sabine; Kristian, Alexander; Sperl, Carolyn; Schatz, Christoph A.; Bjerke, Roger M.; Cuthbertson, Alan S.; Hennekes, Hartwig; Ziegelbauer, Karl; Mumberg, Dominik 分享 收藏
Efficacy of single agent radium-223 in the syngeneic MBT-2 bladder cancer bone growth model in mice Kahkonen, Tiina E.; Suominen, Mari I.; Maki-Jouppila, Jenni H.; Sjoholm, Birgitta; Ahonen, Ilmari; Mumberg, Dominik; Ziegelbauer, Karl; Halleen, Jussi M.; Kakonen, Sanna-Maria; Scholz, Arne 分享 收藏
Increased T cell-activation resulting from the combination of the anti-CEACAM6 function-blocking antibody BAY 1834942 with checkpoint inhibitors targeting either PD-1/PD-L1 or TIM-3 Willuda, Joerg; Boehm, Hans-Henning; Pinkert, Jessica; Trautwein, Mark; Doecke, Wolf-Dietrich; von Ahsen, Oliver; Ziegelbauer, Karl; Offringa, Rienk; Kreft, Bertolt; Beckhove, Philipp 分享 收藏
Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate Sica, Valentina; Bravo-San Pedro, Jose Manuel; Izzo, Valentina; Pol, Jonathan; Pierredon, Sandra; Enot, David; Durand, Sylvere; Bossut, Noelie; Chery, Alexis; Souquere, Sylvie; Pierron, Gerard; Vartholomaiou, Evangelia; Zamzami, Naoufal; Soussi, Thierry; Sauvat, Allan; Mondragon, Laura; Kepp, Oliver; Galluzzi, Lorenzo; Martinou, Jean-Claude; Hess-Stumpp, Holger; Ziegelbauer, Karl; Kroemer, Guido; Maiuri, Maria Chiara 分享 收藏
Rogaratinib: A potent and selective pan-FGFR inhibitor with broad antitumor activity in FGFR-overexpressing preclinical cancer models Gruenewald, Sylvia; Politz, Oliver; Bender, Sebastian; Heroult, Melanie; Lustig, Klemens; Thuss, Uwe; Kneip, Christoph; Kopitz, Charlotte; Zopf, Dieter; Collin, Marie-Pierre; Boemer, Ulf; Ince, Stuart; Ellinghaus, Peter; Mumberg, Dominik; Hess-Stumpp, Holger; Ziegelbauer, Karl 分享 收藏
Synergistic Effect of a Mesothelin-Targeted 227Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models 靶向间皮素的227Th结合物与DNA损伤反应抑制剂在卵巢癌异种移植模型中的协同作用 Wickstroem, Katrine; Hagemann, Urs B.; Cruciani, Veronique; Wengner, Antje M.; Kristian, Alexander; Ellingsen, Christine; Siemeister, Gerhard; Bjerke, Roger M.; Karlsson, Jenny; Ryan, Olav B.; Linden, Lars; Mumberg, Dominik; Ziegelbauer, Karl; Cuthbertson, Alan S. 分享 收藏
Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP Inhibitors In Vitro and In Vivo Siemeister, Gerhard; Mengel, Anne; Fernandez-Montalvan, Amaury E.; Bone, Wilhelm; Schroeder, Jens; Zitzmann-Kolbe, Sabine; Briem, Hans; Prechtl, Stefan; Holton, Simon J.; Moenning, Ursula; von Ahsen, Oliver; Johanssen, Sandra; Cleve, Arwed; Puetter, Vera; Hitchcock, Marion; von Nussbaum, Franz; Brands, Michael; Ziegelbauer, Karl; Mumberg, Dominik 分享 收藏
Anetumab ravtansine has single-agent activity in mesothelin-expressing human ovarian cancer models and potentiates the activity of chemotherapeutics and targeted agents Schatz, Christoph A.; Quanz, Maria; Hagemann, Urs B.; Zitzmann-Kolbe, Sabine; Stelte-Ludwig, Beatrix; Golfier, Sven; Kopitz, Charlotte; Elbi, Cem; Ziegelbauer, Karl; Mumberg, Dominik 分享 收藏
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Synergistic effect of MSLN-TTC in combination with DNA damage response inhibitors Wickstroem, Katrine; Hagemann, Urs B.; Wengner, Antje M.; Kristian, Alexander; Ellingsen, Christine; Siemeister, Gerhard; Bjerke, Roger M.; Karlsson, Jenny; Ryan, Olav B.; Linden, Lars; Kreft, Bertolt; Mumberg, Dominik; Wild, Hanno; Ziegelbauer, Karl; Cuthbertson, Alan 分享 收藏
Mesothelin targeted thorium-227 conjugate (MSLN-TTC): Preclinical evaluation of a new targeted alpha therapeutic in mesothelin-positive cancers Hagemann, Urs B.; Kristian, Alexander; Ellingsen, Christine; Wickstroem, Katrine; Mobergslien, Anne; Karlsson, Jenny; Bjerke, Roger M.; Schatz, Christoph; Kneip, Christoph; Schuhmacher, Joachim; Oedegaardstuen, Liv-Ingrid; Hennekes, Hartwig; Tafuri, Anna; Mumberg, Dominik; Wild, Hanno; Ziegelbauer, Karl; Cuthbertson, Alan S. 分享 收藏
Preclinical activity of PSMA-TTC, a targeted alpha therapeutic in patient-derived prostate cancer models Hammer, Stefanie; Hagemann, Urs B.; Zitzmann-Kolbe, Sabine; Larsen, Aasmund; Ellingsen, Christine; von Ahsen, Oliver; Karlsson, Jenny; Bjerke, Roger M.; Ryan, Olav B.; Lejeune, Pascale; Hennekes, Hartwig; Cuthbertson, Alan; Ziegelbauer, Karl; Mumberg, Dominik 分享 收藏
Preclinical evaluation of a novel interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor in combination with PI3K inhibitor copanlisib or BTK inhibitors in ABC-DLBCL Lange, Martin; Wengner, Antje Margret; Bothe, Ulrich; Boemer, Ulf; Nubbemeyer, Reinhard; Siebeneicher, Holger; Steuber, Holger; Guenther, Judith; Potze, Lisette; Schmidt, Nicole; Politz, Oliver; Doecke, Wolf-Dietrich; Lagkadinou, Eleni; Zollner, Thomas M.; von Nussbaum, Franz; Mumberg, Dominik; Steinmeyer, Andreas; Brands, Michael; Ziegelbauer, Karl 分享 收藏
Increased in vitro potency and in vivo efficacy of FGFR2-targeted thorium-227 conjugate (FGFR2-TTC) in combination with the ATR inhibitor BAY 1895344 Wickstroem, Katrine; Hagemann, Urs B.; Wengner, Antje M.; Sommer, Anette; Kristian, Alexander; Ellingsen, Christine; Bjerke, Roger M.; Karlsson, Jenny; Ryan, Olav B.; Linden, Lars; Kreft, Bertolt; Mumberg, Dominik; Wild, Hanno; Ziegelbauer, Karl; Cuthbertson, Alan 分享 收藏
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