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Christopher M. Flores

janssen r&d us

39H指数
127论文数
5.4K被引数
收录论文 26
发表时间
First-in-human study to evaluate the safety, tolerability and pharmacokinetics of a novel analgesic and antipyretic drug with structural similarity to acetaminophen
err2022-10-01
err2
PREAI
errGelotte, Cathy K.; Vakil, Amy M.; Berwaerts, Joris; Zimmerman, Brenda A.; Eichenbaum, Gary E.; Flores, Christopher M.; Kuffner, Edwin K.
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Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl) piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor
err2020-03-01
err20
errOAAI
errWyatt, Ryan M.; Fraser, Ian; Welty, Natalie; Lord, Brian; Wennerholm, Michelle; Sutton, Steven; Ameriks, Michael K.; Dugovic, Christine; Yun, Sujin; White, Allison; Nguyen, Leslie; Koudriakova, Tatiana; Tian, Gaochao; Suarez, Javier; Szewczuk, Lawrence; Bonnette, William; Ahn, Kay; Ghosh, Brahma; Flores, Christopher M.; Connolly, Peter J.; Zhu, Bin; Macielag, Mark J.; Brandt, Michael R.; Chevalier, Kristen; Zhang, Sui-Po; Lovenberg, Timothy; Bonaventure, Pascal
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Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity (vol 56, pg 1153, 2015)
err2019-03-01
err4
errOAAI
errDouglass, John D.; Zhou, Yin Xiu; Wu, Amy; Zadroga, John A.; Gajda, Angela M.; Lackey, Atreju I.; Lang, Wensheng; Chevalier, Kristen M.; Sutton, Steven W.; Zhang, Sui-Po; Flores, Christopher M.; Connelly, Margery A.; Storch, Judith
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Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine
err2018-05-25
err23
errOAAI
errHaanes, Kristian A.; Labastida-Ramirez, Alejandro; Chan, Kayi Y.; de Vries, Rene; Shook, Brian; Jackson, Paul; Zhang, Jimmy; Flores, Christopher M.; Danser, Alexander H. J.; Villalon, Carlos M.; MaassenVanDenBrink, Antoinette
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Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity
err2015-06-01
err53
errOAAI
errDouglass, John D.; Zhou, Yin Xiu; Wu, Amy; Zadrogra, John A.; Gajda, Angela M.; Lackey, Atreju I.; Lang, Wensheng; Chevalier, Kristen M.; Sutton, Steven W.; Zhang, Sui-Po; Flores, Christopher M.; Connelly, Margery A.; Storch, Judith
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Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)
err2015-04-15
err39
PREAI
errParsons, William H.; Calvo, Raul R.; Cheung, Wing; Lee, Yu-Kai; Patel, Sharmila; Liu, Jian; Youngman, Mark A.; Dax, Scott L.; Stone, Dennis; Qin, Ning; Hutchinson, Tasha; Lubin, Mary Lou; Zhang, Sui-Po; Finley, Michael; Liu, Yi; Brandt, Michael R.; Flores, Christopher M.; Player, Mark R.
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Transient Receptor Potential Melastatin 8 Channel Inhibition Potentiates the Hypothermic Response to Transient Receptor Potential Vanilloid 1 Activation in the Conscious Mouse
err2014-05-01
err17
errOAAI
errFeketa, Viktor V.; Zhang, Yi; Cao, Zhijuan; Balasubramanian, Adithya; Flores, Christopher M.; Player, Mark R.; Marrelli, Sean P.
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Design and Optimization of Benzimidazole-Containing Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists
err2010-12-03
err65
PREAI
errParks, Daniel J.; Parsons, William H.; Colburn, Raymond W.; Meegalla, Sanath K.; Ballentine, Shelley K.; Illig, Carl R.; Qin, Ning; Liu, Yi; Hutchinson, Tasha L.; Lubin, Mary Lou; Stone, Dennis J., Jr.; Baker, Judith F.; Schneider, Craig R.; Ma, Jianya; Damiano, Bruce P.; Flores, Christopher M.; Player, Mark R.
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Ex vivo delta opioid receptor autoradiography: CNS receptor occupancy of two novel compounds over their antihyperalgesic dose range
err2010-08-01
err8
PREAI
errCodd, Ellen E.; Ma, Jianya; Zhang, Sui-Po; Stone, Dennis J., Jr.; Colburn, Raymond W.; Brandt, Michael R.; Chevalier, Kristen M.; Zhu, Yongxin; Peng, Sean; Cai, Chaozhong; Acton, Paul D.; Flores, Christopher M.
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Diabetogenic Effect of a Series of Tricyclic Delta Opioid Agonists Structurally Related to Cyproheptadine
err2010-07-08
err4
PREAI
errCodd, Ellen E.; Baker, Judith; Brandt, Michael R.; Bryant, Stewart; Cai, Chaozhong; Carson, John R.; Chevalier, Kristen M.; Colburn, Raymond W.; Coogan, Timothy P.; Dax, Scott L.; DeCorte, Bart; Kemmerer, Michael; LeGrand, Edmund K.; Lenhard, James M.; Leone, Angelique M.; Lin, Ling; Mabus, John R.; McDonnell, Mark E.; McMillian, Michael K.; McNally, James J.; Stone, Dennis J., Jr.; Wang, Charles Y.; Zhang, Sui-Po; Flores, Christopher M.
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JNJ-20788560 [9-(8-Azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic Acid Diethylamide], a Selective Delta Opioid Receptor Agonist, Is a Potent and Efficacious Antihyperalgesic Agent That Does Not Produce Respiratory Depression, Pharmacologic Tolerance, or Physical Dependence
err2009-04-01
err68
PREAI
errCodd, Ellen E.; Carson, John R.; Colburn, Raymond W.; Stone, Dennis J.; Van Besien, Christopher R.; Zhang, Sui-Po; Wade, Paul R.; Gallantine, Elizabeth L.; Meert, Theo F.; Molino, Lory; Pullan, Shirley; Razler, Christine M.; Dax, Scott L.; Flores, Christopher M.
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Attenuated cold sensitivity in TRPM8 null mice
errNEURON
IF15
err2007-05-01
err666
errOAAI
errColburn, Raymond W.; Lubin, Mary Lou; Stone, Dennis J., Jr.; Wang, Yan; Lawrence, Danielle; D'Andrea, Michael R.; Brandt, Michael R.; Liu, Yi; Flores, Christopher M.; Qin, Ning
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Activation properties of heterologously expressed mammalian TRPV2 - Evidence for species dependence
err2007-05-01
err153
errOAAI
errNeeper, Michael P.; Liu, Yi; Hutchinson, Tasha L.; Wang, Yan; Flores, Christopher M.; Qin, Ning
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Attenuation of capsaicin-evoked mechanical allodynia by peripheral neuropeptide YY1 receptors
errPAIN
IF5.5
err2006-09-01
err48
PREAI
errGibbs, Jennifer L.; Flores, Christopher M.; Hargreaves, Kenneth M.
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