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D

Darren J. Mitchell

GlaxoSmithKline
H指数:22
被引数:1,126

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Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-06-120
PRE
Hirst, David J.; Bamborough, Paul; Al-Mahdi, Niam; Angell, Davina C.; Barnett, Heather A.; Baxter, Andrew; Bit, Rino A.; Brown, Jack A.; Chung, Chun-wa; Craggs, Peter D.; Davis, Robert P.; Demont, Emmanuel H.; Ferrie, Alan; Gordon, Laurie J.; Harada, Isobel; Ho, Tim C. T.; Holyer, Ian D.; Hooper-Greenhill, Edward; Jones, Katherine L.; Lindon, Matthew J.; Lovatt, Cerys; Lugo, David; Maller, Claire; Mcgonagle, Grant; Messenger, Cassie; Mitchell, Darren J.; Pascoe, David D.; Patel, Vipulkumar K.; Patten, Christopher; Poole, Darren L.; Shah, Rishi R.; Rioja, Inmaculada; Stafford, Kayleigh A. J.; Tape, Daniel; Taylor, Simon; Theodoulou, Natalie H.; Tomlinson, Laura; Wall, Ian D.; Wellaway, Christopher R.; White, Gemma; Prinjha, Rab K.; Humphreys, Philip G.
Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-08-1328
PREAI
Jones, Katherine L.; Beaumont, Dominic M.; Bernard, Sharon G.; Bit, Rino A.; Campbell, Simon P.; Chung, Chun-wa; Cutler, Leanne; Demont, Emmanuel H.; Dennis, Kate; Gordon, Laurie; Gray, James R.; Haase, Michael, V; Lewis, Antonia J.; McCleary, Scott; Mitchell, Darren J.; Moore, Susanne M.; Parr, Nigel; Robb, Olivia J.; Smithers, Nicholas; Soden, Peter E.; Suckling, Colin J.; Taylor, Simon; Walker, Ann L.; Watson, Robert J.; Prinjha, Rab K.
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-07-1317
PRE
Seal, Jonathan T.; Atkinson, Stephen J.; Bamborough, Paul; Bassil, Anna; Chung, Chun-Wa; Foley, James; Gordon, Laurie; Grandi, Paola; Gray, James R. J.; Harrison, Lee A.; Kruger, Ryan G.; Matteo, Jeanne J.; McCabe, Michael T.; Messenger, Cassie; Mitchell, Darren; Phillipou, Alex; Preston, Alex; Prinjha, Rab K.; Rianjongdee, Francesco; Rioja, Inmaculada; Taylor, Simon; Wall, Ian D.; Watson, Robert J.; Woolven, James M.; Wyce, Anastasia; Zhang, Xi-Ping; Demont, Emmanuel H.
Identification of a Series of N-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-07-0716
PREAI
Harrison, Lee A.; Atkinson, Stephen J.; Bassil, Anna; Chung, Chun-wa; Grandi, Paola; Gray, James R. J.; Levernier, Etienne; Lewis, Antonia; Lugo, David; Messenger, Cassie; Michon, Anne-Marie; Mitchell, Darren J.; Preston, Alex; Prinjha, Rab K.; Rioja, Inmaculada; Seal, Jonathan T.; Taylor, Simon; Wall, Ian D.; Watson, Robert J.; Woolven, James M.; Demont, Emmanuel H.
Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-03-0419
PREAI
Aylott, Helen E.; Atkinson, Stephen J.; Bamborough, Paul; Bassil, Anna; Chung, Chun-wa; Gordon, Laurie; Grandi, Paola; Gray, James R. J.; Harrison, Lee A.; Hayhow, Thomas G.; Messenger, Cassie; Mitchell, Darren; Phillipou, Alexander; Preston, Alex; Prinjha, Rab K.; Rianjongdee, Francesco; Rioja, Inmaculada; Seal, Jonathan T.; Wall, Ian D.; Watson, Robert J.; Woolven, James M.; Demont, Emmanuel H.
Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-08-0340
OAAI
Wellaway, Christopher R.; Bamborough, Paul; Bernard, Sharon G.; Chung, Chun-wa; Craggs, Peter D.; Cutler, Leanne; Demont, Emmanuel H.; Evans, John P.; Gordon, Laurie; Karamshi, Bhumika; Lewis, Antonia J.; Lindon, Matthew J.; Mitchell, Darren J.; Rioja, Inmaculada; Soden, Peter E.; Taylor, Simon; Watson, Robert J.; Willis, Rob; Woolven, James M.; Wyspianska, Beata S.; Kerr, William J.; Prinjha, Rab K.
The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-07-2344
OAAI
Seal, Jonathan T.; Atkinson, Stephen J.; Aylott, Helen; Bamborough, Paul; Chung, Chun-wa; Copley, Royston C. B.; Gordon, Laurie; Grandi, Paola; Gray, James R. J.; Harrison, Lee A.; Hayhow, Thomas G.; Lindon, Matthew; Messenger, Cassie; Michon, Anne-Marie; Mitchell, Darren; Preston, Alex; Prinjha, Rab K.; Rioja, Inmaculada; Taylor, Simon; Wall, Ian D.; Watson, Robert J.; Woolven, James M.; Demont, Emmanuel H.
Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-07-2138
OAAI
Preston, Alex; Atkinson, Stephen; Bamborough, Paul; Chung, Chun-wa; Craggs, Peter D.; Gordon, Laurie; Grandi, Paola; Gray, James R. J.; Jones, Emma J.; Lindon, Matthew; Michon, Anne-Marie; Mitchell, Darren J.; Prinjha, Rab K.; Rianjongdee, Francesco; Rioja, Inmaculada; Seal, Jonathan; Taylor, Simon; Wall, Ian; Watson, Robert J.; Woolven, James; Demont, Emmanuel H.
GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2020-07-0625
OAAI
Preston, Alex; Atkinson, Stephen J.; Bamborough, Paul; Chung, Chun-wa; Gordon, Laurie J.; Grandi, Paola; Gray, James R. J.; Harrison, Lee A.; Lewis, Antonia J.; Lugo, David; Messenger, Cassie; Michon, Anne-Marie; Mitchell, Darren J.; Prinjha, Rab K.; Rioja, Inmaculada; Seal, Jon; Taylor, Simon; Thesmar, Pierre; Wall, Ian D.; Watson, J.; Woolven, James M.; Demont, Emmanuel H.
Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-01-0648
PREAI
Wellaway, Christopher R.; Amans, Dominique; Bamborough, Paul; Barnett, Heather; Bit, Rino A.; Brown, Jack A.; Carlson, Neil R.; Chung, Chun-wa; Cooper, Anthony W. J.; Craggs, Peter D.; Davis, Robert P.; Dean, Tony W.; Evans, John P.; Gordon, Laurie; Harada, Isobel L.; Hirst, David J.; Humphreys, Philip G.; Jones, Katherine L.; Lewis, Antonia J.; Lindon, Matthew J.; Lugo, Dave; Mahmood, Mahnoor; McCleary, Scott; Medeiros, Patricia; Mitchell, Darren J.; O'Sullivan, Michael; Le Gall, Armelle; Patel, Vipulkumar K.; Patten, Chris; Poole, Darren L.; Shah, Rishi R.; Smith, Jane E.; Stafford, Kayleigh A. J.; Thomas, Pamela J.; Vimal, Mythily; Wall, Ian D.; Watson, Robert J.; Wellaway, Natalie; Yao, Gang; Prinjha, Rab K.
A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification

取得了成功: 使用高通量筛选和命中鉴定发现了一系列具有新型结合模式的新ATAD2溴结构域抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-08-0919
PREAI
Bamborough, Paul; Chung, Chun-wa; Demont, Emmanuel H.; Bridges, Angela M.; Craggs, Peter D.; Dixon, David P.; Francis, Peter; Furze, Rebecca C.; Grandi, Paola; Jones, Emma J.; Karamshi, Bhumika; Locke, Kelly; Lucas, Simon C. C.; Michon, Anne-Marie; Mitchell, Darren J.; Pogany, Peter; Prinjha, Rab K.; Rau, Christina; Maria Roa, Ana; Roberts, Andrew D.; Sheppard, Robert J.; Watson, Robert J.
A Chemical Probe for the ATAD2 Bromodomain
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
2016-08-1765
OAAI
Bamborough, Paul; Chung, Chun-wa; Demont, Emmanuel H.; Furze, Rebecca C.; Bannister, Andrew J.; Che, Ka Hing; Diallo, Hawa; Douault, Clement; Grandi, Paola; Kouzarides, Tony; Michon, Anne-Marie; Mitchell, Darren J.; Prinjha, Rab K.; Rau, Christina; Robson, Samuel; Sheppard, Robert J.; Upton, Richard; Watson, Robert J.
GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain

GSK6853，一种抑制BRPF1溴结构域的化学探针

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2016-05-3057
OAAI
Bamborough, Paul; Barnett, Heather A.; Becher, Isabelle; Bird, Mark J.; Chung, Chun-wa; Craggs, Peter D.; Demont, Emmanuel H.; Diallo, Hawa; Fallon, David J.; Gordon, Laurie J.; Grandi, Paola; Hobbs, Clare I.; Hooper-Greenhill, Edward; Jones, Emma J.; Law, Robert P.; Le Gall, Armelle; Lugo, David; Michon, Anne-Marie; Mitchell, Darren J.; Prinjha, Rab K.; Sheppard, Robert J.; Watson, Allan J. B.; Watson, Robert J.
Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-07-0971
PREAI
Demont, Emmanuel H.; Chung, Chun-wa; Furze, Rebecca C.; Grandi, Paola; Michon, Anne-Marie; Wellaway, Chris; Barrett, Nathalie; Bridges, Angela M.; Craggs, Peter D.; Diallo, Hawa; Dixon, David P.; Douault, Clement; Emmons, Amanda J.; Jones, Emma J.; Karamshi, Bhumika V.; Locke, Kelly; Mitchell, Darren J.; Mouzon, Bernadette H.; Prinjha, Rab K.; Roberts, Andy D.; Sheppard, Robert J.; Watson, Robert J.; Bamborough, Paul

研究方向

暂未获取到该数据
R
Rab K. Prinjha
H 指数:64论文数:229被引数:1.9万
C
Chun‐wa Chung
H 指数:48论文数:141被引数:1.2万
E
Emmanuel H. Demont
H 指数:29论文数:107被引数:2,820
R
Robert J. Watson
H 指数:46论文数:208被引数:6,528
P
Paul Bamborough
H 指数:41论文数:121被引数:6,007
P
Paola Grandi
H 指数:40论文数:139被引数:1.5万
L
Laurie Gordon
H 指数:28论文数:81被引数:2,365
A
Anne‐Marie Michon
H 指数:25论文数:65被引数:1.1万
I
Inmaculada Rioja
H 指数:27论文数:63被引数:2,285
P
Peter D. Craggs
H 指数:18论文数:48被引数:1,981