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J

James Herrington

bristol-myers squibb
H指数:36
被引数:4,311
浏览量:0

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Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-Bβ
MOLECULAR AND CELLULAR BIOLOGY
IF2.7
2023-03-2764
OAAI
Rui, LY; Gunter, DR; Herrington, J; Carter-Su, C
Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2022-12-012
OAAI
Gannam, Zira T. K.; Jamali, Haya; Kweon, Oh Sang; Herrington, James; Shillingford, Shanelle R.; Papini, Christina; Gentzel, Erik; Lolis, Elias; Bennett, Anton M.; Ellman, Jonathan A.; Anderson, Karen S.
An allosteric site on MKP5 reveals a strategy for small-molecule inhibition
SCIENCE SIGNALING
IF6.6
2020-08-2514
OAAI
Gannam, Zachary T. K.; Min, Kisuk; Shillingford, Shanelle R.; Zhang, Lei; Herrington, James; Abriola, Laura; Gareiss, Peter C.; Pantouris, Georgios; Tzouvelekis, Argyrios; Kaminski, Naftali; Zhang, Xinbo; Yu, Jun; Jamali, Haya; Ellman, Jonathan A.; Lolis, Elias; Anderson, Karen S.; Bennett, Anton M.
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain (vol 62, pg 831, 2019)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-02-080
PREAI
Luo, Guanglin; Chen, Ling; Easton, Amy; Newton, Amy; Bourin, Clotilde; Shields, Eric; Mosure, Kathy; Soars, Matthew G.; Knox, Ronald J.; Matchett, Michele; Pieschl, Rick L.; Post-Munson, Debra J.; Wang, Shuya; Herrington, James; Graef, John; Newberry, Kimberly; Sivarao, Digavalli V.; Senapati, Arun; Bristow, Linda J.; Meanwell, Nicholas A.; Thompson, Lorin A.; Dzierba, Carolyn
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain

吲哚-和吲唑-酰基磺酰胺作为治疗疼痛的有效和选择性NaV1.7抑制剂的发现

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-12-2124
PREAI
Luo, Guanglin; Chen, Ling; Easton, Amy; Newton, Amy; Bourin, Clotilde; Shields, Eric; Mosure, Kathy; Soars, Matthew G.; Knox, Ronald J.; Matchett, Michele; Pieschl, Rick L.; Post-Munson, Debra J.; Wang, Shuya; Herrington, James; Graef, John; Newberry, Kimberly; Sivarao, Digavalli V.; Senapati, Arun; Bristow, Linda J.; Meanwell, Nicholas A.; Thompson, Lorin A.; Dzierba, Carolyn
Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation

发现非两性离子芳基磺酰胺作为Nav1.7抑制剂，在临床前行为模型和疼痛神经元激活的转化措施中具有功效

BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2017-10-0122
PREAI
Wu, Yong-Jin; Guernon, Jason; McClure, Andrea; Luo, Guanglin; Rajamani, Ramkumar; Ng, Alicia; Easton, Amy; Newton, Amy; Bourin, Clotilde; Parker, Dawn; Mosure, Kathleen; Barnaby, Omar; Soars, Matthew G.; Knox, Ronald J.; Matchett, Michele; Pieschl, Rick; Herrington, James; Chen, Ping; Sivarao, D. V.; Bristow, Linda J.; Meanwell, Nicholas A.; Bronson, Joanne; Olson, Richard; Thompson, Lorin A.; Dzierba, Carolyn
A Functional NaV1.7-NaVAb Chimera with a Reconstituted High-Affinity ProTx-II Binding Site
MOLECULAR PHARMACOLOGY
IF3
2017-09-0111
OAAI
Rajamani, Ramkumar; Wu, Sophie; Rodrigo, Iyoncy; Gao, Mian; Low, Simon; Megson, Lisa; Wensel, David; Pieschl, Rick L.; Post-Munson, Debra J.; Watson, John; Langley, David R.; Ahlijanian, Michael K.; Bristow, Linda J.; Herrington, James
Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents
EUROPEAN JOURNAL OF PHARMACOLOGY
IF4.7
2017-07-0122
PREAI
Pieschl, Rick L.; Miller, Regina; Jones, Kelli M.; Post-Munson, Debra J.; Chen, Ping; Newberry, Kimberly; Benitex, Yulia; Molski, Thaddeus; Morgan, Daniel; McDonald, Ivar M.; Macor, John E.; Olson, Richard E.; Asaka, Yukiko; Digavalli, Siva; Easton, Amy; Herrington, James; Westphal, Ryan S.; Lodge, Nicholas J.; Zaczek, Robert; Bristow, Linda J.; Li, Yu-Wen
Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-03-1044
PREAI
Wu, Yong-Jin; Guernon, Jason; Shi, Jianliang; Ditta, Jonathan; Robbins, Kevin J.; Rajamani, Ramkumar; Easton, Amy; Newton, Amy; Bourin, Clotilde; Mosure, Kathleen; Soars, Matthew G.; Knox, Ronald J.; Matchett, Michele; Pieschl, Rick L.; Post-Munson, Debra J.; Wang, Shuya; Herrington, James; Graef, John; Newberry, Kimberly; Bristow, Linda J.; Meanwell, Nicholas A.; Olson, Richard; Thompson, Lorin A.; Dzierba, Carolyn
B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor

B-973，α7烟碱型乙酰胆碱受体的新型哌嗪正变构调节剂

EUROPEAN JOURNAL OF PHARMACOLOGY
IF4.7
2017-03-0118
PREAI
Post-Munson, Debra J.; Pieschl, Rick L.; Molski, Thaddeus F.; Graef, John D.; Hendricson, Adam W.; Knox, Ronald J.; McDonald, Ivar M.; Olson, Richard E.; Macor, John E.; Weed, Michael R.; Bristow, Linda J.; Kiss, Laszlo; Ahlijanian, Michael K.; Herrington, James
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-03-0888
PREAI
Volgraf, Matthew; Sellers, Benjamin D.; Jiang, Yu; Wu, Guosheng; Ly, Cuong Q.; Villemure, Elisia; Pastor, Richard M.; Yuen, Po-wai; Lu, Aijun; Luo, Xifeng; Liu, Mingcui; Zhang, Shun; Sun, Liang; Fu, Yuhong; Lupardus, Patrick J.; Wallweber, Heidi J. A.; Liederer, Bianca M.; Deshmukh, Gauri; Plise, Emile; Tay, Suzanne; Reynen, Paul; Herrington, James; Gustafson, Amy; Liu, Yichin; Dirksen, Akim; Dietz, Matthias G. A.; Liu, Yanzhou; Wang, Tzu-Ming; Hanson, Jesse E.; Hackos, David; Scearce-Levie, Kimberly; Schwarz, Jacob B.
A KV2.1 gating modifier binding assay suitable for high throughput screening
CHANNELS
IF3.2
2014-10-2711
OAAI
Schmalhofer, William A.; Ratliff, Kevin S.; Weinglass, Adam B.; Kaczorowski, Gregory J.; Garcia, Maria L.; Herrington, James
Improved Cav2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2013-09-1317
OA
Shao, Pengcheng P.; Ye, Feng; Chakravarty, Prasun K.; Herrington, James B.; Dai, Ge; Bugianesi, Randal M.; Haedo, Rodolfo J.; Swensen, Andrew M.; Warren, Vivien A.; Smith, McHardy M.; Garcia, Maria L.; McManus, Owen B.; Lyons, Kathryn A.; Li, Xiaohua; Green, Mitchell; Jochnowitz, Nina; McGowan, Erin; Mistry, Shruti; Sun, Shu-Yu; Abbadie, Catherine; Kaczorowski, Gregory J.; Duffy, Joseph L.
The Role of Voltage-Gated Potassium Channels Kv2.1 and Kv2.2 in the Regulation of Insulin and Somatostatin Release from Pancreatic Islets
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
2013-02-0165
PREAI
Li, Xiaoyan (Nina); Herrington, James; Petrov, Aleksandr; Ge, Lan; Eiermann, George; Xiong, Yusheng; Jensen, Mette V.; Hohmeier, Hans E.; Newgard, Christopher B.; Garcia, Maria L.; Wagner, Michael; Zhang, Bei B.; Thornberry, Nancy A.; Howard, Andrew D.; Kaczorowski, Gregory J.; Zhou, Yun-Ping
Aminopiperidine Sulfonamide Cav2.2 Channel Inhibitors for the Treatment of Chronic Pain
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2012-11-1227
PREAI
Shao, Pengcheng P.; Ye, Feng; Chakravarty, Prasun K.; Varughese, Deepu J.; Herrington, James B.; Dai, Ge; Bugianesi, Randal M.; Haedo, Rodolfo J.; Swensen, Andrew M.; Warren, Vivien A.; Smith, McHardy M.; Garcia, Maria L.; McManus, Owen B.; Lyons, Kathn A.; Li, Xiaohua; Green, Mitchell; Jochnowitz, Nina; McGowan, Erin; Mistry, Shruti; Sun, Shu-Yu; Abbadie, Catherine; Kaczorowski, Gregory J.; Duffy, Joseph L.
Characterization of the Substituted N-Triazole Oxindole TROX-1, a Small-Molecule, State-Dependent Inhibitor of Cav2 Calcium Channels
MOLECULAR PHARMACOLOGY
IF3
2012-03-0151
PREAI
Swensen, Andrew M.; Herrington, James; Bugianesi, Randal M.; Dai, Ge; Haedo, Rodolfo J.; Ratliff, Kevin S.; Smith, McHardy M.; Warren, Vivien A.; Arneric, Stephen P.; Eduljee, Cyrus; Parker, David; Snutch, Terrance P.; Hoyt, Scott B.; London, Clare; Duffy, Joseph L.; Kaczorowski, Gregory J.; McManus, Owen B.
Identification of Novel and Selective KV2 Channel Inhibitors
MOLECULAR PHARMACOLOGY
IF3
2011-12-0128
PREAI
Herrington, James; Solly, Kelli; Ratliff, Kevin S.; Li, Nina; Zhou, Yun-Ping; Howard, Andrew; Kiss, Laszlo; Garcia, Maria L.; McManus, Owen B.; Deng, Qiaolin; Desai, Ranjit; Xiong, Yusheng; Kaczorowski, Gregory J.
Analgesic Effects of a Substituted N-Triazole Oxindole (TROX-1), a State-Dependent, Voltage-Gated Calcium Channel 2 Blocker
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
2010-08-0186
PREAI
Abbadie, Catherine; McManus, Owen B.; Sun, Shu-Yu; Bugianesi, Randal M.; Dai, Ge; Haedo, Rodolfo J.; Herrington, James B.; Kaczorowski, Gregory J.; Smith, McHardy M.; Swensen, Andrew M.; Warren, Vivien A.; Williams, Brande; Arneric, Stephen P.; Eduljee, Cyrus; Snutch, Terrance P.; Tringham, Elizabeth W.; Jochnowitz, Nina; Liang, Annie; MacIntyre, D. Euan; McGowan, Erin; Mistry, Shruti; White, Valerie V.; Hoyt, Scott B.; London, Clare; Lyons, Kathryn A.; Bunting, Patricia B.; Volksdorf, Sylvia; Duffy, Joseph L.
Blockers of the delayed-rectifier potassium current in pancreatic β-cells enhance glucose-dependent insulin secretion
DIABETES
IF7.5
2006-04-01157
OAAI
Herrington, J; Zhou, YP; Bugianesi, RM; Dulski, PM; Feng, Y; Warren, VA; Smith, MM; Kohler, MG; Garsky, VM; Sanchez, M; Wagner, M; Raphaelli, K; Banerjee, P; Ahaghotu, C; Wunderler, D; Priest, BT; Mehl, JT; Garcia, ML; McManus, OB; Kaczorowski, GJ; Slaughter, RS
Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats
MOLECULAR PHARMACOLOGY
IF3
2006-03-0157
PREAI
Brochu, RM; Dick, IE; Tarpley, JW; McGowan, E; Gunner, D; Herrington, J; Shao, PP; Ok, D; Li, CS; Parsons, WH; Stump, GL; Regan, CP; Lynch, JJ; Lyons, KA; McManus, OB; Clark, S; Ali, Z; Kaczorowski, GJ; Martin, WJ; Priest, BT

研究方向

暂未获取到该数据
G
Gregory J. Kaczorowski
H 指数:64论文数:267被引数:1.3万
C
Christin Carter‐Su
H 指数:57论文数:153被引数:1.1万
O
Owen B. McManus
H 指数:47论文数:224被引数:7,406
M
María L. García
H 指数:88论文数:484被引数:2.7万
L
Linda J. Bristow
H 指数:42论文数:168被引数:6,710
R
Rick L. Pieschl
H 指数:19论文数:59被引数:2,125
D
Debra J. Post-Munson
H 指数:14论文数:33被引数:1,311
R
Randal M. Bugianesi
H 指数:19论文数:31被引数:1,449
A
Amy Easton
H 指数:25论文数:66被引数:4,827
L
Liangyou Rui
H 指数:52论文数:134被引数:1.1万