logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
delete
arrow
返回
L

Lei Xu

Novartis Biomedical Research

41H指数
375论文数
8.8K被引数
收录论文 93
发表时间
logo
Evaluating Data Partitioning Strategies for Accurate Prediction of Protein-Ligand Binding Free Energy Changes in Mutated Proteins评估突变蛋白中蛋白质-配体结合自由能变化准确预测的数据分区策略
errComputational and Structural Biotechnology Journal
IF4.1
err2025-10-14
err0
errOAAI
errLiangxu Xie; Guoming Bao; Dawei Zhang; Lei Xu; Xiaojun Xu; Shan Chang
err分享
err收藏
Effective virtual screening strategy toward JAK3 covalent inhibitors: combining multi‑conformational consensus calculation with covalent docking针对JAK3共价抑制剂的虚拟筛选策略：结合多构象共识计算与共价对接
errMolecular Diversity
IF3.8
err2025-08-21
err0
PREAI
errJingyu Zhu; Genhong Qiu; Lei Xu; Yanfei Cai; Yun Chen; Jian Jin
err分享
err收藏
Screening of triploid in miscarriage tissues using medium-coverage whole genome sequencing with a three-algorithm integrated approach采用三算法集成方法，通过中等覆盖度全基因组测序对流产组织中三倍体进行筛查
errJournal of Assisted Reproduction and Genetics
IF2.7
err2025-08-01
err0
PREAI
errJiayong Zheng; Qian Zhang; Lei Xu; Victor Wei Zhang; Jianqiong Zheng; Chenhui Zhang; Kaixin Chen; Yanan Lai; Hai Wang; Xianjue Zheng; Dongzhi Li
err分享
err收藏
Discovery and Characterization of Novel FGFR1 V561M Inhibitors via Virtual Screening and Molecular Dynamics Simulations通过虚拟筛选和分子动力学模拟发现和表征新型FGFR1 V561M抑制剂
errACS Medicinal Chemistry Letters
IF4
err2025-07-10
err0
PREAI
errYang Lu; Bizhi li; Xiaoli Zheng; Lei Xu; Linghui Zeng; Chong Zhang; Jiankang Zhang
err分享
err收藏
A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent mannercereblon基 glue降解剂通过NEK7以依赖背景的方式调控NLRP3炎症小体
errCell Chemical Biology
IF7.2
err2025-07-09
err0
PREAI
errAude Sylvain; Natacha Stoehr; Fupeng Ma; Artiom Cernijenko; Martin Schröder; Maryam Khoshouei; Melanie Vogelsanger; Michel Schoenboerner; Ashley Burke; Pasupuleti Rao; Jonathan M. Solomon; Joshiawa Paulk; Lei Xu; Janet Dawson; Damien Begue; Peggy Lefeuvre; Erik Ahrne; Andreas Hofmann; Callum J. Dickson; Philip Arabin; Alfred Zimmerlin; Michael Kiffe; Mirjam Froehlicher; Theresa Boersig; Azeddine Elhajouji; Murielle Brichet; Suchithra Menon; Shanming Liu; Matthias Mueller; Charles A. Wartchow; James Lin; Yamel Cardona Gloria; Sabine Dickhöfer; Alexander N.R. Weber; Tatjana Welzel; Jasmin Kuemmerle-Deschner; Christopher J. Farady; Robert Pulz; Frederic Bornancin; Dennis L. Buckley; Zuni I. Bassi
err分享
err收藏
Discovery of Novel c-MET Inhibitors for Hepatocellular Carcinoma Using an Integrated Virtual Screening Approach使用集成虚拟筛选方法发现新型c-MET抑制剂以治疗肝细胞癌
errACS Medicinal Chemistry Letters
IF4
err2025-06-26
err0
PREAI
errRushan Fei; Na Lin; Xin Zhang; Lei Xu; Qingnan Zhang; Zhichao Pan; Xiaowu Dong; Weilin Wang
err分享
err收藏
A small-molecule VHL molecular glue degrader for cysteine dioxygenase 1一种靶向半胱氨酸二氧合酶1的小分子VHL分子胶降解剂
errNature Chemical Biology
IF13.7
err2025-06-24
err0
errOAAI
errAntonin Tutter; Dennis Buckley; Andrei A. Golosov; Xiaolei Ma; Wei Shu; Daniel J. J. McKay; Veronique Darsigny; Dustin Dovala; Rohan Beckwith; Jonathan Solomon; Pasupuleti Rao; Lei Xu; Aleem Fazal; Andreas Lingel; Charles Wartchow; Jennifer S. Cobb; Amanda Hachey; Jennifer Tullai; Gregory A. Michaud
err分享
err收藏
Unveiling the biological variation of lymphocyte subset counts: Insights from a full-spectrum flow cytometer and the BD Multitest™ 6-Color TBNK kit (vol 569, 120152, 2025)揭示淋巴细胞亚群计数中的生物学变异：来自全谱流式细胞仪和BD Multitest™ 6-Color TBNK试剂盒的见解（卷569，120152，2025）
errCLINICA CHIMICA ACTA
IF2.9
err2025-06-01
err0
PREAI
errGuo, Kai; Feng, Xiaoran; Xu, Lei; Du, Zhongli; Ma, Yating; Lu, Hong; Li, Chenbin; Peng, Mingting
err分享
err收藏
Prenatal Diagnosis of Foetal Structural Anomalies Using Medium-Coverage Whole Genome Sequencing (CMA-Seq): A Large-Scale Comparative Study With CMA in 3973 Pregnancies利用中等覆盖度全基因组测序（CMA-Seq）进行胎儿结构异常的产前诊断：一项与CMA在3973例妊娠中的大规模比较研究
errBJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
IF4.3
err2025-05-23
err0
PREAI
errYan Jiang; Fang Liu; Lijuan Zhong; Rong Zhong; Mingxing Liang; Lin Ma; Victor Wei Zhang; Baixue Chen; Qian Zhang; Lei Xu; Wei Zhou
err分享
err收藏
Astragalus polysaccharide alleviates oxidative stress and senescence in chondrocytes in osteoarthritis via GCN2/ATF4/TXN axis黄芪多糖通过GCN2/ATF4/TXN轴缓解骨关节炎中软骨细胞的氧化应激和衰老。
errINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
IF8.5
err2025-05-01
err0
PREAI
errChen, Kai; Qin, Chaoren; Ji, Chenfei; Yu, Yaohui; Wu, Ya; Xu, Lei; Jiang, Yiqiu; Zou, Guoyou
err分享
err收藏
UBE2C mediates follicular thyroid carcinoma invasion and metastasis via K29-Specific vimentin ubiquitinationUBE2C通过K29特异性波形蛋白泛素化介导甲状腺滤泡癌的侵袭和转移
errCANCER LETTERS
IF10.1
err2025-05-01
err0
PREAI
errXu, Lei; Dai, Bao; Zhang, Lingyun; Chen, Weijian; Rong, Shikuo; Chen, Jianghong; Song, Muye; Lan, Ziteng; Liu, Yongchen; Wang, Linhe; Li, Jinghua; Chen, Jian; Wu, Zeyu
err分享
err收藏
Discovery of N-(1,2,4-Thiadiazol-5-yl)benzo[b]oxepine-4-carboxamide Derivatives as Novel Antiresistance Androgen Receptor AntagonistsN-(1,2,4-噻二唑-5-基)苯并[b]氧杂环庚烷-4-甲酰胺衍生物作为新型抗耐药性雄激素受体拮抗剂的发现
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-01-23
err0
PREAI
errLiao, Jianing; Liao, Jinbiao; Wang, Ying; Wang, Xinyue; Chai, Xin; Wang, Huating; Xu, Lei; Shan, Luhu; Xu, Xiaohong; Fu, Weitao; Pan, Peichen; Sheng, Rong; Li, Dan
err分享
err收藏
Discovery of 5-Nitro-N-(3-(trifluoromethyl)phenyl) Pyridin-2-amine as a Novel Pure Androgen Receptor Antagonist against Antiandrogen Resistance
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-11-07
err0
PREAI
errWang, Huating; Wang, Xuwen; Zhong, Haiyang; Cai, Lvtao; Fu, Weitao; Chai, Xin; Liao, Jianing; Sheng, Rong; Shan, Luhu; Xu, Xiaohong; Xu, Lei; Pan, Peichen; Hou, Tingjun; Li, Dan
err分享
err收藏
Luteolin Protects against Vascular Calcification by Modulating SIRT1/CXCR4 Signaling Pathway and Promoting Autophagy
errAAPS JOURNAL
IF3.7
err2024-10-22
err0
PREAI
errYu, Xiaoyu; Xu, Lei; Su, Ce; Wang, Changyuan; Wang, Zimeng; Wang, Yanna; Lu, Xiaolong; Sun, Huijun
err分享
err收藏
Discovery of novel BfmR inhibitors restoring carbapenem susceptibility against carbapenem-resistant Acinetobacter baumannii by structure-based virtual screening and biological evaluation
errEMERGING MICROBES & INFECTIONS
IF7.5
err2024-09-09
err0
errOAAI
errYao, Yue; Lei, Tailong; Gao, Junbo; Xu, Qingye; Xu, Lei; Zhao, Buhui; Qin, Shangshang; Yu, Yunsong; Hua, Xiaoting
err分享
err收藏
RETRACTION: Downregulated expression levels of USP46 promote the resistance of ovarian cancer to cisplatin and are regulated by PUM2
errMOLECULAR MEDICINE REPORTS
IF3.5
err2024-07-30
err0
PREAI
errXu, Lei; Zhang, Bin; Li, Wenlan
err分享
err收藏
LINC00894 Regulates Cerebral Ischemia/Reperfusion Injury by Stabilizing EIF5 and Facilitating ATF4-Mediated Induction of FGF21 and ACOD1 Expression
errNEUROCHEMICAL RESEARCH
IF3.8
err2024-07-26
err0
errOAAI
errChen, Yifei; Cui, Hengxiang; Han, Zhuanzhuan; Xu, Lei; Wang, Lin; Zhang, Yuefei; Liu, Lijun
err分享
err收藏
Identification of novel covalent JAK3 inhibitors through consensus scoring virtual screening: integration of common feature pharmacophore and covalent docking
errMOLECULAR DIVERSITY
IF3.8
err2024-07-15
err1
PREAI
errQiu, Genhong; Yu, Li; Jia, Lei; Cai, Yanfei; Chen, Yun; Jin, Jian; Xu, Lei; Zhu, Jingyu
err分享
err收藏
Combining AI and traditional screening for discovery of a potent ROCK2 inhibitor against lymphoma
errJOURNAL OF MOLECULAR STRUCTURE
IF4.7
err2024-05-01
err1
PREAI
errLu, Yan; Shen, Zheyuan; Shen, Liteng; Ying, Jiaxun; Gao, Jian; Zhao, Jingyi; Geng, Shuangshuang; Chi, Xinglong; Zhang, Tianshu; Xu, Lei; Zhang, Qingnan; Dong, Xiaowu; Xu, Donghang
err分享
err收藏
Developing an Improved Cycle Architecture for AI-Based Generation of New Structures Aimed at Drug Discovery
errMOLECULES
IF4.6
err2024-03-27
err0
errOAAI
errZhang, Chun; Xie, Liangxu; Lu, Xiaohua; Mao, Rongzhi; Xu, Lei; Xu, Xiaojun
err分享
err收藏

研究方向

暂时未获取到该数据
合作学者
合作期刊
吴
吴建华 (Jian Wu)
H 指数: 177 · 论文数: 1.1W
李
李有勇 (Youyong Li)
H 指数: 100 · 论文数: 955
侯
侯廷军 (Tingjun Hou)
H 指数: 92 · 论文数: 691
王
王海 (Hai Wang)
H 指数: 84 · 论文数: 580
锺
锺南山 (Nanshan Zhong)
H 指数: 84 · 论文数: 953
查看更多