Paul A. Slesinger

Icahn School of Medicine at Mount Sinai

48H指数

222论文数

9.7K被引数

收录论文 29

发表时间

A critical residue mediates proper assembly and gating of GIRK2 channels 一个关键残基介导GIRK2通道的正确组装和门控。

Journal of General Physiology

IF2.9

2025-12-19

PREAI

Nguyen, Ha; Mount, Jonathan; Hutchinson, Keino; Zhao, Yihan; Zhao, Yulin; Glaaser, Ian W.; Yuan, Peng; Schlessinger, Avner; Slesinger, Paul A.

Simultaneous two-color imaging with a dual-channel miniscope in freely behaving mice 在行为自由的小鼠中使用双通道微型望远镜同时进行双色成像

Science Advances

IF12.5

2025-07-04

PREAI

Zhe Dong; Yu Feng; Keziah Diego; Austin M. Baggetta; Brian M. Sweis; Zachary T. Pennington; Sophia I. Lamsifer; Yosif Zaki; Federico Sangiuliano; Paul A. Philipsberg; Denisse Morales-Rodriguez; Daniel Kircher; Paul Slesinger; Tristan Shuman; Daniel Aharoni; Denise J. Cai

Major-depressive-disorder-associated dysregulation of ZBTB7A in orbitofrontal cortex promotes astrocyte-mediated stress susceptibility 与重度抑郁症相关的眶额皮质ZBTB7A失调促进了星形胶质细胞介导的压力易感性

Neuron

IF15

2025-06-13

OAAI

Sasha L. Fulton; Jaroslav Bendl; Giuseppina Di Salvo; John F. Fullard; Amni Al-Kachak; Ashley E. Lepack; Andrew F. Stewart; Sumnima Singh; Wolfram F. Poller; Ryan M. Bastle; Mads E. Hauberg; Amanda K. Fakira; Vishwendra Patel; Min Chen; Romain Durand-de Cuttoli; Isabel Gameiro-Ros; Flurin Cathomas; Aarthi Ramakrishnan; Kelly Gleason; Li Shen; Carol A. Tamminga; Ana Milosevic; Scott J. Russo; Filip K. Swirski; Paul A. Slesinger; Ishmail Abdus-Saboor; Robert D. Blitzer; Panos Roussos; Ian Maze

A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures G蛋白门控内向整流钾通道的选择性小分子激动剂可降低肿瘤相关性和诱发性癫痫样活动的小鼠模型中的癫痫样活动

NEUROPHARMACOLOGY

IF4.6

2025-03-01

PREAI

Rifkin, Robert A.; Wu, Xiaoping; Pereira, Brianna; Gill, Brian JA.; Merricks, Edward M.; Michalak, Andrew J.; Goldberg, Alexander R.; Humala, Nelson; Dovas, Athanassios; Rai, Ganesha; Mckhann, Guy M.; Slesinger, Paul A.; Canoll, Peter; Schevon, Catherine

Fully atomistic molecular dynamics modeling of photoswitchable azo-PC lipid bilayers: structure, mechanical properties, and drug permeation 光可切换的偶氮-PC脂质双层的完全原子分子动力学模型: 结构，机械性能和药物渗透

NANOSCALE

IF5.1

2025-01-01

PREAI

Alberto, Kevin A.; Begam, M. N. Hasna; Xiong, Hejian; Shinoda, Wataru; Slesinger, Paul A.; Qin, Zhenpeng; Nielsen, Steven O.

Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model

SCIENCE ADVANCES

IF12.5

2024-11-08

OAAI

Li, Xindi; Liu, Jiayi; Boreland, Andrew J.; Kapadia, Sneha; Zhang, Siwei; Stillitano, Alessandro C.; Abbo, Yara; Clark, Lorraine; Lai, Dongbing; Liu, Yunlong; Barr, Peter B.; Meyers, Jacquelyn L.; Kamarajan, Chella; Kuang, Weipeng; Agrawal, Arpana; Slesinger, Paul A.; Dick, Danielle; Salvatore, Jessica; Tischfield, Jay; Duan, Jubao; Edenberg, Howard J.; Kreimer, Anat; Hart, Ronald P.; Pang, Zhiping P.

A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state 神经发育障碍突变将g蛋白锁定在短暂的预激活状态

NATURE COMMUNICATIONS

IF15.7

2024-08-05

OAAI

Knight, Kevin M.; Krumm, Brian E.; Kapolka, Nicholas J.; Ludlam, W. Grant; Cui, Meng; Mani, Sepehr; Prytkova, Iya; Obarow, Elizabeth G.; Lefevre, Tyler J.; Wei, Wenyuan; Ma, Ning; Huang, Xi-Ping; Fay, Jonathan F.; Vaidehi, Nagarajan; Smrcka, Alan V.; Slesinger, Paul A.; Logothetis, Diomedes E.; Martemyanov, Kirill A.; Roth, Bryan L.; Dohlman, Henrik G.

Understanding Neuropeptide Transmission in the Brain by Optical Uncaging and Release

ACS CHEMICAL NEUROSCIENCE

IF3.9

2023-01-31

OAAI

Xiong, Hejian; Wilson, Blake A.; Slesinger, Paul A.; Qin, Zhenpeng

Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons

MOLECULAR PSYCHIATRY

IF10.1

2022-10-07

OAAI

Popova, Dina; Gameiro-Ros, Isabel; Youssef, Mark M.; Zalamea, Petronio; Morris, Ayeshia D.; Prytkova, Iya; Jadali, Azadeh; Kwan, Kelvin Y.; Kamarajan, Chella; Salvatore, Jessica E.; Xuei, Xiaoling; Chorlian, David B.; Porjesz, Bernice; Kuperman, Samuel; Dick, Danielle M.; Goate, Alison; Edenberg, Howard J.; Tischfield, Jay A.; Pang, Zhiping P.; Slesinger, Paul A.; Hart, Ronald P.

Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk

MOLECULAR PSYCHIATRY

IF10.1

2021-09-07

OAAI

Powell, Samuel K.; O'Shea, Callan; Townsley, Kayla; Prytkova, Iya; Dobrindt, Kristina; Elahi, Rahat; Iskhakova, Marina; Lambert, Tova; Valada, Aditi; Liao, Will; Ho, Seok-Man; Slesinger, Paul A.; Huckins, Laura M.; Akbarian, Schahram; Brennand, Kristen J.

Nanotransducers for wireless neuromodulation

MATTER

IF17.5

2021-05-01

OAAI

Li, Xiuying; Xiong, Hejian; Rommelfanger, Nicholas; Xu, Xueqi; Youn, Jonghae; Slesinger, Paul A.; Hong, Guosong; Qin, Zhenpeng

Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease

NEURON

IF15

2021-01-01

103

OAAI

Wang, Minghui; Li, Aiqun; Sekiya, Michiko; Beckmann, Noam D.; Quan, Xiuming; Schrode, Nadine; Fernando, Michael B.; Yu, Alex; Zhu, Li; Cao, Jiqing; Lyu, Liwei; Horgusluoglu, Emrin; Wang, Qian; Guo, Lei; Wang, Yuan-Shuo; Neff, Ryan; Song, Won-Min; Wang, Erming; Shen, Qi; Zhou, Xianxiao; Ming, Chen; Ho, Seok-Man; Vatansever, Sezen; Kaniskan, H. Umit; Jin, Jian; Zhou, Ming-Ming; Ando, Kanae; Ho, Lap; Slesinger, Paul A.; Yue, Zhenyu; Zhu, Jun; Katsel, Pavel; Gandy, Sam; Ehrlich, Michelle E.; Fossati, Valentina; Noggle, Scott; Cai, Dongming; Haroutunian, Vahram; Iijima, Koichi M.; Schadt, Eric; Brennand, Kristen J.; Zhang, Bin

Near-Infrared Light Triggered-Release in Deep Brain Regions Using Ultra-photosensitive Nanovesicles

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2020-03-20

OAAI

Xiong, Hejian; Li, Xiuying; Kang, Peiyuan; Perish, John; Neuhaus, Frederik; Ploski, Jonathan E.; Kroener, Sven; Ogunyankin, Maria O.; Shin, Jeong Eun; Zasadzinski, Joseph A.; Wang, Hui; Slesinger, Paul A.; Zumbuehl, Andreas; Qin, Zhenpeng

Structural basis for auxiliary subunit KCTD16 regulation of the GABAB receptor

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2019-04-10

OAAI

Zuo, Hao; Glaaser, Ian; Zhao, Yulin; Kurinov, Igor; Mosyak, Lidia; Wang, Haonan; Liu, Jonathan; Park, Jinseo; Frangaj, Aurel; Sturchler, Emmanuel; Zhou, Ming; McDonald, Patricia; Geng, Yong; Slesinger, Paul A.; Fan, Qing R.

GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2018-09-18

OAAI

Rifkin, Robert A.; Huyghe, Deborah; Li, Xiaofan; Parakala, Manasa; Aisenberg, Erin; Moss, Stephen J.; Slesinger, Paul A.

Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?酒精使用障碍的遗传学: 诱导多能干细胞的作用？

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH

IF2.7

2018-07-05

OAAI

Prytkova, Iya; Goate, Alison; Hart, Ronald P.; Slesinger, Paul A.

Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channel

JOURNAL OF GENERAL PHYSIOLOGY

IF2.9

2017-07-18

OAAI

Lacin, Emre; Aryal, Prafulla; Glaaser, Ian W.; Bodhinathan, Karthik; Tsai, Eric; Marsh, Nidaa; Tucker, Stephen J.; Sansom, Mark S. P.; Slesinger, Paul A.

Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol

SCIENTIFIC REPORTS

IF3.9

2017-07-04

OAAI

Glaaser, Ian W.; Slesinger, Paul A.

Small Molecule Modulation of Brain GIRK Channels

BIOPHYSICAL JOURNAL

IF3.1

2017-02-01

OAAI

Glaaser, Ian W.; Slesinger, Paul A.