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O

Owen B. McManus

Johns Hopkins University
H指数:47
被引数:7,406
浏览量:0

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A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology
PAIN
IF5.5
2023-11-141
OA
Liu, Pin W.; Zhang, Hongkang; Werley, Christopher A.; Pichler, Monika; Ryan, Steven J.; Lewarch, Caitlin L.; Jacques, Jane; Grooms, Jennifer; Ferrante, Jean; Li, Guangde; Zhang, Dawei; Bremmer, Nate; Barnett, Adam; Chantre, Romina; Elder, Amy E.; Cohen, Adam E.; Williams, Luis A.; Dempsey, Graham T.; Mcmanus, Owen B.
Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-Associated Excitable Cells
FRONTIERS IN MOLECULAR NEUROSCIENCE
IF3.8
2022-07-041
OAAI
Borja, Gabriel B.; Zhang, Hongkang; Harwood, Benjamin N.; Jacques, Jane; Grooms, Jennifer; Chantre, Romina O.; Zhang, Dawei; Barnett, Adam; Werley, Christopher A.; Lu, Yang; Nagle, Steven F.; McManus, Owen B.; Dempsey, Graham T.
'Channeling' therapeutic discovery for epileptic encephalopathy through iPSC technologies
TRENDS IN PHARMACOLOGICAL SCIENCES
IF19.9
2022-05-0110
OAAI
Simkin, Dina; Ambrosi, Christina; Marshall, Kelly A.; Williams, Luis A.; Eisenberg, Jordyn; Gharib, Mennat; Dempsey, Graham T.; George, Alfred L., Jr.; McManus, Owen B.; Kiskinis, Evangelos
Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls
STEM CELL REPORTS
IF5.1
2022-04-0136
OAAI
Simkin, Dina; Papakis, Vasileios; Bustos, Bernabe, I; Ambrosi, Christina M.; Ryan, Steven J.; Baru, Valeriya; Williams, Luis A.; Dempsey, Graham T.; McManus, Owen B.; Landers, John E.; Lubbe, Steven J.; George, Alfred L., Jr.; Kiskinis, Evangelos
The Opioid Crisis and the Future of Addiction and Pain Therapeutics
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
2019-11-0178
OAAI
Coussens, Nathan P.; Sittampalam, G. Sitta; Jonson, Samantha G.; Hall, Matthew D.; Gorby, Heather E.; Tamiz, Amir P.; McManus, Owen B.; Felder, Christian C.; Rasmussen, Kurt
Inhale, exhale: Probing the inside-out mechanism of nicotine addiction using novel fluorescent sensors
JOURNAL OF GENERAL PHYSIOLOGY
IF2.9
2019-03-223
OAAI
McManus, Owen B.; Werley, Christopher A.; Dempsey, Graham T.
Scalable Measurements of Intrinsic Excitability in Human iPS Cell-Derived Excitatory Neurons Using All-Optical Electrophysiology
NEUROCHEMICAL RESEARCH
IF3.8
2019-01-0214
PREAI
Williams, Luis A.; Joshi, Vaibhav; Murphy, Michael; Ferrante, John; Werley, Christopher A.; Brookings, Theodore; McManus, Owen; Grosse, Johannes; Davies, Ceri H.; Dempsey, Graham T.
Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
IF2.8
2018-07-2437
OAAI
Coussens, Nathan P.; Sittampalam, G. Sitta; Guha, Rajarshi; Brimacombe, Kyle; Grossman, Abigail; Chung, Thomas D. Y.; Weidner, Jeffrey R.; Riss, Terry; Trask, O. Joseph; Auld, Douglas; Dahlin, Jayme L.; Devanaryan, Viswanath; Foley, Timothy L.; Mcgee, James; Kahl, Steven D.; Kales, Stephen C.; Arkin, Michelle; Baell, Jonathan; Bejcek, Bruce; Gal-Edd, Neely; Glicksman, Marcie; Haas, Joseph V.; Iversen, Philip W.; Hoeppner, Marilu; Lathrop, Stacy; Sayers, Eric; Liu, Hanguan; Trawick, Bart; Mcvey, Julie; Lemmon, Vance P.; Li, Zhuyin; McManus, Owen; Minor, Lisa; Napper, Andrew; Wildey, Mary Jo; Pacifici, Robert; Chin, William W.; Xia, Menghang; Xu, Xin; Lal-Nag, Madhu; Hall, Matthew D.; Michael, Sam; Inglese, James; Simeonov, Anton; Austin, Christopher P.
Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-04-2844
OAAI
Qu, Chunrong; Ding, Mingmin; Zhu, Yingmin; Lu, Yungang; Du, Juan; Miller, Melissa; Tian, Jinbin; Zhu, Jinmei; Xui, Jian; Wen, Meng; Er-Bu, Aga; Wan, Jule; Xiao, Yuling; Wu, Meng; McManus, Owen B.; Li, Min; Wu, Jilin; Luo, Huai-Rong; Cao, Zhengyu; Shen, Bing; Wang, Hongbo; Zhu, Michael X.; Hong, Xuechuan
Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels
BRITISH JOURNAL OF PHARMACOLOGY
IF7.7
2015-05-1142
OAAI
Zhu, Yingmin; Lu, Yungang; Qu, Chunrong; Miller, Melissa; Tian, Jinbin; Thakur, Dhananjay P.; Zhu, Jinmei; Deng, Zixin; Hu, Xianming; Wu, Meng; McManus, Owen B.; Li, Min; Hong, Xuechuan; Zhu, Michael X.; Luo, Huai-Rong
Identification and Characterization of ML352: A Novel, Noncompetitive Inhibitor of the Presynaptic Choline Transporter
ACS CHEMICAL NEUROSCIENCE
IF3.9
2015-02-0217
OAAI
Ennis, Elizabeth A.; Wright, Jane; Retzlaff, Cassandra L.; McManus, Owen B.; Lin, Zhinong; Huang, Xiaofang; Wu, Men; Li, Min; Daniels, J. Scott; Lindsley, Craig W.; Hopkins, Corey R.; Blakely, Randy D.
An old probe sheds new light on BK channel pore structure
JOURNAL OF GENERAL PHYSIOLOGY
IF2.9
2014-11-104
OAAI
McManus, Owen B.; Rothberg, Brad S.
Discovery and Characterization of 2-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl) benzamide, ML382: a Potent and Selective Positive Allosteric Modulator of MrgX1

2-(环丙烷磺酰氨基)-N-(2-乙氧基苯基) 苯甲酰胺的发现和表征，ML382: MrgX1的有效和选择性正变构调节剂

CHEMMEDCHEM
IF3.4
2014-09-109
OAAI
Wen, Wandong; Wang, Yan; Li, Zhe; Tseng, Pang-Yen; McManus, Owen B.; Wu, Meng; Li, Min; Lindsley, Craig W.; Dong, Xinzhong; Hopkins, Corey R.
HTS assays for developing the molecular pharmacology of ion channels
CURRENT OPINION IN PHARMACOLOGY
IF4.2
2014-04-0145
PREAI
McManus, Owen B.
Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay
CELLULAR SIGNALLING
IF3.7
2013-12-0128
OA
Storaska, Andrew J.; Mei, Jian P.; Wu, Meng; Li, Min; Wade, Susan M.; Blazer, Levi L.; Sjoegren, Benita; Hopkins, Corey R.; Lindsley, Craig W.; Lin, Zhihong; Babcock, Joseph J.; McManus, Owen B.; Neubig, Richard R.
Improved Cav2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2013-09-1317
OA
Shao, Pengcheng P.; Ye, Feng; Chakravarty, Prasun K.; Herrington, James B.; Dai, Ge; Bugianesi, Randal M.; Haedo, Rodolfo J.; Swensen, Andrew M.; Warren, Vivien A.; Smith, McHardy M.; Garcia, Maria L.; McManus, Owen B.; Lyons, Kathryn A.; Li, Xiaohua; Green, Mitchell; Jochnowitz, Nina; McGowan, Erin; Mistry, Shruti; Sun, Shu-Yu; Abbadie, Catherine; Kaczorowski, Gregory J.; Duffy, Joseph L.
Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2013-05-0670
OA
Yu, Haibo; Lin, Zhihong; Mattmann, Margrith E.; Zou, Beiyan; Terrenoire, Cecile; Zhang, Hongkang; Wu, Meng; McManus, Owen B.; Kass, Robert S.; Lindsley, Craig W.; Hopkins, Corey R.; Li, Min
Aminopiperidine Sulfonamide Cav2.2 Channel Inhibitors for the Treatment of Chronic Pain
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2012-11-1227
PREAI
Shao, Pengcheng P.; Ye, Feng; Chakravarty, Prasun K.; Varughese, Deepu J.; Herrington, James B.; Dai, Ge; Bugianesi, Randal M.; Haedo, Rodolfo J.; Swensen, Andrew M.; Warren, Vivien A.; Smith, McHardy M.; Garcia, Maria L.; McManus, Owen B.; Lyons, Kathn A.; Li, Xiaohua; Green, Mitchell; Jochnowitz, Nina; McGowan, Erin; Mistry, Shruti; Sun, Shu-Yu; Abbadie, Catherine; Kaczorowski, Gregory J.; Duffy, Joseph L.
Discovery of a Series of 2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as Novel Molecular Switches that Modulate Modes of Kv7.2 (KCNQ2) Channel Pharmacology: Identification of (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a Potent, Brain Penetrant Kv7.2 Channel Inhibitor
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2012-07-2630
OA
Cheung, Yiu-Yin; Yu, Haibo; Xu, Kaiping; Zou, Beiyan; Wu, Meng; McManus, Owen B.; Li, Min; Lindsley, Craig W.; Hopkins, Corey R.
Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2012-06-2848
OAAI
Zhang, Hongkang; Zou, Beiyan; Yu, Haibo; Moretti, Alessandra; Wang, Xiaoying; Yan, Wei; Babcock, Joseph J.; Bellin, Milena; McManus, Owen B.; Tomaselli, Gordon; Nan, Fajun; Laugwitz, Karl-Ludwig; Li, Min

研究方向

暂未获取到该数据
G
Gregory J. Kaczorowski
H 指数:64论文数:267被引数:1.3万
M
Meng Wu
H 指数:39论文数:206被引数:5,299
C
Corey R. Hopkins
H 指数:44论文数:280被引数:5,822
C
Craig W. Lindsley
H 指数:86论文数:1,460被引数:3.0万
M
María L. García
H 指数:88论文数:484被引数:2.7万
J
James Herrington
H 指数:36论文数:109被引数:4,311
H
Haibo Yu
H 指数:20论文数:83被引数:1,405
G
Graham T. Dempsey
H 指数:19论文数:49被引数:4,975
G
Ge Dai
H 指数:25论文数:52被引数:3,429
M
McHardy M. Smith
H 指数:34论文数:69被引数:3,860