未登录 Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors Bamborough, Paul; Chung, Chun-wa; Goodwin, Nicole C. C.; Mitchell, Darren J. J.; Neipp, Christopher E. E.; Phillipou, Alex; Preston, Alex; Prinjha, Rab K. K.; Soden, Peter E. E.; Watson, Robert J. J.; Demont, Emmanuel H. H. 分享 收藏
Syrian hamster convalescence from prototype SARS-CoV-2 confers measurable protection against the attenuated disease caused by the Omicron variant Ryan, Kathryn A. A.; Bewley, Kevin R. R.; Watson, Robert J. J.; Burton, Christopher; Carnell, Oliver; Cavell, Breeze E. E.; Challis, Amy; Coombes, Naomi S. S.; Davies, Elizabeth R. R.; Edun-Huges, Jack; Emery, Kirsty; Fell, Rachel; Fotheringham, Susan A. A.; Gooch, Karen E. E.; Gowan, Kathryn; Handley, Alastair; Harris, Debbie J. J.; Hesp, Richard; Hunter, Laura; Humphreys, Richard; Johnson, Rachel; Kennard, Chelsea; Knott, Daniel; Lister, Sian; Morley, Daniel; Ngabo, Didier; Osman, Karen L. L.; Paterson, Jemma; Penn, Elizabeth J. J.; Pullan, Steven T. T.; Richards, Kevin S. S.; Summers, Sian; Thomas, Stephen R. R.; Weldon, Thomas; Wiblin, Nathan R. R.; Rayner, Emma L. L.; Vipond, Richard T. T.; Hallis, Bassam; Salguero, Francisco J. J.; Funnell, Simon G. P.; Hall, Yper 分享 收藏
Activity of a Carbohydrate-Binding Module Therapy, Neumifil, against SARS-CoV-2 Disease in a Hamster Model of Infection Fell, Rachel; Potter, Jane A.; Yuille, Samantha; Salguero, Franscisco J.; Watson, Robert; Ngabo, Didier; Gooch, Karen; Hewson, Roger; Howat, David; Dowall, Stuart 分享 收藏
Influence of Aerosol Delivered BCG Vaccination on Immunological and Disease Parameters Following SARS-CoV-2 Challenge in Rhesus Macaques White, Andrew D.; Sibley, Laura; Sarfas, Charlotte; Morrison, Alexandra L.; Bewley, Kevin; Churchward, Colin; Fotheringham, Susan; Gkolfinos, Konstantinos; Gooch, Karen; Handley, Alastair; Humphries, Holly E.; Hunter, Laura; Kennard, Chelsea; Longet, Stephanie; Mabbutt, Adam; Moffatt, Miriam; Rayner, Emma; Tipton, Tom; Watson, Robert; Hall, Yper; Bodman-Smith, Mark; Gleeson, Fergus; Dennis, Mike; Salguero, Francisco J.; Carroll, Miles; McShane, Helen; Cookson, William; Hopkin, Julian; Sharpe, Sally 分享 收藏
Multigram Synthesis of Tetrasubsituted Dihydrobenzofuran GSK973 Enabled by High-Throughput Experimentation and a Claisen Rearrangement in Flow Alder, Catherine M.; Gray, Matthew; Huff, Chelsea A.; Manning, Calvin O.; Preston, Alex; Rushworth, Philip; Shuster, Leanna E.; Watson, Robert J.; Wheelhouse, Katherine M. P.; Williams, Glynn D.; Demont, Emmanuel H. 分享 收藏
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate Humphreys, Philip G.; Atkinson, Stephen J.; Bamborough, Paul; Bit, Rino A.; Chung, Chun-Wa; Craggs, Peter D.; Cutler, Leanne; Davis, Rob; Ferrie, Alan; Gong, GangLi; Gordon, Laurie J.; Gray, Matthew; Harrison, Lee A.; Hayhow, Thomas G.; Haynes, Andrea; Henley, Nick; Hirst, David J.; Holyer, Ian D.; Lindon, Matthew J.; Lovatt, Cerys; Lugo, David; McCleary, Scott; Molnar, Judit; Osmani, Qendresa; Patten, Chris; Preston, Alex; Rioja, Inmaculada; Seal, Jonathan T.; Smithers, Nicholas; Sun, Fenglai; Tang, Dalin; Taylor, Simon; Theodoulou, Natalie H.; Thomas, Clare; Watson, Robert J.; Wellaway, Christopher R.; Zhu, Linrong; Tomkinson, Nicholas C. O.; Prinjha, Rab K. 分享 收藏
Sequential Delivery of Live Attenuated Influenza Vaccine and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Ferret Model Can Reduce SARS-CoV-2 Shedding and Does Not Result in Enhanced Lung Pathology 在雪貂模型中依次递送减毒活流感疫苗和新型冠状病毒 (SARS-CoV-2) 可以减少SARS-CoV-2脱落，并且不会导致肺部病理增强 Ryan, Kathryn A.; Schewe, Katarzyna E.; Crowe, Jonathan; Fotheringham, Susan A.; Hall, Yper; Humphreys, Richard; Marriott, Anthony C.; Paterson, Jemma; Rayner, Emma; Salguero, Francisco J.; Watson, Robert J.; Whittaker, Catherine J.; Carroll, Miles W.; Dibben, Oliver 分享 收藏
Dose-Dependent Response to Infection with Ebola Virus in the Ferret Model and Evidence of Viral Evolution in the Eye Watson, Robert J.; Tree, Julia; Fotheringham, Susan A.; Hall, Yper; Dong, Xiaofeng; Steeds, Kimberley; Gouriet, Jade; Salguero, Francisco J.; Burton, Christopher; Pitman, James; Easterbrook, Linda; Richards, Kevin S.; Burton, Jane; Bewley, Kevin; Bruce, Christine; Hiscox, Julian A.; Carroll, Miles W.; Funnell, Simon G. P. 分享 收藏
Development of a Hamster Natural Transmission Model of SARS-CoV-2 Infection Dowall, Stuart; Salguero, Francisco J.; Wiblin, Nathan; Fotheringham, Susan; Hatch, Graham; Parks, Simon; Gowan, Kathryn; Harris, Debbie; Carnell, Oliver; Fell, Rachel; Watson, Robert; Graham, Victoria; Gooch, Karen; Hall, Yper; Mizen, Simon; Hewson, Roger 分享 收藏
A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19 Huo, Jiandong; Mikolajek, Halina; Le Bas, Audrey; Clark, Jordan J.; Sharma, Parul; Kipar, Anja; Dormon, Joshua; Norman, Chelsea; Weckener, Miriam; Clare, Daniel K.; Harrison, Peter J.; Tree, Julia A.; Buttigieg, Karen R.; Salguero, Francisco J.; Watson, Robert; Knott, Daniel; Carnell, Oliver; Ngabo, Didier; Elmore, Michael J.; Fotheringham, Susan; Harding, Adam; Ward, Philip N.; Dumoux, Maud; Prince, Tessa; Hall, Yper; Hiscox, Julian A.; Owen, Andrew; James, William; Carroll, Miles W.; Stewart, James P.; Naismith, James H.; Owens, Raymond J.; Moynie, Lucile 分享 收藏
Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression Jones, Katherine L.; Beaumont, Dominic M.; Bernard, Sharon G.; Bit, Rino A.; Campbell, Simon P.; Chung, Chun-wa; Cutler, Leanne; Demont, Emmanuel H.; Dennis, Kate; Gordon, Laurie; Gray, James R.; Haase, Michael, V; Lewis, Antonia J.; McCleary, Scott; Mitchell, Darren J.; Moore, Susanne M.; Parr, Nigel; Robb, Olivia J.; Smithers, Nicholas; Soden, Peter E.; Suckling, Colin J.; Taylor, Simon; Walker, Ann L.; Watson, Robert J.; Prinjha, Rab K. 分享 收藏
ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models Lambe, Teresa; Spencer, Alexandra J.; Thomas, Kelly M.; Gooch, Karen E.; Thomas, Stephen; White, Andrew D.; Humphries, Holly E.; Wright, Daniel; Belij-Rammerstorfer, Sandra; Thakur, Nazia; Conceicao, Carina; Watson, Robert; Alden, Leonie; Allen, Lauren; Aram, Marilyn; Bewley, Kevin R.; Brunt, Emily; Brown, Phillip; Cavell, Breeze E.; Cobb, Rebecca; Fotheringham, Susan A.; Gilbride, Ciaran; Harris, Debbie J.; Ho, Catherine M. K.; Hunter, Laura; Kennard, Chelsea L.; Leung, Stephanie; Lucas, Vanessa; Ngabo, Didier; Ryan, Kathryn A.; Sharpe, Hannah; Sarfas, Charlotte; Sibley, Laura; Slack, Gillian S.; Ulaszewska, Marta; Wand, Nadina; Wiblin, Nathan R.; Gleeson, Fergus V.; Bailey, Dalan; Sharpe, Sally; Charlton, Sue; Salguero, Francisco J.; Carroll, Miles W.; Gilbert, Sarah C. 分享 收藏
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors Lucas, Simon C. C.; Atkinson, Stephen J.; Chung, Chun-Wa; Davis, Rob; Gordon, Laurie; Grandi, Paola; Gray, James J. R.; Grimes, Thomas; Phillipou, Alexander; Preston, Alex G.; Prinjha, Rab K.; Rioja, Inmaculada; Taylor, Simon; Tomkinson, Nicholas C. O.; Wall, Ian; Watson, Robert J.; Woolven, James; Demont, Emmanuel H. 分享 收藏
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors Seal, Jonathan T.; Atkinson, Stephen J.; Bamborough, Paul; Bassil, Anna; Chung, Chun-Wa; Foley, James; Gordon, Laurie; Grandi, Paola; Gray, James R. J.; Harrison, Lee A.; Kruger, Ryan G.; Matteo, Jeanne J.; McCabe, Michael T.; Messenger, Cassie; Mitchell, Darren; Phillipou, Alex; Preston, Alex; Prinjha, Rab K.; Rianjongdee, Francesco; Rioja, Inmaculada; Taylor, Simon; Wall, Ian D.; Watson, Robert J.; Woolven, James M.; Wyce, Anastasia; Zhang, Xi-Ping; Demont, Emmanuel H. 分享 收藏
Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit Rianjongdee, Francesco; Atkinson, Stephen J.; Chung, Chun-Wa; Grandi, Paola; Gray, James R. J.; Kaushansky, Laura J.; Medeiros, Patricia; Messenger, Cassie; Phillipou, Alex; Preston, Alex; Prinjha, Rab K.; Rioja, Inmaculada; Satz, Alexander L.; Taylor, Simon; Wall, Ian D.; Watson, Robert J.; Yao, Gang; Demont, Emmanuel H. 分享 收藏
Identification of a Series of N-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins Harrison, Lee A.; Atkinson, Stephen J.; Bassil, Anna; Chung, Chun-wa; Grandi, Paola; Gray, James R. J.; Levernier, Etienne; Lewis, Antonia; Lugo, David; Messenger, Cassie; Michon, Anne-Marie; Mitchell, Darren J.; Preston, Alex; Prinjha, Rab K.; Rioja, Inmaculada; Seal, Jonathan T.; Taylor, Simon; Wall, Ian D.; Watson, Robert J.; Woolven, James M.; Demont, Emmanuel H. 分享 收藏
Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors Aylott, Helen E.; Atkinson, Stephen J.; Bamborough, Paul; Bassil, Anna; Chung, Chun-wa; Gordon, Laurie; Grandi, Paola; Gray, James R. J.; Harrison, Lee A.; Hayhow, Thomas G.; Messenger, Cassie; Mitchell, Darren; Phillipou, Alexander; Preston, Alex; Prinjha, Rab K.; Rianjongdee, Francesco; Rioja, Inmaculada; Seal, Jonathan T.; Wall, Ian D.; Watson, Robert J.; Woolven, James M.; Demont, Emmanuel H. 分享 收藏
Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19 Salguero, Francisco J.; White, Andrew D.; Slack, Gillian S.; Fotheringham, Susan A.; Bewley, Kevin R.; Gooch, Karen E.; Longet, Stephanie; Humphries, Holly E.; Watson, Robert J.; Hunter, Laura; Ryan, Kathryn A.; Hall, Yper; Sibley, Laura; Sarfas, Charlotte; Allen, Lauren; Aram, Marilyn; Brunt, Emily; Brown, Phillip; Buttigieg, Karen R.; Cavell, Breeze E.; Cobb, Rebecca; Coombes, Naomi S.; Darby, Alistair; Daykin-Pont, Owen; Elmore, Michael J.; Garcia-Dorival, Isabel; Gkolfinos, Konstantinos; Godwin, Kerry J.; Gouriet, Jade; Halkerston, Rachel; Harris, Debbie J.; Hender, Thomas; Ho, Catherine M. K.; Kennard, Chelsea L.; Knott, Daniel; Leung, Stephanie; Lucas, Vanessa; Mabbutt, Adam; Morrison, Alexandra L.; Nelson, Charlotte; Ngabo, Didier; Paterson, Jemma; Penn, Elizabeth J.; Pullan, Steve; Taylor, Irene; Tipton, Tom; Thomas, Stephen; Tree, Julia A.; Turner, Carrie; Vamos, Edith; Wand, Nadina; Wiblin, Nathan R.; Charlton, Sue; Dong, Xiaofeng; Hallis, Bassam; Pearson, Geoffrey; Rayner, Emma L.; Nicholson, Andrew G.; Funnell, Simon G.; Hiscox, Julian A.; Dennis, Mike J.; Gleeson, Fergus, V; Sharpe, Sally; Carroll, Miles W. 分享 收藏
Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity Ryan, Kathryn A.; Bewley, Kevin R.; Fotheringham, Susan A.; Slack, Gillian S.; Brown, Phillip; Hall, Yper; Wand, Nadina, I; Marriott, Anthony C.; Cavell, Breeze E.; Tree, Julia A.; Allen, Lauren; Aram, Marilyn J.; Bean, Thomas J.; Brunt, Emily; Buttigieg, Karen R.; Carter, Daniel P.; Cobb, Rebecca; Coombes, Naomi S.; Findlay-Wilson, Steve J.; Godwin, Kerry J.; Gooch, Karen E.; Gouriet, Jade; Halkerston, Rachel; Harris, Debbie J.; Hender, Thomas H.; Humphries, Holly E.; Hunter, Laura; Ho, Catherine M. K.; Kennard, Chelsea L.; Leung, Stephanie; Longet, Stephanie; Ngabo, Didier; Osman, Karen L.; Paterson, Jemma; Penn, Elizabeth J.; Pullan, Steven T.; Rayner, Emma; Skinner, Oliver; Steeds, Kimberley; Taylor, Irene; Tipton, Tom; Thomas, Stephen; Turner, Carrie; Watson, Robert J.; Wiblin, Nathan R.; Charlton, Sue; Hallis, Bassam; Hiscox, Julian A.; Funnell, Simon; Dennis, Mike J.; Whittaker, Catherine J.; Catton, Michael G.; Druce, Julian; Salguero, Francisco J.; Carroll, Miles W. 分享 收藏
Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model Proud, Pamela C.; Tsitoura, Daphne; Watson, Robert J.; Chua, Brendon Y.; Aram, Marilyn J.; Bewley, Kevin R.; Cavell, Breeze E.; Cobb, Rebecca; Dowall, Stuart; Fotheringham, Susan A.; Ho, Catherine M. K.; Lucas, Vanessa; Ngabo, Didier; Rayner, Emma; Ryan, Kathryn A.; Slack, Gillian S.; Thomas, Stephen; Wand, Nadina, I; Yeates, Paul; Demaison, Christophe; Zeng, Weiguang; Holmes, Ian; Jackson, David C.; Bartlett, Nathan W.; Mercuri, Francesca; Carroll, Miles W. 分享 收藏
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