Mengzhu Zheng

hai nan university

H指数:19

被引数:3,956

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Recent advances in antitumor indole-chalcone derivatives: a mini review

抗肿瘤吲哚查尔酮衍生物的最新进展：一篇简短综述

European Journal of Pharmacology

IF4.7

2025-12-190

PRE

CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes

ADVANCED SCIENCE

IF14.1

2025-11-010

OAAI

Therapeutic Effects and Mechanisms of Baikudong Decoction in Colorectal Cancer: Insights from Network Pharmacology and Experimental Validation

白苦冬汤在结直肠癌中的治疗作用与机制：网络药理学与实验验证的启示

WORLD JOURNAL OF TRADITIONAL CHINESE MEDICINE

IF3.2

2025-10-010

PRE

Discovery of novel pyrimidinetrione derivatives as DprE1 inhibitors with potent antimycobacterial activities

发现具有有效抗分枝杆菌活性的新型嘧啶三酮衍生物作为DprE1抑制剂

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2025-05-010

PRE

Synthesis, biological evaluation and mechanism study of a novel indole-pyridine chalcone derivative as antiproliferative agent against tumor cells through dual targeting tubulin and HK2

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2025-01-010

PRE

Design, synthesis and biological evaluation of dual inhibitors targeting AR/ AR-Vs and PARP1 in castration resistant prostate cancer therapy

BIOMEDICINE & PHARMACOTHERAPY

IF7.5

2024-11-010

OAAI

Sestrin2 plays a protective role in age-related hearing loss by inhibiting NLRP3-inflammasome activity

Sestrin2通过抑制NLRP3-inflammasome活动在年龄相关性听力损失中发挥保护作用

MECHANISMS OF AGEING AND DEVELOPMENT

IF5.1

2024-10-011

PRE

PD-L1/SHP2 dual PROTACs inhibit melanoma by enhancing T-cell killing activity

PD-L1/SHP2双PROTACs通过增强T细胞杀伤活性抑制黑色素瘤

CHINESE CHEMICAL LETTERS

IF8.9

2024-08-010

PRE

Site-Selective Synthesis of Antitumor C5-Aminated Indoles via Neighboring Aldehyde Group Assisted Catellani Reaction

ORGANIC LETTERS

IF5

2023-12-183

PRE

Design, synthesis, and evaluation of PD-L1 degraders to enhance T cell killing activity against melanoma

CHINESE CHEMICAL LETTERS

IF8.9

2023-05-0130

PRE

The development of New Delhi metallo-?-lactamase-1 inhibitors since 2018

新德里金属lactamase-1抑制剂2018年的发展

MICROBIOLOGICAL RESEARCH

IF6.9

2022-08-018

OAAI

5-Hydroxymethylcytosine profiles in plasma cell-free DNA reflect molecular characteristics of diabetic kidney disease

FRONTIERS IN ENDOCRINOLOGY

IF4.6

2022-07-293

OAAI

Proteolysis-targeting chimera molecules targeting SHP2

靶向SHP2的蛋白水解靶向嵌合体分子

FUTURE MEDICINAL CHEMISTRY

IF3.4

2022-03-176

PRE

Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1 (vol 36, 116095, 2021)

来自饮食番茄的Withanolides通过靶向突变IDH1来抑制HT1080癌细胞的生长 (第36卷，116095卷，2021)

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2022-03-010

PRE

Glutamic oxaloacetic transaminase 1 as a potential target in human cancer

谷氨酸草酰乙酸转氨酶1作为人类癌症的潜在靶标

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2022-02-0113

PRE

Chemical Components of the Fruits of Morus nigra Linn.: Methyl Caffeate as a Potential Anticancer Agent by Targeting 3-Phosphoglycerate Dehydrogenase

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

IF6.2

2021-10-1914

PREAI

A natural DYRK1A inhibitor as a potential stimulator for β-cell proliferation in diabetes

CLINICAL AND TRANSLATIONAL MEDICINE

IF6.8

2021-07-199

OAAI

Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-05-26125

PREAI

Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2021-04-018

PREAI

3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment

CELLULAR ONCOLOGY

IF4.8

2021-03-1821

PRE

Mengzhu Zheng

个人简介

教育背景

工作经历

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