未登录 IDE161, a potential first-in-class clinical candidate PARG inhibitor, selectively targets homologous-recombination-deficient and PARP inhibitor resistant breast and ovarian tumors Abed, Monah; Munoz, Diana; Seshadri, Vidya; Federowicz, Steve; Rao, Arjun A.; Bhupathi, Deepthi; Liimatta, Marya; Ousterhout, Rita; Jaipuri, Firoz; Neilan, Claire; Lackner, Mark; White, Mike; Mounir, Zineb 分享 收藏
Discovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis Nara, Susheel J.; Jogi, Srinivas; Cheruku, Srinivas; Kandhasamy, Sarkunam; Jaipuri, Firoz; Kathi, Pavan Kalyan; Reddy, Subba; Sarodaya, Sanket; Cook, Erica M.; Wang, Tao; Sitkoff, Doree; Rossi, Karen A.; Ruzanov, Max; Kiefer, Susan E.; Khan, Javed A.; Gao, Mian; Reddy, Satyanarayana; Sivaprasad, Sankara L. V. J.; Sane, Ramola; Mosure, Kathy; Zhuo, Xiaoliang; Cao, Gary G.; Ziegler, Milinda; Azzara, Anthony; Krupinski, John; Soars, Matthew G.; Ellsworth, Bruce A.; Wacker, Dean A. 分享 收藏
Discovery of indoximod prodrugs and characterization of clinical candidate NLG802 Kumar, Sanjeev; Jaipuri, Firoz A.; Waldo, Jesse P.; Potturi, Hima; Marcinowicz, Agnieszka; Adams, James; Van Allen, Clarissa; Zhuang, Hong; Vahanian, Nicholas; Link, Charles, Jr.; Brincks, Erik L.; Mautino, Mario R. 分享 收藏
Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors 实施CYP指数设计选择性色氨酸-2，3-双加氧酶抑制剂 Parr, Brendan T.; Pastor, Richard; Sellers, Benjamin D.; Pei, Zhonghua; Jaipuri, Firoz A.; Castanedo, Georgette M.; Gazzard, Lewis; Kumar, Sanjeev; Li, Xiaokai; Liu, Wen; Mendonca, Rohan; Pavana, Roheeth K.; Potturi, Hima; Shao, Cheng; Velvadapu, Venkata; Waldo, Jesse P.; Wu, Guosheng; Yuen, Po-wai; Zhang, Zuhui; Zhang, Yamin; Harris, Seth F.; Oh, Angela J.; DiPasquale, Antonio; Dement, Kevin; La, Hank; Goon, Leanne; Gustafson, Amy; VanderPorten, Erica C.; Mautino, Mario R.; Liu, Yichin 分享 收藏
Discovery of Clinical Candidate (1R,4r)-44(R)-24(S)-6-Fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a Potent and Selective Inhibitor of Indoleamine 2,3-Dioxygenase 1 临床候选药物 (1R，4r)-44(R)-24(S)-6-氟-5h-咪唑并 [5，1-a]isoindol-5-yl)-1-羟乙基) cyclohexan-1-ol (Navoximod) 的发现，吲哚胺2，3-双加氧酶1的有效和选择性抑制剂 Kumar, Sanjeev; Waldo, Jesse P.; Jaipuri, Firoz A.; Marcinowicz, Agnieszka; Van Allen, Clarissa; Adams, James; Kesharwani, Tanay; Zhang, Xiaoxia; Metz, Richard; Oh, Angela J.; Harris, Seth F.; Mautino, Mario R. 分享 收藏
A novel prodrug of indoximod with enhanced pharmacokinetic properties Mautino, Mario R.; Kumar, Sanjeev; Zhuang, Hong; Waldo, Jesse; Jaipuri, Firoz; Potturi, Hima; Brincks, Erik; Adams, James; Marcinowicz, Agnieszka; Van Allen, Clarissa; Vahanian, Nicholas; Link, Charles J. 分享 收藏
Novel specific- and dual-tryptophan-2,3-dioxygenase (TDO) and indoleamine-2,3-dioxygenase (IDO) inhibitors for tumor immunotherapy Mautino, Mario R.; Metz, Richard A.; Jaipuri, Firoz; Waldo, Jesse; Kumar, Sanjeev; Marcinowicz-Flick, Agnieszka; Potturi, Hima; Adams, James T.; Van Allen, Clarissa; Vahanian, Nicholas N.; Link, Charles J. 分享 收藏
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